Prospecção fitoquímica e determinação do potencial antioxidante in vitro da Licania tomentosa (Benth.)

Detalhes bibliográficos
Autor(a) principal: Silva, Jonathan Augusto da
Data de Publicação: 2021
Outros Autores: Martins, Julielle dos Santos, Paulino, Maria Lúcia Vieira de Britto, Almeida, Anderson Soares de, Pavão, Jessé Marques da Silva Junior, Santos, Aldenir Feitosa dos
Tipo de documento: Artigo
Idioma: por
Título da fonte: Diversitas Journal
Texto Completo: https://diversitasjournal.com.br/diversitas_journal/article/view/908
Resumo: ABSTRACT: Scientific name Licance Tomentosa (Benth.), OITI belongs to the Chrysobalanaceae family, which covers 17 genera and approximately 450 shrub and tree species, scattered by tropical and subtropical regions. Its genre, Licance, is predominantly neotropical, composed of small and large trees, which are widely distributed on the globe, passing through Mexico, Florida, Antilles, to the south of Brazil (Feitosa, Xavier & Randau, 2012). In popular medicine OITI is used in the treatment of diabetes (Agra, Freitas & Barbosa-Filho, 2007), however, still without scientific proof. Studies developed by Miranda and employees (2002), regarding pharmacological action, indicates that the seed presents antiviral action against the herpes virus. In addition, isolated sheet compounds and fruits indicate anti -Chinogenic action (Fernandes et al., 2003) and also Leishmanicide (Ribeiro et al., 2014). In this context, the present work aims to determine the potential for free radicals (AAO%) of the ethanolic extract of L. tomentosa sheet, from the DPPH radical sequestration method, which consists of quantitatively evaluating the reduction of DPPH from of the color change - which passes from purple to yellowish - according to the concentration of antioxidants in the samples. In order to do so, a qualitative phytochemical prospecting was initially performed, which demonstrated the presence of classes of compounds of great pharmacological importance such as flobatenic tannins, catechine flavonoids, steroids and saponins. The result obtained shows the L. tomentosa sheet extract is efficient in the DPPH radical kidnapping, presenting a% of 50% (CE50%) at the concentration of 63.03 μg / ml. Which indicates a potential only about twice as low as the antioxidant potential of the standard extract of G. biloba, which is well known for such characteristic. In this sense, more studies are necessary to elucidate the relationship between the reducing activity and the concentration of the phenolic constituents of its extract, well evaluation of its antioxidant potential through other methodologies. We thank Cesmac for the availability of their laboratories for the elaboration of the experiments. KEYWORDS: L. tomentosa, phytochemical prospecting, dpph, antioxidant activity.
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spelling Prospecção fitoquímica e determinação do potencial antioxidante in vitro da Licania tomentosa (Benth.) ABSTRACT: Scientific name Licance Tomentosa (Benth.), OITI belongs to the Chrysobalanaceae family, which covers 17 genera and approximately 450 shrub and tree species, scattered by tropical and subtropical regions. Its genre, Licance, is predominantly neotropical, composed of small and large trees, which are widely distributed on the globe, passing through Mexico, Florida, Antilles, to the south of Brazil (Feitosa, Xavier & Randau, 2012). In popular medicine OITI is used in the treatment of diabetes (Agra, Freitas & Barbosa-Filho, 2007), however, still without scientific proof. Studies developed by Miranda and employees (2002), regarding pharmacological action, indicates that the seed presents antiviral action against the herpes virus. In addition, isolated sheet compounds and fruits indicate anti -Chinogenic action (Fernandes et al., 2003) and also Leishmanicide (Ribeiro et al., 2014). In this context, the present work aims to determine the potential for free radicals (AAO%) of the ethanolic extract of L. tomentosa sheet, from the DPPH radical sequestration method, which consists of quantitatively evaluating the reduction of DPPH from of the color change - which passes from purple to yellowish - according to the concentration of antioxidants in the samples. In order to do so, a qualitative phytochemical prospecting was initially performed, which demonstrated the presence of classes of compounds of great pharmacological importance such as flobatenic tannins, catechine flavonoids, steroids and saponins. The result obtained shows the L. tomentosa sheet extract is efficient in the DPPH radical