Neonatal candidiasis and candidemia: A literature review

Detalhes bibliográficos
Autor(a) principal: Luz, Gabriela Alves
Data de Publicação: 2021
Outros Autores: Schneider, Gabriela Coleta, Carmo, Monique Santos do
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/14326
Resumo: The aim of this study was to conduct a literature review on neonatal candidiasis and candidemia, addressing etiopathogenesis, epidemiology, virulence factors, risk factors, clinical manifestations, diagnosis, treatment, prevention, immune response, susceptibility to antifungals, strategies for reduction of morbidity and mortality and future perspectives. Articles published in the last ten years in the PubMed, Medline and Google Scholar databases were listed. Candidiasis and neonatal candidemia are important causes of morbidity and mortality worldwide, so that more than 750,000 cases are registered annually. The most susceptible newborns are premature, low birth weight, immunosuppressed, using catheters, mechanical ventilation and parenteral nutrition. Stricter control of risk factors within the hospital environment associated with the care of professionals is required, in addition to the rational use of antifungals in the prevention or treatment of candidiasis and candidemia. It is also important to highlight the gradual change in the epidemiological course of these pathologies due to the emergence of new non-albicans species that can represent a serious risk for neonates. Public policies aimed at the proper management of candidiasis and candidemia are necessary.
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spelling Neonatal candidiasis and candidemia: A literature review Candidiasis y candidemia neonatales: Revisión de la literatura Candidíase e candidemia neonatal: Revisão de literatura CandidíaseCandidemiaCandidaNeonatos.CandidiasisCandidemiaCandidaRecién nacidos.CandidiasisCandidemiaCandidaNeonates.The aim of this study was to conduct a literature review on neonatal candidiasis and candidemia, addressing etiopathogenesis, epidemiology, virulence factors, risk factors, clinical manifestations, diagnosis, treatment, prevention, immune response, susceptibility to antifungals, strategies for reduction of morbidity and mortality and future perspectives. Articles published in the last ten years in the PubMed, Medline and Google Scholar databases were listed. Candidiasis and neonatal candidemia are important causes of morbidity and mortality worldwide, so that more than 750,000 cases are registered annually. The most susceptible newborns are premature, low birth weight, immunosuppressed, using catheters, mechanical ventilation and parenteral nutrition. Stricter control of risk factors within the hospital environment associated with the care of professionals is required, in addition to the rational use of antifungals in the prevention or treatment of candidiasis and candidemia. It is also important to highlight the gradual change in the epidemiological course of these pathologies due to the emergence of new non-albicans species that can represent a serious risk for neonates. Public policies aimed at the proper management of candidiasis and candidemia are necessary.El objetivo de este estudio fue realizar una revisión de la literatura sobre candidiasis y candidemia neonatal, abordando etiopatogenia, epidemiología, factores de virulencia, factores de riesgo, manifestaciones clínicas, diagnóstico, tratamiento, prevención, respuesta inmunológica, susceptibilidad a antifúngicos, estrategias de reducción de la morbilidad y mortalidad y perspectivas de futuro. Se enumeraron los artículos publicados en los últimos diez años en las bases de datos PubMed, Medline y Google Scholar. La candidiasis y la candidemia neonatal son causas importantes de morbilidad y mortalidad a nivel mundial, por lo que se registran más de 750.000 casos al año. Los recién nacidos más susceptibles son los prematuros, de bajo peso al nacer, inmunosuprimidos, que utilizan catéteres, ventilación mecánica y nutrición parenteral. Se requiere un control más estricto de los factores de riesgo dentro del ámbito hospitalario asociados a la atención de los profesionales, además del uso racional de antifúngicos en la prevención o tratamiento de la candidiasis y candidemia. También es importante destacar el cambio paulatino en el curso epidemiológico de estas patologías debido a la aparición de nuevas especies no albicans que pueden representar un grave riesgo para los neonatos. Son necesarias políticas públicas orientadas al manejo adecuado de la candidiasis y la candidemia.O objetivo desse estudo foi realizar uma revisão de literatura sobre a candidíase e candidemia neonatal abordando a etiopatogenia, epidemiologia, fatores de virulência, fatores de risco, manifestações clínicas, diagnóstico, tratamento, prevenção, resposta imunológica, padrão de susceptibilidade aos antifúngicos, estratégias para redução da morbimortalidade e perspectivas futuras. Foram elencados artigos publicados nos últimos dez anos nas bases de dados PubMed, Medline e Google Scholar. A candidíase e a candidemia neonatal são importantes causas de morbidade e mortalidade em todo