Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophy

Detalhes bibliográficos
Autor(a) principal: Garcia Filho, Carlos Alexandre de Amorim [UNIFESP]
Data de Publicação: 2011
Outros Autores: Prata, Tiago dos Santos [UNIFESP], Sousa, Aline Katia Siqueira [UNIFESP], Doi, Larissa Morimoto [UNIFESP], Melo Jr., Luiz Alberto Soares [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-27492011000300002
http://repositorio.unifesp.br/handle/11600/6486
Resumo: PURPOSE: Low intraocular pressure (IOP) measured by Goldmann applanation tonometry (GAT) is one of the ocular manifestations of Steinert's myotonic dystrophy. The goal of this study was to evaluate the corneal-compensated IOP as well as corneal properties (central corneal thickness and corneal hysteresis) in patients with myotonic dystrophy. METHODS: A total of 12 eyes of 6 patients with Steinert's myotonic dystrophy (dystrophy group) and 12 eyes of 6 age-, race-, and gender-matched healthy volunteers (control group) were included in the study. GAT, Dynamic Contour Tonometry (DCT-Pascal) and Ocular Response Analyzer (ORA) were used to assess the IOP. Central corneal thickness was obtained by ultrasound pachymetry, and corneal hysteresis was analyzed using the ORA device. In light of the multiplicity of tests performed, the significance level was set at 0.01 rather than 0.05. RESULTS: The mean (standard deviation [SD]) GAT, DCT, and corneal-compensated ORA IOP in the dystrophy group were 5.4 (1.4) mmHg, 9.7 (1.5) mmHg, and 10.1 (2.6) mmHg, respectively. The mean (SD) GAT, DCT, and corneal-compensated ORA IOP in the control group was 12.6 (2.9) mmHg, 15.5 (2.7) mmHg, and 15.8 (3.4) mmHg, respectively. There were significant differences in IOP values between dystrophy and control groups obtained by GAT (mean, -7.2 mmHg; 99% confidence interval [CI], -10.5 to -3.9 mmHg; P<0.001), DCT (mean, -5.9 mmHg; 99% CI, -8.9 to -2.8 mmHg; P<0.001), and corneal-compensated ORA measurements (mean, -5.7 mmHg; 99% CI, -10.4 to -1.0 mmHg; P=0.003). The mean (SD) central corneal thickness was similar in the dystrophy (542 [31] µm) and control (537 [11] µm) groups (P=0.65). The mean (SD) corneal hysteresis in the dystrophy and control groups were 11.2 (1.5) mmHg and 9.7 (1.2) mmHg, respectively (P=0.04). CONCLUSIONS: Patients with Steinert's myotonic dystrophy showed lower Goldmann and corneal-compensated IOP in comparison with healthy individuals. Since central corneal thickness and corneal hysteresis did not differ significantly between groups, the lower IOP readings documented in this dystrophy seem not to be related to changes in corneal properties.
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spelling Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophyPressão intraocular, espessura corneal e histerese corneal em distrofia miotônica de SteinertIntraocular pressureTonometry, ocularMyotonic dystrophyOcular hypotensionCorneaCorneal topographyPressão intraocularTonometria ocularDistrofia miotônicaHipotensão ocularCórneaTopografia da córneaPURPOSE: Low intraocular pressure (IOP) measured by Goldmann applanation tonometry (GAT) is one of the ocular manifestations of Steinert's myotonic dystrophy. The goal of this study was to evaluate the corneal-compensated IOP as well as corneal properties (central corneal thickness and corneal hysteresis) in patients with myotonic dystrophy. METHODS: A total of 12 eyes of 6 patients with Steinert's myotonic dystrophy (dystrophy group) and 12 eyes of 6 age-, race-, and gender-matched healthy volunteers (control group) were included in the study. GAT, Dynamic Contour Tonometry (DCT-Pascal) and Ocular Response Analyzer (ORA) were used to assess the IOP. Central corneal thickness was obtained by ultrasound pachymetry, and corneal hysteresis was analyzed using the ORA device. In light of the multiplicity of tests performed, the significance level was set at 0.01 rather than 0.05. RESULTS: The mean (standard deviation [SD]) GAT, DCT, and corneal-compensated ORA IOP in the dystrophy group were 5.4 (1.4) mmHg, 9.7 (1.5) mmHg, and 10.1 (2.6) mmHg, respectively. The mean (SD) GAT, DCT, and corneal-compensated ORA IOP in the control group was 12.6 (2.9) mmHg, 15.5 (2.7) mmHg, and 15.8 (3.4) mmHg, respectively. There were significant differences in IOP values between dystrophy and control groups obtained by GAT (mean, -7.2 mmHg; 99% confidence interval [CI], -10.5 to -3.9 mmHg; P<0.001), DCT (mean, -5.9 mmHg; 99% CI, -8.9 to -2.8 mmHg; P<0.001), and corneal-compensated ORA measurements (mean, -5.7 mmHg; 99% CI, -10.4 to -1.0 mmHg; P=0.003). The mean (SD) central corneal thickness was similar in the dystrophy (542 [31] µm) and control (537 [11] µm) groups (P=0.65). The mean (SD) corneal hysteresis in the dystrophy and control groups were 11.2 (1.5) mmHg and 9.7 (1.2) mmHg, respectively (P=0.04). CONCLUSIONS: Patients with Steinert's myotonic dystrophy showed lower Goldmann and corneal-compensated IOP in comparison with healthy individuals. Since central corneal thickness and corneal hysteresis did not differ significantly between groups, the lower IOP readings documented in this dystrophy seem not to be related to changes in corneal properties.OBJETIVOS: Pressão intraocular (PIO) baixa medida por meio da tonometria de aplanação de Goldmann (TAG) é uma das manifestações oculares da distrofia miotônica de Steinert. O objetivo deste estudo foi avaliar a pressão intraocular compensada para as propriedades corneais (espessura corneal central e histerese corneal) em pacientes com distrofia miotônica. MÉTODOS: Um total de 12 olhos de 6 pacientes com distrofia miotônica de Steinert (grupo distrofia) e 12 olhos de 6 voluntários sadios (grupo controle) pareados para idade, raça e sexo foram incluídos no estudo. Tonometria de aplanação de Goldmann, tonometria de contorno dinâmico (TCD-Pascal) e analisador de resposta ocular (ORA) foram usados para medir a pressão intraocular. A espessura corneal central foi obtida por meio da paquimetria ultrassônica e a histerese corneal foi analizada usando o aparelho ORA. RESULTADOS: A pressão intraocular média (desvio-padrão) da TAG, TCD e compensada para a córnea do ORA no grupo distrofia foram 5,4 (1,4) mmHg, 9,7 (1,5) mmHg e 10,1 (2,6) mmHg, respectivamente. A pressão intraocular média (desvio-padrão) da TAG, TCD e compensada para a córnea do ORA no grupo controle foram 12,6 (2,9) mmHg, 15,5 (2,7) mmHg e 15,8 (3,4) mmHg, respectivamente. Houve diferença significativa nos valores da pressão intraocular entre os grupos distrofia e controle obtidas pela TAG (média, -7,2 mmHg; intervalo de confiança (IC) de 99%, -10,5 a -3,9 mmHg; P<0,001), TCD (média, -5,9 mmHg; IC de 99%, -8,9 a -2,8 mmHg; P<0,001) e ORA compensada para córnea (média, -5,7 mmHg; IC de 99%, -10,4 a -1,0 mmHg; P=0,003). A espessura corneal média (desvio-padrão) foi similar nos grupos distrofia (542 [31] µm) e controle (537 [11] µm) (P=0,65). A histerese corneal média (desvio-padrão) nos grupos distrofia e controle foram de 11,2 (1,5) mmHg e 9,7 (1,2) mmHg, respectivamente (P=0,04). CONCLUSÃO: Os pacientes com distrofia miotônica de Steinert apresentaram valores menores de pressão intraocular medidas tanto com Goldmann quanto compensadas para a córnea em comparação com indivíduos sadios. Uma vez que os valores da espessura corneal central e histerese corneal não diferiram significantemente entre os grupos, os valores baixos da pressão intraocular encontrados nos pacientes com distrofia miotônica não parecem estar relacionados com as propriedades corneais.Universidade Federal de São Paulo (UNIFESP) Departamento de OftalmologiaUNIFESP, Depto. de OftalmologiaSciELOConselho Brasileiro de OftalmologiaUniversidade Federal de São Paulo (UNIFESP)Garcia Filho, Carlos Alexandre de Amorim [UNIFESP]Prata, Tiago dos Santos [UNIFESP]Sousa, Aline Katia Siqueira [UNIFESP]Doi, Larissa Morimoto [UNIFESP]Melo Jr., Luiz Alberto Soares [UNIFESP]2015-06-14T13:43:07Z2015-06-14T13:43:07Z2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion161-162application/pdfhttp://dx.doi.org/10.1590/S0004-27492011000300002Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 74, n. 3, p. 161-162, 2011.10.1590/S0004-27492011000300002S0004-27492011000300002.pdf0004-2749S0004-27492011000300002http://repositorio.unifesp.br/handle/11600/6486WOS:000294822300002engArquivos Brasileiros de Oftalmologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T16:42:34Zoai:repositorio.unifesp.br/:11600/6486Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T16:42:34Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophy
Pressão intraocular, espessura corneal e histerese corneal em distrofia miotônica de Steinert
title Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophy
spellingShingle Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophy
Garcia Filho, Carlos Alexandre de Amorim [UNIFESP]
Intraocular pressure
Tonometry, ocular
Myotonic dystrophy
Ocular hypotension
Cornea
Corneal topography
Pressão intraocular
Tonometria ocular
Distrofia miotônica
Hipotensão ocular
Córnea
Topografia da córnea
title_short Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophy
title_full Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophy
title_fullStr Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophy
title_full_unstemmed Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophy
title_sort Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophy
author Garcia Filho, Carlos Alexandre de Amorim [UNIFESP]
author_facet Garcia Filho, Carlos Alexandre de Amorim [UNIFESP]
Prata, Tiago dos Santos [UNIFESP]
Sousa, Aline Katia Siqueira [UNIFESP]
Doi, Larissa Morimoto [UNIFESP]
Melo Jr., Luiz Alberto Soares [UNIFESP]
author_role author
author2 Prata, Tiago dos Santos [UNIFESP]
Sousa, Aline Katia Siqueira [UNIFESP]
Doi, Larissa Morimoto [UNIFESP]
Melo Jr., Luiz Alberto Soares [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Garcia Filho, Carlos Alexandre de Amorim [UNIFESP]
Prata, Tiago dos Santos [UNIFESP]
Sousa, Aline Katia Siqueira [UNIFESP]
Doi, Larissa Morimoto [UNIFESP]
Melo Jr., Luiz Alberto Soares [UNIFESP]
dc.subject.por.fl_str_mv Intraocular pressure
Tonometry, ocular
Myotonic dystrophy
Ocular hypotension
Cornea
Corneal topography
Pressão intraocular
Tonometria ocular
Distrofia miotônica
Hipotensão ocular
Córnea
Topografia da córnea
topic Intraocular pressure
Tonometry, ocular
Myotonic dystrophy
Ocular hypotension
Cornea
Corneal topography
Pressão intraocular
Tonometria ocular
Distrofia miotônica
Hipotensão ocular
Córnea
Topografia da córnea
description PURPOSE: Low intraocular pressure (IOP) measured by Goldmann applanation tonometry (GAT) is one of the ocular manifestations of Steinert's myotonic dystrophy. The goal of this study was to evaluate the corneal-compensated IOP as well as corneal properties (central corneal thickness and corneal hysteresis) in patients with myotonic dystrophy. METHODS: A total of 12 eyes of 6 patients with Steinert's myotonic dystrophy (dystrophy group) and 12 eyes of 6 age-, race-, and gender-matched healthy volunteers (control group) were included in the study. GAT, Dynamic Contour Tonometry (DCT-Pascal) and Ocular Response Analyzer (ORA) were used to assess the IOP. Central corneal thickness was obtained by ultrasound pachymetry, and corneal hysteresis was analyzed using the ORA device. In light of the multiplicity of tests performed, the significance level was set at 0.01 rather than 0.05. RESULTS: The mean (standard deviation [SD]) GAT, DCT, and corneal-compensated ORA IOP in the dystrophy group were 5.4 (1.4) mmHg, 9.7 (1.5) mmHg, and 10.1 (2.6) mmHg, respectively. The mean (SD) GAT, DCT, and corneal-compensated ORA IOP in the control group was 12.6 (2.9) mmHg, 15.5 (2.7) mmHg, and 15.8 (3.4) mmHg, respectively. There were significant differences in IOP values between dystrophy and control groups obtained by GAT (mean, -7.2 mmHg; 99% confidence interval [CI], -10.5 to -3.9 mmHg; P<0.001), DCT (mean, -5.9 mmHg; 99% CI, -8.9 to -2.8 mmHg; P<0.001), and corneal-compensated ORA measurements (mean, -5.7 mmHg; 99% CI, -10.4 to -1.0 mmHg; P=0.003). The mean (SD) central corneal thickness was similar in the dystrophy (542 [31] µm) and control (537 [11] µm) groups (P=0.65). The mean (SD) corneal hysteresis in the dystrophy and control groups were 11.2 (1.5) mmHg and 9.7 (1.2) mmHg, respectively (P=0.04). CONCLUSIONS: Patients with Steinert's myotonic dystrophy showed lower Goldmann and corneal-compensated IOP in comparison with healthy individuals. Since central corneal thickness and corneal hysteresis did not differ significantly between groups, the lower IOP readings documented in this dystrophy seem not to be related to changes in corneal properties.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-01
2015-06-14T13:43:07Z
2015-06-14T13:43:07Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-27492011000300002
Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 74, n. 3, p. 161-162, 2011.
10.1590/S0004-27492011000300002
S0004-27492011000300002.pdf
0004-2749
S0004-27492011000300002
http://repositorio.unifesp.br/handle/11600/6486
WOS:000294822300002
url http://dx.doi.org/10.1590/S0004-27492011000300002
http://repositorio.unifesp.br/handle/11600/6486
identifier_str_mv Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 74, n. 3, p. 161-162, 2011.
10.1590/S0004-27492011000300002
S0004-27492011000300002.pdf
0004-2749
S0004-27492011000300002
WOS:000294822300002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Oftalmologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 161-162
application/pdf
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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