The influence of levodopa on respiratory function in Parkinson's disease patients: a systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Ferreira, Francisco José Silva
Data de Publicação: 2021
Outros Autores: Gonçalves, Paulo Eduardo, Lima, Alice Santos, Garção, Diogo Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/22262
Resumo: There is no consensus in the literature about the influence of levodopa on respiratory disorders, which are the main cause of death in Parkinson’s disease patients. Thus, the aim of this study was to conduct a systematic review and meta-analysis to assess the influence of levodopa on lung function in patients with Parkinson’s disease. A systematic search was performed in the MEDLINE-PubMed, Lilacs, IEEE Xplore Digital Library and Cochrane Library databases, until July 2020. Eligibility, screening, data extraction and quality assessment of the studies found were conducted independently by a minimum of two reviewers. The meta-analysis was made using RevMan 5, using standardized difference of means (SDM) with the random effects model and 95% confidence interval. The presence of heterogeneity was evaluated through the percentage of i². In total, 78 studies were identified; of these,7 were included in the review and meta-analysis after considering the inclusion and exclusion criteria. By comparing the 'on' and 'off' levodopa states, in the outcomes of interest found in the included studies, the following results were obtained in the meta-analysis: FVC (SMD of 0.12, p = 0.41); FEV1 (SMD of 0.10, p = 0.47); PEF (SMD of -0.00, p = 0.99); FEV1/FVC (SMD 0.04, p = 0.76). The conducted study suggested that there was no influence of levodopa treatment on any of the pulmonary variables assessed in patients with Parkinson’s disease.    
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spelling The influence of levodopa on respiratory function in Parkinson's disease patients: a systematic review and meta-analysisLa influencia de la levodopa en la función respiratoria en pacientes con enfermedad de Parkinson: revisión sistemática y metanálisisA influência da levodopa na função respiratória em pacientes com doença de Parkinson: uma revisão sistemática e meta-análiseLevodopaCapacidade vitalCapacidade pulmonar totalMedidas de volume pulmonarDoença de ParkinsonVolume de ventilação pulmonar.Parkinson diseaseLevodopaVital CapacityTotal lung capacityLung volume measurementsTidal volume.Enfermedad de ParkinsonLevodopaCapacidad vitalCapacidad pulmonar totalMediciones del volume pulmonarVolumen de ventilación pulmonar.There is no consensus in the literature about the influence of levodopa on respiratory disorders, which are the main cause of death in Parkinson’s disease patients. Thus, the aim of this study was to conduct a systematic review and meta-analysis to assess the influence of levodopa on lung function in patients with Parkinson’s disease. A systematic search was performed in the MEDLINE-PubMed, Lilacs, IEEE Xplore Digital Library and Cochrane Library databases, until July 2020. Eligibility, screening, data extraction and quality assessment of the studies found were conducted independently by a minimum of two reviewers. The meta-analysis was made using RevMan 5, using standardized difference of means (SDM) with the random effects model and 95% confidence interval. The presence of heterogeneity was evaluated through the percentage of i². In total, 78 studies were identified; of these,7 were included in the review and meta-analysis after considering the inclusion and exclusion criteria. By comparing the 'on' and 'off' levodopa states, in the outcomes of interest found in the included studies, the following results were obtained in the meta-analysis: FVC (SMD of 0.12, p = 0.41); FEV1 (SMD of 0.10, p = 0.47); PEF (SMD of -0.00, p = 0.99); FEV1/FVC (SMD 0.04, p = 0.76). The conducted study suggested that there was no influence of levodopa treatment on any of the pulmonary variables assessed in patients with Parkinson’s disease.    