Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/26032 |
Resumo: | The COVID-19 pandemic, since 2019, has contributed to aggravating situations that increase the risk of colonization or infection by multidrug-resistant bacteria, such as the indiscriminate use of antimicrobials. The aim of this study was to investigate the relationship between bacterial resistance and negative clinical outcome. A cross-sectional and retrospective study was carried out, where data were collected from the medical records of patients hospitalized in different hospital units (ICU, ward, isolation and neonatology units), from January to December 2021. Inclusion criteria were patients reported with colonization or infection by multidrug-resistant bacteria during hospitalization and with complete data. There were 128 positive samples, with a mean age of 68.2 years. There was a statistically significant difference in mortality when comparing patients younger than 50 years and the age groups between 70-80 years (p=0.006) and above 80 years (p=0.03). Among the three main pathogens isolated and their high mortality rate, there was no statistically significant difference in terms of the overall mortality rate for Acinetobacter baumannii (p = 0.54), Klebsiella pneumoniae (p = 1) and Pseudomonas aeruginosa (p = 1). = 0.82). A statistically significant result was detected for mortality and use of quinolones (p = 0.047) and a trend towards significance for polymyxin (p = 0.09). It was concluded that there was high mortality in patients colonized or infected by multidrug-resistant bacteria in a hospital setting, mainly over 70 years old. The use of quinolones, aminoglycosides and polymyxin seems to be related to higher mortality. |
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Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021Evolución clínica de pacientes colonizados e infectados por bacterias multirresistentes en un hospital privado de Fortaleza/Ceará, en 2021Desfecho clínico de pacientes colonizados e infectados por bactérias multirresistentes em hospital privado de Fortaleza/Ceará, em 2021AntimicrobianosBactériaMortalidadeColonizaçãoInfecção.AntimicrobialsMortalityColonizationBacteriumInfection.AntimicrobianosBacteriaMortalidadColonizaciónInfección.The COVID-19 pandemic, since 2019, has contributed to aggravating situations that increase the risk of colonization or infection by multidrug-resistant bacteria, such as the indiscriminate use of antimicrobials. The aim of this study was to investigate the relationship between bacterial resistance and negative clinical outcome. A cross-sectional and retrospective study was carried out, where data were collected from the medical records of patients hospitalized in different hospital units (ICU, ward, isolation and neonatology units), from January to December 2021. Inclusion criteria were patients reported with colonization or infection by multidrug-resistant bacteria during hospitalization and with complete data. There were 128 positive samples, with a mean age of 68.2 years. There was a statistically significant difference in mortality when comparing patients younger than 50 years and the age groups between 70-80 years (p=0.006) and above 80 years (p=0.03). Among the three main pathogens isolated and their high mortality rate, there was no statistically significant difference in terms of the overall mortality rate for Acinetobacter baumannii (p = 0.54), Klebsiella pneumoniae (p = 1) and Pseudomonas aeruginosa (p = 1). = 0.82). A statistically significant result was detected for mortality and use of quinolones (p = 0.047) and a trend towards significance for polymyxin (p = 0.09). It was concluded that there was high mortality in patients colonized or infected by multidrug-resistant bacteria in a hospital setting, mainly over 70 years old. The use of quinolones, aminoglycosides and polymyxin seems to be related to higher mortality.La pandemia de COVID-19, desde 2019, ha contribuido a agravar situaciones que aumentan el riesgo de colonización o infección por bacterias multirresistentes, como el uso indiscriminado de antimicrobianos. El objetivo de este estudio fue investigar la relación entre la resistencia bacteriana y el resultado clínico negativo. Se realizó un estudio transversal y retrospectivo, donde se recogieron datos de las historias clínicas de pacientes hospitalizados en diferentes unidades hospitalarias (UCI, sala, aislamiento y neonatología), de enero a diciembre de 2021. Los criterios de inclusión fueron pacientes reportados con colonización o infección por bacterias multirresistentes durante la hospitalización y con datos completos. Hubo 128 muestras positivas, con una edad media de 68,2 años. Hubo diferencia estadísticamente significativa en la mortalidad al comparar pacientes menores de 50 años y los grupos de edad entre 70-80 años (p=0,006) y mayores de 80 años (p=0,03). Entre los tres principales patógenos aislados y su alta tasa de mortalidad, no hubo diferencia estadísticamente significativa en cuanto a la tasa de mortalidad global para Acinetobacter baumannii (p = 0,54), Klebsiella pneumoniae (p = 1) y Pseudomonas aeruginosa (p = 1). = 0,82). Se detectó un resultado estadísticamente significativo para mortalidad y uso de quinolonas (p = 0,047) y tendencia a la significación para polimixina (p = 0,09). Se concluyó que existe una alta mortalidad en pacientes colonizados o infectados por bacterias multirresistentes en un medio hospitalario, principalmente mayores de 70 años. El uso de quinolonas, aminoglucósidos y polimixina parece estar relacionado con una mayor mortalidad.A pandemia pela COVID-19, desde 2019, vem contribuindo para agravar situações que aumentam o risco de desenvolvimento de colonização ou infecção por bactérias multirresistentes, como o uso indiscriminado de antimicrobianos. O objetivo deste estudo foi investigar a relação entre resistência bacteriana e desfecho clínico negativo. Foi realizado estudo do tipo transversal e retrospectivo, onde foram coletados dados dos prontuários de pacientes internados em diferentes unidades hospitalares (UTI, enfermaria, isolamento e neonatologia), de janeiro a dezembro de 2021. Os critérios de inclusão foram os pacientes notificados com colonização ou