Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/4613 http://dx.doi.org/10.1590/S0100-879X2008001100014 |
Resumo: | Chronic neurodegenerative processes have been identified in the rat forebrain after prolonged survival following hyperthermia (HT) initiated a few hours after transient global ischemia. Since transient global ischemia and ischemic penumbra share pathophysiological similarities, this study addressed the effects of HT induced after recirculation of focal brain ischemia on infarct size during long survival times. Adult male Wistar rats underwent intra-luminal occlusion of the left middle cerebral artery for 60 min followed by HT (39.0-39.5°C) or normothermia. Control procedures included none and sham surgery with and without HT, and middle cerebral artery occlusion alone. Part I: 6-h HT induced at recirculation. Part II: 2-h HT induced at 2-, 6-, or 24-h recirculation. Part III: 2-h HT initiated at recirculation or 6-h HT initiated at 2-, 6- or 24-h recirculation. Survival periods were 7 days, 2 or 6 months. The effects of post-ischemic HT on cortex and striatum were evaluated histopathologically by measuring the area of remaining tissue in the infarcted hemisphere at -0.30 mm from bregma. Six-hour HT initiated from 6-h recirculation caused a significant decrease in the remaining cortical tissue between 7-day (N = 8) and 2-month (N = 8) survivals (98.46 ± 1.14 to 73.62 ± 8.99%, respectively). When induced from 24-h recirculation, 6-h HT caused a significant reduction of the remaining cortical tissue between 2- (N = 8) and 6-month (N = 9) survivals (94.97 ± 5.02 vs 63.26 ± 11.97%, respectively). These data indicate that post-ischemic HT triggers chronic neurodegenerative processes in ischemic penumbra, suggesting that similar fever-triggered effects may annul the benefit of early recirculation in stroke patients over the long-term. |
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Favero-Filho, Luiz Antonio [UNIFESP]Borges, Andrea Aurélio [UNIFESP]Grassl, Christian [UNIFESP]Lopes, Antonio Carlos [UNIFESP]Sinigaglia-Coimbra, Rita [UNIFESP]Coimbra, Cicero Galli [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:38:47Z2015-06-14T13:38:47Z2008-11-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 11, p. 1029-1036, 2008.0100-879Xhttp://repositorio.unifesp.br/handle/11600/4613http://dx.doi.org/10.1590/S0100-879X2008001100014S0100-879X2008001100014.pdfS0100-879X200800110001410.1590/S0100-879X2008001100014WOS:000261960500014Chronic neurodegenerative processes have been identified in the rat forebrain after prolonged survival following hyperthermia (HT) initiated a few hours after transient global ischemia. Since transient global ischemia and ischemic penumbra share pathophysiological similarities, this study addressed the effects of HT induced after recirculation of focal brain ischemia on infarct size during long survival times. Adult male Wistar rats underwent intra-luminal occlusion of the left middle cerebral artery for 60 min followed by HT (39.0-39.5°C) or normothermia. Control procedures included none and sham surgery with and without HT, and middle cerebral artery occlusion alone. Part I: 6-h HT induced at recirculation. Part II: 2-h HT induced at 2-, 6-, or 24-h recirculation. Part III: 2-h HT initiated at recirculation or 6-h HT initiated at 2-, 6- or 24-h recirculation. Survival periods were 7 days, 2 or 6 months. The effects of post-ischemic HT on cortex and striatum were evaluated histopathologically by measuring the area of remaining tissue in the infarcted hemisphere at -0.30 mm from bregma. Six-hour HT initiated from 6-h recirculation caused a significant decrease in the remaining cortical tissue between 7-day (N = 8) and 2-month (N = 8) survivals (98.46 ± 1.14 to 73.62 ± 8.99%, respectively). When induced from 24-h recirculation, 6-h HT caused a significant reduction of the remaining cortical tissue between 2- (N = 8) and 6-month (N = 9) survivals (94.97 ± 5.02 vs 63.26 ± 11.97%, respectively). These data indicate that post-ischemic HT triggers chronic neurodegenerative processes in ischemic penumbra, suggesting that similar fever-triggered effects may annul the benefit of early recirculation in stroke patients over the long-term.Universidade Federal de São Paulo (UNIFESP) Laboratório de Fisiopatologia Clínica e ExperimentalUniversidade Federal de São Paulo (UNIFESP) Departamento de Neurologia e NeurocirurgiaUniversidade Federal de São Paulo (UNIFESP) Departamento de MedicinaUniversidade Federal de São Paulo (UNIFESP) Centro de Microscopia EletrônicaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina COLSAN-UNIFESPUNIFESP, Laboratório de Fisiopatologia Clínica e ExperimentalUNIFESP, Depto. de Neurologia e NeurocirurgiaUNIFESP, Depto. de MedicinaUNIFESP, Centro de Microscopia EletrônicaUNIFESP, EPM, COLSAN-UNIFESPSciELO1029-1036engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchHyperthermiaIschemic penumbraNeurodegenerationRat focal ischemiaHyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat braininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2008001100014.pdfapplication/pdf683298${dspace.ui.url}/bitstream/11600/4613/1/S0100-879X2008001100014.pdf71bc059a0dd87950428e0ab3f7651c69MD51open accessTEXTS0100-879X2008001100014.pdf.txtS0100-879X2008001100014.pdf.txtExtracted texttext/plain33203${dspace.ui.url}/bitstream/11600/4613/2/S0100-879X2008001100014.pdf.txt13761cc2e80d1e1e7aa99a58fd403b5aMD52open access11600/46132021-09-30 11:01:06.981open accessoai:repositorio.unifesp.br:11600/4613Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-09-30T14:01:06Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain |
title |
Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain |
spellingShingle |
Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain Favero-Filho, Luiz Antonio [UNIFESP] Hyperthermia Ischemic penumbra Neurodegeneration Rat focal ischemia |
title_short |
Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain |
title_full |
Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain |
title_fullStr |
Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain |
title_full_unstemmed |
Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain |
title_sort |
Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain |
author |
Favero-Filho, Luiz Antonio [UNIFESP] |
author_facet |
Favero-Filho, Luiz Antonio [UNIFESP] Borges, Andrea Aurélio [UNIFESP] Grassl, Christian [UNIFESP] Lopes, Antonio Carlos [UNIFESP] Sinigaglia-Coimbra, Rita [UNIFESP] Coimbra, Cicero Galli [UNIFESP] |
author_role |
author |
author2 |
Borges, Andrea Aurélio [UNIFESP] Grassl, Christian [UNIFESP] Lopes, Antonio Carlos [UNIFESP] Sinigaglia-Coimbra, Rita [UNIFESP] Coimbra, Cicero Galli [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Favero-Filho, Luiz Antonio [UNIFESP] Borges, Andrea Aurélio [UNIFESP] Grassl, Christian [UNIFESP] Lopes, Antonio Carlos [UNIFESP] Sinigaglia-Coimbra, Rita [UNIFESP] Coimbra, Cicero Galli [UNIFESP] |
dc.subject.eng.fl_str_mv |
Hyperthermia Ischemic penumbra Neurodegeneration Rat focal ischemia |
topic |
Hyperthermia Ischemic penumbra Neurodegeneration Rat focal ischemia |
description |
Chronic neurodegenerative processes have been identified in the rat forebrain after prolonged survival following hyperthermia (HT) initiated a few hours after transient global ischemia. Since transient global ischemia and ischemic penumbra share pathophysiological similarities, this study addressed the effects of HT induced after recirculation of focal brain ischemia on infarct size during long survival times. Adult male Wistar rats underwent intra-luminal occlusion of the left middle cerebral artery for 60 min followed by HT (39.0-39.5°C) or normothermia. Control procedures included none and sham surgery with and without HT, and middle cerebral artery occlusion alone. Part I: 6-h HT induced at recirculation. Part II: 2-h HT induced at 2-, 6-, or 24-h recirculation. Part III: 2-h HT initiated at recirculation or 6-h HT initiated at 2-, 6- or 24-h recirculation. Survival periods were 7 days, 2 or 6 months. The effects of post-ischemic HT on cortex and striatum were evaluated histopathologically by measuring the area of remaining tissue in the infarcted hemisphere at -0.30 mm from bregma. Six-hour HT initiated from 6-h recirculation caused a significant decrease in the remaining cortical tissue between 7-day (N = 8) and 2-month (N = 8) survivals (98.46 ± 1.14 to 73.62 ± 8.99%, respectively). When induced from 24-h recirculation, 6-h HT caused a significant reduction of the remaining cortical tissue between 2- (N = 8) and 6-month (N = 9) survivals (94.97 ± 5.02 vs 63.26 ± 11.97%, respectively). These data indicate that post-ischemic HT triggers chronic neurodegenerative processes in ischemic penumbra, suggesting that similar fever-triggered effects may annul the benefit of early recirculation in stroke patients over the long-term. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-11-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:38:47Z |
dc.date.available.fl_str_mv |
2015-06-14T13:38:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 11, p. 1029-1036, 2008. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/4613 http://dx.doi.org/10.1590/S0100-879X2008001100014 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2008001100014.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2008001100014 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2008001100014 |
dc.identifier.wos.none.fl_str_mv |
WOS:000261960500014 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 11, p. 1029-1036, 2008. 0100-879X S0100-879X2008001100014.pdf S0100-879X2008001100014 10.1590/S0100-879X2008001100014 WOS:000261960500014 |
url |
http://repositorio.unifesp.br/handle/11600/4613 http://dx.doi.org/10.1590/S0100-879X2008001100014 |
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eng |
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Brazilian Journal of Medical and Biological Research |
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openAccess |
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1029-1036 |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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