Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects

Detalhes bibliográficos
Autor(a) principal: Carvalho, Karina I. [UNIFESP]
Data de Publicação: 2008
Outros Autores: Maeda, Solange [UNIFESP], Marti, Luciana, Yamashita, Jane [UNIFESP], Haslett, Patrick A. J., Kallas, Esper Georges [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/handle/11600/30674
http://dx.doi.org/10.1111/j.1365-2567.2007.02756.x
Resumo: Leprosy and human immunodeficiency virus-1 (HIV-1) are examples of human infections where interactions between the pathogen and the host cellular immunity determine the clinical manifestations of disease. Hence, a significant immunopathological interaction between HIV-1 and leprosy might be expected. in the present study we explored several aspects of cellular immunity in patients co-infected with HIV-1 and Mycobacterium leprae. Twenty-eight individuals were studied, comprising four groups: healthy controls, HIV-1 and M. leprae co-infection, HIV-1 mono-infection, and M. leprae mono-infection. Subjects in the mono-infection and co-infection groups were matched as far as possible for bacillary load and HIV disease status, as appropriate. Peripheral blood mononuclear cells (PBMC) were analysed using six- and seven-colour flow cytometry to evaluate T-cell subpopulations and their activation status, dendritic cell (DC) distribution phenotypes and expression of IL-4 by T cells. the co-infected group exhibited lower CD4 : CD8 ratios, higher levels of CD8(+) T-cell activation, increased V delta 1 : V delta 2 T cell ratios and decreased percentages of plasmacytoid DC, compared with HIV-1 mono-infected subjects. Across infected groups, IL-4 production by CD4(+) T lymphocytes was positively correlated with the percentage of effector memory CD4(+) T cells, suggesting antigenically driven differentiation of this population of T cells in both HIV-1 and M. leprae infections. Co-infection with M. leprae may exacerbate the immunopathology of HIV-1 disease. A T helper 2 (Th2) bias in the CD4(+) T-cell response was evident in both HIV-1 infection and leprosy, but no additive effect was apparent in co-infected patients.
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spelling Carvalho, Karina I. [UNIFESP]Maeda, Solange [UNIFESP]Marti, LucianaYamashita, Jane [UNIFESP]Haslett, Patrick A. J.Kallas, Esper Georges [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Univ MiamiAlbert Einstein Res Inst2016-01-24T13:51:24Z2016-01-24T13:51:24Z2008-06-01Immunology. Malden: Wiley-Blackwell, v. 124, n. 2, p. 206-214, 2008.0019-2805http://repositorio.unifesp.br/handle/11600/30674http://dx.doi.org/10.1111/j.1365-2567.2007.02756.x10.1111/j.1365-2567.2007.02756.xWOS:000255924900007Leprosy and human immunodeficiency virus-1 (HIV-1) are examples of human infections where interactions between the pathogen and the host cellular immunity determine the clinical manifestations of disease. Hence, a significant immunopathological interaction between HIV-1 and leprosy might be expected. in the present study we explored several aspects of cellular immunity in patients co-infected with HIV-1 and Mycobacterium leprae. Twenty-eight individuals were studied, comprising four groups: healthy controls, HIV-1 and M. leprae co-infection, HIV-1 mono-infection, and M. leprae mono-infection. Subjects in the mono-infection and co-infection groups were matched as far as possible for bacillary load and HIV disease status, as appropriate. Peripheral blood mononuclear cells (PBMC) were analysed using six- and seven-colour flow cytometry to evaluate T-cell subpopulations and their activation status, dendritic cell (DC) distribution phenotypes and expression of IL-4 by T cells. the co-infected group exhibited lower CD4 : CD8 ratios, higher levels of CD8(+) T-cell activation, increased V delta 1 : V delta 2 T cell ratios and decreased percentages of plasmacytoid DC, compared with HIV-1 mono-infected subjects. Across infected groups, IL-4 production by CD4(+) T lymphocytes was positively correlated with the percentage of effector memory CD4(+) T cells, suggesting antigenically driven differentiation of this population of T cells in both HIV-1 and M. leprae infections. Co-infection with M. leprae may exacerbate the immunopathology of HIV-1 disease. A T helper 2 (Th2) bias in the CD4(+) T-cell response was evident in both HIV-1 infection and leprosy, but no additive effect was apparent in co-infected patients.Universidade Federal de São Paulo, São Paulo, BrazilUniv Miami, Coral Gables, FL 33124 USAAlbert Einstein Res Inst, São Paulo, BrazilUniversidade Federal de São Paulo, EPM, São Paulo, BrazilWeb of Science206-214engWiley-BlackwellImmunologyhttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlinfo:eu-repo/semantics/openAccessHIVleprosyco-infectionlymphocytesIL-4Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjectsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/306742022-07-08 10:22:02.064metadata only accessoai:repositorio.unifesp.br:11600/30674Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:17:22.362671Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects
title Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects
spellingShingle Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects
Carvalho, Karina I. [UNIFESP]
HIV
leprosy
co-infection
lymphocytes
IL-4
title_short Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects
title_full Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects
title_fullStr Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects
title_full_unstemmed Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects
title_sort Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects
author Carvalho, Karina I. [UNIFESP]
author_facet Carvalho, Karina I. [UNIFESP]
Maeda, Solange [UNIFESP]
Marti, Luciana
Yamashita, Jane [UNIFESP]
Haslett, Patrick A. J.
