PRELIMINARY STUDY OF THE EXTRACT OF THE BARKS OF Licania macrophylla BENTH: PHYTOCHEMICALS AND TOXICOLOGICAL ASPECTS

• Autor(a) principal: Ramos, Ryan da Silva
• Data de Publicação: 2014
• Outros Autores: Silva de Almeida, Sheylla Susan Moreira da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Biota Amazônia
• Texto Completo: https://periodicos.unifap.br/index.php/biota/article/view/920

The objective of this research was to evaluate the phytochemical, physicochemical and toxicity profile of ethanol crude extract of L. macrophyllain relation to Artemiasalina L. The Phytochemical analysis of the ethanol crude extract of the barks and stem and physicochemical calculation were performed by methods found in the Brazilian Pharmacopoeia. Phytochemical analysis detected saponins, organic acids, reducing sugars, tannins, anthraquinones, and depsidedepsidone. In relation to the physicochemical parameters, it showed pH = 4.64, due to the occurrence of saponins, organic acids and tannins; lipid = 0.55% indicates that the material presents few lipids of low molecular weight; humidity = 12.09% ± 0.12, relates to a small amount of water, indispensable for non occurrence of development of microorganisms or enzymatic degradation. Waste by incineration is within the pharmacognostic standards of 8.30% ± 0.54. The crude extract is practically nontoxic with LC50 = 1253μg/mL, since the mortality rate and LC50 should be higher than 1000μg/mL to be considered nontoxic. Phytochemical analysis have confirmed, in part, the use of species for phytotherapic purposes, however, the type of treatment and packaging can influence the determination of secondary metabolites. The adopted physicochemical parameters have shown that the species is free of decomposersagents.Keywords: Herbal medicine; L. macrophilla Benth; Toxicity; Physicochemical.