Serum and cellular interleukin-6 in haemodialysis patients: relationship with energy expenditure
Autor(a) principal: | |
---|---|
Data de Publicação: | 2007 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/29517 http://dx.doi.org/10.1093/ndt/gfl705 |
Resumo: | Background. Inflammation is a highly prevalent condition among end-stage renal disease (ESRD) patients and it has been implicated with several metabolic derangements. Considering the harmful effect of hypermetabolism on nutritional status and clinical outcomes of ESRD patients, we aimed to investigate the relationship between proinflammatory cytokine interleukin-6 (IL-6) and energy expenditure in this population.Methods. This cross-sectional study enrolled 80 adult haemodialysis patients for the evaluation of serum IL-6 and energy expenditure. the production of IL-6 by peripheral blood mononuclear cells (PBMCs) (spontaneous and endotoxin-stimulated production) was examined in a subgroup of 30 haemodialysis patients and in 11 healthy control subjects. IL-6 was measured by immunoenzymatic assay. the resting energy expenditure was evaluated by means of indirect calorimetry. Body composition was assessed by bioelectrical impedance analysis and skinfold thicknesses.Results. Serum IL-6 [6.3 (2.2-163.5) pg/ml] correlated positively with age (R = 0.26; P = 0.02) and C-reactive protein (R = 0.31; P < 0.01). Resting energy expenditure correlated positively with lean body mass (R = 0.68; P < 0.001) and BMI (R = 0.44; P < 0.001), and negatively with Kt/V (R = -0.37; P < 0.01). in the multivariate analysis, controlling for age and lean body mass, serum IL-6 was positively associated with resting energy expenditure (n = 80; beta = 2.4; P = 0.01). the production of IL-6 by PBMCs did not reach statistically significant differences between patients and controls [spontaneous production 6541 (96-7739) pg/ml vs 3410 (50-7806) pg/ml, respectively; and stimulated production 6530 (579-7671) pg/ml vs 5304 (1527-7670) pg/ml, respectively]. IL-6 secreted by monocytes showed no association with either serum IL-6 or resting energy expenditure.Conclusion. Serum IL-6 was associated with an increase of energy expenditure in haemodialysis patients. |
id |
UFSP_df197ef59380dad16892a70706e11ac1 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/29517 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Kamimura, Maria Ayako [UNIFESP]Draibe, Sergio Antonio [UNIFESP]Dalboni, Maria Aparecida [UNIFESP]Cendoroglo, Miguel [UNIFESP]Avesani, Carla M. [UNIFESP]Manfredi, Silvia R. [UNIFESP]Canziani, Maria E. F. [UNIFESP]Cuppari, Lilian [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T12:41:53Z2016-01-24T12:41:53Z2007-03-01Nephrology Dialysis Transplantation. Oxford: Oxford Univ Press, v. 22, n. 3, p. 839-844, 2007.0931-0509http://repositorio.unifesp.br/handle/11600/29517http://dx.doi.org/10.1093/ndt/gfl70510.1093/ndt/gfl705WOS:000244430800030Background. Inflammation is a highly prevalent condition among end-stage renal disease (ESRD) patients and it has been implicated with several metabolic derangements. Considering the harmful effect of hypermetabolism on nutritional status and clinical outcomes of ESRD patients, we aimed to investigate the relationship between proinflammatory cytokine interleukin-6 (IL-6) and energy expenditure in this population.Methods. This cross-sectional study enrolled 80 adult haemodialysis patients for the evaluation of serum IL-6 and energy expenditure. the production of IL-6 by peripheral blood mononuclear cells (PBMCs) (spontaneous and endotoxin-stimulated production) was examined in a subgroup of 30 haemodialysis patients and in 11 healthy control subjects. IL-6 was measured by immunoenzymatic assay. the resting energy expenditure was evaluated by means of indirect calorimetry. Body composition was assessed by bioelectrical impedance analysis and skinfold thicknesses.Results. Serum IL-6 [6.3 (2.2-163.5) pg/ml] correlated positively with age (R = 0.26; P = 0.02) and C-reactive protein (R = 0.31; P < 0.01). Resting energy expenditure correlated positively with lean body mass (R = 0.68; P < 0.001) and BMI (R = 0.44; P < 0.001), and negatively with Kt/V (R = -0.37; P < 0.01). in the multivariate analysis, controlling for age and lean body mass, serum IL-6 was positively associated with resting energy expenditure (n = 80; beta = 2.4; P = 0.01). the production of IL-6 by PBMCs did not reach statistically significant differences between patients and controls [spontaneous production 6541 (96-7739) pg/ml vs 3410 (50-7806) pg/ml, respectively; and stimulated production 6530 (579-7671) pg/ml vs 5304 (1527-7670) pg/ml, respectively]. IL-6 secreted by monocytes showed no association with either serum IL-6 or resting energy expenditure.Conclusion. Serum IL-6 was associated with an increase of energy expenditure in haemodialysis patients.Universidade Federal de São Paulo, Div Nephrol, BR-04039000 São Paulo, BrazilUniversidade Federal de São Paulo, Nutr Program, BR-04039000 São Paulo, BrazilUniversidade Federal de São Paulo, Div Nephrol, BR-04039000 São Paulo, BrazilUniversidade Federal de São Paulo, Nutr Program, BR-04039000 São Paulo, BrazilWeb of Science839-844engOxford Univ PressNephrology Dialysis Transplantationhttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.htmlinfo:eu-repo/semantics/openAccessenergy expenditurehaemodialysisinflammationinterleukin-6monocytesSerum and cellular interleukin-6 in haemodialysis patients: relationship with energy expenditureinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/295172023-01-12 21:39:41.837metadata only accessoai:repositorio.unifesp.br:11600/29517Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-01-13T00:39:41Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Serum and cellular interleukin-6 in haemodialysis patients: relationship with energy expenditure |
