Chemical constituents and in vivo preliminary evaluation of the toxicological activity of Ouratea spectabilis (OCHNACEAE) and Clitoria guianensis (Fabaceae) leaves
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Bioscience journal (Online) |
Texto Completo: | https://seer.ufu.br/index.php/biosciencejournal/article/view/62323 |
Resumo: | Clitoria guianensis and Ouratea spectabilis, found in the Brazilian Cerrado, are used in folk medicine, despite the few chemical and biological studies reported in the literature. The present study aims to investigate the toxicity and effect of extracts from both species on the microcrustacean Artemia salina, and to determine the chemical composition of the hexane extract of O. spectabilis leaves and the EtOAc fraction of C. guianensis leaves. Kaempferitrin, a flavonoid isolated from of the EtOAc fraction of C. guianensis leaves, was identified by chemical analysis. Analysis of the hexane extract of O. spectabilis leaves using gas chromatography-mass spectrometry (GC-MS) suggested the presence of twenty-five known substances. The Hex, EtOAc, and EtOH crude extracts of C. guianensis leaves exhibited high and moderate toxicity against Artemia salina, with median lethal dose values (LD50) of 43.7, 25.4, and 233.4 mg.L−1, respectively. The acetone extract of O. spectabilis leaves showed moderate toxicity against Artemia salina with an LD50 value of 115.13 mg.L−1. |
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Chemical constituents and in vivo preliminary evaluation of the toxicological activity of Ouratea spectabilis (OCHNACEAE) and Clitoria guianensis (Fabaceae) leavesArtemia salinaCerradoKaempferitrin.Biological SciencesClitoria guianensis and Ouratea spectabilis, found in the Brazilian Cerrado, are used in folk medicine, despite the few chemical and biological studies reported in the literature. The present study aims to investigate the toxicity and effect of extracts from both species on the microcrustacean Artemia salina, and to determine the chemical composition of the hexane extract of O. spectabilis leaves and the EtOAc fraction of C. guianensis leaves. Kaempferitrin, a flavonoid isolated from of the EtOAc fraction of C. guianensis leaves, was identified by chemical analysis. Analysis of the hexane extract of O. spectabilis leaves using gas chromatography-mass spectrometry (GC-MS) suggested the presence of twenty-five known substances. The Hex, EtOAc, and EtOH crude extracts of C. guianensis leaves exhibited high and moderate toxicity against Artemia salina, with median lethal dose values (LD50) of 43.7, 25.4, and 233.4 mg.L−1, respectively. The acetone extract of O. spectabilis leaves showed moderate toxicity against Artemia salina with an LD50 value of 115.13 mg.L−1.As espécies Clitoria guianensis e Ouratea spectabilis, encontradas no Cerrado brasileiro, são utilizadas na medicina popular, apesar de não apresentarem estudos químicos e biológicos reportados na literatura. O presente trabalho busca investigar a toxicidade frente ao microcrustáceo Artemia salina, dos extratos destas espécies, assim como a composição química do extrato hexânico das folhas de O. spectabilis e da fração EtOAc das folhas de C. guianensis. O estudo químico da fração EtOAc das folhas de C. guianensis resultou no isolamento de um flavonoide conhecido como Kaempferitrin. A análise do extrato hexânico das folhas de O. spectabilis, por CG-EM, sugere a presença de 13 substâncias conhecidas. Os extratos Hex, EtOAc e EtOH bruto de C. guianensis mostraram alta e moderada toxicidade frente a Artemia salina, respectivamente, com valores de dose letal (DL50) de 43.7, 25.4 e 233.4 mg.L-1. O extrato acetônico das folhas de O. spectabilis apresentou moderada toxicidade frente a Artemia salina com DL50 de 114.8 mg.L-1.Universidade Federal de Uberlândia2023-01-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufu.br/index.php/biosciencejournal/article/view/6232310.14393/BJ-v39n0a2023-62323Bioscience Journal ; Vol. 39 (2023): Continuous Publication; e39010Bioscience Journal ; v. 39 (2023): Continuous Publication; e390101981-3163reponame:Bioscience journal (Online)instname:Universidade Federal de Uberlândia (UFU)instacron:UFUenghttps://seer.ufu.br/index.php/biosciencejournal/article/view/62323/35500Brazil; Contemporary Copyright (c) 2023 Frank Bruno Vieira de Sousa, Állefe Barbosa Cruz, Daniela Francisca Soares, Camila Luiza Cunha, Juliana C. Holzbachhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSousa, Frank Bruno Vieira deCruz, Állefe BarbosaSoares, Daniela FranciscaCunha, Camila LuizaHolzbach, Juliana C.2024-01-31T19:16:18Zoai:ojs.www.seer.ufu.br:article/62323Revistahttps://seer.ufu.br/index.php/biosciencejournalPUBhttps://seer.ufu.br/index.php/biosciencejournal/oaibiosciencej@ufu.br||1981-31631516-3725opendoar:2024-01-31T19:16:18Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)false |
