Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1590/S1415-47572011005000051 http://repositorio.unifesp.br/handle/11600/6170 |
Resumo: | Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon. |
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Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian AmazonBrazilian Amazon populationCR1 haplotypesKnops blood group polymorphismmalariaComplement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon.Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Instituto Nacional de Ciência e Tecnologia em Células Tronco e Terapia CelularUniversidade de São Paulo Faculdade de Medicina de Ribeirão PretoUniversidade de São Paulo Faculdade de Ciências Farmacêuticas de Ribeirão PretoIowa State University Department of Animal ScienceHemocentro do AmazonasUniversidade Federal de São Paulo (UNIFESP)Santa Casa de São Paulo Faculdade de Ciências MédicasUNIFESPSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Sociedade Brasileira de GenéticaUniversidade de São Paulo (USP)Iowa State University Department of Animal ScienceHemocentro do AmazonasUniversidade Federal de São Paulo (UNIFESP)Santa Casa de São Paulo Faculdade de Ciências MédicasFontes, Aparecida MariaKashima, SimoneBonfim-silva, RicardoAzevedo, RocheleAbraham, Kuruvilla JosephAlbuquerque, Sérgio Roberto LopesBordin, Jose Orlando [UNIFESP]Langhi Júnior, Dante MárioCovas, Dimas Tadeu2015-06-14T13:42:46Z2015-06-14T13:42:46Z2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion539-545application/pdfhttp://dx.doi.org/10.1590/S1415-47572011005000051Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 34, n. 4, p. 539-545, 2011.10.1590/S1415-47572011005000051S1415-47572011000400002.pdf1415-4757S1415-47572011000400002http://repositorio.unifesp.br/handle/11600/6170WOS:000297789600002engGenetics and Molecular Biologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T06:02:28Zoai:repositorio.unifesp.br/:11600/6170Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T06:02:28Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon |
| title |
Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon |
| spellingShingle |
Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon Fontes, Aparecida Maria Brazilian Amazon population CR1 haplotypes Knops blood group polymorphism malaria |
| title_short |
Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon |
| title_full |
Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon |
| title_fullStr |
Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon |
| title_full_unstemmed |
Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon |
| title_sort |
Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon |
| author |
Fontes, Aparecida Maria |
| author_facet |
Fontes, Aparecida Maria Kashima, Simone Bonfim-silva, Ricardo Azevedo, Rochele Abraham, Kuruvilla Joseph Albuquerque, Sérgio Roberto Lopes Bordin, Jose Orlando [UNIFESP] Langhi Júnior, Dante Mário Covas, Dimas Tadeu |
| author_role |
author |
| author2 |
Kashima, Simone Bonfim-silva, Ricardo Azevedo, Rochele Abraham, Kuruvilla Joseph Albuquerque, Sérgio Roberto Lopes Bordin, Jose Orlando [UNIFESP] Langhi Júnior, Dante Mário Covas, Dimas Tadeu |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Iowa State University Department of Animal Science Hemocentro do Amazonas Universidade Federal de São Paulo (UNIFESP) Santa Casa de São Paulo Faculdade de Ciências Médicas |
| dc.contributor.author.fl_str_mv |
Fontes, Aparecida Maria Kashima, Simone Bonfim-silva, Ricardo Azevedo, Rochele Abraham, Kuruvilla Joseph Albuquerque, Sérgio Roberto Lopes Bordin, Jose Orlando [UNIFESP] Langhi Júnior, Dante Mário Covas, Dimas Tadeu |
| dc.subject.por.fl_str_mv |
Brazilian Amazon population CR1 haplotypes Knops blood group polymorphism malaria |
| topic |
Brazilian Amazon population CR1 haplotypes Knops blood group polymorphism malaria |
| description |
Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon. |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011-01-01 2015-06-14T13:42:46Z 2015-06-14T13:42:46Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1415-47572011005000051 Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 34, n. 4, p. 539-545, 2011. 10.1590/S1415-47572011005000051 S1415-47572011000400002.pdf 1415-4757 S1415-47572011000400002 http://repositorio.unifesp.br/handle/11600/6170 WOS:000297789600002 |
| url |
http://dx.doi.org/10.1590/S1415-47572011005000051 http://repositorio.unifesp.br/handle/11600/6170 |
| identifier_str_mv |
Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 34, n. 4, p. 539-545, 2011. 10.1590/S1415-47572011005000051 S1415-47572011000400002.pdf 1415-4757 S1415-47572011000400002 WOS:000297789600002 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Genetics and Molecular Biology |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
539-545 application/pdf |
| dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
| publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1814268420984668160 |