Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients

Detalhes bibliográficos
Autor(a) principal: Azevedo,Kátia Martins Lopes de
Data de Publicação: 2012
Outros Autores: Setúbal,Sérgio, Camacho,Luiz Antonio Bastos, Garcia,Rita de Cássia Nasser Cubel, Siqueira,Marilda Mendonça, Pereira,Renata Freire Alves, Oliveira,Solange Artimos de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000300010
Resumo: Erythrovirus B19 (B19V) infection may cause red cell aplasia in patients infected with human immunodeficiency virus (HIV). The introduction of highly active antiretroviral therapy (HAART) has improved the immune function of these patients by modifying the course of B19V infection. The purpose of this study was to estimate the frequency of B19 seroconversion in a cohort of HIV-infected patients and evaluate the occurrence of B19V-related anaemia during the seroconversion period. Adult HIV-infected patients were studied at a public hospital in Niterói, state of Rio de Janeiro, Brazil. IgG and IgM antibodies against B19V were detected by an enzyme-linked immunosorbent assay and B19 viraemia was assayed by polymerase chain reaction. Medical records were reviewed for any clinical evaluation of anaemia. Seroconversion was detected in 31.8% of the 88 individuals who began the study as anti-B19V IgG-negative. No clinical manifestations of B19V infection were detected during the period of seroconversion. Patients who seroconverted were 5.40 times more likely to have anaemia than those who did not [odds ratio 5.40 (95% confidence interval: 1.33-22.93)]. Anaemia was detected in eight patients. All patients recovered from anaemia by either beginning or continuing HAART, without requiring blood transfusions. In the HAART era, B19V infection may only be associated with a course of disease characterised by less severe chronic anaemia. This milder course of B19V-associated disease is likely due to the increased immune function of HAART-treated patients.
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spelling Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patientshuman parvovirus B19seroconversionHIV infectionanaemiaErythrovirus B19 (B19V) infection may cause red cell aplasia in patients infected with human immunodeficiency virus (HIV). The introduction of highly active antiretroviral therapy (HAART) has improved the immune function of these patients by modifying the course of B19V infection. The purpose of this study was to estimate the frequency of B19 seroconversion in a cohort of HIV-infected patients and evaluate the occurrence of B19V-related anaemia during the seroconversion period. Adult HIV-infected patients were studied at a public hospital in Niterói, state of Rio de Janeiro, Brazil. IgG and IgM antibodies against B19V were detected by an enzyme-linked immunosorbent assay and B19 viraemia was assayed by polymerase chain reaction. Medical records were reviewed for any clinical evaluation of anaemia. Seroconversion was detected in 31.8% of the 88 individuals who began the study as anti-B19V IgG-negative. No clinical manifestations of B19V infection were detected during the period of seroconversion. Patients who seroconverted were 5.40 times more likely to have anaemia than those who did not [odds ratio 5.40 (95% confidence interval: 1.33-22.93)]. Anaemia was detected in eight patients. All patients recovered from anaemia by either beginning or continuing HAART, without requiring blood transfusions. In the HAART era, B19V infection may only be associated with a course of disease characterised by less severe chronic anaemia. This milder course of B19V-associated disease is likely due to the increased immune function of HAART-treated patients.Instituto Oswaldo Cruz, Ministério da Saúde2012-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000300010Memórias do Instituto Oswaldo Cruz v.107 n.3 2012reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762012000300010info:eu-repo/semantics/openAccessAzevedo,Kátia Martins Lopes deSetúbal,SérgioCamacho,Luiz Antonio BastosGarcia,Rita de Cássia Nasser CubelSiqueira,Marilda MendonçaPereira,Renata Freire AlvesOliveira,Solange Artimos deeng2020-04-25T17:51:11Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:18:16.79Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients
title Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients
spellingShingle Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients
Azevedo,Kátia Martins Lopes de
human parvovirus B19
seroconversion
HIV infection
anaemia
title_short Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients
title_full Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients
