Impacto da dieta dissociada no índice internacional de qualidade da dieta e nos biomarcadores de estresse oxidativo

Detalhes bibliográficos
Autor(a) principal: Paixão, Mírian Patrícia Castro Pereira
Data de Publicação: 2011
Tipo de documento: Tese
Idioma: por
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: http://locus.ufv.br/handle/123456789/463
Resumo: Obesity is a chronic disease that contributes to the development of oxidative stress, increased risk of developing cardiovascular disease and metabolic syndrome. Alternatives for the treatment of obesity various types of low-calorie diets have been used, among these, the dissociated diet. This diet recommends that carbohydrate and protein should not be consumed in a meal together in order to promote greater efficiency and accelerate the metabolic process of weight reduction. The aim of this study was to investigate the effect of dietary carbohydrate and protein in dissociated diets on biomarkers of oxidative stress represented by circulating levels of oxidized low density lipoprotein (oxLDL) and plasma total antioxidant capacity (TAC) and their associations with anthropometric, biochemical, and dietary oxidative in men in conditions of overweight and obesity. The study included 31 healthy men with BMI between 26.5 and 35.2 kg/m2, who followed the diet for 8 weeks with caloric restriction the 250 kcal. The subjects were randomly divided into three groups according to the type of diet. For the control group (GCT), was prescribed a diet balanced in nutrients, the group of day-carbohydrate (GCD) was prescribed a high carbohydrate / low-protein lunch and dinner, while in the night- carbohydrate group (GCN) the distribution of macronutrients in the meals was the reverse of the GCD. At the beginning and end of this study were analyzed anthropometric measurements, body composition using the deuterium and the serum glucose, insulin, cholesterol and fractions, triglycerides, uric acid, ceruloplasmin, TAC and oxLDL. Diet composition and the overall quality of the usual diet and during the intervention were analyzed using food diaries and Dietary Quality Index- International (IDQI). At the end of eight weeks, the volunteers had an average weight loss of 4.26 ± 1.47% in GCT, 3.29 ± 2.46 in the GCD, and 4.85 ± 3.01% at GCN and there was a reduction in BMI, WC and HC in the significant when compared to the initial period. There were no differences between groups in the observed changes in anthropometric measurements. The average caloric restriction was 26.01 ± 22.03% in GCT, 31.70 ± 30.28% in the GCN and 16.87 ± 26.67% in the GCD and there was no difference between groups. The quality of the overall diet and nutritional composition showed no significant variations between groups, with the exception of sodium and selenium, which showed a greater reduction in BCM when compared to the other groups (p <0.05). According IDQI the diet of the volunteers was characterized as low quality both in the evaluation of habitual intake and during the intervention. The oxidative and biochemical variables analyzed have not changed significantly between the groups during the study with the exception of serum glucose rose in the GCD and HDL-C which is elevated and insulin decreased in the GCT group (p <0.05), but remained within the normal range. Despite dietary and endogenous variables that could influence serum concentrations of biomarkers of oxidative stress have not changed substantially, TAC rose at the GCT and GCD (p <0.05). While the serum concentration of oxLDL was higher in GCT compared to other groups (p <0.05) and its concentration decreased not significantly only in GCD (p> 0.05). There were no associations between variations in TAC and oxLDL and quantity supplied of carbohydrate or protein meals in there that the dissociation of the diet (p> 0.05). The same analysis was performed for IDQI and their partial scores with respect to TAC and oxLDL and no correlation was observed between these variables, even after adjustment (p> 0.05). We conclude that although the dissociated diet have promoted weight loss and reduction of other anthropometric variables, no relationship was observed between TAC and oxLDL with biochemical variables, and dietary oxidative studied.
