Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/30674 http://dx.doi.org/10.1111/j.1365-2567.2007.02756.x |
Resumo: | Leprosy and human immunodeficiency virus-1 (HIV-1) are examples of human infections where interactions between the pathogen and the host cellular immunity determine the clinical manifestations of disease. Hence, a significant immunopathological interaction between HIV-1 and leprosy might be expected. in the present study we explored several aspects of cellular immunity in patients co-infected with HIV-1 and Mycobacterium leprae. Twenty-eight individuals were studied, comprising four groups: healthy controls, HIV-1 and M. leprae co-infection, HIV-1 mono-infection, and M. leprae mono-infection. Subjects in the mono-infection and co-infection groups were matched as far as possible for bacillary load and HIV disease status, as appropriate. Peripheral blood mononuclear cells (PBMC) were analysed using six- and seven-colour flow cytometry to evaluate T-cell subpopulations and their activation status, dendritic cell (DC) distribution phenotypes and expression of IL-4 by T cells. the co-infected group exhibited lower CD4 : CD8 ratios, higher levels of CD8(+) T-cell activation, increased V delta 1 : V delta 2 T cell ratios and decreased percentages of plasmacytoid DC, compared with HIV-1 mono-infected subjects. Across infected groups, IL-4 production by CD4(+) T lymphocytes was positively correlated with the percentage of effector memory CD4(+) T cells, suggesting antigenically driven differentiation of this population of T cells in both HIV-1 and M. leprae infections. Co-infection with M. leprae may exacerbate the immunopathology of HIV-1 disease. A T helper 2 (Th2) bias in the CD4(+) T-cell response was evident in both HIV-1 infection and leprosy, but no additive effect was apparent in co-infected patients. |
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Carvalho, Karina I. [UNIFESP]Maeda, Solange [UNIFESP]Marti, LucianaYamashita, Jane [UNIFESP]Haslett, Patrick A. J.Kallas, Esper Georges [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Univ MiamiAlbert Einstein Res Inst2016-01-24T13:51:24Z2016-01-24T13:51:24Z2008-06-01Immunology. Malden: Wiley-Blackwell, v. 124, n. 2, p. 206-214, 2008.0019-2805http://repositorio.unifesp.br/handle/11600/30674http://dx.doi.org/10.1111/j.1365-2567.2007.02756.x10.1111/j.1365-2567.2007.02756.xWOS:000255924900007Leprosy and human immunodeficiency virus-1 (HIV-1) are examples of human infections where interactions between the pathogen and the host cellular immunity determine the clinical manifestations of disease. Hence, a significant immunopathological interaction between HIV-1 and leprosy might be expected. in the present study we explored several aspects of cellular immunity in patients co-infected with HIV-1 and Mycobacterium leprae. Twenty-eight individuals were studied, comprising four groups: healthy controls, HIV-1 and M. leprae co-infection, HIV-1 mono-infection, and M. leprae mono-infection. Subjects in the mono-infection and co-infection groups were matched as far as possible for bacillary load and HIV disease status, as appropriate. Peripheral blood mononuclear cells (PBMC) were analysed using six- and seven-colour flow cytometry to evaluate T-cell subpopulations and their activation status, dendritic cell (DC) distribution phenotypes and expression of IL-4 by T cells. the co-infected group exhibited lower CD4 : CD8 ratios, higher levels of CD8(+) T-cell activation, increased V delta 1 : V delta 2 T cell ratios and decreased percentages of plasmacytoid DC, compared with HIV-1 mono-infected subjects. Across infected groups, IL-4 production by CD4(+) T lymphocytes was positively correlated with the percentage of effector memory CD4(+) T cells, suggesting antigenically driven differentiation of this population of T cells in both HIV-1 and M. leprae infections. Co-infection with M. leprae may exacerbate the immunopathology of HIV-1 disease. A T helper 2 (Th2) bias in the CD4(+) T-cell response was evident in both HIV-1 infection and leprosy, but no additive effect was apparent in co-infected patients.Universidade Federal de São Paulo, São Paulo, BrazilUniv Miami, Coral Gables, FL 33124 USAAlbert Einstein Res Inst, São Paulo, BrazilUniversidade Federal de São Paulo, EPM, São Paulo, BrazilWeb of Science206-214engWiley-BlackwellImmunologyhttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlinfo:eu-repo/semantics/openAccessHIVleprosyco-infectionlymphocytesIL-4Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjectsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/306742022-07-08 10:22:02.064metadata only accessoai:repositorio.unifesp.br:11600/30674Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:17:22.362671Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects |
