Non linear analysis of heart rate variability in HIV/AIDS infections
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/29636 |
Resumo: | The availability of Antiretroviral Therapy (ART) resulted in a drastic reduction of morbidity and mortality associated with the human immunodeficiency virus (HIV). However, the therapy has a series of adverse effects, including autonomic dysfunction. The analysis of HRV allows the evaluation of the sympathetic and parasympathetic involvement in the cardiac neuromodulation. Given the above, the objetives were: to verify whether HIV infections produce changes in cardiac autonomic modulation; to identify whether the cardiac autonomic modulation of the HIV-infected population is sensitive to respiratory sinus arrhythmia (RSA); and to investigate whether time to diagnosis of HIV infection influences HRV. A total of 49 individuals with HIV/AIDS and 21 healthy individuals were assessed. HRV measurements were taken for 20 minutes in the supine position, using the heart rate monitor Polar RS810CX, followed by the RSA maneuver. In both conditions, the RR intervals, typical of HRV, were analyzed by linear and nonlinear indices. Only two nonlinear indices, i.e., %REC and Shannon Entropy, showed statistically significant difference (p=0.004), when comparing both HIV/AIDS and control groups, indicating reduced HRV in the HIV/AIDS group. It is suggested that the RSA maneuver, in turn, improved the autonomic modulation, because the reduction of %REC after the maneuver indicates increase in the parasympathetic modulation. In this way, it is concluded that the HIV/AIDS group showed decreased HRV in the nonlinear analysis; and increased vagal modulation was observed during the ART maneuver. The time to diagnosis has shown to have no influence on HRV. |
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Non linear analysis of heart rate variability in HIV/AIDS infectionsAnálisis no lineal de la variabilidad de la frecuencia cardíaca en infecciones por VIH/SIDAAnálise não linear da variabilidade da frequência cardíaca em infecções por HIV/AIDSAutonomic nervous systemHeart rateImmunodeficiencyInfectious diseases.Sistema nervioso autónomoFrecuencia cardiacaInmunodeficienciaEnfermedades infecciosas.Sistema nervoso autônomoFrequência cardíacaImunodeficiênciaDoenças infecciosas.The availability of Antiretroviral Therapy (ART) resulted in a drastic reduction of morbidity and mortality associated with the human immunodeficiency virus (HIV). However, the therapy has a series of adverse effects, including autonomic dysfunction. The analysis of HRV allows the evaluation of the sympathetic and parasympathetic involvement in the cardiac neuromodulation. Given the above, the objetives were: to verify whether HIV infections produce changes in cardiac autonomic modulation; to identify whether the cardiac autonomic modulation of the HIV-infected population is sensitive to respiratory sinus arrhythmia (RSA); and to investigate whether time to diagnosis of HIV infection influences HRV. A total of 49 individuals with HIV/AIDS and 21 healthy individuals were assessed. HRV measurements were taken for 20 minutes in the supine position, using the heart rate monitor Polar RS810CX, followed by the RSA maneuver. In both conditions, the RR intervals, typical of HRV, were analyzed by linear and nonlinear indices. Only two nonlinear indices, i.e., %REC and Shannon Entropy, showed statistically significant difference (p=0.004), when comparing both HIV/AIDS and control groups, indicating reduced HRV in the HIV/AIDS group. It is suggested that the RSA maneuver, in turn, improved the autonomic modulation, because the reduction of %REC after the maneuver indicates increase in the parasympathetic modulation. In this way, it is concluded that the HIV/AIDS group showed decreased HRV in the nonlinear analysis; and increased vagal modulation was observed during the ART maneuver. The time to diagnosis has shown to have no influence on HRV.La disponibilidad de la Terapia Antirretroviral (TAR) ha resultado en una reducción drástica de la morbilidad y mortalidad asociadas con el virus de la inmunodeficiencia humana (VIH). Sin embargo, la terapia tiene una serie de efectos adversos, incluida la disfunción autonómica. El