Frequency of TGF-beta and IFN-gamma Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients
Autor(a) principal: | |
---|---|
Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/37161 http://dx.doi.org/10.1155/2014/904730 |
Resumo: | Genetic variations in TGF-beta and IFN-gamma may interfere with proinflammatory cytokine production and, consequently, may be involved with inflammatory diseases, as acute kidney injury (AKI). We considered that genetic polymorphisms of these cytokines may have a crucial role in the outcome of critically ill patients. To investigate whether the genetic polymorphisms of rs1800470 (codon 10 T/C), rs1800471 (codon 25 C/G) from the TGF-beta, and rs2430561 (+874 T/A) from IFN-gamma may be a risk factor for ICU patients to the development of AKI and/or death. in a prospective nested case-control study, were included 139 ICU patients who developed AKI, 164 ICU patients without AKI, and 244 healthy individuals. We observed a higher frequency to T/A genotype for IFN-gamma (intermediate producer phenotype) and higher frequency of TT GG and TC GG genotype (high producer) for TGF-beta polymorphism in overall population. However, these polymorphisms have not been shown as a predictor of risk for AKI and death. We found an increased prevalence of high and intermediate producer phenotypes from TGF-beta and IFN-gamma, respectively, in patients in ICU setting. However, the studied genetic polymorphism of the TGF-beta and IFN-gamma was not associated as a risk factor for AKI or death in our population. |
id |
UFSP_f8b7a40b6c4aec32939f6fa07b411fd9 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/37161 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Grabulosa, Caren Cristina [UNIFESP]Batista, Marcelo Costa [UNIFESP]Cendoroglo Neto, Miguel [UNIFESP]Quinto, BeataMarie Redublo [UNIFESP]Narciso, RobertoMonte, Julio Cesar [UNIFESP]Durao, Marcelino [UNIFESP]Rizzo, Luiz VicentePavao Santos, Oscar Fernando [UNIFESP]Dalboni, Maria Aparecida [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Hosp Israelita Albert EinsteinTufts Univ New England Med CtrUniv Nove Julho2016-01-24T14:34:57Z2016-01-24T14:34:57Z2014-01-01Biomed Research International. New York: Hindawi Publishing Corporation, 6 p., 2014.2314-6133http://repositorio.unifesp.br/handle/11600/37161http://dx.doi.org/10.1155/2014/904730WOS000340156600001.pdf10.1155/2014/904730WOS:000340156600001Genetic variations in TGF-beta and IFN-gamma may interfere with proinflammatory cytokine production and, consequently, may be involved with inflammatory diseases, as acute kidney injury (AKI). We considered that genetic polymorphisms of these cytokines may have a crucial role in the outcome of critically ill patients. To investigate whether the genetic polymorphisms of rs1800470 (codon 10 T/C), rs1800471 (codon 25 C/G) from the TGF-beta, and rs2430561 (+874 T/A) from IFN-gamma may be a risk factor for ICU patients to the development of AKI and/or death. in a prospective nested case-control study, were included 139 ICU patients who developed AKI, 164 ICU patients without AKI, and 244 healthy individuals. We observed a higher frequency to T/A genotype for IFN-gamma (intermediate producer phenotype) and higher frequency of TT GG and TC GG genotype (high producer) for TGF-beta polymorphism in overall population. However, these polymorphisms have not been shown as a predictor of risk for AKI and death. We found an increased prevalence of high and intermediate producer phenotypes from TGF-beta and IFN-gamma, respectively, in patients in ICU setting. However, the studied genetic polymorphism of the TGF-beta and IFN-gamma was not associated as a risk factor for AKI or death in our population.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, UNIFESP, Div Nephrol, São Paulo, BrazilHosp Israelita Albert Einstein, São Paulo, BrazilTufts Univ New England Med Ctr, Boston, MA USAUniv Nove Julho, UNINOVE, São Paulo, BrazilUniversidade Federal de São Paulo, UNIFESP, Div Nephrol, São Paulo, BrazilFAPESP: 07/58363-0Web of Science6engHindawi Publishing CorporationBiomed Research InternationalFrequency of TGF-beta and IFN-gamma Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000340156600001.pdfapplication/pdf1221652${dspace.ui.url}/bitstream/11600/37161/1/WOS000340156600001.pdfdb22ef0e0f6a4bea40860771f2937df9MD51open accessTEXTWOS000340156600001.pdf.txtWOS000340156600001.pdf.txtExtracted texttext/plain31531${dspace.ui.url}/bitstream/11600/37161/2/WOS000340156600001.pdf.txt1bff5ef26dfe7f4ffdbd42a08427504cMD52open access11600/371612021-10-05 21:57:23.52open accessoai:repositorio.unifesp.br:11600/37161Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-06T00:57:23Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Frequency of TGF-beta and IFN-gamma Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients |
