Chemical characterization, antimicrobial activity and cardiac effects in rat heart of the ethyl acetate fraction of Syzygium cumini (L.) Skeels
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/40000 |
Resumo: | Plants are important sources of secondary metabolites responsible for various biological activities. In this research, was evaluated the effect action ethyl acetate fraction of Syzygium cumini leaves (Sc-AcOEt) in the antimicrobial activity, contractile and electrical effects in isolated rat hearts and the chemical characterization. Antimicrobial activity was assessed using the disk-diffusion method and the determination of the minimum inhibitory concentration. The contractile and electrical effects were tested using the Langendorf method. The chemical characterization was evaluated through quantification and HPLC analyzes. P. aeruginosa was not viable in any concentration of the fraction (MIC 0,125 mg/mL), while S. aureus showed a MIC of 0.5 mg/mL. K. pneumoniae and E. coli had the highest MIC (1 mg/mL). A reduction in LVDP was observed after heart perfusion with 0.1 mg/mL of Sc-AcOEt. No change was observed in the duration of systole and diastole at all concentrations and in the electrocardiographic parameters. Total phenols, total flavonoids and total flavonols contents of Sc-AcOEt, calculated from the respective calibration curves, were 21.556µg/mg AGE, 617.222µg/mg QE and 315,222µg/mg RE, respectively. In addition, the HPLC analysis of Sc-AcOEt showed the presence of gallic acid, quercetin-3-glucoside, naringin and myricetin as main components. Thus, the Sc-AcOEt has important antimicrobial and cardiac activities possibly due to its chemical constituents. |
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Chemical characterization, antimicrobial activity and cardiac effects in rat heart of the ethyl acetate fraction of Syzygium cumini (L.) Skeels Caracterización química, actividad antimicrobiana y efectos cardiacos en corazón de rato de la fracción de acetato de etilo de Syzygium cumini (L.) SkeelsCaracterização química, atividade antimicrobiana e efeitos cardíacos em coração de rato da fração acetato de etila de Syzygium cumini (L.) SkeelsJambolanCompuestos fenólicosAntimicrobianoContracción cardíaca.JambolãoCompostos fenólicosAntimicrobianoContração cardíaca.JambolãoPhenolic compoundsAntimicrobialCardiac contraction.Plants are important sources of secondary metabolites responsible for various biological activities. In this research, was evaluated the effect action ethyl acetate fraction of Syzygium cumini leaves (Sc-AcOEt) in the antimicrobial activity, contractile and electrical effects in isolated rat hearts and the chemical characterization. Antimicrobial activity was assessed using the disk-diffusion method and the determination of the minimum inhibitory concentration. The contractile and electrical effects were tested using the Langendorf method. The chemical characterization was evaluated through quantification and HPLC analyzes. P. aeruginosa was not viable in any concentration of the fraction (MIC 0,125 mg/mL), while S. aureus showed a MIC of 0.5 mg/mL. K. pneumoniae and E. coli had the highest MIC (1 mg/mL). A reduction in LVDP was observed after heart perfusion with 0.1 mg/mL of Sc-AcOEt. No change was observed in the duration of systole and diastole at all concentrations and in the electrocardiographic parameters. Total phenols, total flavonoids and total flavonols contents of Sc-AcOEt, calculated from the respective calibration curves, were 21.556µg/mg AGE, 617.222µg/mg QE and 315,222µg/mg RE, respectively. In addition, the HPLC analysis of Sc-AcOEt showed the presence of gallic acid, quercetin-3-glucoside, naringin and myricetin as main components. Thus, the Sc-AcOEt has important antimicrobial and cardiac activities possibly due to its chemical constituents.Las plantas son fuentes importantes de metabolitos secundarios responsables de diversas actividades biológicas. En este investigación se evaluó el efecto de la fracción de acetato de etilo de hojas de Syzygium cumini (Sc-AcOEt) sobre la actividad antimicrobiana, efectos contráctiles y eléctricos en corazones aislados de rata y caracterización química. La actividad antimicrobiana se evaluó por el método de difusión en disco