No existe consenso en la literatura sobre la influencia de la levodopa en los trastornos respiratorios, que son la principal causa de muerte en pacientes con enfermedad de Parkinson. Por tanto, el objetivo del estudio fue realizar una revisión sistemática y un metanálisis para evaluar el impacto de la levodopa en la función pulmonar en pacientes con enfermedad de Parkinson. Se realizó una búsqueda sistemática en las bases de datos MEDLINE-PubMed, Lilacs, IEEE Xplore Digital Library y Cochrane Library, hasta julio de 2020. La elegibilidad, cribado, extracción de datos y evaluación de la calidad de los estudios encontrados fueron realizados por al menos dos revisores. A continuación, se realizó un metanálisis utilizando RevMan 5, utilizando la diferencia de medias estandarizada con el modelo de efectos aleatorios y el intervalo de confianza del 95%. La presencia de heterogeneidad se evaluó mediante el porcentaje de i². En total, se identificaron 78 estudios; de estos, 7 se incluyeron en la revisión y metanálisis después de considerar los criterios de inclusión y exclusión. Al comparar los estados de levodopa "on" y "off", en los resultados de interés encontrados en los estudios incluidos, se obtuvieron los siguientes resultados en el metanálisis: FVC (SDM de 0,12, p = 0,41); FEV1 (SDM 0,10, p = 0,47); PEF (SDM -0,00, p = 0,99); FEV1 / FVC (SDM 0,04, p = 0,76). El estudio realizado sugirió que no hubo impacto del tratamiento con levodopa en ninguna de las variables pulmonares evaluadas en pacientes con enfermedad de Parkinson.Não existe um consenso na literatura sobre a influência da levodopa sobre as disfunções respiratórias, que são a principal causa de morte em pacientes com doença de Parkinson. Assim, o objetivo desse estudo foi conduzir uma revisão sistemática e meta-análise para avaliar qual a influência da levodopa na função pulmonar em pacientes com doença de Parkinson. Foi realizada uma procura sistemática nos bancos de dados MEDLINE-PubMed, Lilacs, IEEE Xplore Digital Library e Cochrane Library, até julho de 2020. Elegibilidade, triagem, extração de dados e avaliação de qualidade dos estudos encontrados foram conduzidas independentemente por um mínimo de dois revisores. A meta-análise foi então conduzida através do RevMan 5, utilizando diferença padronizada de médias com o modelo de efeitos aleatórios e intervalo de confiança de 95%. A presença de heterogeneidade foi avaliada através do percentual de i². No total, 78 estudos foram identificados; destes, 7 foram incluídos na revisão e meta-análise depois de considerados os critérios de inclusão e exclusão. Através do confrontamento dos estados ‘‘on’’ e ‘‘off’’ levodopa, nos desfechos de interesse encontradas nos estudos incluídos, foram obtidos os seguintes resultados na meta-análise: FVC (SMD de 0.12, p = 0.41); FEV1 (SMD de 0.10, p = 0.47); PEF (SMD de -0.00, p = 0.99); FEV1/FVC (SMD de 0.04, p = 0.76). O estudo conduzido sugeriu não haver influência do tratamento com levodopa em quaisquer das variáveis pulmonares avaliadas em pacientes com doença de Parkinson.Research, Society and Development2021-11-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2226210.33448/rsd-v10i14.22262Research, Society and Development; Vol. 10 No. 14; e457101422262Research, Society and Development; Vol. 10 Núm. 14; e457101422262Research, Society and Development; v. 10 n. 14; e4571014222622525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/22262/19781Copyright (c) 2021 Francisco José Silva Ferreira; Paulo Eduardo Gonçalves; Alice Santos Lima; Diogo Costa Garçãohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFerreira, Francisco José Silva Gonçalves, Paulo EduardoLima, Alice Santos Garção, Diogo Costa 2021-12-04T11:48:39Zoai:ojs.pkp.sfu.ca:article/22262Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:41:29.162008Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv The influence of levodopa on respiratory function in Parkinson's disease patients: a systematic review and meta-analysis
La influencia de la levodopa en la función respiratoria en pacientes con enfermedad de Parkinson: revisión sistemática y metanálisis
A influência da levodopa na função respiratória em pacientes com doença de Parkinson: uma revisão sistemática e meta-análise
title The influence of levodopa on respiratory function in Parkinson's disease patients: a systematic review and meta-analysis
spellingShingle The influence of levodopa on respiratory function in Parkinson's disease patients: a systematic review and meta-analysis
Ferreira, Francisco José Silva
Levodopa
Capacidade vital
Capacidade pulmonar total
Medidas de volume pulmonar
Doença de Parkinson
Volume de ventilação pulmonar.
