Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/36995 http://dx.doi.org/10.1016/j.autneu.2013.06.002 |
Resumo: | Polyphenols consumption detected in red wine and grape juice may prevent or help in the treatment of hypertension. However, cardiovascular autonomic effects of polyphenols were poorly studied. Therefore, we evaluated the effects of resveratrol and grape juice treatments in hemodynamics, baroreflex sensitivity, heart rate (HR) and blood pressure (BP) variability and cardiac redox parameters. Male Wistar rats were divided in 3 groups (n = 7/each) and treated for 30 days: only L-NAME-treated (60 mg/kg/day by oral gavage), L-NAME + resveratrol (L-NAME + R) and L-NAME + grape juice (L-NAME + G). BP signal was directly recorded and pulse interval (PI) and systolic arterial pressure (SAP) variability were analyzed in time and frequency domains. Baroreflex sensitivity (BRS) was determined by the alpha index. Oxidized and reduced glutathione concentrations were determined in cardiac tissue. L-NAME increased BP with no differences among groups (mean BP: L-NAME = 124 +/- 4, L-NAME + R = 126 +/- 3 and L-NAME + G = 125 +/- 4 mmHg). PI and SAP variability expressed by total variance were also similar among groups. However, normalized low frequency (LF) and high frequency (HF) components of PI variability were lower and higher, respectively, in both R and G-treated groups when compared to only L-NAME group. Interestingly, sympathetic modulation to the vessels (LF from SAP variability) and BRS were decreased and increased, respectively, only in L-NAME + R rats. Additionally, GSH/GSSG ratios were higher in L-NAME + R and L-NAME + G than in L-NAME group. Our results indicate that resveratrol and grape juice treatments can modulate autonomic function and promote cardiac redox benefits even when nitric oxide is decreased. Moreover, resveratrol influences not only cardiac but also vascular autonomic modulation. (C) 2013 Elsevier B.V. All rights reserved. |
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Dillenburg, Denise RuttkeMostarda, Cristiano [UNIFESP]Moraes-Silva, Ivana Cinthya [UNIFESP]Ferreira, DaianeBos, Denielli da Silva GoncalvesMachado Duarte, Ana AmeliaIrigoyen, Maria Claudia [UNIFESP]Rigatto, KatyaUniversidade Federal de São Paulo (UNIFESP)Univ Fed Ciencias SaudeFundacao Univ CardiolUniv Maranhao2016-01-24T14:34:44Z2016-01-24T14:34:44Z2013-12-01Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 179, n. 1-2, p. 9-13, 2013.1566-0702http://repositorio.unifesp.br/handle/11600/36995http://dx.doi.org/10.1016/j.autneu.2013.06.002WOS000329002900003.pdf10.1016/j.autneu.2013.06.002WOS:000329002900003Polyphenols consumption detected in red wine and grape juice may prevent or help in the treatment of hypertension. However, cardiovascular autonomic effects of polyphenols were poorly studied. Therefore, we evaluated the effects of resveratrol and grape juice treatments in hemodynamics, baroreflex sensitivity, heart rate (HR) and blood pressure (BP) variability and cardiac redox parameters. Male Wistar rats were divided in 3 groups (n = 7/each) and treated for 30 days: only L-NAME-treated (60 mg/kg/day by oral gavage), L-NAME + resveratrol (L-NAME + R) and L-NAME + grape juice (L-NAME + G). BP signal was directly recorded and pulse interval (PI) and systolic arterial pressure (SAP) variability were analyzed in time and frequency domains. Baroreflex sensitivity (BRS) was determined by the alpha index. Oxidized and reduced glutathione concentrations were determined in cardiac tissue. L-NAME increased BP with no differences among groups (mean BP: L-NAME = 124 +/- 4, L-NAME + R = 126 +/- 3 and L-NAME + G = 125 +/- 4 mmHg). PI and SAP variability expressed by total variance were also similar among groups. However, normalized low frequency (LF) and high frequency (HF) components of PI variability were lower and higher, respectively, in both R and G-treated groups when compared to only L-NAME group. Interestingly, sympathetic modulation to the vessels (LF from SAP variability) and BRS were decreased and increased, respectively, only in L-NAME + R rats. Additionally, GSH/GSSG ratios were higher in L-NAME + R and L-NAME + G than in L-NAME group. Our results indicate that resveratrol and grape juice treatments can modulate autonomic function and promote cardiac redox benefits even when nitric oxide is decreased. Moreover, resveratrol influences not only cardiac but also vascular autonomic modulation. (C) 2013 Elsevier B.V. All rights reserved.Univ São Paulo, Escola Paulista Med, Inst Coracao InCor, Unidade Hipertensao, São Paulo, BrazilUniv Fed Ciencias Saude, Dept Ciencias Basicas Saude, Porto Alegre, RS, BrazilFundacao Univ Cardiol, Inst Cardiol, Unidade Pesquisa, Porto Alegre, RS, BrazilUniv Maranhao, UFMA, Hosp Univ Matemo Infantil, Sao Luis, BrazilUniv São Paulo, Escola Paulista Med, Inst Coracao InCor, Unidade Hipertensao, São Paulo, BrazilWeb of Science9-13engElsevier B.V.Autonomic Neuroscience-basic & Clinicalhttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessAutonomic modulationResveratrolL-NAMEGrape juiceResveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000329002900003.pdfapplication/pdf470944${dspace.ui.url}/bitstream/11600/36995/1/WOS000329002900003.pdf2cb1c13bf7cea99bddeb551f402fba46MD51open accessTEXTWOS000329002900003.pdf.txtWOS000329002900003.pdf.txtExtracted texttext/plain27538${dspace.ui.url}/bitstream/11600/36995/2/WOS000329002900003.pdf.txtdeecef7abdad7356a6202399e1e30d9fMD52open access11600/369952023-01-30 22:19:12.123open accessoai:repositorio.unifesp.br:11600/36995Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-01-31T01:19:12Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats |