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spelling Paixão, Mírian Patrícia Castro Pereirahttp://lattes.cnpq.br/9001805537017932Costa, Neuza Maria Brunorohttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4781709D6Gomide, Lucio Alberto de Mirandahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4781895A9Bressan, Josefinahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4781728Y2Rosado, Eliane Lopeshttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4703173J2Oliveira, Leandro Licursi dehttp://lattes.cnpq.br/0578231392218162Ribeiro, Sônia Machado Rochahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4701461E02015-03-26T12:25:08Z2013-05-062015-03-26T12:25:08Z2011-08-01PAIXÃO, Mírian Patrícia Castro Pereira. Impact of diet dissociated in the diet quality index-international and biomarkers of oxidative stress. 2011. 135 f. Tese (Doutorado em Ciência de Alimentos; Tecnologia de Alimentos; Engenharia de Alimentos) - Universidade Federal de Viçosa, Viçosa, 2011.http://locus.ufv.br/handle/123456789/463Obesity is a chronic disease that contributes to the development of oxidative stress, increased risk of developing cardiovascular disease and metabolic syndrome. Alternatives for the treatment of obesity various types of low-calorie diets have been used, among these, the dissociated diet. This diet recommends that carbohydrate and protein should not be consumed in a meal together in order to promote greater efficiency and accelerate the metabolic process of weight reduction. The aim of this study was to investigate the effect of dietary carbohydrate and protein in dissociated diets on biomarkers of oxidative stress represented by circulating levels of oxidized low density lipoprotein (oxLDL) and plasma total antioxidant capacity (TAC) and their associations with anthropometric, biochemical, and dietary oxidative in men in conditions of overweight and obesity. The study included 31 healthy men with BMI between 26.5 and 35.2 kg/m2, who followed the diet for 8 weeks with caloric restriction the 250 kcal. The subjects were randomly divided into three groups according to the type of diet. For the control group (GCT), was prescribed a diet balanced in nutrients, the group of day-carbohydrate (GCD) was prescribed a high carbohydrate / low-protein lunch and dinner, while in the night- carbohydrate group (GCN) the distribution of macronutrients in the meals was the reverse of the GCD. At the beginning and end of this study were analyzed anthropometric measurements, body composition using the deuterium and the serum glucose, insulin, cholesterol and fractions, triglycerides, uric acid, ceruloplasmin, TAC and oxLDL. Diet composition and the overall quality of the usual diet and during the intervention were analyzed using food diaries and Dietary Quality Index- International (IDQI). At the end of eight weeks, the volunteers had an average weight loss of 4.26 ± 1.47% in GCT, 3.29 ± 2.46 in the GCD, and 4.85 ± 3.01% at GCN and there was a reduction in BMI, WC and HC in the significant when compared to the initial period. There were no differences between groups in the observed changes in anthropometric measurements. The average caloric restriction was 26.01 ± 22.03% in GCT, 31.70 ± 30.28% in the GCN and 16.87 ± 26.67% in the GCD and there was no difference between groups. The quality of the overall diet and nutritional composition showed no significant variations between groups, with the exception of sodium and selenium, which showed a greater reduction in BCM when compared to the other groups (p <0.05). According IDQI the diet of the volunteers was characterized as low quality both in the evaluation of habitual intake and during the intervention. The oxidative and biochemical variables analyzed have not changed significantly between the groups during the study with the exception of serum glucose rose in the GCD and HDL-C which is elevated and insulin decreased in the GCT group (p <0.05), but remained within the normal range. Despite dietary and endogenous variables that could influence serum concentrations of biomarkers of oxidative stress have not changed substantially, TAC rose at the GCT and GCD (p <0.05). While the serum concentration of oxLDL was higher in GCT compared to other groups (p <0.05) and its concentration decreased not significantly only in GCD (p> 0.05). There were no associations between variations in TAC and oxLDL and quantity supplied of carbohydrate or protein meals in there that the dissociation of the diet (p> 0.05). The same analysis was performed for IDQI and their partial scores with respect to TAC and oxLDL and no correlation was observed between these variables, even after adjustment (p> 0.05). We conclude that although the dissociated diet have promoted weight loss and reduction of other anthropometric variables, no relationship was observed between TAC and oxLDL with biochemical variables, and dietary oxidative studied.A obesidade é uma doença crônica que contribui para o desenvolvimento do estresse oxidativo, aumento do risco de desenvolvimento de doenças cardiovasculares e da síndrome metabólica. Na busca de alternativas para o tratamento da obesidade vários tipos de dietas hipocalóricas tem sido utilizada, dentre estas, encontra-se a dieta dissociada. Esta dieta preconiza que carboidratos e proteínas não devem ser consumidos juntos em uma refeição, a fim de promover uma maior eficiência metabólica e acelerar o processo de redução ponderal. Dessa forma, o objetivo deste estudo foi investigar o efeito da dieta dissociada em carboidrato e proteína sobre os biomarcadores do estresse oxidativo representados pelos níveis circulantes de lipoproteína de baixa densidade oxidada (LDLox) e a capacidade antioxidante total do plasma (CAT) e suas associações com variáveis antropométricas, bioquímicas, oxidativa e dietéticas, em homens em condição de sobrepeso e obesidade. Participaram deste estudo 31 homens saudáveis com IMC entre 26,5 e 35,2 kg/m2, que seguiram a dieta por 8 semanas com uma restrição calórica de 250 kcal. Os indivíduos foram distribuídos aleatoriamente em três grupos de acordo com o tipo de dieta. Para o grupo controle (GCT), foi prescrita uma dieta equilibrada em macronutrientes; para o grupo de carboidrato diurno (GCD), foi prescrito almoço hiperglicídico/hipoprotéico e jantar hipoglicídico/hiperprotéico, enquanto que no grupo do carboidrato noturno (GCN), a distribuição dos carboidratos e proteínas nas grandes refeições foi o inverso do GCD. No início e no final deste estudo foram aferidas as medidas antropométricas, de composição corporal utilizando-se o deutério e a concentração sérica de glicose, insulina, colesterol e suas frações, triglicerídeos, acido úrico, ceruloplasmina, CAT e LDLox. A composição da dieta e a qualidade global da dieta habitual e durante a intervenção, foram analisadas por meio de diários alimentares e do Índice Internacional de Qualidade da Dieta (IQDI). Ao final das 8 semanas, verificou-se que os voluntários deste estudo tiveram perda de peso média de 4,26 ± 1,47 % no GCT, 3,29 ± 2,46 no GCD e 4,85 ± 3,01 % no GCN e também houve redução no IMC, CC e CQ significativa quando comparado ao período inicial. Não houve diferenças entre os grupos nas mudanças observadas nas medidas antropométricas. A média de restrição calórica foi de 26,01±22,03% no GCT, 31,70±30,28% no GCN e 16,87±26,67% no GCD e não houve diferença entre os grupos. A qualidade da dieta global da dieta e sua composição nutricional não apresentaram variações significativas entre os grupos, com exceção do sódio e selênio, que apresentaram redução maior no GCN quando comparados aos outros grupos (p<0,05). De acordo com IQDI, a dieta dos voluntários foi caracterizada como de baixa qualidade, tanto na avaliação da ingestão habitual quanto durante a intervenção. As variáveis bioquímicas e oxidativas não sofreram modificações significativas entre os grupos durante o estudo, com exceção da glicose sérica que aumentou no GCD. No GCT, as concentrações de HDL-c subiram enquanto as de insulina foram reduzidas (p<0,05), mas se mantiveram no dentro da faixa de normalidade. Apesar das variáveis endógenas e dietéticas que poderiam influenciar as concentrações séricas dos biomarcadores do estresse oxidativo não terem sofrido variações significativas, a CAT se elevou no GCT e GCD (p<0,05). A concentração sérica de LDLox, no entanto,foi mais elevada no GCT, quando comparada aos demais grupos (p<0,05) e a sua concentração diminuiu de forma não significativa exclusivamente no GCD (p>0,05). Não foram observadas associações entre as variações da CAT e da LDLox e a quantidade ofertada de carboidrato ou proteína nas refeições em que houve a dissociação da dieta (p>0,05). As mesmas análises foram realizadas para o IQDI e seus escores parciais com relação à CAT e LDLox e não constatou-se correlação entre essas variáveis, mesmo após ajustes (p>0,05). Conclui-se que apesar da dieta dissociada ter promovido perda ponderal e redução de outras variáveis antropométricas não houve relação entre a CAT e a LDLox com as variáveis bioquímicas, oxidativas e dietéticas estudadas.application/pdfporUniversidade Federal de ViçosaDoutorado em Ciência e