Interrelationship between COVID-19 and diabetes mellitus: a systematic review

• Autor(a) principal: Marinho, Felipe Pereira
• Data de Publicação: 2021
• Outros Autores: Loyola, Isabella Santos de, Monteiro, Igor de Oliveira Freire, Castro, Tiffani Marioto, Carvalho, Maria das Graças de Souza, Garcia, José Antonio Dias, Silvério, Alessandra Cristina Pupin, Santos, Gérsika Bitencourt
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/12191
• topic: COVID-19; Diabetes; Coronavirus; Mechanisms; Infection; Systematic review.; COVID-19; Diabetes; Coronavirus; Mecanismos; Infección; Revisión sistemática.; COVID-19; Diabetes; Coronavírus; Mecanismos; Infecção; Revisão sistemática.

Introduction: Individuals with diabetes are at a higher risk of hospitalization and mortality from viral, bacterial and fungal infections. Coronavírus-2019 (COVID-19), caused by severe acute respiratory syndrome coronavírus-2 (SARS-CoV-2), spread rapidly to countries and claimed thousands of lives by December 2020. Notably, in several studies, diabetes is one of the most reported comorbidities in patients with severe COVID-19. Objective: Discuss the influence of diabetes on the prognosis of patients with COVID-19 through a literature review. Methodology: It is a systematic review study. To identify the literature published until December 2020, individual search strategies were applied to the following electronic databases: PubMed, Medline, Lilacs and SciELO. Results: It can be noted that based on the new clinical data obtained from COVID-19 patients, several mechanisms, such as cytokine storm, pulmonary and endothelial dysfunction and hypercoagulation, which can make individuals with diabetes more vulnerable to COVID-19. Epidemiological studies show that poorly controlled diabetes is a risk factor for several infectious diseases. Conclusion: Given the clinical importance of diabetes and the pandemic nature of coronaviruses, understanding how diabetes affects the severity of COVID-19 is critical to the development of public awareness and personalized treatment for individuals affected by the disease.