Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
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Data de Publicação: | 2017 |
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Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/54931 http://dx.doi.org/10.3389/fimmu.2017.00224 |
Resumo: | Dimorphic fungi are agents of systemic mycoses associated with significant morbidity and frequent lethality in the Americas. Among the pathogenic species are Paracoccidioides brasiliensis and Paracoccidioides lutzii, which predominate in South America |
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Travassos, Luiz R. [UNIFESP]Taborda, Carlos P. [UNIFESP]2020-07-17T14:02:39Z2020-07-17T14:02:39Z2017Frontiers In Immunology. Lausanne, v. 8, p. -, 2017.1664-3224https://repositorio.unifesp.br/handle/11600/54931http://dx.doi.org/10.3389/fimmu.2017.00224WOS000395863200001.pdf10.3389/fimmu.2017.00224WOS:000395863200001Dimorphic fungi are agents of systemic mycoses associated with significant morbidity and frequent lethality in the Americas. Among the pathogenic species are Paracoccidioides brasiliensis and Paracoccidioides lutzii, which predominate in South AmericaHistoplasma capsulatum, Coccidioides posadasii, and Coccidioides immitis, and the Sporothrix spp. complex are other important pathogens. Associated with dimorphic fungi other important infections are caused by yeast such as Candida spp. and Cryptococcus spp. or mold such as Aspergillus spp., which are also fungal agents of deadly infections. Nowadays, the actual tendency of therapy is the development of a pan-fungal vaccine. This is, however, not easy because of the complexity of eukaryotic cells and the particularities of different species and isolates. Albeit there are several experimental vaccines being studied, we will focus mainly on peptide vaccines or epitopes of T-cell receptors inducing protective fungal responses. These peptides can be carried by antibody inducing beta-( 1,3)-glucan oligo or polysaccharides, or be mixed with them for administration. The present review discusses the efficacy of linear peptide epitopes in the context of antifungal immunization and vaccine proposition.FAPESPCAPESUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, BrazilUniv Fed Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Lab Med Mycol IMTSP HCFMUSP LIM53, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, BrazilUniv Fed Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Lab Med Mycol IMTSP HCFMUSP LIM53, Sao Paulo, BrazilFAPESP: 2016/08730-6FAPESP: 2010/51423-0Web of Science-engFrontiers Media SaFrontiers In ImmunologypeptidevaccineantibodyfungiParacoccidioidesLinear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidatesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLausanne8info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000395863200001.pdfapplication/pdf724433${dspace.ui.url}/bitstream/11600/54931/1/WOS000395863200001.pdffdc8dd891e55eb6552b956f0f2becfe0MD51open accessTEXTWOS000395863200001.pdf.txtWOS000395863200001.pdf.txtExtracted texttext/plain66725${dspace.ui.url}/bitstream/11600/54931/2/WOS000395863200001.pdf.txt10e7ea76cae74d941899d4a83f4a97edMD52open accessTHUMBNAILWOS000395863200001.pdf.jpgWOS000395863200001.pdf.jpgIM Thumbnailimage/jpeg6690${dspace.ui.url}/bitstream/11600/54931/4/WOS000395863200001.pdf.jpga9a598be306075c7b44fc6f4bcad007aMD54open access11600/549312022-08-01 05:24:04.813open accessoai:repositorio.unifesp.br:11600/54931Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-08-01T08:24:04Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates |
title |
Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates |
spellingShingle |
Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates Travassos, Luiz R. [UNIFESP] peptide vaccine antibody fungi Paracoccidioides |
title_short |
Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates |
title_full |
Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates |
title_fullStr |
Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates |
title_full_unstemmed |
Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates |
title_sort |
Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates |
author |
Travassos, Luiz R. [UNIFESP] |
author_facet |
Travassos, Luiz R. [UNIFESP] Taborda, Carlos P. [UNIFESP] |
author_role |
author |
author2 |
Taborda, Carlos P. [UNIFESP] |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Travassos, Luiz R. [UNIFESP] Taborda, Carlos P. [UNIFESP] |
dc.subject.eng.fl_str_mv |
peptide vaccine antibody fungi Paracoccidioides |
topic |
peptide vaccine antibody fungi Paracoccidioides |
description |
Dimorphic fungi are agents of systemic mycoses associated with significant morbidity and frequent lethality in the Americas. Among the pathogenic species are Paracoccidioides brasiliensis and Paracoccidioides lutzii, which predominate in South America |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-07-17T14:02:39Z |
dc.date.available.fl_str_mv |
2020-07-17T14:02:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Frontiers In Immunology. Lausanne, v. 8, p. -, 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/54931 http://dx.doi.org/10.3389/fimmu.2017.00224 |
dc.identifier.issn.none.fl_str_mv |
1664-3224 |
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WOS000395863200001.pdf |
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10.3389/fimmu.2017.00224 |
dc.identifier.wos.none.fl_str_mv |
WOS:000395863200001 |
identifier_str_mv |
Frontiers In Immunology. Lausanne, v. 8, p. -, 2017. 1664-3224 WOS000395863200001.pdf 10.3389/fimmu.2017.00224 WOS:000395863200001 |
url |
https://repositorio.unifesp.br/handle/11600/54931 http://dx.doi.org/10.3389/fimmu.2017.00224 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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Frontiers In Immunology |
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info:eu-repo/semantics/openAccess |
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openAccess |
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- |
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Lausanne |
dc.publisher.none.fl_str_mv |
Frontiers Media Sa |
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Frontiers Media Sa |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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