kidnapping, presenting a% of 50% (CE50%) at the concentration of 63.03 μg / ml. Which indicates a potential only about twice as low as the antioxidant potential of the standard extract of G. biloba, which is well known for such characteristic. In this sense, more studies are necessary to elucidate the relationship between the reducing activity and the concentration of the phenolic constituents of its extract, well evaluation of its antioxidant potential through other methodologies. We thank Cesmac for the availability of their laboratories for the elaboration of the experiments. KEYWORDS: L. tomentosa, phytochemical prospecting, dpph, antioxidant activity.RESUMO: De nome científico Licania tomentosa (Benth.), a oiti pertence à família Chrysobalanaceae, que abrange 17 gêneros e aproximadamente 450 espécies arbustivas e arbóreas, espalhadas por regiões tropicais e subtropicais. O seu gênero, Licania, é predominantemente neotropical, composto por árvores de pequeno e grande porte, que estão amplamente distribuídas no globo, passando pelo México, Flórida, Antilhas, até o sul do Brasil (FEITOSA, XAVIER & RANDAU, 2012). Na medicina popular a Oiti é utilizada no tratamento de diabetes (AGRA, FREITAS & BARBOSA-FILHO, 2007), no entanto, ainda sem comprovação científica. Estudos desenvolvidos por Miranda e colaboradores (2002), a respeito da ação farmacológica, indica que a semente apresenta ação antiviral frente ao vírus herpes. Além disso, compostos isolados da folha e frutos indicam ação anticarcinogênica (FERNANDES et al., 2003) e também leishmanicida (RIBEIRO et al., 2014). Neste contexto, o presente trabalho objetiva determinar o potencial de neutralização de radicais livres (AAO%) do extrato etanólico da folha da L. tomentosa, a partir do método de sequestro do radical DPPH, que consiste em avaliar quantitativamente a redução do DPPH a partir da alteração de cor – que passa de púrpura para amarelada – em função da concentração de antioxidantes nas amostras. Para tanto, foi realizada inicialmente uma prospecção fitoquímica qualitativa, que demostrou a presença de classes de compostos de grande importância farmacológica tais como taninos flobatênicos, flavonoides catequinas, esteróides e saponinas. O resultado o obtido mostra o extrato folha da L. tomentosa é eficiente no sequestro do radical DPPH, apresentando uma AAO% de 50% (CE50%) na concentração de 63,03 µg/mL. O que indica um potencial apenas cerca de duas vezes inferior ao potencial antioxidante do extrato padrão da G. biloba, que é bastante conhecida por tal característica. Nesse sentido, faz-se necessário mais estudos para elucidar a relação entre a atividade redutora e a concentração dos constituintes fenólicos de seu extrato, bem avaliação do seu potencial antioxidante por meio de outras metodologias. Agradecemos aos CESMAC pela disponibilidade de seus laboratórios para elaboração dos experimentos. PALAVRAS-CHAVE: L. tomentosa, prospecção fitoquímica, DPPH, atividade antioxidante.Universidade Estadual de Alagoas - Eduneal2021-05-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://diversitasjournal.com.br/diversitas_journal/article/view/90810.17648/diversitas-journal-v6i2-908Diversitas Journal; v. 6 n. 2 (2021): Educação para o desenvolvimento socioeconômico ; 2099-21082525-521510.17648/diversitas-journal-v6i2reponame:Diversitas Journalinstname:Universidade Estadual de Alagoas (UNEAL)instacron:UNEALporhttps://diversitasjournal.com.br/diversitas_journal/article/view/908/1372Copyright (c) 2021 Jonathan Augusto da Silva, Julielle dos Santos Martins, Maria Lúcia Vieira de Britto Paulino, Anderson Soares de Almeida, Jessé Marques da Silva Junior Pavão, Aldenir Feitosa dos Santoshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Jonathan Augusto daMartins, Julielle dos SantosPaulino, Maria Lúcia Vieira de BrittoAlmeida, Anderson Soares dePavão, Jessé Marques da Silva JuniorSantos, Aldenir Feitosa dos2021-08-12T20:37:44Zoai:ojs.emnuvens.com.br:article/908Revistahttps://diversitasjournal.com.br/diversitas_journal/indexPUBhttps://www.e-publicacoes.uerj.br/index.php/muralinternacional/oairevistadiversitasjournal@gmail.com2525-52152525-5215opendoar:2023-01-13T09:47:00.507089Diversitas Journal - Universidade Estadual de Alagoas (UNEAL)false
dc.title.none.fl_str_mv Prospecção fitoquímica e determinação do potencial antioxidante in vitro da Licania tomentosa (Benth.)
title Prospecção fitoquímica e determinação do potencial antioxidante in vitro da Licania tomentosa (Benth.)
spellingShingle Prospecção fitoquímica e determinação do potencial antioxidante in vitro da Licania tomentosa (Benth.)
