Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021

Detalhes bibliográficos
Autor(a) principal: Lima, Cicero Allan Landim de Oliveira
Data de Publicação: 2022
Outros Autores: Moreira, Ana Lívia Gomes, Mesquita, Rafael Ferreira, Lima, Luan Victor Almeida, Aquino, Bruno Pinheiro, Medeiros, Melissa Soares
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/26032
Resumo: The COVID-19 pandemic, since 2019, has contributed to aggravating situations that increase the risk of colonization or infection by multidrug-resistant bacteria, such as the indiscriminate use of antimicrobials. The aim of this study was to investigate the relationship between bacterial resistance and negative clinical outcome. A cross-sectional and retrospective study was carried out, where data were collected from the medical records of patients hospitalized in different hospital units (ICU, ward, isolation and neonatology units), from January to December 2021. Inclusion criteria were patients reported with colonization or infection by multidrug-resistant bacteria during hospitalization and with complete data. There were 128 positive samples, with a mean age of 68.2 years. There was a statistically significant difference in mortality when comparing patients younger than 50 years and the age groups between 70-80 years (p=0.006) and above 80 years (p=0.03). Among the three main pathogens isolated and their high mortality rate, there was no statistically significant difference in terms of the overall mortality rate for Acinetobacter baumannii (p = 0.54), Klebsiella pneumoniae (p = 1) and Pseudomonas aeruginosa (p = 1). = 0.82). A statistically significant result was detected for mortality and use of quinolones (p = 0.047) and a trend towards significance for polymyxin (p = 0.09). It was concluded that there was high mortality in patients colonized or infected by multidrug-resistant bacteria in a hospital setting, mainly over 70 years old. The use of quinolones, aminoglycosides and polymyxin seems to be related to higher mortality.
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spelling Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021Evolución clínica de pacientes colonizados e infectados por bacterias multirresistentes en un hospital privado de Fortaleza/Ceará, en 2021Desfecho clínico de pacientes colonizados e infectados por bactérias multirresistentes em hospital privado de Fortaleza/Ceará, em 2021AntimicrobianosBactériaMortalidadeColonizaçãoInfecção.AntimicrobialsMortalityColonizationBacteriumInfection.AntimicrobianosBacteriaMortalidadColonizaciónInfección.The COVID-19 pandemic, since 2019, has contributed to aggravating situations that increase the risk of colonization or infection by multidrug-resistant bacteria, such as the indiscriminate use of antimicrobials. The aim of this study was to investigate the relationship between bacterial resistance and negative clinical outcome. A cross-sectional and retrospective study was carried out, where data were collected from the medical records of patients hospitalized in different hospital units (ICU, ward, isolation and neonatology units), from January to December 2021. Inclusion criteria were patients reported with colonization or infection by multidrug-resistant bacteria during hospitalization and with complete data. There were 128 positive samples, with a mean age of 68.2 years. There was a statistically significant difference in mortality when comparing patients younger than 50 years and the age groups between 70-80 years (p=0.006) and above 80 years (p=0.03). Among the three main pathogens isolated and their high mortality rate, there was no statistically significant difference in terms of the overall mortality rate for Acinetobacter baumannii (p = 0.54), Klebsiella pneumoniae (p = 1) and Pseudomonas aeruginosa (p = 1). = 0.82). A statistically significant result was detected for mortality and use of quinolones (p = 0.047) and a trend towards significance for polymyxin (p = 0.09). It was concluded that there was high mortality in patients colonized or infected by multidrug-resistant bacteria in a hospital setting, mainly over 70 years old. The use of quinolones, aminoglycosides and polymyxin seems to be related to higher mortality.La pandemia de COVID-19, desde 2019, ha contribuido a agravar situaciones que aumentan el riesgo de colonización o infección por bacterias multirresistentes, como el uso indiscriminado de antimicrobianos. El objetivo de este estudio fue investigar la relación entre la resistencia bacteriana y el resultado