Kallas, Esper Georges [UNIFESP]
author_role author
author2 Maeda, Solange [UNIFESP]
Marti, Luciana
Yamashita, Jane [UNIFESP]
Haslett, Patrick A. J.
Kallas, Esper Georges [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.institution.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Univ Miami
Albert Einstein Res Inst
dc.contributor.author.fl_str_mv Carvalho, Karina I. [UNIFESP]
Maeda, Solange [UNIFESP]
Marti, Luciana
Yamashita, Jane [UNIFESP]
Haslett, Patrick A. J.
Kallas, Esper Georges [UNIFESP]
dc.subject.eng.fl_str_mv HIV
leprosy
co-infection
lymphocytes
IL-4
topic HIV
leprosy
co-infection
lymphocytes
IL-4
description Leprosy and human immunodeficiency virus-1 (HIV-1) are examples of human infections where interactions between the pathogen and the host cellular immunity determine the clinical manifestations of disease. Hence, a significant immunopathological interaction between HIV-1 and leprosy might be expected. in the present study we explored several aspects of cellular immunity in patients co-infected with HIV-1 and Mycobacterium leprae. Twenty-eight individuals were studied, comprising four groups: healthy controls, HIV-1 and M. leprae co-infection, HIV-1 mono-infection, and M. leprae mono-infection. Subjects in the mono-infection and co-infection groups were matched as far as possible for bacillary load and HIV disease status, as appropriate. Peripheral blood mononuclear cells (PBMC) were analysed using six- and seven-colour flow cytometry to evaluate T-cell subpopulations and their activation status, dendritic cell (DC) distribution phenotypes and expression of IL-4 by T cells. the co-infected group exhibited lower CD4 : CD8 ratios, higher levels of CD8(+) T-cell activation, increased V delta 1 : V delta 2 T cell ratios and decreased percentages of plasmacytoid DC, compared with HIV-1 mono-infected subjects. Across infected groups, IL-4 production by CD4(+) T lymphocytes was positively correlated with the percentage of effector memory CD4(+) T cells, suggesting antigenically driven differentiation of this population of T cells in both HIV-1 and M. leprae infections. Co-infection with M. leprae may exacerbate the immunopathology of HIV-1 disease. A T helper 2 (Th2) bias in the CD4(+) T-cell response was evident in both HIV-1 infection and leprosy, but no additive effect was apparent in co-infected patients.
publishDate 2008
dc.date.issued.fl_str_mv 2008-06-01
dc.date.accessioned.fl_str_mv 2016-01-24T13:51:24Z
dc.date.available.fl_str_mv 2016-01-24T13:51:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Immunology. Malden: Wiley-Blackwell, v. 124, n. 2, p. 206-214, 2008.
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/handle/11600/30674
http://dx.doi.org/10.1111/j.1365-2567.2007.02756.x
dc.identifier.issn.none.fl_str_mv 0019-2805
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-2567.2007.02756.x
dc.identifier.wos.none.fl_str_mv WOS:000255924900007
identifier_str_mv Immunology. Malden: Wiley-Blackwell, v. 124, n. 2, p. 206-214, 2008.
0019-2805
10.1111/j.1365-2567.2007.02756.x
WOS:000255924900007
url http://repositorio.unifesp.br/handle/11600/30674
http://dx.doi.org/10.1111/j.1365-2567.2007.02756.x
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Immunology
dc.rights.driver.fl_str_mv http://olabout.wiley.com/WileyCDA/Section/id-406071.html
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://olabout.wiley.com/WileyCDA/Section/id-406071.html
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 206-214
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv
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