Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats

Detalhes bibliográficos
Autor(a) principal: Penhavel, Maria Vitória Carmo
Data de Publicação: 2013
Outros Autores: Nascimento, Victor Henrique Tavares, Durães, Eliana Ferreira Ribeiro, Carneiro, Fabiana Pirani, Sousa, João Batista de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/28801
https://dx.doi.org/10.1590/S0102-86502013000500003
Resumo: PURPOSE: To evaluate the healing effect of carbon dioxide therapy on skin wounds induced on the back of rats. METHODS: Sixteen rats underwent excision of a round dermal-epidermal dorsal skin flap of 2.5 cm in diameter. The animals were divided into two groups, as follows: carbon dioxide group - subcutaneous injections of carbon dioxide on the day of operation and at three, six and nine days postoperatively; control group - no postoperative wound treatment. Wounds were photographed on the day of operation and at six and 14 days postoperatively for analysis of wound area and major diameter. All animals were euthanized on day 14 after surgery. The dorsal skin and the underlying muscle layer containing the wound were resected for histopathological analysis. RESULTS: There was no statistically significant difference between groups in the percentage of wound closure, in histopathological findings, or in the reduction of wound area and major diameter at 14 days postoperatively. CONCLUSION: Under the experimental conditions in which this study was conducted, carbon dioxide therapy had no effects on the healing of acute skin wounds in rats.
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spelling Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of ratsCuraDióxido de carbonoPeleRatosPURPOSE: To evaluate the healing effect of carbon dioxide therapy on skin wounds induced on the back of rats. METHODS: Sixteen rats underwent excision of a round dermal-epidermal dorsal skin flap of 2.5 cm in diameter. The animals were divided into two groups, as follows: carbon dioxide group - subcutaneous injections of carbon dioxide on the day of operation and at three, six and nine days postoperatively; control group - no postoperative wound treatment. Wounds were photographed on the day of operation and at six and 14 days postoperatively for analysis of wound area and major diameter. All animals were euthanized on day 14 after surgery. The dorsal skin and the underlying muscle layer containing the wound were resected for histopathological analysis. RESULTS: There was no statistically significant difference between groups in the percentage of wound closure, in histopathological findings, or in the reduction of wound area and major diameter at 14 days postoperatively. CONCLUSION: Under the experimental conditions in which this study was conducted, carbon dioxide therapy had no effects on the healing of acute skin wounds in rats.Faculdade de Medicina (FMD)Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2017-12-07T05:02:47Z2017-12-07T05:02:47Z2013-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPENHAVEL, Maria Vitória Carmo et al. Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 5, p. 334-339, maio 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000500003. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000500003&lng=en&nrm=iso. Acesso em: 04 dez. 2020.http://repositorio.unb.br/handle/10482/28801https://dx.doi.org/10.1590/S0102-86502013000500003Acta Cirúrgica Brasileira - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000500003&lng=en&tlng=en. Acesso em: 04 dez. 2020.info:eu-repo/semantics/openAccessPenhavel, Maria Vitória CarmoNascimento, Victor Henrique TavaresDurães, Eliana Ferreira RibeiroCarneiro, Fabiana PiraniSousa, João Batista deengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-08-25T02:15:27Zoai:repositorio.unb.br:10482/28801Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-08-25T02:15:27Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
spellingShingle Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
Penhavel, Maria Vitória Carmo
Cura
Dióxido de carbono
Pele
Ratos
title_short Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title_full Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title_fullStr Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title_full_unstemmed Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title_sort Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
author Penhavel, Maria Vitória Carmo
author_facet Penhavel, Maria Vitória Carmo
Nascimento, Victor Henrique Tavares
Durães, Eliana Ferreira Ribeiro
Carneiro, Fabiana Pirani
Sousa, João Batista de
author_role author
author2 Nascimento, Victor Henrique Tavares
Durães, Eliana Ferreira Ribeiro
Carneiro, Fabiana Pirani
Sousa, João Batista de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Penhavel, Maria Vitória Carmo
Nascimento, Victor Henrique Tavares
Durães, Eliana Ferreira Ribeiro
Carneiro, Fabiana Pirani
Sousa, João Batista de
dc.subject.por.fl_str_mv Cura
Dióxido de carbono
Pele
Ratos
topic Cura
Dióxido de carbono
Pele
Ratos
description PURPOSE: To evaluate the healing effect of carbon dioxide therapy on skin wounds induced on the back of rats. METHODS: Sixteen rats underwent excision of a round dermal-epidermal dorsal skin flap of 2.5 cm in diameter. The animals were divided into two groups, as follows: carbon dioxide group - subcutaneous injections of carbon dioxide on the day of operation and at three, six and nine days postoperatively; control group - no postoperative wound treatment. Wounds were photographed on the day of operation and at six and 14 days postoperatively for analysis of wound area and major diameter. All animals were euthanized on day 14 after surgery. The dorsal skin and the underlying muscle layer containing the wound were resected for histopathological analysis. RESULTS: There was no statistically significant difference between groups in the percentage of wound closure, in histopathological findings, or in the reduction of wound area and major diameter at 14 days postoperatively. CONCLUSION: Under the experimental conditions in which this study was conducted, carbon dioxide therapy had no effects on the healing of acute skin wounds in rats.
publishDate 2013
dc.date.none.fl_str_mv 2013-05
2017-12-07T05:02:47Z
2017-12-07T05:02:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv PENHAVEL, Maria Vitória Carmo et al. Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 5, p. 334-339, maio 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000500003. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000500003&lng=en&nrm=iso. Acesso em: 04 dez. 2020.
http://repositorio.unb.br/handle/10482/28801
https://dx.doi.org/10.1590/S0102-86502013000500003
identifier_str_mv PENHAVEL, Maria Vitória Carmo et al. Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 5, p. 334-339, maio 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000500003. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000500003&lng=en&nrm=iso. Acesso em: 04 dez. 2020.
url http://repositorio.unb.br/handle/10482/28801
https://dx.doi.org/10.1590/S0102-86502013000500003
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
instacron_str UNB
institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
repository.mail.fl_str_mv repositorio@unb.br
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