Correlation between changes in the gastrointestinal microbiota with the onset and complications of Parkinson's disease: the role of inflammatory cytokines in the bidirectional gut-brain axis

• Autor(a) principal: Sales, Pablo Cleber Sousa Lopes
• Data de Publicação: 2021
• Outros Autores: Sousa Neto, Almir Vieira de, Costa, Lahuan Araujo, Fonseca, Mikhail de Morais Veras da, Mendonça, Gabriela de Souza, Araújo, Ligia Viana de, Araújo, Vitória Stefanny Cunha, Cardoso, Ana Maria Santos, Jordão, Paulo Victor de Sousa, Araujo, Brenda Dias, Sousa Filho, Charles Ponte de, Teixeira, Louise Ribeiro, Ferreira , José Guilherme de Oliveira Rodrigues, Pacheco, Rafaela Costa, Bastos, André Pessoa Silva, Cardoso, Brenda Ellen Meneses, Araújo, Larruama Soares Figueiredo de, Lima, Bianca Sampaio, Pires, Vivian Saeger, Souza, Luan Kelves Miranda de
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/12788
• topic: Microbiota; Parkinson's Disease; Neurodegeneration; Inflammation; Cytokines.; Microbiota; Enfermedad de Parkinson; Neurodegeneración; Inflamación; Citocinas.; Microbiota; Doença de Parkinson; Neurodegeneração; Inflamação; Citocinas.

Humans developed a symbiotic relationship with their gut microbiota, a complex microbial community made up of bacteria, archaea, protists and viruses, including bacteriophages. The enteric nervous system (SNE) is a gateway to bidirectional communication between the brain and the intestine, mainly through the vagus nerve (VN). Therefore, environmental exposure plays a fundamental role in both the composition and functionality of the intestinal microbiome and can contribute to susceptibility to neurodegenerative disorders, such as Parkinson's disease (PD). This is a systematic review of the literature using the data bases PUBMED, Scielo and MEDLINE, using the descriptors present in the Health Sciences Descriptors (DeCS): Parkinson's disease, cytokines, microbiota and gastrointestinal tract. It can be mentioned that the neuropathological characteristic of PD is the generalized appearance of alpha-synuclein (α-Syn) aggregates in the central and peripheral nervous systems, including the SNE. Many studies suggest that intestinal toxins can induce the formation of α-Syn aggregates in the SNE, which can then be transmitted to the CNS via the VN. PD is strongly associated with aging and its negative effects on homeostatic mechanisms that protect against inflammation, oxidative stress and protein malfunction. Thus, this study intends to carry out, based on analyzes of inflammatory cytokines and intestinal microbiota, how dysbiosis can contribute to the onset or complications of PD, promoting a correlation between clinical and laboratory manifestations and prognosis, as well as describing the main mechanisms causal factors that are still poorly understood.