Potential of photobiomodulation therapy in the treatment of skeletal muscle atrophy

• Autor(a) principal: Gonçalves, Silma Rodrigues
• Data de Publicação: 2021
• Outros Autores: Tim, Carla Roberta, Martignago, Cintia Cristina Santi, Silva, Marcelo Cavenaghi Pereira, Anaruma, Carlos Alberto, Garcia, Lívia Assis
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/8527
• topic: Fototerapia; Láseres; Atrofia muscular; Rehabilitación.; Fototerapia; Lasers; Atrofia muscular; Reabilitação.; Phototherapy; Lasers; Muscle atrophy; Rehabilitation.

Atrophy of striated skeletal muscle tissue is a complex process caused by an imbalance between the degradation and synthesis of myofibrillar proteins, leading to a reduction in muscle strength and, consequently, influencing the emotional behavior, mental health and quality of life of individuals. Thus, the attenuation of the atrophy and stimulus for the formation of new muscle tissue is a challenge for rehabilitation. Considerable efforts have been devoted to the establishment of new treatments, however, reliable experimental and clinical data are still lacking for its clinical application. Among the therapeutic resources available, photobiomodulation therapy (PBMT, from the English photobiomodulation therapy) has great potential, as it is often used as a promising therapeutic strategy for the rehabilitation of skeletal muscle tissue. Within this context, the aim of this study is to provide, through a narrative review, an understanding of the current available evidence on the importance of PBMT in the treatment of skeletal muscle atrophy. The searches were performed in the bibliographic databases of PubMed / MEDLINE, Virtual Health Library (VHL), Web of Science and SciELO. The evidence found in this study points out that PBMT can be proposed as an effective therapeutic intervention in the treatment of muscle atrophy, due to the potential to stimulate myogenic regulatory factors that promote the activation and proliferation of satellite cells and the consequent increase in the formation of muscle fibers, as well as how to attenuate and cellular apoptosis the proteolysis pathways of muscle fiber.