The relationship between ras protein and odontogenic lesions
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Science |
Texto Completo: | https://ojs.ict.unesp.br/index.php/cob/article/view/1572 |
Resumo: | Odontogenic lesions comprise a diverse group of lesions which usually affect the oral cavity and are derived from embryonic dental tissues. Their mechanisms of development and progression are still not fully known, but there are some studies investigating the participation of specific proteins in these events. Objective: The objective of this study was to investigate the expression of KRAS protein in these pathologies and also to correlate the protein expression with the behaviour of the lesions studied. Material and Methods: Immunohistochemical analysis of 20 cases was performed for each one of the following lesions: dentigerous cyst (DC), odontogenic keratocyst (OKC) and ameloblastoma (AB), totalising 60 cases to be analysed. Results: By considering the KRAS immune-expression, there were 11 cases (55%) presenting over-expression (score 3) in the basal layer of DC and 13 cases (65%) in the supra-basal layer. A similar finding was observed in the analysis of OKC, with eight cases (40%) in the supra-basal layer (score 3) and only five cases (25%) in the basal layer. As for AB, the over-expression was found in six cases (30%). Conclusion: Therefore, one believes that the KRAS expression in odontogenic lesions is inversely proportional to their aggressive behaviour.KeywordsKRAS; Odontogenic lesions; Immunohistochemistry |
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oai:ojs.pkp.sfu.ca:article/1572 |
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UNESP-20 |
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Brazilian Dental Science |
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spelling |
The relationship between ras protein and odontogenic lesionsOdontogenic lesions comprise a diverse group of lesions which usually affect the oral cavity and are derived from embryonic dental tissues. Their mechanisms of development and progression are still not fully known, but there are some studies investigating the participation of specific proteins in these events. Objective: The objective of this study was to investigate the expression of KRAS protein in these pathologies and also to correlate the protein expression with the behaviour of the lesions studied. Material and Methods: Immunohistochemical analysis of 20 cases was performed for each one of the following lesions: dentigerous cyst (DC), odontogenic keratocyst (OKC) and ameloblastoma (AB), totalising 60 cases to be analysed. Results: By considering the KRAS immune-expression, there were 11 cases (55%) presenting over-expression (score 3) in the basal layer of DC and 13 cases (65%) in the supra-basal layer. A similar finding was observed in the analysis of OKC, with eight cases (40%) in the supra-basal layer (score 3) and only five cases (25%) in the basal layer. As for AB, the over-expression was found in six cases (30%). Conclusion: Therefore, one believes that the KRAS expression in odontogenic lesions is inversely proportional to their aggressive behaviour.KeywordsKRAS; Odontogenic lesions; ImmunohistochemistryInstitute of Science and Technology of São José dos Campos2018-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttps://ojs.ict.unesp.br/index.php/cob/article/view/157210.14295/bds.2018.v21i3.1572Brazilian Dental Science; Vol. 21 No. 3 (2018): Jul. - Sep. / 2018 - Published Aug 2018; 307-314Brazilian Dental Science; v. 21 n. 3 (2018): Jul. - Sep. / 2018 - Published Aug 2018; 307-3142178-6011reponame:Brazilian Dental Scienceinstname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)instacron:UNESPenghttps://ojs.ict.unesp.br/index.php/cob/article/view/1572/1264https://ojs.ict.unesp.br/index.php/cob/article/view/1572/3346https://ojs.ict.unesp.br/index.php/cob/article/view/1572/3347Copyright (c) 2018 Brazilian Dental Scienceinfo:eu-repo/semantics/openAccessSilva, Camila Duarte daSilva, Igor Boaventura daCosta, VictorCarvalho, Yasmin RodarteTango, Estela Kaminagakura2020-01-28T12:08:17Zoai:ojs.pkp.sfu.ca:article/1572Revistahttp://bds.ict.unesp.br/PUBhttp://ojs.fosjc.unesp.br/index.php/index/oaisergio@fosjc.unesp.br||sergio@fosjc.unesp.br2178-60112178-6011opendoar:2022-11-08T16:30:16.732857Brazilian Dental Science - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)true |
