Basic sciences in normal and abnormal palate development

Detalhes bibliográficos
Autor(a) principal: Sandy, Jonathan R.
Data de Publicação: 2015
Outros Autores: Brown, Nathan L.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Brazilian journal of oral sciences (Online)
Texto Completo: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641022
Resumo: Orofacial clefting is one of the most common congenital malformations with an incidence of 1 in 500 to 1000 live births. Cleft lip and cleft palate may occur in isolation, in combination or as part of one of the 400 or more syndromes linked to orofacial clefting. Clefting causes problems with feeding, speech, hearing and the dentition. Patients and their families bear a significant emotional burden. Despite the high frequency and significance of the malformation, the aetiology of nonsyndromic cleft lip and palate is poorly understood. It has a complex multifactorial aetiology, both population-based and laboratory-based research has identified numerous genetic and environmental factors as causative agents and the list is continually expanding. Leading scientists are now beginning to question whether this trait is too complex to fully understand. This report provides a comprehensive and up-todate review of research into palatogenesis and non-syndromic oral clefting
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spelling Basic sciences in normal and abnormal palate developmentPalatogenesisCleft palateReviewOrofacial clefting is one of the most common congenital malformations with an incidence of 1 in 500 to 1000 live births. Cleft lip and cleft palate may occur in isolation, in combination or as part of one of the 400 or more syndromes linked to orofacial clefting. Clefting causes problems with feeding, speech, hearing and the dentition. Patients and their families bear a significant emotional burden. Despite the high frequency and significance of the malformation, the aetiology of nonsyndromic cleft lip and palate is poorly understood. It has a complex multifactorial aetiology, both population-based and laboratory-based research has identified numerous genetic and environmental factors as causative agents and the list is continually expanding. Leading scientists are now beginning to question whether this trait is too complex to fully understand. This report provides a comprehensive and up-todate review of research into palatogenesis and non-syndromic oral cleftingUniversidade Estadual de Campinas2015-10-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/864102210.20396/bjos.v1i2.8641022Brazilian Journal of Oral Sciences; v. 1 n. 2 (2002): Jul./Sept.; 60-70Brazilian Journal of Oral Sciences; Vol. 1 No. 2 (2002): Jul./Sept.; 60-701677-3225reponame:Brazilian journal of oral sciences (Online)instname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPporhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641022/8558Sandy, Jonathan R.Brown, Nathan L.info:eu-repo/semantics/openAccess2016-02-25T09:33:01Zoai:ojs.periodicos.sbu.unicamp.br:article/8641022Revistahttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/PUBhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/oaibrjorals@fop.unicamp.br||brjorals@fop.unicamp.br1677-32251677-3217opendoar:2016-02-25T09:33:01Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)false
dc.title.none.fl_str_mv Basic sciences in normal and abnormal palate development
title Basic sciences in normal and abnormal palate development
spellingShingle Basic sciences in normal and abnormal palate development
Sandy, Jonathan R.
Palatogenesis
Cleft palate
Review
title_short Basic sciences in normal and abnormal palate development
title_full Basic sciences in normal and abnormal palate development
title_fullStr Basic sciences in normal and abnormal palate development
title_full_unstemmed Basic sciences in normal and abnormal palate development
title_sort Basic sciences in normal and abnormal palate development
author Sandy, Jonathan R.
author_facet Sandy, Jonathan R.
Brown, Nathan L.
author_role author
author2 Brown, Nathan L.
author2_role author
dc.contributor.author.fl_str_mv Sandy, Jonathan R.
Brown, Nathan L.
dc.subject.por.fl_str_mv Palatogenesis
Cleft palate
Review
topic Palatogenesis
Cleft palate
Review
description Orofacial clefting is one of the most common congenital malformations with an incidence of 1 in 500 to 1000 live births. Cleft lip and cleft palate may occur in isolation, in combination or as part of one of the 400 or more syndromes linked to orofacial clefting. Clefting causes problems with feeding, speech, hearing and the dentition. Patients and their families bear a significant emotional burden. Despite the high frequency and significance of the malformation, the aetiology of nonsyndromic cleft lip and palate is poorly understood. It has a complex multifactorial aetiology, both population-based and laboratory-based research has identified numerous genetic and environmental factors as causative agents and the list is continually expanding. Leading scientists are now beginning to question whether this trait is too complex to fully understand. This report provides a comprehensive and up-todate review of research into palatogenesis and non-syndromic oral clefting
publishDate 2015
dc.date.none.fl_str_mv 2015-10-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641022
10.20396/bjos.v1i2.8641022
url https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641022
identifier_str_mv 10.20396/bjos.v1i2.8641022
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641022/8558
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Estadual de Campinas
publisher.none.fl_str_mv Universidade Estadual de Campinas
dc.source.none.fl_str_mv Brazilian Journal of Oral Sciences; v. 1 n. 2 (2002): Jul./Sept.; 60-70
Brazilian Journal of Oral Sciences; Vol. 1 No. 2 (2002): Jul./Sept.; 60-70
1677-3225
reponame:Brazilian journal of oral sciences (Online)
instname:Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP
instname_str Universidade Estadual de Campinas (UNICAMP)
instacron_str UNICAMP
institution UNICAMP
reponame_str Brazilian journal of oral sciences (Online)
collection Brazilian journal of oral sciences (Online)
repository.name.fl_str_mv Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)
repository.mail.fl_str_mv brjorals@fop.unicamp.br||brjorals@fop.unicamp.br
_version_ 1800216398216036352

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