Basic sciences in normal and abnormal palate development
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian journal of oral sciences (Online) |
Texto Completo: | https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641022 |
Resumo: | Orofacial clefting is one of the most common congenital malformations with an incidence of 1 in 500 to 1000 live births. Cleft lip and cleft palate may occur in isolation, in combination or as part of one of the 400 or more syndromes linked to orofacial clefting. Clefting causes problems with feeding, speech, hearing and the dentition. Patients and their families bear a significant emotional burden. Despite the high frequency and significance of the malformation, the aetiology of nonsyndromic cleft lip and palate is poorly understood. It has a complex multifactorial aetiology, both population-based and laboratory-based research has identified numerous genetic and environmental factors as causative agents and the list is continually expanding. Leading scientists are now beginning to question whether this trait is too complex to fully understand. This report provides a comprehensive and up-todate review of research into palatogenesis and non-syndromic oral clefting |
id |
UNICAMP-8_39b591d67e866b79d9386dd0c53882a5 |
---|---|
oai_identifier_str |
oai:ojs.periodicos.sbu.unicamp.br:article/8641022 |
network_acronym_str |
UNICAMP-8 |
network_name_str |
Brazilian journal of oral sciences (Online) |
repository_id_str |
|
spelling |
Basic sciences in normal and abnormal palate developmentPalatogenesisCleft palateReviewOrofacial clefting is one of the most common congenital malformations with an incidence of 1 in 500 to 1000 live births. Cleft lip and cleft palate may occur in isolation, in combination or as part of one of the 400 or more syndromes linked to orofacial clefting. Clefting causes problems with feeding, speech, hearing and the dentition. Patients and their families bear a significant emotional burden. Despite the high frequency and significance of the malformation, the aetiology of nonsyndromic cleft lip and palate is poorly understood. It has a complex multifactorial aetiology, both population-based and laboratory-based research has identified numerous genetic and environmental factors as causative agents and the list is continually expanding. Leading scientists are now beginning to question whether this trait is too complex to fully understand. This report provides a comprehensive and up-todate review of research into palatogenesis and non-syndromic oral cleftingUniversidade Estadual de Campinas2015-10-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/864102210.20396/bjos.v1i2.8641022Brazilian Journal of Oral Sciences; v. 1 n. 2 (2002): Jul./Sept.; 60-70Brazilian Journal of Oral Sciences; Vol. 1 No. 2 (2002): Jul./Sept.; 60-701677-3225reponame:Brazilian journal of oral sciences (Online)instname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPporhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641022/8558Sandy, Jonathan R.Brown, Nathan L.info:eu-repo/semantics/openAccess2016-02-25T09:33:01Zoai:ojs.periodicos.sbu.unicamp.br:article/8641022Revistahttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/PUBhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/oaibrjorals@fop.unicamp.br||brjorals@fop.unicamp.br1677-32251677-3217opendoar:2016-02-25T09:33:01Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)false |
dc.title.none.fl_str_mv |
Basic sciences in normal and abnormal palate development |
title |
Basic sciences in normal and abnormal palate development |
spellingShingle |
Basic sciences in normal and abnormal palate development Sandy, Jonathan R. Palatogenesis Cleft palate Review |
title_short |
Basic sciences in normal and abnormal palate development |
title_full |
Basic sciences in normal and abnormal palate development |
title_fullStr |
Basic sciences in normal and abnormal palate development |
title_full_unstemmed |
Basic sciences in normal and abnormal palate development |
title_sort |
Basic sciences in normal and abnormal palate development |
author |
Sandy, Jonathan R. |
author_facet |
Sandy, Jonathan R. Brown, Nathan L. |
author_role |
author |
author2 |
Brown, Nathan L. |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Sandy, Jonathan R. Brown, Nathan L. |
dc.subject.por.fl_str_mv |
Palatogenesis Cleft palate Review |
topic |
Palatogenesis Cleft palate Review |
description |
Orofacial clefting is one of the most common congenital malformations with an incidence of 1 in 500 to 1000 live births. Cleft lip and cleft palate may occur in isolation, in combination or as part of one of the 400 or more syndromes linked to orofacial clefting. Clefting causes problems with feeding, speech, hearing and the dentition. Patients and their families bear a significant emotional burden. Despite the high frequency and significance of the malformation, the aetiology of nonsyndromic cleft lip and palate is poorly understood. It has a complex multifactorial aetiology, both population-based and laboratory-based research has identified numerous genetic and environmental factors as causative agents and the list is continually expanding. Leading scientists are now beginning to question whether this trait is too complex to fully understand. This report provides a comprehensive and up-todate review of research into palatogenesis and non-syndromic oral clefting |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641022 10.20396/bjos.v1i2.8641022 |
url |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641022 |
identifier_str_mv |
10.20396/bjos.v1i2.8641022 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641022/8558 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Oral Sciences; v. 1 n. 2 (2002): Jul./Sept.; 60-70 Brazilian Journal of Oral Sciences; Vol. 1 No. 2 (2002): Jul./Sept.; 60-70 1677-3225 reponame:Brazilian journal of oral sciences (Online) instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
instname_str |
Universidade Estadual de Campinas (UNICAMP) |
instacron_str |
UNICAMP |
institution |
UNICAMP |
reponame_str |
Brazilian journal of oral sciences (Online) |
collection |
Brazilian journal of oral sciences (Online) |
repository.name.fl_str_mv |
Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP) |
repository.mail.fl_str_mv |
brjorals@fop.unicamp.br||brjorals@fop.unicamp.br |
_version_ |
1800216398216036352 |