title |
Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects |
spellingShingle |
Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects Carvalho, Karina I. [UNIFESP] HIV leprosy co-infection lymphocytes IL-4 |
title_short |
Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects |
title_full |
Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects |
title_fullStr |
Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects |
title_full_unstemmed |
Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects |
title_sort |
Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects |
author |
Carvalho, Karina I. [UNIFESP] |
author_facet |
Carvalho, Karina I. [UNIFESP] Maeda, Solange [UNIFESP] Marti, Luciana Yamashita, Jane [UNIFESP] Haslett, Patrick A. J. Kallas, Esper Georges [UNIFESP] |
author_role |
author |
author2 |
Maeda, Solange [UNIFESP] Marti, Luciana Yamashita, Jane [UNIFESP] Haslett, Patrick A. J. Kallas, Esper Georges [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Univ Miami Albert Einstein Res Inst |
dc.contributor.author.fl_str_mv |
Carvalho, Karina I. [UNIFESP] Maeda, Solange [UNIFESP] Marti, Luciana Yamashita, Jane [UNIFESP] Haslett, Patrick A. J. Kallas, Esper Georges [UNIFESP] |
dc.subject.eng.fl_str_mv |
HIV leprosy co-infection lymphocytes IL-4 |
topic |
HIV leprosy co-infection lymphocytes IL-4 |
description |
Leprosy and human immunodeficiency virus-1 (HIV-1) are examples of human infections where interactions between the pathogen and the host cellular immunity determine the clinical manifestations of disease. Hence, a significant immunopathological interaction between HIV-1 and leprosy might be expected. in the present study we explored several aspects of cellular immunity in patients co-infected with HIV-1 and Mycobacterium leprae. Twenty-eight individuals were studied, comprising four groups: healthy controls, HIV-1 and M. leprae co-infection, HIV-1 mono-infection, and M. leprae mono-infection. Subjects in the mono-infection and co-infection groups were matched as far as possible for bacillary load and HIV disease status, as appropriate. Peripheral blood mononuclear cells (PBMC) were analysed using six- and seven-colour flow cytometry to evaluate T-cell subpopulations and their activation status, dendritic cell (DC) distribution phenotypes and expression of IL-4 by T cells. the co-infected group exhibited lower CD4 : CD8 ratios, higher levels of CD8(+) T-cell activation, increased V delta 1 : V delta 2 T cell ratios and decreased percentages of plasmacytoid DC, compared with HIV-1 mono-infected subjects. Across infected groups, IL-4 production by CD4(+) T lymphocytes was positively correlated with the percentage of effector memory CD4(+) T cells, suggesting antigenically driven differentiation of this population of T cells in both HIV-1 and M. leprae infections. Co-infection with M. leprae may exacerbate the immunopathology of HIV-1 disease. A T helper 2 (Th2) bias in the CD4(+) T-cell response was evident in both HIV-1 infection and leprosy, but no additive effect was apparent in co-infected patients. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-06-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:51:24Z |
dc.date.available.fl_str_mv |
2016-01-24T13:51:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Immunology. Malden: Wiley-Blackwell, v. 124, n. 2, p. 206-214, 2008. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/30674 http://dx.doi.org/10.1111/j.1365-2567.2007.02756.x |
dc.identifier.issn.none.fl_str_mv |
0019-2805 |
dc.identifier.doi.none.fl_str_mv |
10.1111/j.1365-2567.2007.02756.x |
dc.identifier.wos.none.fl_str_mv |
WOS:000255924900007 |
identifier_str_mv |
Immunology. Malden: Wiley-Blackwell, v. 124, n. 2, p. 206-214, 2008. 0019-2805 10.1111/j.1365-2567.2007.02756.x WOS:000255924900007 |
url |
http://repositorio.unifesp.br/handle/11600/30674 http://dx.doi.org/10.1111/j.1365-2567.2007.02756.x |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Immunology |
dc.rights.driver.fl_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
206-214 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1783460272058400768 |