Silva, Jonathan Augusto da
title_short Prospecção fitoquímica e determinação do potencial antioxidante in vitro da Licania tomentosa (Benth.)
title_full Prospecção fitoquímica e determinação do potencial antioxidante in vitro da Licania tomentosa (Benth.)
title_fullStr Prospecção fitoquímica e determinação do potencial antioxidante in vitro da Licania tomentosa (Benth.)
title_full_unstemmed Prospecção fitoquímica e determinação do potencial antioxidante in vitro da Licania tomentosa (Benth.)
title_sort Prospecção fitoquímica e determinação do potencial antioxidante in vitro da Licania tomentosa (Benth.)
author Silva, Jonathan Augusto da
author_facet Silva, Jonathan Augusto da
Martins, Julielle dos Santos
Paulino, Maria Lúcia Vieira de Britto
Almeida, Anderson Soares de
Pavão, Jessé Marques da Silva Junior
Santos, Aldenir Feitosa dos
author_role author
author2 Martins, Julielle dos Santos
Paulino, Maria Lúcia Vieira de Britto
Almeida, Anderson Soares de
Pavão, Jessé Marques da Silva Junior
Santos, Aldenir Feitosa dos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Jonathan Augusto da
Martins, Julielle dos Santos
Paulino, Maria Lúcia Vieira de Britto
Almeida, Anderson Soares de
Pavão, Jessé Marques da Silva Junior
Santos, Aldenir Feitosa dos
description ABSTRACT: Scientific name Licance Tomentosa (Benth.), OITI belongs to the Chrysobalanaceae family, which covers 17 genera and approximately 450 shrub and tree species, scattered by tropical and subtropical regions. Its genre, Licance, is predominantly neotropical, composed of small and large trees, which are widely distributed on the globe, passing through Mexico, Florida, Antilles, to the south of Brazil (Feitosa, Xavier & Randau, 2012). In popular medicine OITI is used in the treatment of diabetes (Agra, Freitas & Barbosa-Filho, 2007), however, still without scientific proof. Studies developed by Miranda and employees (2002), regarding pharmacological action, indicates that the seed presents antiviral action against the herpes virus. In addition, isolated sheet compounds and fruits indicate anti -Chinogenic action (Fernandes et al., 2003) and also Leishmanicide (Ribeiro et al., 2014). In this context, the present work aims to determine the potential for free radicals (AAO%) of the ethanolic extract of L. tomentosa sheet, from the DPPH radical sequestration method, which consists of quantitatively evaluating the reduction of DPPH from of the color change - which passes from purple to yellowish - according to the concentration of antioxidants in the samples. In order to do so, a qualitative phytochemical prospecting was initially performed, which demonstrated the presence of classes of compounds of great pharmacological importance such as flobatenic tannins, catechine flavonoids, steroids and saponins. The result obtained shows the L. tomentosa sheet extract is efficient in the DPPH radical kidnapping, presenting a% of 50% (CE50%) at the concentration of 63.03 μg / ml. Which indicates a potential only about twice as low as the antioxidant potential of the standard extract of G. biloba, which is well known for such characteristic. In this sense, more studies are necessary to elucidate the relationship between the reducing activity and the concentration of the phenolic constituents of its extract, well evaluation of its antioxidant potential through other methodologies. We thank Cesmac for the availability of their laboratories for the elaboration of the experiments. KEYWORDS: L. tomentosa, phytochemical prospecting, dpph, antioxidant activity.
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dc.publisher.none.fl_str_mv Universidade Estadual de Alagoas - Eduneal
publisher.none.fl_str_mv Universidade Estadual de Alagoas - Eduneal
dc.source.none.fl_str_mv Diversitas Journal; v. 6 n. 2 (2021): Educação para o desenvolvimento socioeconômico ; 2099-2108
2525-5215
10.17648/diversitas-journal-v6i2
reponame:Diversitas Journal
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reponame_str Diversitas Journal
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