dc.title.none.fl_str_mv |
Chemical constituents and in vivo preliminary evaluation of the toxicological activity of Ouratea spectabilis (OCHNACEAE) and Clitoria guianensis (Fabaceae) leaves |
title |
Chemical constituents and in vivo preliminary evaluation of the toxicological activity of Ouratea spectabilis (OCHNACEAE) and Clitoria guianensis (Fabaceae) leaves |
spellingShingle |
Chemical constituents and in vivo preliminary evaluation of the toxicological activity of Ouratea spectabilis (OCHNACEAE) and Clitoria guianensis (Fabaceae) leaves Sousa, Frank Bruno Vieira de Artemia salina Cerrado Kaempferitrin. Biological Sciences |
title_short |
Chemical constituents and in vivo preliminary evaluation of the toxicological activity of Ouratea spectabilis (OCHNACEAE) and Clitoria guianensis (Fabaceae) leaves |
title_full |
Chemical constituents and in vivo preliminary evaluation of the toxicological activity of Ouratea spectabilis (OCHNACEAE) and Clitoria guianensis (Fabaceae) leaves |
title_fullStr |
Chemical constituents and in vivo preliminary evaluation of the toxicological activity of Ouratea spectabilis (OCHNACEAE) and Clitoria guianensis (Fabaceae) leaves |
title_full_unstemmed |
Chemical constituents and in vivo preliminary evaluation of the toxicological activity of Ouratea spectabilis (OCHNACEAE) and Clitoria guianensis (Fabaceae) leaves |
title_sort |
Chemical constituents and in vivo preliminary evaluation of the toxicological activity of Ouratea spectabilis (OCHNACEAE) and Clitoria guianensis (Fabaceae) leaves |
author |
Sousa, Frank Bruno Vieira de |
author_facet |
Sousa, Frank Bruno Vieira de Cruz, Állefe Barbosa Soares, Daniela Francisca Cunha, Camila Luiza Holzbach, Juliana C. |
author_role |
author |
author2 |
Cruz, Állefe Barbosa Soares, Daniela Francisca Cunha, Camila Luiza Holzbach, Juliana C. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Sousa, Frank Bruno Vieira de Cruz, Állefe Barbosa Soares, Daniela Francisca Cunha, Camila Luiza Holzbach, Juliana C. |
dc.subject.por.fl_str_mv |
Artemia salina Cerrado Kaempferitrin. Biological Sciences |
topic |
Artemia salina Cerrado Kaempferitrin. Biological Sciences |
description |
Clitoria guianensis and Ouratea spectabilis, found in the Brazilian Cerrado, are used in folk medicine, despite the few chemical and biological studies reported in the literature. The present study aims to investigate the toxicity and effect of extracts from both species on the microcrustacean Artemia salina, and to determine the chemical composition of the hexane extract of O. spectabilis leaves and the EtOAc fraction of C. guianensis leaves. Kaempferitrin, a flavonoid isolated from of the EtOAc fraction of C. guianensis leaves, was identified by chemical analysis. Analysis of the hexane extract of O. spectabilis leaves using gas chromatography-mass spectrometry (GC-MS) suggested the presence of twenty-five known substances. The Hex, EtOAc, and EtOH crude extracts of C. guianensis leaves exhibited high and moderate toxicity against Artemia salina, with median lethal dose values (LD50) of 43.7, 25.4, and 233.4 mg.L−1, respectively. The acetone extract of O. spectabilis leaves showed moderate toxicity against Artemia salina with an LD50 value of 115.13 mg.L−1. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/62323 10.14393/BJ-v39n0a2023-62323 |
url |
https://seer.ufu.br/index.php/biosciencejournal/article/view/62323 |
identifier_str_mv |
10.14393/BJ-v39n0a2023-62323 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/62323/35500 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Brazil; Contemporary |
dc.publisher.none.fl_str_mv |
Universidade Federal de Uberlândia |
publisher.none.fl_str_mv |
Universidade Federal de Uberlândia |
dc.source.none.fl_str_mv |
Bioscience Journal ; Vol. 39 (2023): Continuous Publication; e39010 Bioscience Journal ; v. 39 (2023): Continuous Publication; e39010 1981-3163 reponame:Bioscience journal (Online) instname:Universidade Federal de Uberlândia (UFU) instacron:UFU |
instname_str |
Universidade Federal de Uberlândia (UFU) |
instacron_str |
UFU |
institution |
UFU |
reponame_str |
Bioscience journal (Online) |
collection |
Bioscience journal (Online) |
repository.name.fl_str_mv |
Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU) |
repository.mail.fl_str_mv |
biosciencej@ufu.br|| |
_version_ |
1797069065132441600 |