Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo

Detalhes bibliográficos
Autor(a) principal: Lopes, Stefanie C. P.
Data de Publicação: 2009
Outros Autores: Blanco, Yara C., Justo, Giselle Z. [UNIFESP], Nogueira, Paulo A., Rodrigues, Francisco L. S., Goelnitz, Uta, Wunderlich, Gerhard, Facchini, Gustavo, Brocchi, Marcelo, Duran, Nelson, Costa, Fabio Trindade Maranhão [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/001300000wpqj
DOI: 10.1128/AAC.00693-08
Texto Completo: http://dx.doi.org/10.1128/AAC.00693-08
http://repositorio.unifesp.br/handle/11600/31480
Resumo: Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge.
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spelling Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in VivoViolacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge.Univ Estadual Campinas, UNICAMP, Dept Parasitol, Inst Biol, BR-13083970 Campinas, SP, BrazilUniv Estadual Campinas, UNICAMP, Dept Microbiol & Imunol, Inst Biol, BR-13083970 Campinas, SP, BrazilUniversidade Federal de São Paulo, UNIFESP, Dept Bioquim, BR-04044020 São Paulo, BrazilCEPEM, IPEPATRO, BR-78900970 Porto Velho, RO, BrazilUniv São Paulo, Dept Parasitol, ICB2, São Paulo, BrazilUniv Estadual Campinas, Dept Fisiol & Biofis, Inst Biol, BR-13083970 Campinas, SP, BrazilUniv Estadual Campinas, Lab Quim Biol, Inst Quim, BR-13083970 Campinas, SP, BrazilUniversidade Federal de São Paulo, UNIFESP, Dept Bioquim, BR-04044020 São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)FAPESP: 2004/00638-6CNPq: 470587/2006-7Amer Soc MicrobiologyUniversidade Estadual de Campinas (UNICAMP)Universidade Federal de São Paulo (UNIFESP)CEPEMUniversidade de São Paulo (USP)Lopes, Stefanie C. P.Blanco, Yara C.Justo, Giselle Z. [UNIFESP]Nogueira, Paulo A.Rodrigues, Francisco L. S.Goelnitz, UtaWunderlich, GerhardFacchini, GustavoBrocchi, MarceloDuran, NelsonCosta, Fabio Trindade Maranhão [UNIFESP]2016-01-24T13:52:28Z2016-01-24T13:52:28Z2009-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2149-2152application/pdfhttp://dx.doi.org/10.1128/AAC.00693-08Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 53, n. 5, p. 2149-2152, 2009.10.1128/AAC.00693-08WOS000265528700060.pdf0066-4804http://repositorio.unifesp.br/handle/11600/31480WOS:000265528700060ark:/48912/001300000wpqjengAntimicrobial Agents and Chemotherapyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T09:04:29Zoai:repositorio.unifesp.br/:11600/31480Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:41:52.266827Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo
title Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo
spellingShingle Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo
Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo
Lopes, Stefanie C. P.
Lopes, Stefanie C. P.
title_short Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo
title_full Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo
title_fullStr Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo
Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo
title_full_unstemmed Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo
Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo
title_sort Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo
author Lopes, Stefanie C. P.
author_facet Lopes, Stefanie C. P.
Lopes, Stefanie C. P.
Blanco, Yara C.
Justo, Giselle Z. [UNIFESP]
Nogueira, Paulo A.
Rodrigues, Francisco L. S.
Goelnitz, Uta
Wunderlich, Gerhard
Facchini, Gustavo
Brocchi, Marcelo
Duran, Nelson
Costa, Fabio Trindade Maranhão [UNIFESP]
Blanco, Yara C.
Justo, Giselle Z. [UNIFESP]
Nogueira, Paulo A.
Rodrigues, Francisco L. S.
Goelnitz, Uta
Wunderlich, Gerhard
Facchini, Gustavo
Brocchi, Marcelo
Duran, Nelson
Costa, Fabio Trindade Maranhão [UNIFESP]
author_role author
author2 Blanco, Yara C.
Justo, Giselle Z. [UNIFESP]
Nogueira, Paulo A.
Rodrigues, Francisco L. S.
Goelnitz, Uta
Wunderlich, Gerhard
Facchini, Gustavo
Brocchi, Marcelo
Duran, Nelson
Costa, Fabio Trindade Maranhão [UNIFESP]
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
CEPEM
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Lopes, Stefanie C. P.
Blanco, Yara C.
Justo, Giselle Z. [UNIFESP]
Nogueira, Paulo A.
Rodrigues, Francisco L. S.
Goelnitz, Uta
Wunderlich, Gerhard
Facchini, Gustavo
Brocchi, Marcelo
Duran, Nelson
Costa, Fabio Trindade Maranhão [UNIFESP]
description Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge.
publishDate 2009
dc.date.none.fl_str_mv 2009-05-01
2016-01-24T13:52:28Z
2016-01-24T13:52:28Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1128/AAC.00693-08
Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 53, n. 5, p. 2149-2152, 2009.
10.1128/AAC.00693-08
WOS000265528700060.pdf
0066-4804
http://repositorio.unifesp.br/handle/11600/31480
WOS:000265528700060
dc.identifier.dark.fl_str_mv ark:/48912/001300000wpqj
url http://dx.doi.org/10.1128/AAC.00693-08
http://repositorio.unifesp.br/handle/11600/31480
identifier_str_mv Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 53, n. 5, p. 2149-2152, 2009.
10.1128/AAC.00693-08
WOS000265528700060.pdf
0066-4804
WOS:000265528700060
ark:/48912/001300000wpqj
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antimicrobial Agents and Chemotherapy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2149-2152
application/pdf
dc.publisher.none.fl_str_mv Amer Soc Microbiology
publisher.none.fl_str_mv Amer Soc Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822245959383384064
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.00693-08

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