Use of convalescent plasma in serious patients by COVID-19: Qualitative case series review

Detalhes bibliográficos
Autor(a) principal: Rocha, Gabriel Couto
Data de Publicação: 2021
Outros Autores: Camelier, Aquiles Assunção, Santana, Lorhany dos Santos, Camelier, Fernanda Warken Rosa, Maciel, Roberto Rodrigues Bandeira Tosta
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/11988
Resumo: The objective of this research was to find and evaluate the efficacy and safety of the use of plasma from recovered patients for the treatment of critically ill patients with COVID-19 (SARS-CoV-2), through a series of cases. The search took place in scientific databases such as Lilacs, MEDLINE, Google Academics, Scielo and Science Direct. After applying the filters for advanced search, and tracking by title, the pre-included abstracts were read, then evaluated in full for data extraction and synthesis of information and results. At the end, three case series observational studies were included. The patients in the study were using medications in a parallel way to the procedure (eg: antibiotics, antiviral drugs and steroids). Patients, in general, had improvements in most clinical symptoms, as well as in the decrease in SARS-CoV-2 viral titers, no adverse event was passive to alert. It is concluded that the evidences found in this work are heterogeneous and with a lot of limitations, about transfused dose, time of treatment and criteria to choose the patients, therefore, due to the presented restrictions, it is necessary to carry out clinical trials with outlined study designs, to certify the safety and effectiveness of the treatment.
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spelling Use of convalescent plasma in serious patients by COVID-19: Qualitative case series reviewUso de plasma de convalecencia en pacientes graves por COVID-19: Revisión cualitativa de series de casosUso do plasma convalescente em pacientes graves pelo COVID-19: Revisão qualitativa de série de casosCOVID-19Plasma de convalecenciaTerapia inmunológicaSeguridadEficacia.COVID-19Plasma ConvalescenteTerapia ImunológicaSegurançaEfetividade.COVID-19Convalescent plasmaImmunological TherapySafetyEffectiveness.The objective of this research was to find and evaluate the efficacy and safety of the use of plasma from recovered patients for the treatment of critically ill patients with COVID-19 (SARS-CoV-2), through a series of cases. The search took place in scientific databases such as Lilacs, MEDLINE, Google Academics, Scielo and Science Direct. After applying the filters for advanced search, and tracking by title, the pre-included abstracts were read, then evaluated in full for data extraction and synthesis of information and results. At the end, three case series observational studies were included. The patients in the study were using medications in a parallel way to the procedure (eg: antibiotics, antiviral drugs and steroids). Patients, in general, had improvements in most clinical symptoms, as well as in the decrease in SARS-CoV-2 viral titers, no adverse event was passive to alert. It is concluded that the evidences found in this work are heterogeneous and with a lot of limitations, about transfused dose, time of treatment and criteria to choose the patients, therefore, due to the presented restrictions, it is necessary to carry out clinical trials with outlined study designs, to certify the safety and effectiveness of the treatment.El objetivo de esta investigación fue encontrar y evaluar la eficacia y seguridad del uso de plasma de pacientes recuperados para el tratamiento de pacientes críticos con COVID-19 (SARS-CoV-2), a través de una serie de casos. La búsqueda se realizó en bases de datos científicas como Lilacs, MEDLINE, Google Academics, Scielo y Science Direct. Después de aplicar los filtros para la búsqueda avanzada y el seguimiento por título, se leyeron los resúmenes pre-inclusos y luego se evaluaron en su totalidad para la extracción de datos y la síntesis de información y resultados. Al final, se incluyeron tres estudios observacionales de series de casos. Los pacientes del estudio estaban usando medicamentos de manera paralela al procedimiento (por ejemplo: antibióticos, medicamentos antivirales y esteroides). Los pacientes, en general, tuvieron mejorías en la mayoría de los síntomas clínicos, así como en la disminución de los títulos virales del SARS-CoV-2, ningún evento adverso fue pasivo a alerta. Se concluye que las evidencias encontradas en este trabajo son heterogéneas y con muchas limitaciones, en cuanto a dosis transfundida, tiempo de tratamiento y criterios para elegir a los pacientes, por lo que, debido a las restricciones presentadas, es necesario realizar ensayos clínicos con diseños de estudio perfilados, para certificar la seguridad y eficacia del tratamiento.O objetivo desta pesquisa foi encontrar e avaliar a eficácia e a segurança do uso de plasma de pacientes recuperados para o tratamento de pacientes graves com COVID-19 (SARS-CoV-2), atraves de série de casos. A bsuca ocorreu nas bases de dados científicas como, Lilacs, MEDLINE, Google Academics, Scielo e Science Direct. Após a aplicação dos filtros para busca avançada, e do rastreamento por título, foi feito a leitura dos resumos pré-inclusos, depois avaliados na integra para extração de dados e síntese das informações e resultados. Ao final, três estudos observacionais do tipo série de casos foram incluídos. Os pacientes em estudo, estava usando madicamentos de forma paralela ao procedimento (ex.: antibioticios, antiviais