o mundo, de forma que mais de 750.000 casos são registrados anualmente. Os recém-nascidos mais susceptíveis são os prematuros, de baixo peso, imunosuprimidos, sob o uso de cateter, ventilação mecânica e nutrição parenteral. É necessário um controle mais rígido dos fatores de risco dentro do ambiente hospitalar associado ao cuidado dos profissionais, além do uso racional de antifúngicos seja na prevenção ou tratamento da candidíase e candidemia. É importante ressaltar também sobre a mudança gradual no curso epidemiológico dessas patologias pela emergência de novas espécies não albicans que podem representar sério risco para os neonatos. Políticas públicas direcionadas para o manejo adequado da candidíase e candidemia são necessárias.Research, Society and Development2021-04-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1432610.33448/rsd-v10i4.14326Research, Society and Development; Vol. 10 No. 4; e53710414326Research, Society and Development; Vol. 10 Núm. 4; e53710414326Research, Society and Development; v. 10 n. 4; e537104143262525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/14326/12976Copyright (c) 2021 Gabriela Alves Luz; Gabriela Coleta Schneider; Monique Santos do Carmohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Luz, Gabriela AlvesSchneider, Gabriela ColetaCarmo, Monique Santos do 2021-04-25T11:21:26Zoai:ojs.pkp.sfu.ca:article/14326Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:35:28.555839Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Neonatal candidiasis and candidemia: A literature review
Candidiasis y candidemia neonatales: Revisión de la literatura
Candidíase e candidemia neonatal: Revisão de literatura
title Neonatal candidiasis and candidemia: A literature review
spellingShingle Neonatal candidiasis and candidemia: A literature review
Luz, Gabriela Alves
Candidíase
Candidemia
Candida
Neonatos.
Candidiasis
Candidemia
Candida
Recién nacidos.
Candidiasis
Candidemia
Candida
Neonates.
title_short Neonatal candidiasis and candidemia: A literature review
title_full Neonatal candidiasis and candidemia: A literature review
title_fullStr Neonatal candidiasis and candidemia: A literature review
title_full_unstemmed Neonatal candidiasis and candidemia: A literature review
title_sort Neonatal candidiasis and candidemia: A literature review
author Luz, Gabriela Alves
author_facet Luz, Gabriela Alves
Schneider, Gabriela Coleta
Carmo, Monique Santos do
author_role author
author2 Schneider, Gabriela Coleta
Carmo, Monique Santos do
author2_role author
author
dc.contributor.author.fl_str_mv Luz, Gabriela Alves
Schneider, Gabriela Coleta
Carmo, Monique Santos do
dc.subject.por.fl_str_mv Candidíase
Candidemia
Candida
Neonatos.
Candidiasis
Candidemia
Candida
Recién nacidos.
Candidiasis
Candidemia
Candida
Neonates.
topic Candidíase
Candidemia
Candida
Neonatos.
Candidiasis
Candidemia
Candida
Recién nacidos.
Candidiasis
Candidemia
Candida
Neonates.
description The aim of this study was to conduct a literature review on neonatal candidiasis and candidemia, addressing etiopathogenesis, epidemiology, virulence factors, risk factors, clinical manifestations, diagnosis, treatment, prevention, immune response, susceptibility to antifungals, strategies for reduction of morbidity and mortality and future perspectives. Articles published in the last ten years in the PubMed, Medline and Google Scholar databases were listed. Candidiasis and neonatal candidemia are important causes of morbidity and mortality worldwide, so that more than 750,000 cases are registered annually. The most susceptible newborns are premature, low birth weight, immunosuppressed, using catheters, mechanical ventilation and parenteral nutrition. Stricter control of risk factors within the hospital environment associated with the care of professionals is required, in addition to the rational use of antifungals in the prevention or treatment of candidiasis and candidemia. It is also important to highlight the gradual change in the epidemiological course of these pathologies due to the emergence of new non-albicans species that can represent a serious risk for neonates. Public policies aimed at the proper management of candidiasis and candidemia are necessary.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-22
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14326
10.33448/rsd-v10i4.14326
url https://rsdjournal.org/index.php/rsd/article/view/14326
identifier_str_mv 10.33448/rsd-v10i4.14326
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14326/12976
dc.rights.driver.fl_str_mv Copyright (c) 2021 Gabriela Alves Luz; Gabriela Coleta Schneider; Monique Santos do Carmo
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Gabriela Alves Luz; Gabriela Coleta Schneider; Monique Santos do Carmo
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 4; e53710414326
Research, Society and Development; Vol. 10 Núm. 4; e53710414326
Research, Society and Development; v. 10 n. 4; e53710414326
2525-3409
reponame:Research, Society and Development
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instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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