title |
Frequency of TGF-beta and IFN-gamma Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients |
spellingShingle |
Frequency of TGF-beta and IFN-gamma Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients Grabulosa, Caren Cristina [UNIFESP] |
title_short |
Frequency of TGF-beta and IFN-gamma Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients |
title_full |
Frequency of TGF-beta and IFN-gamma Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients |
title_fullStr |
Frequency of TGF-beta and IFN-gamma Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients |
title_full_unstemmed |
Frequency of TGF-beta and IFN-gamma Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients |
title_sort |
Frequency of TGF-beta and IFN-gamma Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients |
author |
Grabulosa, Caren Cristina [UNIFESP] |
author_facet |
Grabulosa, Caren Cristina [UNIFESP] Batista, Marcelo Costa [UNIFESP] Cendoroglo Neto, Miguel [UNIFESP] Quinto, BeataMarie Redublo [UNIFESP] Narciso, Roberto Monte, Julio Cesar [UNIFESP] Durao, Marcelino [UNIFESP] Rizzo, Luiz Vicente Pavao Santos, Oscar Fernando [UNIFESP] Dalboni, Maria Aparecida [UNIFESP] |
author_role |
author |
author2 |
Batista, Marcelo Costa [UNIFESP] Cendoroglo Neto, Miguel [UNIFESP] Quinto, BeataMarie Redublo [UNIFESP] Narciso, Roberto Monte, Julio Cesar [UNIFESP] Durao, Marcelino [UNIFESP] Rizzo, Luiz Vicente Pavao Santos, Oscar Fernando [UNIFESP] Dalboni, Maria Aparecida [UNIFESP] |
author2_role |
author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Hosp Israelita Albert Einstein Tufts Univ New England Med Ctr Univ Nove Julho |
dc.contributor.author.fl_str_mv |
Grabulosa, Caren Cristina [UNIFESP] Batista, Marcelo Costa [UNIFESP] Cendoroglo Neto, Miguel [UNIFESP] Quinto, BeataMarie Redublo [UNIFESP] Narciso, Roberto Monte, Julio Cesar [UNIFESP] Durao, Marcelino [UNIFESP] Rizzo, Luiz Vicente Pavao Santos, Oscar Fernando [UNIFESP] Dalboni, Maria Aparecida [UNIFESP] |
description |
Genetic variations in TGF-beta and IFN-gamma may interfere with proinflammatory cytokine production and, consequently, may be involved with inflammatory diseases, as acute kidney injury (AKI). We considered that genetic polymorphisms of these cytokines may have a crucial role in the outcome of critically ill patients. To investigate whether the genetic polymorphisms of rs1800470 (codon 10 T/C), rs1800471 (codon 25 C/G) from the TGF-beta, and rs2430561 (+874 T/A) from IFN-gamma may be a risk factor for ICU patients to the development of AKI and/or death. in a prospective nested case-control study, were included 139 ICU patients who developed AKI, 164 ICU patients without AKI, and 244 healthy individuals. We observed a higher frequency to T/A genotype for IFN-gamma (intermediate producer phenotype) and higher frequency of TT GG and TC GG genotype (high producer) for TGF-beta polymorphism in overall population. However, these polymorphisms have not been shown as a predictor of risk for AKI and death. We found an increased prevalence of high and intermediate producer phenotypes from TGF-beta and IFN-gamma, respectively, in patients in ICU setting. However, the studied genetic polymorphism of the TGF-beta and IFN-gamma was not associated as a risk factor for AKI or death in our population. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:34:57Z |
dc.date.available.fl_str_mv |
2016-01-24T14:34:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Biomed Research International. New York: Hindawi Publishing Corporation, 6 p., 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/37161 http://dx.doi.org/10.1155/2014/904730 |
dc.identifier.issn.none.fl_str_mv |
2314-6133 |
dc.identifier.file.none.fl_str_mv |
WOS000340156600001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1155/2014/904730 |
dc.identifier.wos.none.fl_str_mv |
WOS:000340156600001 |
identifier_str_mv |
Biomed Research International. New York: Hindawi Publishing Corporation, 6 p., 2014. 2314-6133 WOS000340156600001.pdf 10.1155/2014/904730 WOS:000340156600001 |
url |
http://repositorio.unifesp.br/handle/11600/37161 http://dx.doi.org/10.1155/2014/904730 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Biomed Research International |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6 |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/37161/1/WOS000340156600001.pdf ${dspace.ui.url}/bitstream/11600/37161/2/WOS000340156600001.pdf.txt |
bitstream.checksum.fl_str_mv |
db22ef0e0f6a4bea40860771f2937df9 1bff5ef26dfe7f4ffdbd42a08427504c |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764113341841408 |