Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin

Detalhes bibliográficos
Autor(a) principal: Nencioni,ALA
Data de Publicação: 2009
Outros Autores: Barreto,SA, Lebrun,I, Florio,JC, Lourenço,GA, Dorce,VAC
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200007
Resumo: TsTX is an α-type sodium channel toxin that stimulates the discharge of neurotransmitters from neurons. In the present study we investigated which neurotransmitters are released in the hippocampus after TsTX injection and if they are responsible for electrographic or histopathological effects. Microdialysis revealed that the toxin increased glutamate extracellular levels in the hippocampus; however, levels of gamma-aminobutyric acid (GABA), glycine, 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were not significantly altered. Neurodegeneration in pyramidal cells of hippocampus and electroencephalographic alterations caused by the toxin were blocked by pretreatment with riluzole, a glutamate release inhibitor. The present results suggest a specific activity of TsTX in the hippocampus which affects only glutamate release.
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spelling Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxinscorpion toxinmicrodialysishippocampusneurotransmittersneurodegenerationriluzoleTsTX is an α-type sodium channel toxin that stimulates the discharge of neurotransmitters from neurons. In the present study we investigated which neurotransmitters are released in the hippocampus after TsTX injection and if they are responsible for electrographic or histopathological effects. Microdialysis revealed that the toxin increased glutamate extracellular levels in the hippocampus; however, levels of gamma-aminobutyric acid (GABA), glycine, 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were not significantly altered. Neurodegeneration in pyramidal cells of hippocampus and electroencephalographic alterations caused by the toxin were blocked by pretreatment with riluzole, a glutamate release inhibitor. The present results suggest a specific activity of TsTX in the hippocampus which affects only glutamate release.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200007Journal of Venomous Animals and Toxins including Tropical Diseases v.15 n.2 2009reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/S1678-91992009000200007info:eu-repo/semantics/openAccessNencioni,ALABarreto,SALebrun,IFlorio,JCLourenço,GADorce,VACeng2009-06-09T00:00:00Zoai:scielo:S1678-91992009000200007Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2009-06-09T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin
title Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin
spellingShingle Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin
Nencioni,ALA
scorpion toxin
microdialysis
hippocampus
neurotransmitters
neurodegeneration
riluzole
title_short Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin
title_full Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin
title_fullStr Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin
title_full_unstemmed Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin
title_sort Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin
author Nencioni,ALA
author_facet Nencioni,ALA
Barreto,SA
Lebrun,I
Florio,JC
Lourenço,GA
Dorce,VAC
author_role author
author2 Barreto,SA
Lebrun,I
Florio,JC
Lourenço,GA
Dorce,VAC
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Nencioni,ALA
Barreto,SA
Lebrun,I
Florio,JC
Lourenço,GA
Dorce,VAC
dc.subject.por.fl_str_mv scorpion toxin
microdialysis
hippocampus
neurotransmitters
neurodegeneration
riluzole
topic scorpion toxin
microdialysis
hippocampus
neurotransmitters
neurodegeneration
riluzole
description TsTX is an α-type sodium channel toxin that stimulates the discharge of neurotransmitters from neurons. In the present study we investigated which neurotransmitters are released in the hippocampus after TsTX injection and if they are responsible for electrographic or histopathological effects. Microdialysis revealed that the toxin increased glutamate extracellular levels in the hippocampus; however, levels of gamma-aminobutyric acid (GABA), glycine, 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were not significantly altered. Neurodegeneration in pyramidal cells of hippocampus and electroencephalographic alterations caused by the toxin were blocked by pretreatment with riluzole, a glutamate release inhibitor. The present results suggest a specific activity of TsTX in the hippocampus which affects only glutamate release.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-91992009000200007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.15 n.2 2009
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
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