title |
Serum and cellular interleukin-6 in haemodialysis patients: relationship with energy expenditure |
spellingShingle |
Serum and cellular interleukin-6 in haemodialysis patients: relationship with energy expenditure Kamimura, Maria Ayako [UNIFESP] energy expenditure haemodialysis inflammation interleukin-6 monocytes |
title_short |
Serum and cellular interleukin-6 in haemodialysis patients: relationship with energy expenditure |
title_full |
Serum and cellular interleukin-6 in haemodialysis patients: relationship with energy expenditure |
title_fullStr |
Serum and cellular interleukin-6 in haemodialysis patients: relationship with energy expenditure |
title_full_unstemmed |
Serum and cellular interleukin-6 in haemodialysis patients: relationship with energy expenditure |
title_sort |
Serum and cellular interleukin-6 in haemodialysis patients: relationship with energy expenditure |
author |
Kamimura, Maria Ayako [UNIFESP] |
author_facet |
Kamimura, Maria Ayako [UNIFESP] Draibe, Sergio Antonio [UNIFESP] Dalboni, Maria Aparecida [UNIFESP] Cendoroglo, Miguel [UNIFESP] Avesani, Carla M. [UNIFESP] Manfredi, Silvia R. [UNIFESP] Canziani, Maria E. F. [UNIFESP] Cuppari, Lilian [UNIFESP] |
author_role |
author |
author2 |
Draibe, Sergio Antonio [UNIFESP] Dalboni, Maria Aparecida [UNIFESP] Cendoroglo, Miguel [UNIFESP] Avesani, Carla M. [UNIFESP] Manfredi, Silvia R. [UNIFESP] Canziani, Maria E. F. [UNIFESP] Cuppari, Lilian [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Kamimura, Maria Ayako [UNIFESP] Draibe, Sergio Antonio [UNIFESP] Dalboni, Maria Aparecida [UNIFESP] Cendoroglo, Miguel [UNIFESP] Avesani, Carla M. [UNIFESP] Manfredi, Silvia R. [UNIFESP] Canziani, Maria E. F. [UNIFESP] Cuppari, Lilian [UNIFESP] |
dc.subject.eng.fl_str_mv |
energy expenditure haemodialysis inflammation interleukin-6 monocytes |
topic |
energy expenditure haemodialysis inflammation interleukin-6 monocytes |
description |
Background. Inflammation is a highly prevalent condition among end-stage renal disease (ESRD) patients and it has been implicated with several metabolic derangements. Considering the harmful effect of hypermetabolism on nutritional status and clinical outcomes of ESRD patients, we aimed to investigate the relationship between proinflammatory cytokine interleukin-6 (IL-6) and energy expenditure in this population.Methods. This cross-sectional study enrolled 80 adult haemodialysis patients for the evaluation of serum IL-6 and energy expenditure. the production of IL-6 by peripheral blood mononuclear cells (PBMCs) (spontaneous and endotoxin-stimulated production) was examined in a subgroup of 30 haemodialysis patients and in 11 healthy control subjects. IL-6 was measured by immunoenzymatic assay. the resting energy expenditure was evaluated by means of indirect calorimetry. Body composition was assessed by bioelectrical impedance analysis and skinfold thicknesses.Results. Serum IL-6 [6.3 (2.2-163.5) pg/ml] correlated positively with age (R = 0.26; P = 0.02) and C-reactive protein (R = 0.31; P < 0.01). Resting energy expenditure correlated positively with lean body mass (R = 0.68; P < 0.001) and BMI (R = 0.44; P < 0.001), and negatively with Kt/V (R = -0.37; P < 0.01). in the multivariate analysis, controlling for age and lean body mass, serum IL-6 was positively associated with resting energy expenditure (n = 80; beta = 2.4; P = 0.01). the production of IL-6 by PBMCs did not reach statistically significant differences between patients and controls [spontaneous production 6541 (96-7739) pg/ml vs 3410 (50-7806) pg/ml, respectively; and stimulated production 6530 (579-7671) pg/ml vs 5304 (1527-7670) pg/ml, respectively]. IL-6 secreted by monocytes showed no association with either serum IL-6 or resting energy expenditure.Conclusion. Serum IL-6 was associated with an increase of energy expenditure in haemodialysis patients. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-03-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:41:53Z |
dc.date.available.fl_str_mv |
2016-01-24T12:41:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Nephrology Dialysis Transplantation. Oxford: Oxford Univ Press, v. 22, n. 3, p. 839-844, 2007. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/29517 http://dx.doi.org/10.1093/ndt/gfl705 |
dc.identifier.issn.none.fl_str_mv |
0931-0509 |
dc.identifier.doi.none.fl_str_mv |
10.1093/ndt/gfl705 |
dc.identifier.wos.none.fl_str_mv |
WOS:000244430800030 |
identifier_str_mv |
Nephrology Dialysis Transplantation. Oxford: Oxford Univ Press, v. 22, n. 3, p. 839-844, 2007. 0931-0509 10.1093/ndt/gfl705 WOS:000244430800030 |
url |
http://repositorio.unifesp.br/handle/11600/29517 http://dx.doi.org/10.1093/ndt/gfl705 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Nephrology Dialysis Transplantation |
dc.rights.driver.fl_str_mv |
http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
839-844 |
dc.publisher.none.fl_str_mv |
Oxford Univ Press |
publisher.none.fl_str_mv |
Oxford Univ Press |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764115917144064 |