y por la determinación de la concentración inhibitoria mínima. Los efectos contráctiles y eléctricos se probaron mediante el método de Langendorf. La caracterización química se evaluó mediante cuantificación y análisis HPLC. P. aeruginosa no fue viable a ninguna concentración de la fracción (MIC 0,125 mg/mL), mientras que S. aureus tuvo una MIC de 0,5 mg/mL. K. pneumoniae y E. coli tuvieron la MIC más alta (1 mg/mL). Se observó un efecto inotrópico negativo después de la perfusión cardíaca con 0,1 mg/mL Sc-AcOEt. No hubo cambios en la duración de la sístole y la diástole y en los parámetros electrocardiográficos en todas las concentraciones. Los contenidos de fenoles totales, flavonoides totales y flavonoles totales de Sc-AcOEt, calculados a partir de las respectivas curvas de calibración, fueron de 21,556 µg/mg AGE, 617,222 µg/mg QE y 315,222 µg/mg RE, respectivamente. Además, el análisis HPLC de Sc-AcOEt mostró la presencia de ácido gálico, quercetina-3-glucósido, naringina y miricetina como componentes principales. Por lo tanto, el Sc-AcOEt tiene importantes actividades antimicrobianas y cardíacas posiblemente debido a sus constituyentes químicos.As plantas são importantes fontes de metabólitos secundários responsáveis por diversas atividades biológicas. Nesta pesquisa, foi avaliado o efeito da fração acetato de etila das folhas de Syzygium cumini (Sc-AcOEt) na atividade antimicrobiana, efeitos contráteis e elétricos em corações isolados de ratos e a caracterização química. A atividade antimicrobiana foi avaliada pelo método de disco-difusão e pela determinação da concentração inibitória mínima. Os efeitos contráteis e elétricos foram testados pelo método de Langendorf. A caracterização química foi avaliada por meio de quantificação e análises de HPLC. P. aeruginosa não foi viável em nenhuma concentração da fração (CIM 0,125 mg/mL), enquanto S. aureus apresentou CIM de 0,5 mg/mL. K. pneumoniae e E. coli tiveram a CIM mais alta (1 mg/mL). Observou-se um efeito inotrópico negativo após perfusão cardíaca com 0,1 mg/mL de Sc-AcOEt. Não houve alteração na duração da sístole e diástole e nos parâmetros eletrocardiográficos em todas as concentrações. Os teores de fenóis totais, flavonoides totais e flavonóis totais de Sc-AcOEt, calculados a partir das respectivas curvas de calibração, foram 21,556µg/mg AGE, 617,222µg/mg QE e 315,222µg/mg RE, respectivamente. Além disso, a análise por HPLC de Sc-AcOEt mostrou a presença de ácido gálico, quercetina-3-glicosídeo, naringina e miricetina como componentes principais. Assim, a Sc-AcOEt possui importantes atividades antimicrobiana e cardíaca possivelmente devido aos seus constituintes químicos.Research, Society and Development2023-01-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4000010.33448/rsd-v12i2.40000Research, Society and Development; Vol. 12 No. 2; e12612240000Research, Society and Development; Vol. 12 Núm. 2; e12612240000Research, Society and Development; v. 12 n. 2; e126122400002525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/40000/32791Copyright (c) 2023 Karina Oliveira Mota; Anamaria Mendonça Santos; Amanda Silva Santos; Andreza Melo de Araujo; Andrea Yu Kwan Villar Shan ; Carla Maria Lins de Vasconcelos; Brancilene Santos de Araújohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMota, Karina Oliveira Santos, Anamaria Mendonça Santos, Amanda Silva Araujo, Andreza Melo de Shan , Andrea Yu Kwan Villar Vasconcelos, Carla Maria Lins de Araújo, Brancilene Santos de 2023-02-14T20:07:52Zoai:ojs.pkp.sfu.ca:article/40000Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-02-14T20:07:52Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Chemical characterization, antimicrobial activity and cardiac effects in rat heart of the ethyl acetate fraction of Syzygium cumini (L.) Skeels Caracterización química, actividad antimicrobiana y efectos cardiacos en corazón de rato de la fracción de acetato de etilo de Syzygium cumini (L.) Skeels Caracterização química, atividade antimicrobiana e efeitos cardíacos em coração de rato da fração acetato de etila de Syzygium cumini (L.) Skeels |
title |
Chemical characterization, antimicrobial activity and cardiac effects in rat heart of the ethyl acetate fraction of Syzygium cumini (L.) Skeels |
spellingShingle |
