Study of Photodynamic Therapy (PDT) in the repair of tissue injuries: clinical case study

• Autor(a) principal: Moura, José Pedro Gomes
• Data de Publicação: 2018
• Outros Autores: Brandão, Lethicia Barreto, Barcessat, Ana Rita Pinheiro
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Estação Científica (UNIFAP)
• Texto Completo: https://periodicos.unifap.br/index.php/estacao/article/view/3511
• topic: Healing; Photosensitizer; Oxidative stress; Cicatrização. Fotossensibilizador. Estresse oxidativo

Photodynamic Therapy (PDT) is a therapeutic modality used for the purpose of microbial and tumor reduction. It is the combination of a photosensitizer with electromagnetic radiation to the tissue oxygen, generating a high local cytotoxic effect, leading to the cell or microorganism to death. The objective of this research was to evaluate the clinical evolution of human wounds treated and not treated with PDT. For this study, sixteen individuals with two wounds each were used, each one being divided into two groups: 1) PDT group: treated one of its wounds with PDT and; 2) control group: treated its other wound with conventional therapy with physiological solution (0.9%). The lesions of both groups received equal coverage with silver alginate, being photographed and measured in two periods to evaluate healing. One hundred percent of the lesions treated with PDT presented reduction in their area and clinical improvement, while in the control group there was a 70% reduction of the lesions. The clinical evolution of the wounds was more favorable in those in which PDT was used both for the reduction of the area and for the reduction of pain sensitivity, and photodynamic therapy was shown to be useful, effective and promising in the treatment of wounds.