análisis HRV permite la evaluación de la participación simpática y parasimpática en la neuromodulación cardíaca. Dado lo anterior, los objetivos fueron: verificar si las infecciones por VIH producen cambios en la modulación autonómica cardíaca; identificar si la modulación autonómica cardíaca de la población infectada por el VIH es sensible a la arritmia sinusal respiratoria (RSA); e investigar si el momento del diagnóstico de la infección por el VIH influye en la VFC. Se evaluaron 49 personas con VIH/SIDA y 21 personas sanas. Las mediciones de HRV se realizaron durante 20 minutos en posición supina, utilizando el monitor de frecuencia cardíaca Polar RS810CX, seguido de la maniobra RSA. En ambas condiciones, los intervalos RR, típicos de HRV, fueron analizados por índices lineales y no lineales. Solo dos índices no lineales, es decir, %REC y Entropía de Shannon, mostraron una diferencia estadísticamente significativa (p=0,004) al comparar los grupos de control y VIH/SIDA, lo que indica una reducción en la VFC en el grupo de VIH/SIDA. Se sugiere que la maniobra RSA, a su vez, mejoró la modulación autonómica, ya que la reducción en %REC después de la maniobra indica un aumento en la modulación parasimpática. Por lo tanto, se puede concluir que el grupo de VIH/SIDA tuvo una VFC disminuida en el análisis no lineal; y se observó un aumento de la modulación vagal durante la maniobra ART. Se demostró que el tiempo hasta el diagnóstico no tiene influencia en la VFC.A disponibilidade da Terapia Antirretroviral (TARV) resultou em uma redução drástica da morbimortalidade associada ao vírus da imunodeficiência humana (HIV). No entanto, a terapia tem uma série de efeitos adversos, incluindo disfunção autonômica. A análise da VFC permite avaliar o envolvimento simpático e parassimpático na neuromodulação cardíaca. Diante do exposto, os objetivos foram: verificar se as infecções pelo HIV produzem alterações na modulação autonômica cardíaca; identificar se a modulação autonômica cardíaca da população infectada pelo HIV é sensível à arritmia sinusal respiratória (ASR); e investigar se o tempo de diagnóstico da infecção pelo HIV influencia a VFC. Foram avaliados 49 indivíduos com HIV/AIDS e 21 indivíduos saudáveis. As medidas da VFC foram realizadas por 20 minutos em decúbito dorsal, utilizando o monitor de frequência cardíaca Polar RS810CX, seguida da manobra RSA. Em ambas as condições, os intervalos RR, típicos da VFC, foram analisados por índices lineares e não lineares. Apenas dois índices não lineares, ou seja, %REC e Shannon Entropy, apresentaram diferença estatisticamente significativa (p=0,004), quando comparados os grupos HIV/AIDS e controle, indicando redução da VFC no grupo HIV/AIDS. Sugere-se que a manobra RSA, por sua vez, melhorou a modulação autonômica, pois a redução do %REC após a manobra indica aumento da modulação parassimpática. Desta forma, conclui-se que o grupo HIV/AIDS apresentou VFC diminuída na análise não linear; e aumento da modulação vagal foi observado durante a manobra de ART. O tempo até o diagnóstico mostrou não ter influência na VFC.Research, Society and Development2022-05-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2963610.33448/rsd-v11i7.29636Research, Society and Development; Vol. 11 No. 7; e26111729636Research, Society and Development; Vol. 11 Núm. 7; e26111729636Research, Society and Development; v. 11 n. 7; e261117296362525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/29636/27823Copyright (c) 2022 Marilita Falangola Accioly; Gabriela Aguiar Mesquita Galdino; Gesileny Vieira Silva; Graziella Paula Neri ; Gabriela Figueiredo Borges; Fernanda Regina de Moraeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAccioly, Marilita Falangola Galdino, Gabriela Aguiar Mesquita Silva, Gesileny Vieira Neri , Graziella Paula Borges, Gabriela Figueiredo Moraes, Fernanda Regina de 2022-06-06T15:12:05Zoai:ojs.pkp.sfu.ca:article/29636Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:46:39.494925Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Non linear analysis of heart rate variability in HIV/AIDS infections Análisis no lineal de la variabilidad de la frecuencia cardíaca en infecciones por VIH/SIDA Análise não linear da variabilidade da frequência cardíaca em infecções por HIV/AIDS |