Chemical characterization, antimicrobial activity and cardiac effects in rat heart of the ethyl acetate fraction of Syzygium cumini (L.) Skeels Mota, Karina Oliveira Jambolan Compuestos fenólicos Antimicrobiano Contracción cardíaca. Jambolão Compostos fenólicos Antimicrobiano Contração cardíaca. Jambolão Phenolic compounds Antimicrobial Cardiac contraction. |
title_short |
Chemical characterization, antimicrobial activity and cardiac effects in rat heart of the ethyl acetate fraction of Syzygium cumini (L.) Skeels |
title_full |
Chemical characterization, antimicrobial activity and cardiac effects in rat heart of the ethyl acetate fraction of Syzygium cumini (L.) Skeels |
title_fullStr |
Chemical characterization, antimicrobial activity and cardiac effects in rat heart of the ethyl acetate fraction of Syzygium cumini (L.) Skeels |
title_full_unstemmed |
Chemical characterization, antimicrobial activity and cardiac effects in rat heart of the ethyl acetate fraction of Syzygium cumini (L.) Skeels |
title_sort |
Chemical characterization, antimicrobial activity and cardiac effects in rat heart of the ethyl acetate fraction of Syzygium cumini (L.) Skeels |
author |
Mota, Karina Oliveira |
author_facet |
Mota, Karina Oliveira Santos, Anamaria Mendonça Santos, Amanda Silva Araujo, Andreza Melo de Shan , Andrea Yu Kwan Villar Vasconcelos, Carla Maria Lins de Araújo, Brancilene Santos de |
author_role |
author |
author2 |
Santos, Anamaria Mendonça Santos, Amanda Silva Araujo, Andreza Melo de Shan , Andrea Yu Kwan Villar Vasconcelos, Carla Maria Lins de Araújo, Brancilene Santos de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Mota, Karina Oliveira Santos, Anamaria Mendonça Santos, Amanda Silva Araujo, Andreza Melo de Shan , Andrea Yu Kwan Villar Vasconcelos, Carla Maria Lins de Araújo, Brancilene Santos de |
dc.subject.por.fl_str_mv |
Jambolan Compuestos fenólicos Antimicrobiano Contracción cardíaca. Jambolão Compostos fenólicos Antimicrobiano Contração cardíaca. Jambolão Phenolic compounds Antimicrobial Cardiac contraction. |
topic |
Jambolan Compuestos fenólicos Antimicrobiano Contracción cardíaca. Jambolão Compostos fenólicos Antimicrobiano Contração cardíaca. Jambolão Phenolic compounds Antimicrobial Cardiac contraction. |
description |
Plants are important sources of secondary metabolites responsible for various biological activities. In this research, was evaluated the effect action ethyl acetate fraction of Syzygium cumini leaves (Sc-AcOEt) in the antimicrobial activity, contractile and electrical effects in isolated rat hearts and the chemical characterization. Antimicrobial activity was assessed using the disk-diffusion method and the determination of the minimum inhibitory concentration. The contractile and electrical effects were tested using the Langendorf method. The chemical characterization was evaluated through quantification and HPLC analyzes. P. aeruginosa was not viable in any concentration of the fraction (MIC 0,125 mg/mL), while S. aureus showed a MIC of 0.5 mg/mL. K. pneumoniae and E. coli had the highest MIC (1 mg/mL). A reduction in LVDP was observed after heart perfusion with 0.1 mg/mL of Sc-AcOEt. No change was observed in the duration of systole and diastole at all concentrations and in the electrocardiographic parameters. Total phenols, total flavonoids and total flavonols contents of Sc-AcOEt, calculated from the respective calibration curves, were 21.556µg/mg AGE, 617.222µg/mg QE and 315,222µg/mg RE, respectively. In addition, the HPLC analysis of Sc-AcOEt showed the presence of gallic acid, quercetin-3-glucoside, naringin and myricetin as main components. Thus, the Sc-AcOEt has important antimicrobial and cardiac activities possibly due to its chemical constituents. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/40000 10.33448/rsd-v12i2.40000 |
url |
https://rsdjournal.org/index.php/rsd/article/view/40000 |
identifier_str_mv |
10.33448/rsd-v12i2.40000 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/40000/32791 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 12 No. 2; e12612240000 Research, Society and Development; Vol. 12 Núm. 2; e12612240000 Research, Society and Development; v. 12 n. 2; e12612240000 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052617457664000 |