title_fullStr Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients
title_full_unstemmed Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients
title_sort Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients
author Azevedo,Kátia Martins Lopes de
author_facet Azevedo,Kátia Martins Lopes de
Setúbal,Sérgio
Camacho,Luiz Antonio Bastos
Garcia,Rita de Cássia Nasser Cubel
Siqueira,Marilda Mendonça
Pereira,Renata Freire Alves
Oliveira,Solange Artimos de
author_role author
author2 Setúbal,Sérgio
Camacho,Luiz Antonio Bastos
Garcia,Rita de Cássia Nasser Cubel
Siqueira,Marilda Mendonça
Pereira,Renata Freire Alves
Oliveira,Solange Artimos de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Azevedo,Kátia Martins Lopes de
Setúbal,Sérgio
Camacho,Luiz Antonio Bastos
Garcia,Rita de Cássia Nasser Cubel
Siqueira,Marilda Mendonça
Pereira,Renata Freire Alves
Oliveira,Solange Artimos de
dc.subject.por.fl_str_mv human parvovirus B19
seroconversion
HIV infection
anaemia
topic human parvovirus B19
seroconversion
HIV infection
anaemia
dc.description.none.fl_txt_mv Erythrovirus B19 (B19V) infection may cause red cell aplasia in patients infected with human immunodeficiency virus (HIV). The introduction of highly active antiretroviral therapy (HAART) has improved the immune function of these patients by modifying the course of B19V infection. The purpose of this study was to estimate the frequency of B19 seroconversion in a cohort of HIV-infected patients and evaluate the occurrence of B19V-related anaemia during the seroconversion period. Adult HIV-infected patients were studied at a public hospital in Niterói, state of Rio de Janeiro, Brazil. IgG and IgM antibodies against B19V were detected by an enzyme-linked immunosorbent assay and B19 viraemia was assayed by polymerase chain reaction. Medical records were reviewed for any clinical evaluation of anaemia. Seroconversion was detected in 31.8% of the 88 individuals who began the study as anti-B19V IgG-negative. No clinical manifestations of B19V infection were detected during the period of seroconversion. Patients who seroconverted were 5.40 times more likely to have anaemia than those who did not [odds ratio 5.40 (95% confidence interval: 1.33-22.93)]. Anaemia was detected in eight patients. All patients recovered from anaemia by either beginning or continuing HAART, without requiring blood transfusions. In the HAART era, B19V infection may only be associated with a course of disease characterised by less severe chronic anaemia. This milder course of B19V-associated disease is likely due to the increased immune function of HAART-treated patients.
description Erythrovirus B19 (B19V) infection may cause red cell aplasia in patients infected with human immunodeficiency virus (HIV). The introduction of highly active antiretroviral therapy (HAART) has improved the immune function of these patients by modifying the course of B19V infection. The purpose of this study was to estimate the frequency of B19 seroconversion in a cohort of HIV-infected patients and evaluate the occurrence of B19V-related anaemia during the seroconversion period. Adult HIV-infected patients were studied at a public hospital in Niterói, state of Rio de Janeiro, Brazil. IgG and IgM antibodies against B19V were detected by an enzyme-linked immunosorbent assay and B19 viraemia was assayed by polymerase chain reaction. Medical records were reviewed for any clinical evaluation of anaemia. Seroconversion was detected in 31.8% of the 88 individuals who began the study as anti-B19V IgG-negative. No clinical manifestations of B19V infection were detected during the period of seroconversion. Patients who seroconverted were 5.40 times more likely to have anaemia than those who did not [odds ratio 5.40 (95% confidence interval: 1.33-22.93)]. Anaemia was detected in eight patients. All patients recovered from anaemia by either beginning or continuing HAART, without requiring blood transfusions. In the HAART era, B19V infection may only be associated with a course of disease characterised by less severe chronic anaemia. This milder course of B19V-associated disease is likely due to the increased immune function of HAART-treated patients.
publishDate 2012
dc.date.none.fl_str_mv 2012-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000300010
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000300010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762012000300010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.107 n.3 2012
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
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institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
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