dc.title.none.fl_str_mv |
The relationship between ras protein and odontogenic lesions |
title |
The relationship between ras protein and odontogenic lesions |
spellingShingle |
The relationship between ras protein and odontogenic lesions Silva, Camila Duarte da |
title_short |
The relationship between ras protein and odontogenic lesions |
title_full |
The relationship between ras protein and odontogenic lesions |
title_fullStr |
The relationship between ras protein and odontogenic lesions |
title_full_unstemmed |
The relationship between ras protein and odontogenic lesions |
title_sort |
The relationship between ras protein and odontogenic lesions |
author |
Silva, Camila Duarte da |
author_facet |
Silva, Camila Duarte da Silva, Igor Boaventura da Costa, Victor Carvalho, Yasmin Rodarte Tango, Estela Kaminagakura |
author_role |
author |
author2 |
Silva, Igor Boaventura da Costa, Victor Carvalho, Yasmin Rodarte Tango, Estela Kaminagakura |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Silva, Camila Duarte da Silva, Igor Boaventura da Costa, Victor Carvalho, Yasmin Rodarte Tango, Estela Kaminagakura |
description |
Odontogenic lesions comprise a diverse group of lesions which usually affect the oral cavity and are derived from embryonic dental tissues. Their mechanisms of development and progression are still not fully known, but there are some studies investigating the participation of specific proteins in these events. Objective: The objective of this study was to investigate the expression of KRAS protein in these pathologies and also to correlate the protein expression with the behaviour of the lesions studied. Material and Methods: Immunohistochemical analysis of 20 cases was performed for each one of the following lesions: dentigerous cyst (DC), odontogenic keratocyst (OKC) and ameloblastoma (AB), totalising 60 cases to be analysed. Results: By considering the KRAS immune-expression, there were 11 cases (55%) presenting over-expression (score 3) in the basal layer of DC and 13 cases (65%) in the supra-basal layer. A similar finding was observed in the analysis of OKC, with eight cases (40%) in the supra-basal layer (score 3) and only five cases (25%) in the basal layer. As for AB, the over-expression was found in six cases (30%). Conclusion: Therefore, one believes that the KRAS expression in odontogenic lesions is inversely proportional to their aggressive behaviour.KeywordsKRAS; Odontogenic lesions; Immunohistochemistry |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.ict.unesp.br/index.php/cob/article/view/1572 10.14295/bds.2018.v21i3.1572 |
url |
https://ojs.ict.unesp.br/index.php/cob/article/view/1572 |
identifier_str_mv |
10.14295/bds.2018.v21i3.1572 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.ict.unesp.br/index.php/cob/article/view/1572/1264 https://ojs.ict.unesp.br/index.php/cob/article/view/1572/3346 https://ojs.ict.unesp.br/index.php/cob/article/view/1572/3347 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Brazilian Dental Science info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Brazilian Dental Science |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/vnd.openxmlformats-officedocument.wordprocessingml.document application/vnd.openxmlformats-officedocument.wordprocessingml.document |
dc.publisher.none.fl_str_mv |
Institute of Science and Technology of São José dos Campos |
publisher.none.fl_str_mv |
Institute of Science and Technology of São José dos Campos |
dc.source.none.fl_str_mv |
Brazilian Dental Science; Vol. 21 No. 3 (2018): Jul. - Sep. / 2018 - Published Aug 2018; 307-314 Brazilian Dental Science; v. 21 n. 3 (2018): Jul. - Sep. / 2018 - Published Aug 2018; 307-314 2178-6011 reponame:Brazilian Dental Science instname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Brazilian Dental Science |
collection |
Brazilian Dental Science |
repository.name.fl_str_mv |
Brazilian Dental Science - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP) |
repository.mail.fl_str_mv |
sergio@fosjc.unesp.br||sergio@fosjc.unesp.br |
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1788346900309606400 |