title |
Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats |
spellingShingle |
Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats Dillenburg, Denise Ruttke Autonomic modulation Resveratrol L-NAME Grape juice |
title_short |
Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats |
title_full |
Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats |
title_fullStr |
Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats |
title_full_unstemmed |
Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats |
title_sort |
Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats |
author |
Dillenburg, Denise Ruttke |
author_facet |
Dillenburg, Denise Ruttke Mostarda, Cristiano [UNIFESP] Moraes-Silva, Ivana Cinthya [UNIFESP] Ferreira, Daiane Bos, Denielli da Silva Goncalves Machado Duarte, Ana Amelia Irigoyen, Maria Claudia [UNIFESP] Rigatto, Katya |
author_role |
author |
author2 |
Mostarda, Cristiano [UNIFESP] Moraes-Silva, Ivana Cinthya [UNIFESP] Ferreira, Daiane Bos, Denielli da Silva Goncalves Machado Duarte, Ana Amelia Irigoyen, Maria Claudia [UNIFESP] Rigatto, Katya |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Univ Fed Ciencias Saude Fundacao Univ Cardiol Univ Maranhao |
dc.contributor.author.fl_str_mv |
Dillenburg, Denise Ruttke Mostarda, Cristiano [UNIFESP] Moraes-Silva, Ivana Cinthya [UNIFESP] Ferreira, Daiane Bos, Denielli da Silva Goncalves Machado Duarte, Ana Amelia Irigoyen, Maria Claudia [UNIFESP] Rigatto, Katya |
dc.subject.eng.fl_str_mv |
Autonomic modulation Resveratrol L-NAME Grape juice |
topic |
Autonomic modulation Resveratrol L-NAME Grape juice |
description |
Polyphenols consumption detected in red wine and grape juice may prevent or help in the treatment of hypertension. However, cardiovascular autonomic effects of polyphenols were poorly studied. Therefore, we evaluated the effects of resveratrol and grape juice treatments in hemodynamics, baroreflex sensitivity, heart rate (HR) and blood pressure (BP) variability and cardiac redox parameters. Male Wistar rats were divided in 3 groups (n = 7/each) and treated for 30 days: only L-NAME-treated (60 mg/kg/day by oral gavage), L-NAME + resveratrol (L-NAME + R) and L-NAME + grape juice (L-NAME + G). BP signal was directly recorded and pulse interval (PI) and systolic arterial pressure (SAP) variability were analyzed in time and frequency domains. Baroreflex sensitivity (BRS) was determined by the alpha index. Oxidized and reduced glutathione concentrations were determined in cardiac tissue. L-NAME increased BP with no differences among groups (mean BP: L-NAME = 124 +/- 4, L-NAME + R = 126 +/- 3 and L-NAME + G = 125 +/- 4 mmHg). PI and SAP variability expressed by total variance were also similar among groups. However, normalized low frequency (LF) and high frequency (HF) components of PI variability were lower and higher, respectively, in both R and G-treated groups when compared to only L-NAME group. Interestingly, sympathetic modulation to the vessels (LF from SAP variability) and BRS were decreased and increased, respectively, only in L-NAME + R rats. Additionally, GSH/GSSG ratios were higher in L-NAME + R and L-NAME + G than in L-NAME group. Our results indicate that resveratrol and grape juice treatments can modulate autonomic function and promote cardiac redox benefits even when nitric oxide is decreased. Moreover, resveratrol influences not only cardiac but also vascular autonomic modulation. (C) 2013 Elsevier B.V. All rights reserved. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-12-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:34:44Z |
dc.date.available.fl_str_mv |
2016-01-24T14:34:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 179, n. 1-2, p. 9-13, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/36995 http://dx.doi.org/10.1016/j.autneu.2013.06.002 |
dc.identifier.issn.none.fl_str_mv |
1566-0702 |
dc.identifier.file.none.fl_str_mv |
WOS000329002900003.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.autneu.2013.06.002 |
dc.identifier.wos.none.fl_str_mv |
WOS:000329002900003 |
identifier_str_mv |
Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 179, n. 1-2, p. 9-13, 2013. 1566-0702 WOS000329002900003.pdf 10.1016/j.autneu.2013.06.002 WOS:000329002900003 |
url |
http://repositorio.unifesp.br/handle/11600/36995 http://dx.doi.org/10.1016/j.autneu.2013.06.002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Autonomic Neuroscience-basic & Clinical |
dc.rights.driver.fl_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9-13 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
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Elsevier B.V. |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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