Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism

• Autor(a) principal: Almeida, Sandro Soares [UNIFESP]
• Data de Publicação: 2017
• Outros Autores: Corgosinho, Flavia Campos [UNIFESP], Amorim, Carlos Eduardo Neves [UNIFESP], Gregnani, Marcos Fernandes [UNIFESP], Campos, Raquel Munhoz da Silveira [UNIFESP], Masquio, Deborah Cristina Landi [UNIFESP], Sanches, Priscila de Lima [UNIFESP], Piano, Aline de [UNIFESP], Pesquero, João Bosco [UNIFESP], Dâmaso, Ana Raimunda [UNIFESP], Mello, Marco Tulio de [UNIFESP], Tufik, Sergio [UNIFESP], Araujo, Ronaldo de Carvalho [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: https://dx.doi.org/10.1177/1470320317703451; https://repositorio.unifesp.br/handle/11600/54795
• topic: Interdisciplinary therapy; Metabolic syndrome; Obesity; Angiotensin-converting enzyme; Polymorphism

Introduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents. Methods: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Genomic DNA was extracted from circulating leukocytes. Results: Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Regarding lipid profile, subjects with ID and DD genotypes from both groups reduced their low-density lipoprotein cholesterol levels significantly. The metabolic parameters from the ID and DD genotypes of the non-metabolic syndrome group showed a significantly improved insulin response. Conclusion: In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. In addition, the I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly. These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy.