Factor analysis applied to genome prediction for high-dimensional phenotypes in pigs

• Autor(a) principal: Teixeira, F.R.F.
• Data de Publicação: 2016
• Outros Autores: Nascimento, M., Nascimento, A.C.C., Silva, F.F. e, Cruz, C.D., Azevedo, C.F., Paixão, D.M., Barroso, L.M.A., Verardo, L.L., Resende, M.D.V. de, Guimarães, S.E.F., Lopes, P.S.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: LOCUS Repositório Institucional da UFV
• Texto Completo: http://dx.doi.org/10.4238/gmr.15028231; http://www.locus.ufv.br/handle/123456789/12800
• topic: Genome-enabled prediction; Multivariate analysis; SNP effects

The aim of the present study was to propose and evaluate the use of factor analysis (FA) in obtaining latent variables (factors) that represent a set of pig traits simultaneously, for use in genomewide selection (GWS) studies. We used crosses between outbred F2 populations of Brazilian Piau X commercial pigs. Data were obtained on 345 F2 pigs, genotyped for 237 SNPs, with 41 traits. FA allowed us to obtain four biologically interpretable factors: “weight”, “fat”, “loin”, and “performance”. These factors were used as dependent variables in multiple regression models of genomic selection (Bayes A, Bayes B, RR-BLUP, and Bayesian LASSO). The use of FA is presented as an interesting alternative to select individuals for multiple variables simultaneously in GWS studies; accuracy measurements of the factors were similar to those obtained when the original traits were considered individually. The similarities between the top 10% of individuals selected by the factor, and those selected by the individual traits, were also satisfactory. Moreover, the estimated markers effects for the traits were similar to those found for the relevant factor.