Frequency of TGF-beta and IFN-gamma Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients

• Autor(a) principal: Grabulosa, Caren Cristina [UNIFESP]
• Data de Publicação: 2014
• Outros Autores: Batista, Marcelo Costa [UNIFESP], Cendoroglo Neto, Miguel [UNIFESP], Quinto, BeataMarie Redublo [UNIFESP], Narciso, Roberto, Monte, Julio Cesar [UNIFESP], Durao, Marcelino [UNIFESP], Rizzo, Luiz Vicente, Pavao Santos, Oscar Fernando [UNIFESP], Dalboni, Maria Aparecida [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://repositorio.unifesp.br/handle/11600/37161; http://dx.doi.org/10.1155/2014/904730

Genetic variations in TGF-beta and IFN-gamma may interfere with proinflammatory cytokine production and, consequently, may be involved with inflammatory diseases, as acute kidney injury (AKI). We considered that genetic polymorphisms of these cytokines may have a crucial role in the outcome of critically ill patients. To investigate whether the genetic polymorphisms of rs1800470 (codon 10 T/C), rs1800471 (codon 25 C/G) from the TGF-beta, and rs2430561 (+874 T/A) from IFN-gamma may be a risk factor for ICU patients to the development of AKI and/or death. in a prospective nested case-control study, were included 139 ICU patients who developed AKI, 164 ICU patients without AKI, and 244 healthy individuals. We observed a higher frequency to T/A genotype for IFN-gamma (intermediate producer phenotype) and higher frequency of TT GG and TC GG genotype (high producer) for TGF-beta polymorphism in overall population. However, these polymorphisms have not been shown as a predictor of risk for AKI and death. We found an increased prevalence of high and intermediate producer phenotypes from TGF-beta and IFN-gamma, respectively, in patients in ICU setting. However, the studied genetic polymorphism of the TGF-beta and IFN-gamma was not associated as a risk factor for AKI or death in our population.