title |
Non linear analysis of heart rate variability in HIV/AIDS infections |
spellingShingle |
Non linear analysis of heart rate variability in HIV/AIDS infections Accioly, Marilita Falangola Autonomic nervous system Heart rate Immunodeficiency Infectious diseases. Sistema nervioso autónomo Frecuencia cardiaca Inmunodeficiencia Enfermedades infecciosas. Sistema nervoso autônomo Frequência cardíaca Imunodeficiência Doenças infecciosas. |
title_short |
Non linear analysis of heart rate variability in HIV/AIDS infections |
title_full |
Non linear analysis of heart rate variability in HIV/AIDS infections |
title_fullStr |
Non linear analysis of heart rate variability in HIV/AIDS infections |
title_full_unstemmed |
Non linear analysis of heart rate variability in HIV/AIDS infections |
title_sort |
Non linear analysis of heart rate variability in HIV/AIDS infections |
author |
Accioly, Marilita Falangola |
author_facet |
Accioly, Marilita Falangola Galdino, Gabriela Aguiar Mesquita Silva, Gesileny Vieira Neri , Graziella Paula Borges, Gabriela Figueiredo Moraes, Fernanda Regina de |
author_role |
author |
author2 |
Galdino, Gabriela Aguiar Mesquita Silva, Gesileny Vieira Neri , Graziella Paula Borges, Gabriela Figueiredo Moraes, Fernanda Regina de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Accioly, Marilita Falangola Galdino, Gabriela Aguiar Mesquita Silva, Gesileny Vieira Neri , Graziella Paula Borges, Gabriela Figueiredo Moraes, Fernanda Regina de |
dc.subject.por.fl_str_mv |
Autonomic nervous system Heart rate Immunodeficiency Infectious diseases. Sistema nervioso autónomo Frecuencia cardiaca Inmunodeficiencia Enfermedades infecciosas. Sistema nervoso autônomo Frequência cardíaca Imunodeficiência Doenças infecciosas. |
topic |
Autonomic nervous system Heart rate Immunodeficiency Infectious diseases. Sistema nervioso autónomo Frecuencia cardiaca Inmunodeficiencia Enfermedades infecciosas. Sistema nervoso autônomo Frequência cardíaca Imunodeficiência Doenças infecciosas. |
description |
The availability of Antiretroviral Therapy (ART) resulted in a drastic reduction of morbidity and mortality associated with the human immunodeficiency virus (HIV). However, the therapy has a series of adverse effects, including autonomic dysfunction. The analysis of HRV allows the evaluation of the sympathetic and parasympathetic involvement in the cardiac neuromodulation. Given the above, the objetives were: to verify whether HIV infections produce changes in cardiac autonomic modulation; to identify whether the cardiac autonomic modulation of the HIV-infected population is sensitive to respiratory sinus arrhythmia (RSA); and to investigate whether time to diagnosis of HIV infection influences HRV. A total of 49 individuals with HIV/AIDS and 21 healthy individuals were assessed. HRV measurements were taken for 20 minutes in the supine position, using the heart rate monitor Polar RS810CX, followed by the RSA maneuver. In both conditions, the RR intervals, typical of HRV, were analyzed by linear and nonlinear indices. Only two nonlinear indices, i.e., %REC and Shannon Entropy, showed statistically significant difference (p=0.004), when comparing both HIV/AIDS and control groups, indicating reduced HRV in the HIV/AIDS group. It is suggested that the RSA maneuver, in turn, improved the autonomic modulation, because the reduction of %REC after the maneuver indicates increase in the parasympathetic modulation. In this way, it is concluded that the HIV/AIDS group showed decreased HRV in the nonlinear analysis; and increased vagal modulation was observed during the ART maneuver. The time to diagnosis has shown to have no influence on HRV. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-23 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/29636 10.33448/rsd-v11i7.29636 |
url |
https://rsdjournal.org/index.php/rsd/article/view/29636 |
identifier_str_mv |
10.33448/rsd-v11i7.29636 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/29636/27823 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 7; e26111729636 Research, Society and Development; Vol. 11 Núm. 7; e26111729636 Research, Society and Development; v. 11 n. 7; e26111729636 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052712588673024 |