e esteroides). Os pacientes, de forma geral, tiveram melhoras na maioria dos sintomas clinicos, como também, na diminuição dos títulos virais do SARS-CoV-2,  nenhum evento adverso foi passivo de alerta. Conclue-se que as evidências encontradas neste trabalho são heterogênas e com bastante limitações, acerca de dose tranfundida, tempo de tratamento e critérios para elegir os pacientes, assim, devido as restrinções apresentadas, se faz necessiário realizações de ensaios clínicos com desenhos de estudo delineados, para certificar a segurança e efetividade do tratamento.Research, Society and Development2021-01-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1198810.33448/rsd-v10i1.11988Research, Society and Development; Vol. 10 No. 1; e50810111988Research, Society and Development; Vol. 10 Núm. 1; e50810111988Research, Society and Development; v. 10 n. 1; e508101119882525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/11988/10806Copyright (c) 2021 Gabriel Couto Rocha; Aquiles Assunção Camelier; Lorhany dos Santos Santana; Fernanda Warken Rosa Camelier; Roberto Rodrigues Bandeira Tosta Macielhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRocha, Gabriel CoutoCamelier, Aquiles AssunçãoSantana, Lorhany dos SantosCamelier, Fernanda Warken RosaMaciel, Roberto Rodrigues Bandeira Tosta2021-02-20T21:19:23Zoai:ojs.pkp.sfu.ca:article/11988Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:33:40.901865Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Use of convalescent plasma in serious patients by COVID-19: Qualitative case series review
Uso de plasma de convalecencia en pacientes graves por COVID-19: Revisión cualitativa de series de casos
Uso do plasma convalescente em pacientes graves pelo COVID-19: Revisão qualitativa de série de casos
title Use of convalescent plasma in serious patients by COVID-19: Qualitative case series review
spellingShingle Use of convalescent plasma in serious patients by COVID-19: Qualitative case series review
Rocha, Gabriel Couto
COVID-19
Plasma de convalecencia
Terapia inmunológica
Seguridad
Eficacia.
COVID-19
Plasma Convalescente
Terapia Imunológica
Segurança
Efetividade.
COVID-19
Convalescent plasma
Immunological Therapy
Safety
Effectiveness.
title_short Use of convalescent plasma in serious patients by COVID-19: Qualitative case series review
title_full Use of convalescent plasma in serious patients by COVID-19: Qualitative case series review
title_fullStr Use of convalescent plasma in serious patients by COVID-19: Qualitative case series review
title_full_unstemmed Use of convalescent plasma in serious patients by COVID-19: Qualitative case series review
title_sort Use of convalescent plasma in serious patients by COVID-19: Qualitative case series review
author Rocha, Gabriel Couto
author_facet Rocha, Gabriel Couto
Camelier, Aquiles Assunção
Santana, Lorhany dos Santos
Camelier, Fernanda Warken Rosa
Maciel, Roberto Rodrigues Bandeira Tosta
author_role author
author2 Camelier, Aquiles Assunção
Santana, Lorhany dos Santos
Camelier, Fernanda Warken Rosa
Maciel, Roberto Rodrigues Bandeira Tosta
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rocha, Gabriel Couto
Camelier, Aquiles Assunção
Santana, Lorhany dos Santos
Camelier, Fernanda Warken Rosa
Maciel, Roberto Rodrigues Bandeira Tosta
dc.subject.por.fl_str_mv COVID-19
Plasma de convalecencia
Terapia inmunológica
Seguridad
Eficacia.
COVID-19
Plasma Convalescente
Terapia Imunológica
Segurança
Efetividade.
COVID-19
Convalescent plasma
Immunological Therapy
Safety
Effectiveness.
topic COVID-19
Plasma de convalecencia
Terapia inmunológica
Seguridad
Eficacia.
COVID-19
Plasma Convalescente
Terapia Imunológica
Segurança
Efetividade.
COVID-19
Convalescent plasma
Immunological Therapy
Safety
Effectiveness.
description The objective of this research was to find and evaluate the efficacy and safety of the use of plasma from recovered patients for the treatment of critically ill patients with COVID-19 (SARS-CoV-2), through a series of cases. The search took place in scientific databases such as Lilacs, MEDLINE, Google Academics, Scielo and Science Direct. After applying the filters for advanced search, and tracking by title, the pre-included abstracts were read, then evaluated in full for data extraction and synthesis of information and results. At the end, three case series observational studies were included. The patients in the study were using medications in a parallel way to the procedure (eg: antibiotics, antiviral drugs and steroids). Patients, in general, had improvements in most clinical symptoms, as well as in the decrease in SARS-CoV-2 viral titers, no adverse event was passive to alert. It is concluded that the evidences found in this work are heterogeneous and with a lot of limitations, about transfused dose, time of treatment and criteria to choose the patients, therefore, due to the presented restrictions, it is necessary to carry out clinical trials with outlined study designs, to certify the safety and effectiveness of the treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/11988
10.33448/rsd-v10i1.11988
url https://rsdjournal.org/index.php/rsd/article/view/11988
identifier_str_mv 10.33448/rsd-v10i1.11988
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/11988/10806
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 1; e50810111988
Research, Society and Development; Vol. 10 Núm. 1; e50810111988
Research, Society and Development; v. 10 n. 1; e50810111988
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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