Tecnologia de AlimentosUFVBRCiência de Alimentos; Tecnologia de Alimentos; Engenharia de AlimentosDieta dissociadaEstresse oxidativoObesidadeDiet dissociatedOxidative stressObesityCNPQ::CIENCIAS AGRARIAS::CIENCIA E TECNOLOGIA DE ALIMENTOS::CIENCIA DE ALIMENTOSImpacto da dieta dissociada no índice internacional de qualidade da dieta e nos biomarcadores de estresse oxidativoImpact of diet dissociated in the diet quality index-international and biomarkers of oxidative stressinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALtexto completo.pdfapplication/pdf1289684https://locus.ufv.br//bitstream/123456789/463/1/texto%20completo.pdf1caa84df1b401beba89946243cbd6ee8MD51TEXTtexto completo.pdf.txttexto completo.pdf.txtExtracted texttext/plain247931https://locus.ufv.br//bitstream/123456789/463/2/texto%20completo.pdf.txtc9492f165b00727648ad9c5023ed8e4bMD52THUMBNAILtexto completo.pdf.jpgtexto completo.pdf.jpgIM Thumbnailimage/jpeg3468https://locus.ufv.br//bitstream/123456789/463/3/texto%20completo.pdf.jpg62f0e379c31d690c799d9c10d10d8557MD53123456789/4632016-04-06 23:06:44.442oai:locus.ufv.br:123456789/463Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452016-04-07T02:06:44LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.por.fl_str_mv Impacto da dieta dissociada no índice internacional de qualidade da dieta e nos biomarcadores de estresse oxidativo
dc.title.alternative.eng.fl_str_mv Impact of diet dissociated in the diet quality index-international and biomarkers of oxidative stress
title Impacto da dieta dissociada no índice internacional de qualidade da dieta e nos biomarcadores de estresse oxidativo
spellingShingle Impacto da dieta dissociada no índice internacional de qualidade da dieta e nos biomarcadores de estresse oxidativo
Paixão, Mírian Patrícia Castro Pereira
Dieta dissociada
Estresse oxidativo
Obesidade
Diet dissociated
Oxidative stress
Obesity
CNPQ::CIENCIAS AGRARIAS::CIENCIA E TECNOLOGIA DE ALIMENTOS::CIENCIA DE ALIMENTOS
title_short Impacto da dieta dissociada no índice internacional de qualidade da dieta e nos biomarcadores de estresse oxidativo
title_full Impacto da dieta dissociada no índice internacional de qualidade da dieta e nos biomarcadores de estresse oxidativo
title_fullStr Impacto da dieta dissociada no índice internacional de qualidade da dieta e nos biomarcadores de estresse oxidativo
title_full_unstemmed Impacto da dieta dissociada no índice internacional de qualidade da dieta e nos biomarcadores de estresse oxidativo
title_sort Impacto da dieta dissociada no índice internacional de qualidade da dieta e nos biomarcadores de estresse oxidativo
author Paixão, Mírian Patrícia Castro Pereira
author_facet Paixão, Mírian Patrícia Castro Pereira
author_role author
dc.contributor.authorLattes.por.fl_str_mv http://lattes.cnpq.br/9001805537017932
dc.contributor.author.fl_str_mv Paixão, Mírian Patrícia Castro Pereira
dc.contributor.advisor-co1.fl_str_mv Costa, Neuza Maria Brunoro
dc.contributor.advisor-co1Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4781709D6
dc.contributor.advisor-co2.fl_str_mv Gomide, Lucio Alberto de Miranda
dc.contributor.advisor-co2Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4781895A9
dc.contributor.advisor1.fl_str_mv Bressan, Josefina
dc.contributor.advisor1Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4781728Y2
dc.contributor.referee1.fl_str_mv Rosado, Eliane Lopes
dc.contributor.referee1Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4703173J2
dc.contributor.referee2.fl_str_mv Oliveira, Leandro Licursi de
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/0578231392218162
dc.contributor.referee3.fl_str_mv Ribeiro, Sônia Machado Rocha
dc.contributor.referee3Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4701461E0
contributor_str_mv Costa, Neuza Maria Brunoro
Gomide, Lucio Alberto de Miranda
Bressan, Josefina
Rosado, Eliane Lopes
Oliveira, Leandro Licursi de
Ribeiro, Sônia Machado Rocha
dc.subject.por.fl_str_mv Dieta dissociada
Estresse oxidativo
Obesidade
topic Dieta dissociada
Estresse oxidativo
Obesidade
Diet dissociated
Oxidative stress
Obesity
CNPQ::CIENCIAS AGRARIAS::CIENCIA E TECNOLOGIA DE ALIMENTOS::CIENCIA DE ALIMENTOS
dc.subject.eng.fl_str_mv Diet dissociated
Oxidative stress
Obesity
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS AGRARIAS::CIENCIA E TECNOLOGIA DE ALIMENTOS::CIENCIA DE ALIMENTOS
