Key clinical evidence of stem cell therapy in burn healing: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/32781 |
Resumo: | Objective: To analyze the main clinical evidence of stem cell therapy in the healing of burns. Methodology: This is a systematic review carried out using the PRISMA method, in the electronic databases PubMed, Scopus and Web of Science, using the following descriptors: “stem cell”, “hematopoetic stem cells'”, “embryonic stem cell”, “burn”, “burned” and “burn units”. Full texts, available in Portuguese, English or Spanish, published between January 2005 and April 2022 were included; human studies (clinical studies). Results: Four articles made up the final sample of this review, with publication frequency between 2005 and 2022. In total, 328 burn patients were treated with stem cells. The therapy showed positive results in terms of faster wound healing, lower rate of infection and complications, higher survival rate and faster hospital discharge. Conclusion: It was found that stem cell therapy in burn patients can increase the effectiveness of local treatment and improve surgical skin restoration. However, more clinical trials need to be encouraged in order to more accurately justify the use of this therapy in these patients. |
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Key clinical evidence of stem cell therapy in burn healing: a systematic reviewEvidencia clínica clave de la terapia con células madre en la curación de quemaduras: una revisión sistemáticaPrincipais evidências clínicas da terapia com células-tronco na cicatrização de queimaduras: uma revisão sistemáticaCélulas madre mesenquimatosasQuemadurasRevisión.Células-tronco mesenquimalQueimadurasRevisão.Mesenchymal stem cellsBurnsReview.Objective: To analyze the main clinical evidence of stem cell therapy in the healing of burns. Methodology: This is a systematic review carried out using the PRISMA method, in the electronic databases PubMed, Scopus and Web of Science, using the following descriptors: “stem cell”, “hematopoetic stem cells'”, “embryonic stem cell”, “burn”, “burned” and “burn units”. Full texts, available in Portuguese, English or Spanish, published between January 2005 and April 2022 were included; human studies (clinical studies). Results: Four articles made up the final sample of this review, with publication frequency between 2005 and 2022. In total, 328 burn patients were treated with stem cells. The therapy showed positive results in terms of faster wound healing, lower rate of infection and complications, higher survival rate and faster hospital discharge. Conclusion: It was found that stem cell therapy in burn patients can increase the effectiveness of local treatment and improve surgical skin restoration. However, more clinical trials need to be encouraged in order to more accurately justify the use of this therapy in these patients.Objetivo: Analizar las principales evidencias clínicas de la terapia con células madre en la cicatrización de quemaduras. Metodología: Se trata de una revisión sistemática realizada mediante el método PRISMA, en las bases de datos electrónicas PubMed, Scopus y Web of Science, utilizando los siguientes descriptores: “stem cell”, “hematopoetic stem cells'”, “embryonic stem cell”, “burn”, “burned” y “burn units”. Se incluyeron textos completos, disponibles en portugués, inglés o español, publicados entre enero de 2005 y abril de 2022; estudios en humanos (estudios clínicos). Resultados: Cuatro artículos conformaron la muestra final de esta revisión, con frecuencia de publicación entre 2005 y 2022. En total, 328 pacientes quemados fueron tratados con células madre. La terapia mostró resultados positivos en términos de cicatrización de heridas más rápida, menor tasa de infección y complicaciones, mayor tasa de supervivencia y un alta hospitalaria más rápida. Conclusión: Se encontró que la terapia con células madre en pacientes quemados puede aumentar la efectividad del tratamiento local y mejorar la restauración quirúrgica de la piel. Sin embargo, es necesario impulsar más ensayos clínicos para justificar con mayor precisión el uso de esta terapia en estos pacientes.Objetivo: Analisar as principais evidências clínicas da terapia com células-tronco na cicatrização de queimaduras. Metodologia: Trata-se de uma revisão sistemática realizada por meio do método PRISMA, nas bases de dados eletrônicas PubMed, Scopus e Web of Science, por meio dos seguintes descritores: “stem cell”, “hematopoetic stem cells'”, “embryonic stem cell”, “burn”, “burned” e “burn units”. Foram incluídos textos completos, disponíveis em português, inglês ou espanhol, publicados entre janeiro de 2005 a abril de 2022; estudos realizados em humanos (estudos clínicos). Resultados: Quatro artigos compuseram a amostra final dessa revisão, com frequência de publicação entre 2005 a 2022. No total, 328 pacientes com queimaduras foram tratados com células-tronco. A terapia apresentou resultados positivos quanto a cicatrização mais rápida das lesões, menor taxa de infecção e complicações decorrentes, maior taxa