Parkinson disease
Levodopa
Vital Capacity
Total lung capacity
Lung volume measurements
Tidal volume.
Enfermedad de Parkinson
Levodopa
Capacidad vital
Capacidad pulmonar total
Mediciones del volume pulmonar
Volumen de ventilación pulmonar.
title_short The influence of levodopa on respiratory function in Parkinson's disease patients: a systematic review and meta-analysis
title_full The influence of levodopa on respiratory function in Parkinson's disease patients: a systematic review and meta-analysis
title_fullStr The influence of levodopa on respiratory function in Parkinson's disease patients: a systematic review and meta-analysis
title_full_unstemmed The influence of levodopa on respiratory function in Parkinson's disease patients: a systematic review and meta-analysis
title_sort The influence of levodopa on respiratory function in Parkinson's disease patients: a systematic review and meta-analysis
author Ferreira, Francisco José Silva
author_facet Ferreira, Francisco José Silva
Gonçalves, Paulo Eduardo
Lima, Alice Santos
Garção, Diogo Costa
author_role author
author2 Gonçalves, Paulo Eduardo
Lima, Alice Santos
Garção, Diogo Costa
author2_role author
author
author
dc.contributor.author.fl_str_mv Ferreira, Francisco José Silva
Gonçalves, Paulo Eduardo
Lima, Alice Santos
Garção, Diogo Costa
dc.subject.por.fl_str_mv Levodopa
Capacidade vital
Capacidade pulmonar total
Medidas de volume pulmonar
Doença de Parkinson
Volume de ventilação pulmonar.
Parkinson disease
Levodopa
Vital Capacity
Total lung capacity
Lung volume measurements
Tidal volume.
Enfermedad de Parkinson
Levodopa
Capacidad vital
Capacidad pulmonar total
Mediciones del volume pulmonar
Volumen de ventilación pulmonar.
topic Levodopa
Capacidade vital
Capacidade pulmonar total
Medidas de volume pulmonar
Doença de Parkinson
Volume de ventilação pulmonar.
Parkinson disease
Levodopa
Vital Capacity
Total lung capacity
Lung volume measurements
Tidal volume.
Enfermedad de Parkinson
Levodopa
Capacidad vital
Capacidad pulmonar total
Mediciones del volume pulmonar
Volumen de ventilación pulmonar.
description There is no consensus in the literature about the influence of levodopa on respiratory disorders, which are the main cause of death in Parkinson’s disease patients. Thus, the aim of this study was to conduct a systematic review and meta-analysis to assess the influence of levodopa on lung function in patients with Parkinson’s disease. A systematic search was performed in the MEDLINE-PubMed, Lilacs, IEEE Xplore Digital Library and Cochrane Library databases, until July 2020. Eligibility, screening, data extraction and quality assessment of the studies found were conducted independently by a minimum of two reviewers. The meta-analysis was made using RevMan 5, using standardized difference of means (SDM) with the random effects model and 95% confidence interval. The presence of heterogeneity was evaluated through the percentage of i². In total, 78 studies were identified; of these,7 were included in the review and meta-analysis after considering the inclusion and exclusion criteria. By comparing the 'on' and 'off' levodopa states, in the outcomes of interest found in the included studies, the following results were obtained in the meta-analysis: FVC (SMD of 0.12, p = 0.41); FEV1 (SMD of 0.10, p = 0.47); PEF (SMD of -0.00, p = 0.99); FEV1/FVC (SMD 0.04, p = 0.76). The conducted study suggested that there was no influence of levodopa treatment on any of the pulmonary variables assessed in patients with Parkinson’s disease.    
publishDate 2021
dc.date.none.fl_str_mv 2021-11-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/22262
10.33448/rsd-v10i14.22262
url https://rsdjournal.org/index.php/rsd/article/view/22262
identifier_str_mv 10.33448/rsd-v10i14.22262
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/22262/19781
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 14; e457101422262
Research, Society and Development; Vol. 10 Núm. 14; e457101422262
Research, Society and Development; v. 10 n. 14; e457101422262
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052641992245248

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