description Obesity is a chronic disease that contributes to the development of oxidative stress, increased risk of developing cardiovascular disease and metabolic syndrome. Alternatives for the treatment of obesity various types of low-calorie diets have been used, among these, the dissociated diet. This diet recommends that carbohydrate and protein should not be consumed in a meal together in order to promote greater efficiency and accelerate the metabolic process of weight reduction. The aim of this study was to investigate the effect of dietary carbohydrate and protein in dissociated diets on biomarkers of oxidative stress represented by circulating levels of oxidized low density lipoprotein (oxLDL) and plasma total antioxidant capacity (TAC) and their associations with anthropometric, biochemical, and dietary oxidative in men in conditions of overweight and obesity. The study included 31 healthy men with BMI between 26.5 and 35.2 kg/m2, who followed the diet for 8 weeks with caloric restriction the 250 kcal. The subjects were randomly divided into three groups according to the type of diet. For the control group (GCT), was prescribed a diet balanced in nutrients, the group of day-carbohydrate (GCD) was prescribed a high carbohydrate / low-protein lunch and dinner, while in the night- carbohydrate group (GCN) the distribution of macronutrients in the meals was the reverse of the GCD. At the beginning and end of this study were analyzed anthropometric measurements, body composition using the deuterium and the serum glucose, insulin, cholesterol and fractions, triglycerides, uric acid, ceruloplasmin, TAC and oxLDL. Diet composition and the overall quality of the usual diet and during the intervention were analyzed using food diaries and Dietary Quality Index- International (IDQI). At the end of eight weeks, the volunteers had an average weight loss of 4.26 ± 1.47% in GCT, 3.29 ± 2.46 in the GCD, and 4.85 ± 3.01% at GCN and there was a reduction in BMI, WC and HC in the significant when compared to the initial period. There were no differences between groups in the observed changes in anthropometric measurements. The average caloric restriction was 26.01 ± 22.03% in GCT, 31.70 ± 30.28% in the GCN and 16.87 ± 26.67% in the GCD and there was no difference between groups. The quality of the overall diet and nutritional composition showed no significant variations between groups, with the exception of sodium and selenium, which showed a greater reduction in BCM when compared to the other groups (p <0.05). According IDQI the diet of the volunteers was characterized as low quality both in the evaluation of habitual intake and during the intervention. The oxidative and biochemical variables analyzed have not changed significantly between the groups during the study with the exception of serum glucose rose in the GCD and HDL-C which is elevated and insulin decreased in the GCT group (p <0.05), but remained within the normal range. Despite dietary and endogenous variables that could influence serum concentrations of biomarkers of oxidative stress have not changed substantially, TAC rose at the GCT and GCD (p <0.05). While the serum concentration of oxLDL was higher in GCT compared to other groups (p <0.05) and its concentration decreased not significantly only in GCD (p> 0.05). There were no associations between variations in TAC and oxLDL and quantity supplied of carbohydrate or protein meals in there that the dissociation of the diet (p> 0.05). The same analysis was performed for IDQI and their partial scores with respect to TAC and oxLDL and no correlation was observed between these variables, even after adjustment (p> 0.05). We conclude that although the dissociated diet have promoted weight loss and reduction of other anthropometric variables, no relationship was observed between TAC and oxLDL with biochemical variables, and dietary oxidative studied.
publishDate 2011
dc.date.issued.fl_str_mv 2011-08-01
dc.date.available.fl_str_mv 2013-05-06
2015-03-26T12:25:08Z
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dc.identifier.citation.fl_str_mv PAIXÃO, Mírian Patrícia Castro Pereira. Impact of diet dissociated in the diet quality index-international and biomarkers of oxidative stress. 2011. 135 f. Tese (Doutorado em Ciência de Alimentos; Tecnologia de Alimentos; Engenharia de Alimentos) - Universidade Federal de Viçosa, Viçosa, 2011.
dc.identifier.uri.fl_str_mv http://locus.ufv.br/handle/123456789/463
identifier_str_mv PAIXÃO, Mírian Patrícia Castro Pereira. Impact of diet dissociated in the diet quality index-international and biomarkers of oxidative stress. 2011. 135 f. Tese (Doutorado em Ciência de Alimentos; Tecnologia de Alimentos; Engenharia de Alimentos) - Universidade Federal de Viçosa, Viçosa, 2011.
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