clínico negativo. Se realizó un estudio transversal y retrospectivo, donde se recogieron datos de las historias clínicas de pacientes hospitalizados en diferentes unidades hospitalarias (UCI, sala, aislamiento y neonatología), de enero a diciembre de 2021. Los criterios de inclusión fueron pacientes reportados con colonización o infección por bacterias multirresistentes durante la hospitalización y con datos completos. Hubo 128 muestras positivas, con una edad media de 68,2 años. Hubo diferencia estadísticamente significativa en la mortalidad al comparar pacientes menores de 50 años y los grupos de edad entre 70-80 años (p=0,006) y mayores de 80 años (p=0,03). Entre los tres principales patógenos aislados y su alta tasa de mortalidad, no hubo diferencia estadísticamente significativa en cuanto a la tasa de mortalidad global para Acinetobacter baumannii (p = 0,54), Klebsiella pneumoniae (p = 1) y Pseudomonas aeruginosa (p = 1). = 0,82). Se detectó un resultado estadísticamente significativo para mortalidad y uso de quinolonas (p = 0,047) y tendencia a la significación para polimixina (p = 0,09). Se concluyó que existe una alta mortalidad en pacientes colonizados o infectados por bacterias multirresistentes en un medio hospitalario, principalmente mayores de 70 años. El uso de quinolonas, aminoglucósidos y polimixina parece estar relacionado con una mayor mortalidad.A pandemia pela COVID-19, desde 2019, vem contribuindo para agravar situações que aumentam o risco de desenvolvimento de colonização ou infecção por bactérias multirresistentes, como o uso indiscriminado de antimicrobianos. O objetivo deste estudo foi investigar a relação entre resistência bacteriana e desfecho clínico negativo. Foi realizado estudo do tipo transversal e retrospectivo, onde foram coletados dados dos prontuários de pacientes internados em diferentes unidades hospitalares (UTI, enfermaria, isolamento e neonatologia), de janeiro a dezembro de 2021. Os critérios de inclusão foram os pacientes notificados com colonização ou infecção por bactérias multirresistentes durante o internamento e com dados completos. Foram 128 amostras positivas, com média de idade 68,2 anos. Houve diferença estatisticamente significante em mortalidade ao comparar pacientes com menos de 50 anos e os grupos de faixa etária entre 70-80 anos (p=0,006) e acima de 80 anos (p=0,03). Dentre os três principais patógenos isolados e a elevada taxa de mortalidade dos mesmos, não houve diferença estatisticamente significativa em relação a taxa de mortalidade global para Acinetobacter baumannii (p = 0,54), Klebsiella pneumoniae (p = 1) e Pseudomonas aeruginosa (p = 0,82). Detectou-se resultado estatisticamente significativo para mortalidade e utilização de quinolonas (p = 0,047) e uma tendência a significância para polimixina (p = 0,09). Concluiu-se que houve elevada mortalidade em pacientes colonizados ou infectados por bactérias multirresistentes em âmbito hospitalar, principalmente acima de 70 anos de idade. O uso de quinolonas, aminoglicosídeos e polimixina parece estar relacionado a maior mortalidade.Research, Society and Development2022-02-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2603210.33448/rsd-v11i2.26032Research, Society and Development; Vol. 11 No. 2; e58611226032Research, Society and Development; Vol. 11 Núm. 2; e58611226032Research, Society and Development; v. 11 n. 2; e586112260322525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/26032/22928Copyright (c) 2022 Cicero Allan Landim de Oliveira Lima; Ana Lívia Gomes Moreira; Rafael Ferreira Mesquita; Luan Victor Almeida Lima; Bruno Pinheiro Aquino; Melissa Soares Medeiroshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLima, Cicero Allan Landim de Oliveira Moreira, Ana Lívia Gomes Mesquita, Rafael Ferreira Lima, Luan Victor Almeida Aquino, Bruno Pinheiro Medeiros, Melissa Soares 2022-02-07T01:42:50Zoai:ojs.pkp.sfu.ca:article/26032Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:44:10.401228Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021
Evolución clínica de pacientes colonizados e infectados por bacterias multirresistentes en un hospital privado de Fortaleza/Ceará, en 2021
Desfecho clínico de pacientes colonizados e infectados por bactérias multirresistentes em hospital privado de Fortaleza/Ceará, em 2021
title Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021
spellingShingle Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021
Lima, Cicero Allan Landim de Oliveira
Antimicrobianos
Bactéria
Mortalidade
Colonização
Infecção.