de sobrevida e alta hospitalar mais rápida. Conclusão: Verificou-se que a terapia com células-tronco em pacientes queimados pode aumentar a eficácia do tratamento local e melhorar a restauração cirúrgica da pele. Porém, mais ensaios clínicos precisam ser estimulados a fim de justificar com maior precisão o uso desta terapêutica nestes pacientes.Research, Society and Development2022-07-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3278110.33448/rsd-v11i10.32781Research, Society and Development; Vol. 11 No. 10; e184111032781Research, Society and Development; Vol. 11 Núm. 10; e184111032781Research, Society and Development; v. 11 n. 10; e1841110327812525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/32781/27679Copyright (c) 2022 Juliana Alves de Souza; Letícia de Sousa Eduardo; Geny Vitória Albuquerque Gomes; Risoneide Bezerra da Silva; Debora Raquel do Nascimento; José William Araújo do Nascimentohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSouza, Juliana Alves de Eduardo, Letícia de SousaGomes, Geny Vitória AlbuquerqueSilva, Risoneide Bezerra da Nascimento, Debora Raquel do Nascimento, José William Araújo do 2022-08-12T22:23:03Zoai:ojs.pkp.sfu.ca:article/32781Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:48:39.341593Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Key clinical evidence of stem cell therapy in burn healing: a systematic review Evidencia clínica clave de la terapia con células madre en la curación de quemaduras: una revisión sistemática Principais evidências clínicas da terapia com células-tronco na cicatrização de queimaduras: uma revisão sistemática |
title |
Key clinical evidence of stem cell therapy in burn healing: a systematic review |
spellingShingle |
Key clinical evidence of stem cell therapy in burn healing: a systematic review Souza, Juliana Alves de Células madre mesenquimatosas Quemaduras Revisión. Células-tronco mesenquimal Queimaduras Revisão. Mesenchymal stem cells Burns Review. |
title_short |
Key clinical evidence of stem cell therapy in burn healing: a systematic review |
title_full |
Key clinical evidence of stem cell therapy in burn healing: a systematic review |
title_fullStr |
Key clinical evidence of stem cell therapy in burn healing: a systematic review |
title_full_unstemmed |
Key clinical evidence of stem cell therapy in burn healing: a systematic review |
title_sort |
Key clinical evidence of stem cell therapy in burn healing: a systematic review |
author |
Souza, Juliana Alves de |
author_facet |
Souza, Juliana Alves de Eduardo, Letícia de Sousa Gomes, Geny Vitória Albuquerque Silva, Risoneide Bezerra da Nascimento, Debora Raquel do Nascimento, José William Araújo do |
author_role |
author |
author2 |
Eduardo, Letícia de Sousa Gomes, Geny Vitória Albuquerque Silva, Risoneide Bezerra da Nascimento, Debora Raquel do Nascimento, José William Araújo do |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Souza, Juliana Alves de Eduardo, Letícia de Sousa Gomes, Geny Vitória Albuquerque Silva, Risoneide Bezerra da Nascimento, Debora Raquel do Nascimento, José William Araújo do |
dc.subject.por.fl_str_mv |
Células madre mesenquimatosas Quemaduras Revisión. Células-tronco mesenquimal Queimaduras Revisão. Mesenchymal stem cells Burns Review. |
topic |
Células madre mesenquimatosas Quemaduras Revisión. Células-tronco mesenquimal Queimaduras Revisão. Mesenchymal stem cells Burns Review. |
description |
Objective: To analyze the main clinical evidence of stem cell therapy in the healing of burns. Methodology: This is a systematic review carried out using the PRISMA method, in the electronic databases PubMed, Scopus and Web of Science, using the following descriptors: “stem cell”, “hematopoetic stem cells'”, “embryonic stem cell”, “burn”, “burned” and “burn units”. Full texts, available in Portuguese, English or Spanish, published between January 2005 and April 2022 were included; human studies (clinical studies). Results: Four articles made up the final sample of this review, with publication frequency between 2005 and 2022. In total, 328 burn patients were treated with stem cells. The therapy showed positive results in terms of faster wound healing, lower rate of infection and complications, higher survival rate and faster hospital discharge. Conclusion: It was found that stem cell therapy in burn patients can increase the effectiveness of local treatment and improve surgical skin restoration. However, more clinical trials need to be encouraged in order to more accurately justify the use of this therapy in these patients. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/32781 10.33448/rsd-v11i10.32781 |
url |
https://rsdjournal.org/index.php/rsd/article/view/32781 |
identifier_str_mv |
10.33448/rsd-v11i10.32781 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/32781/27679 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 10; e184111032781 Research, Society and Development; Vol. 11 Núm. 10; e184111032781 Research, Society and Development; v. 11 n. 10; e184111032781 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052796926689280 |