infecção por bactérias multirresistentes durante o internamento e com dados completos. Foram 128 amostras positivas, com média de idade 68,2 anos. Houve diferença estatisticamente significante em mortalidade ao comparar pacientes com menos de 50 anos e os grupos de faixa etária entre 70-80 anos (p=0,006) e acima de 80 anos (p=0,03). Dentre os três principais patógenos isolados e a elevada taxa de mortalidade dos mesmos, não houve diferença estatisticamente significativa em relação a taxa de mortalidade global para Acinetobacter baumannii (p = 0,54), Klebsiella pneumoniae (p = 1) e Pseudomonas aeruginosa (p = 0,82). Detectou-se resultado estatisticamente significativo para mortalidade e utilização de quinolonas (p = 0,047) e uma tendência a significância para polimixina (p = 0,09). Concluiu-se que houve elevada mortalidade em pacientes colonizados ou infectados por bactérias multirresistentes em âmbito hospitalar, principalmente acima de 70 anos de idade. O uso de quinolonas, aminoglicosídeos e polimixina parece estar relacionado a maior mortalidade.Research, Society and Development2022-02-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2603210.33448/rsd-v11i2.26032Research, Society and Development; Vol. 11 No. 2; e58611226032Research, Society and Development; Vol. 11 Núm. 2; e58611226032Research, Society and Development; v. 11 n. 2; e586112260322525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/26032/22928Copyright (c) 2022 Cicero Allan Landim de Oliveira Lima; Ana Lívia Gomes Moreira; Rafael Ferreira Mesquita; Luan Victor Almeida Lima; Bruno Pinheiro Aquino; Melissa Soares Medeiroshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLima, Cicero Allan Landim de Oliveira Moreira, Ana Lívia Gomes Mesquita, Rafael Ferreira Lima, Luan Victor Almeida Aquino, Bruno Pinheiro Medeiros, Melissa Soares 2022-02-07T01:42:50Zoai:ojs.pkp.sfu.ca:article/26032Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:44:10.401228Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021 Evolución clínica de pacientes colonizados e infectados por bacterias multirresistentes en un hospital privado de Fortaleza/Ceará, en 2021 Desfecho clínico de pacientes colonizados e infectados por bactérias multirresistentes em hospital privado de Fortaleza/Ceará, em 2021 |
title |
Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021 |
spellingShingle |
Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021 Lima, Cicero Allan Landim de Oliveira Antimicrobianos Bactéria Mortalidade Colonização Infecção. Antimicrobials Mortality Colonization Bacterium Infection. Antimicrobianos Bacteria Mortalidad Colonización Infección. |
title_short |
Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021 |
title_full |
Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021 |
title_fullStr |
Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021 |
title_full_unstemmed |
Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021 |
title_sort |
Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021 |
author |
Lima, Cicero Allan Landim de Oliveira |
author_facet |
Lima, Cicero Allan Landim de Oliveira Moreira, Ana Lívia Gomes Mesquita, Rafael Ferreira Lima, Luan Victor Almeida Aquino, Bruno Pinheiro Medeiros, Melissa Soares |
author_role |
author |
author2 |
Moreira, Ana Lívia Gomes Mesquita, Rafael Ferreira Lima, Luan Victor Almeida Aquino, Bruno Pinheiro Medeiros, Melissa Soares |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Lima, Cicero Allan Landim de Oliveira Moreira, Ana Lívia Gomes Mesquita, Rafael Ferreira Lima, Luan Victor Almeida Aquino, Bruno Pinheiro Medeiros, Melissa Soares |
dc.subject.por.fl_str_mv |
Antimicrobianos Bactéria Mortalidade Colonização Infecção. Antimicrobials Mortality Colonization Bacterium Infection. Antimicrobianos Bacteria Mortalidad Colonización Infección. |
topic |
Antimicrobianos Bactéria Mortalidade Colonização Infecção. Antimicrobials Mortality Colonization Bacterium Infection. Antimicrobianos Bacteria Mortalidad Colonización Infección. |
description |
The COVID-19 pandemic, since 2019, has contributed to aggravating situations that increase the risk of colonization or infection by multidrug-resistant bacteria, such as the indiscriminate use of antimicrobials. The aim of this study was to investigate the relationship between bacterial resistance and negative clinical outcome. A cross-sectional and retrospective study was carried out, where data were collected from the medical records of patients hospitalized in different hospital units (ICU, ward, isolation and neonatology units), from January to December 2021. Inclusion criteria were patients reported with colonization or infection by multidrug-resistant bacteria during hospitalization and with complete data. There were 128 positive samples, with a mean age of 68.2 years. There was a statistically significant difference in mortality when comparing patients younger than 50 years and the age groups between 70-80 years (p=0.006) and above 80 years (p=0.03). Among the three main pathogens isolated and their high mortality rate, there was no statistically significant difference in terms of the overall mortality rate for Acinetobacter baumannii (p = 0.54), Klebsiella pneumoniae (p = 1) and Pseudomonas aeruginosa (p = 1). = 0.82). A statistically significant result was detected for mortality and use of quinolones (p = 0.047) and a trend towards significance for polymyxin (p = 0.09). It was concluded that there was high mortality in patients colonized or infected by multidrug-resistant bacteria in a hospital setting, mainly over 70 years old. The use of quinolones, aminoglycosides and polymyxin seems to be related to higher mortality. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-06 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/26032 10.33448/rsd-v11i2.26032 |
url |
https://rsdjournal.org/index.php/rsd/article/view/26032 |
identifier_str_mv |
10.33448/rsd-v11i2.26032 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/26032/22928 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 2; e58611226032 Research, Society and Development; Vol. 11 Núm. 2; e58611226032 Research, Society and Development; v. 11 n. 2; e58611226032 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052704019709952 |