Antimicrobials
Mortality
Colonization
Bacterium
Infection.
Antimicrobianos
Bacteria
Mortalidad
Colonización
Infección.
title_short Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021
title_full Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021
title_fullStr Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021
title_full_unstemmed Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021
title_sort Clinical outcome of patients colonized and infected by multidrug-resistant bacteria in a private hospital in Fortaleza/Ceará, in 2021
author Lima, Cicero Allan Landim de Oliveira
author_facet Lima, Cicero Allan Landim de Oliveira
Moreira, Ana Lívia Gomes
Mesquita, Rafael Ferreira
Lima, Luan Victor Almeida
Aquino, Bruno Pinheiro
Medeiros, Melissa Soares
author_role author
author2 Moreira, Ana Lívia Gomes
Mesquita, Rafael Ferreira
Lima, Luan Victor Almeida
Aquino, Bruno Pinheiro
Medeiros, Melissa Soares
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Cicero Allan Landim de Oliveira
Moreira, Ana Lívia Gomes
Mesquita, Rafael Ferreira
Lima, Luan Victor Almeida
Aquino, Bruno Pinheiro
Medeiros, Melissa Soares
dc.subject.por.fl_str_mv Antimicrobianos
Bactéria
Mortalidade
Colonização
Infecção.
Antimicrobials
Mortality
Colonization
Bacterium
Infection.
Antimicrobianos
Bacteria
Mortalidad
Colonización
Infección.
topic Antimicrobianos
Bactéria
Mortalidade
Colonização
Infecção.
Antimicrobials
Mortality
Colonization
Bacterium
Infection.
Antimicrobianos
Bacteria
Mortalidad
Colonización
Infección.
description The COVID-19 pandemic, since 2019, has contributed to aggravating situations that increase the risk of colonization or infection by multidrug-resistant bacteria, such as the indiscriminate use of antimicrobials. The aim of this study was to investigate the relationship between bacterial resistance and negative clinical outcome. A cross-sectional and retrospective study was carried out, where data were collected from the medical records of patients hospitalized in different hospital units (ICU, ward, isolation and neonatology units), from January to December 2021. Inclusion criteria were patients reported with colonization or infection by multidrug-resistant bacteria during hospitalization and with complete data. There were 128 positive samples, with a mean age of 68.2 years. There was a statistically significant difference in mortality when comparing patients younger than 50 years and the age groups between 70-80 years (p=0.006) and above 80 years (p=0.03). Among the three main pathogens isolated and their high mortality rate, there was no statistically significant difference in terms of the overall mortality rate for Acinetobacter baumannii (p = 0.54), Klebsiella pneumoniae (p = 1) and Pseudomonas aeruginosa (p = 1). = 0.82). A statistically significant result was detected for mortality and use of quinolones (p = 0.047) and a trend towards significance for polymyxin (p = 0.09). It was concluded that there was high mortality in patients colonized or infected by multidrug-resistant bacteria in a hospital setting, mainly over 70 years old. The use of quinolones, aminoglycosides and polymyxin seems to be related to higher mortality.
publishDate 2022
dc.date.none.fl_str_mv 2022-02-06
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/26032
10.33448/rsd-v11i2.26032
url https://rsdjournal.org/index.php/rsd/article/view/26032
identifier_str_mv 10.33448/rsd-v11i2.26032
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/26032/22928
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 2; e58611226032
Research, Society and Development; Vol. 11 Núm. 2; e58611226032
Research, Society and Development; v. 11 n. 2; e58611226032
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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