Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa

Detalhes bibliográficos
Autor(a) principal: Balsalobre, Leonardo [UNIFESP]
Data de Publicação: 2013
Outros Autores: Pezato, Rogerio [UNIFESP], Perez-Novo, Claudina, Alves, Maria Teresa S. [UNIFESP], Santos, Rodrigo P. [UNIFESP], Bachert, Claus, Weckx, Luc L. M. [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/handle/11600/36209
http://dx.doi.org/10.1186/1916-0216-42-29
Resumo: Objective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software.Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05).Conclusion: the lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.
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spelling Balsalobre, Leonardo [UNIFESP]Pezato, Rogerio [UNIFESP]Perez-Novo, ClaudinaAlves, Maria Teresa S. [UNIFESP]Santos, Rodrigo P. [UNIFESP]Bachert, ClausWeckx, Luc L. M. [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Univ Ghent2016-01-24T14:31:35Z2016-01-24T14:31:35Z2013-04-15Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.1916-0216http://repositorio.unifesp.br/handle/11600/36209http://dx.doi.org/10.1186/1916-0216-42-29WOS000318410400001.pdf10.1186/1916-0216-42-29WOS:000318410400001Objective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software.Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05).Conclusion: the lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.Universidade Federal de São Paulo, Dept Otolaryngol Head & Neck Surg, São Paulo, BrazilUniv Ghent, Ghent Univ Hosp, Dept Otorhinolaryngol, Upper Airway Res Lab, B-9000 Ghent, BelgiumUniversidade Federal de São Paulo, Dept Pathol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Otolaryngol Head & Neck Surg, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, São Paulo, BrazilWeb of Science5engBiomed Central LtdJournal of Otolaryngology-head & Neck SurgeryTGF-beta 1Nasal polypsRhinosinusitisMucosaEpithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000318410400001.pdfapplication/pdf3160643${dspace.ui.url}/bitstream/11600/36209/1/WOS000318410400001.pdf44b86cf4902e3ae5b3246d537f2ddf47MD51open accessTEXTWOS000318410400001.pdf.txtWOS000318410400001.pdf.txtExtracted texttext/plain21379${dspace.ui.url}/bitstream/11600/36209/2/WOS000318410400001.pdf.txtfa09ae89f0c04a7756796312b8eeae47MD52open access11600/362092022-06-02 09:05:53.641open accessoai:repositorio.unifesp.br:11600/36209Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:13:42.482236Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa
title Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa
spellingShingle Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa
Balsalobre, Leonardo [UNIFESP]
TGF-beta 1
Nasal polyps
Rhinosinusitis
Mucosa
title_short Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa
title_full Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa
title_fullStr Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa
title_full_unstemmed Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa
title_sort Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa
author Balsalobre, Leonardo [UNIFESP]
author_facet Balsalobre, Leonardo [UNIFESP]
Pezato, Rogerio [UNIFESP]
Perez-Novo, Claudina
Alves, Maria Teresa S. [UNIFESP]
Santos, Rodrigo P. [UNIFESP]
Bachert, Claus
Weckx, Luc L. M. [UNIFESP]
author_role author
author2 Pezato, Rogerio [UNIFESP]
Perez-Novo, Claudina
Alves, Maria Teresa S. [UNIFESP]
Santos, Rodrigo P. [UNIFESP]
Bachert, Claus
Weckx, Luc L. M. [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.institution.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Univ Ghent
dc.contributor.author.fl_str_mv Balsalobre, Leonardo [UNIFESP]
Pezato, Rogerio [UNIFESP]
Perez-Novo, Claudina
Alves, Maria Teresa S. [UNIFESP]
Santos, Rodrigo P. [UNIFESP]
Bachert, Claus
Weckx, Luc L. M. [UNIFESP]
dc.subject.eng.fl_str_mv TGF-beta 1
Nasal polyps
Rhinosinusitis
Mucosa
topic TGF-beta 1
Nasal polyps
Rhinosinusitis
Mucosa
description Objective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software.Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05).Conclusion: the lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.
publishDate 2013
dc.date.issued.fl_str_mv 2013-04-15
dc.date.accessioned.fl_str_mv 2016-01-24T14:31:35Z
dc.date.available.fl_str_mv 2016-01-24T14:31:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/handle/11600/36209
http://dx.doi.org/10.1186/1916-0216-42-29
dc.identifier.issn.none.fl_str_mv 1916-0216
dc.identifier.file.none.fl_str_mv WOS000318410400001.pdf
dc.identifier.doi.none.fl_str_mv 10.1186/1916-0216-42-29
dc.identifier.wos.none.fl_str_mv WOS:000318410400001
identifier_str_mv Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.
1916-0216
WOS000318410400001.pdf
10.1186/1916-0216-42-29
WOS:000318410400001
url http://repositorio.unifesp.br/handle/11600/36209
http://dx.doi.org/10.1186/1916-0216-42-29
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Journal of Otolaryngology-head & Neck Surgery
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5
dc.publisher.none.fl_str_mv Biomed Central Ltd
publisher.none.fl_str_mv Biomed Central Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
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