Amastigotes forms of Trypanosoma cruzi detected in a renal allograft

Detalhes bibliográficos
Autor(a) principal: Carvalho, Maria Fernanda C.
Data de Publicação: 1997
Outros Autores: Franco, Marcello Fabiano de [UNIFESP], Soares, Vitor Augusto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0036-46651997000400008
http://repositorio.unifesp.br/handle/11600/498
Resumo: Trypanosoma cruzi, the causative agent of Chagas disease assumes two distinct forms in vertebrate hosts: circulating trypomastigote and tissular amastigote. This latter form infects predominantly the myocardium, smooth and skeletal muscle, and central nervous system. The present work describes for the first time the detection of amastigote forms of T. cruzi in the renal parenchyma of a kidney graft recipient one month after transplantation. The patient was serologically negative for Chagas disease and received no blood transfusion prior to transplant. The cadaver donor was from an endemic area for Chagas disease. The recipient developed the acute form of the disease with detection of amastigote forms of T. cruzi in the renal allograft biopsy and circulating trypomastigote forms. The present report demonstrates that T. cruzi can infect the renal parenchyma. This mode of transmission warrants in endemic areas of Chagas disease
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spelling Amastigotes forms of Trypanosoma cruzi detected in a renal allograftChagas diseaseTrypanosoma cruziKidney transplantationTrypanosoma cruzi, the causative agent of Chagas disease assumes two distinct forms in vertebrate hosts: circulating trypomastigote and tissular amastigote. This latter form infects predominantly the myocardium, smooth and skeletal muscle, and central nervous system. The present work describes for the first time the detection of amastigote forms of T. cruzi in the renal parenchyma of a kidney graft recipient one month after transplantation. The patient was serologically negative for Chagas disease and received no blood transfusion prior to transplant. The cadaver donor was from an endemic area for Chagas disease. The recipient developed the acute form of the disease with detection of amastigote forms of T. cruzi in the renal allograft biopsy and circulating trypomastigote forms. The present report demonstrates that T. cruzi can infect the renal parenchyma. This mode of transmission warrants in endemic areas of Chagas diseaseDetecção de formas amastigotas do Trypanosoma cruziem enxerto renalA doença de Chagas é zoonose transmitida pelo Trypanosoma cruzi, o qual apresenta duas formas distintas no hospedeiro vertebrado, a tripomastigota circulante e a amastigota tecidual. Esta última parasita freqüentemente os tecidos musculares cardíaco, liso e estriado, e o tecido nervoso. Até o presente momento nunca foram detectados formas amastigotas em parênquima renal. O presente relato descreve, pela primeira vez, a detecção de formas amastigotas do T. cruzi em parênquima renal em receptor de enxerto de rim, com testes sorológicos negativos para a doença de Chagas e ausência de transfusões prévias, observado 1 mês após o transplante renal com doador cadáver proveniente de região endêmica. O paciente desenvolveu doença de Chagas aguda com detecção de formas tripomastigotas circulantes. Como a única forma de transmissão desta zoonose pelo enxerto é através de órgão parasitado com formas amastigotas, sugere-se fortemente que o rim transplantado foi o responsável pela transmissão da doença de Chagas, no presente caso. Esta é a via de infecção que deve ser levada em consideração em transplantes nas áreas endêmicasUNESPUNIFESPUNIFESP, EPM, São Paulo, BrazilSciELOInstituto de Medicina TropicalUniversidade Estadual Paulista (UNESP)Universidade Federal de São Paulo (UNIFESP)Carvalho, Maria Fernanda C.Franco, Marcello Fabiano de [UNIFESP]Soares, Vitor Augusto2015-06-14T13:24:37Z2015-06-14T13:24:37Z1997-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion223-226application/pdfhttp://dx.doi.org/10.1590/S0036-46651997000400008Revista do Instituto de Medicina Tropical de São Paulo. Instituto de Medicina Tropical, v. 39, n. 4, p. 223-226, 1997.10.1590/S0036-46651997000400008S0036-46651997000400008.pdf0036-4665S0036-46651997000400008http://repositorio.unifesp.br/handle/11600/498engRevista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T14:18:17Zoai:repositorio.unifesp.br/:11600/498Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T14:18:17Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Amastigotes forms of Trypanosoma cruzi detected in a renal allograft
title Amastigotes forms of Trypanosoma cruzi detected in a renal allograft
spellingShingle Amastigotes forms of Trypanosoma cruzi detected in a renal allograft
Carvalho, Maria Fernanda C.
Chagas disease
Trypanosoma cruzi
Kidney transplantation
title_short Amastigotes forms of Trypanosoma cruzi detected in a renal allograft
title_full Amastigotes forms of Trypanosoma cruzi detected in a renal allograft
title_fullStr Amastigotes forms of Trypanosoma cruzi detected in a renal allograft
title_full_unstemmed Amastigotes forms of Trypanosoma cruzi detected in a renal allograft
title_sort Amastigotes forms of Trypanosoma cruzi detected in a renal allograft
author Carvalho, Maria Fernanda C.
author_facet Carvalho, Maria Fernanda C.
Franco, Marcello Fabiano de [UNIFESP]
Soares, Vitor Augusto
author_role author
author2 Franco, Marcello Fabiano de [UNIFESP]
Soares, Vitor Augusto
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Carvalho, Maria Fernanda C.
Franco, Marcello Fabiano de [UNIFESP]
Soares, Vitor Augusto
dc.subject.por.fl_str_mv Chagas disease
Trypanosoma cruzi
Kidney transplantation
topic Chagas disease
Trypanosoma cruzi
Kidney transplantation
description Trypanosoma cruzi, the causative agent of Chagas disease assumes two distinct forms in vertebrate hosts: circulating trypomastigote and tissular amastigote. This latter form infects predominantly the myocardium, smooth and skeletal muscle, and central nervous system. The present work describes for the first time the detection of amastigote forms of T. cruzi in the renal parenchyma of a kidney graft recipient one month after transplantation. The patient was serologically negative for Chagas disease and received no blood transfusion prior to transplant. The cadaver donor was from an endemic area for Chagas disease. The recipient developed the acute form of the disease with detection of amastigote forms of T. cruzi in the renal allograft biopsy and circulating trypomastigote forms. The present report demonstrates that T. cruzi can infect the renal parenchyma. This mode of transmission warrants in endemic areas of Chagas disease
publishDate 1997
dc.date.none.fl_str_mv 1997-07-01
2015-06-14T13:24:37Z
2015-06-14T13:24:37Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0036-46651997000400008
Revista do Instituto de Medicina Tropical de São Paulo. Instituto de Medicina Tropical, v. 39, n. 4, p. 223-226, 1997.
10.1590/S0036-46651997000400008
S0036-46651997000400008.pdf
0036-4665
S0036-46651997000400008
http://repositorio.unifesp.br/handle/11600/498
url http://dx.doi.org/10.1590/S0036-46651997000400008
http://repositorio.unifesp.br/handle/11600/498
identifier_str_mv Revista do Instituto de Medicina Tropical de São Paulo. Instituto de Medicina Tropical, v. 39, n. 4, p. 223-226, 1997.
10.1590/S0036-46651997000400008
S0036-46651997000400008.pdf
0036-4665
S0036-46651997000400008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 223-226
application/pdf
dc.publisher.none.fl_str_mv Instituto de Medicina Tropical
publisher.none.fl_str_mv Instituto de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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