CCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestry
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/26284 https://dx.doi.org/10.1590/S1415-47572004000300002 |
Resumo: | This study reports the frequencies of the CCR5D32 mutation of the beta-chemokine 5 gene and discusses the possible effects of past and recent gene flow in three quilombo remnants (Brazilians communities with anthropological African ancestry whose ancestors were escaped slaves): Rio das Rãs, Mocambo, and São Gonçalo in the northeastern region of Brazil. The CCR5D32 allele frequency of the Mocambo population was significantly higher (5.6%) than that found in the Rio das Rãs (1%) and São Gonçalo (0.9%) populations. These differences may reflect different proportions of parental populations in the founders individuals, a founder-effect and/or different histories of inter-ethnic contact. The frequency of the CCR5D32 allele in the Mocambo sample is similar to that found in those urban Brazilian populations which have a large amount of European genetic input, indicating a European contribution to the gene pool of this population and suggesting that, perhaps since its foundation, Mocambo has had a high level of admixture or experienced a founder-effect. |
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Carvalho, Mônica W.P.Leboute, Ana P.M.Oliveira, Silviene F.Sousa, Sandra M.B.Klautau-Guimarães, Maria de NazaréSimões, Aguinaldo L.2017-12-07T04:41:34Z2017-12-07T04:41:34Z2004Genet. Mol. Biol.,v.27,n.3,p.321-325,2004http://repositorio.unb.br/handle/10482/26284https://dx.doi.org/10.1590/S1415-47572004000300002This study reports the frequencies of the CCR5D32 mutation of the beta-chemokine 5 gene and discusses the possible effects of past and recent gene flow in three quilombo remnants (Brazilians communities with anthropological African ancestry whose ancestors were escaped slaves): Rio das Rãs, Mocambo, and São Gonçalo in the northeastern region of Brazil. The CCR5D32 allele frequency of the Mocambo population was significantly higher (5.6%) than that found in the Rio das Rãs (1%) and São Gonçalo (0.9%) populations. These differences may reflect different proportions of parental populations in the founders individuals, a founder-effect and/or different histories of inter-ethnic contact. The frequency of the CCR5D32 allele in the Mocambo sample is similar to that found in those urban Brazilian populations which have a large amount of European genetic input, indicating a European contribution to the gene pool of this population and suggesting that, perhaps since its foundation, Mocambo has had a high level of admixture or experienced a founder-effect.Em processamentoSociedade Brasileira de GenéticaCCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCCR5genetic polymorphismSub-Saharan Afro-derived Brazilian populationsethnic-grouspecific markerinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALa02v27n3.pdfapplication/pdf73587http://repositorio2.unb.br/jspui/bitstream/10482/26284/1/a02v27n3.pdf00e1b2fb21f994480b2522cb8dc30d51MD51open access10482/262842023-09-28 18:01:55.044open accessoai:repositorio2.unb.br:10482/26284Biblioteca Digital de Teses e DissertaçõesPUBhttps://repositorio.unb.br/oai/requestopendoar:2023-09-28T21:01:55Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.pt_BR.fl_str_mv |
CCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestry |
title |
CCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestry |
spellingShingle |
CCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestry Carvalho, Mônica W.P. CCR5 genetic polymorphism Sub-Saharan Afro-derived Brazilian populations ethnic-grouspecific marker |
title_short |
CCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestry |
title_full |
CCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestry |
title_fullStr |
CCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestry |
title_full_unstemmed |
CCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestry |
title_sort |
CCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestry |
author |
Carvalho, Mônica W.P. |
author_facet |
Carvalho, Mônica W.P. Leboute, Ana P.M. Oliveira, Silviene F. Sousa, Sandra M.B. Klautau-Guimarães, Maria de Nazaré Simões, Aguinaldo L. |
author_role |
author |
author2 |
Leboute, Ana P.M. Oliveira, Silviene F. Sousa, Sandra M.B. Klautau-Guimarães, Maria de Nazaré Simões, Aguinaldo L. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, Mônica W.P. Leboute, Ana P.M. Oliveira, Silviene F. Sousa, Sandra M.B. Klautau-Guimarães, Maria de Nazaré Simões, Aguinaldo L. |
dc.subject.keyword.pt_BR.fl_str_mv |
CCR5 genetic polymorphism Sub-Saharan Afro-derived Brazilian populations ethnic-grouspecific marker |
topic |
CCR5 genetic polymorphism Sub-Saharan Afro-derived Brazilian populations ethnic-grouspecific marker |
description |
This study reports the frequencies of the CCR5D32 mutation of the beta-chemokine 5 gene and discusses the possible effects of past and recent gene flow in three quilombo remnants (Brazilians communities with anthropological African ancestry whose ancestors were escaped slaves): Rio das Rãs, Mocambo, and São Gonçalo in the northeastern region of Brazil. The CCR5D32 allele frequency of the Mocambo population was significantly higher (5.6%) than that found in the Rio das Rãs (1%) and São Gonçalo (0.9%) populations. These differences may reflect different proportions of parental populations in the founders individuals, a founder-effect and/or different histories of inter-ethnic contact. The frequency of the CCR5D32 allele in the Mocambo sample is similar to that found in those urban Brazilian populations which have a large amount of European genetic input, indicating a European contribution to the gene pool of this population and suggesting that, perhaps since its foundation, Mocambo has had a high level of admixture or experienced a founder-effect. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004 |
dc.date.accessioned.fl_str_mv |
2017-12-07T04:41:34Z |
dc.date.available.fl_str_mv |
2017-12-07T04:41:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Genet. Mol. Biol.,v.27,n.3,p.321-325,2004 |
dc.identifier.uri.fl_str_mv |
http://repositorio.unb.br/handle/10482/26284 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://dx.doi.org/10.1590/S1415-47572004000300002 |
identifier_str_mv |
Genet. Mol. Biol.,v.27,n.3,p.321-325,2004 |
url |
http://repositorio.unb.br/handle/10482/26284 https://dx.doi.org/10.1590/S1415-47572004000300002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
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Universidade de Brasília (UnB) |
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UNB |
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UNB |
reponame_str |
Repositório Institucional da UnB |
collection |
Repositório Institucional da UnB |
bitstream.url.fl_str_mv |
http://repositorio2.unb.br/jspui/bitstream/10482/26284/1/a02v27n3.pdf |
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00e1b2fb21f994480b2522cb8dc30d51 |
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Repositório Institucional da UnB - Universidade de Brasília (UnB) |
repository.mail.fl_str_mv |
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1803573659989704704 |