Safety and efficacy of bacterial cellulose obtained from sugarcane molasses in the healing and tissue remodeling process: a narrative review

Detalhes bibliográficos
Autor(a) principal: Santos, Lara Emanuele Santana
Data de Publicação: 2021
Outros Autores: Carvalho, Rafaela de Siqueira Ferraz, Santos , Kelly Monteiro dos, Martins, René Duarte, Pinto, Flávia Cristina Morone
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/22773
Resumo: This study aimed to analyse the safety and efficacy of bacterial cellulose (CB) produced from sugarcane molasses, through studies conducted and published by the Sugarcane Biopolymers Research Group, POLISA©, Biopolymers for Health. This is a narrative review of the literature that was conducted from the collection of publications on sugarcane biopolymers, linked to POLISA©, Biopolymers for Health researchers. Twenty one studies published between the years 2002 to 2020 were selected, of which 11 studies related to pre-clinical evaluation and 10 to clinical evaluation. Studies involving toxicological and biocompatibility assessments described the safety and risks related to the use of CB, while those of clinical evaluation investigated the healing process and tissue remodelling, and estimated its effectiveness as a dressing. In conclusion, CB did not prove to be cytotoxic, genotoxic or acutely toxic, showing high biocompatibility, in addition, it proved to be effective in inducing the healing process and tissue remodeling.
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spelling Safety and efficacy of bacterial cellulose obtained from sugarcane molasses in the healing and tissue remodeling process: a narrative review Seguridad y eficacia de la celulosa bacteriana obtenida de la melaza de caña de azúcar en el proceso de cicatrización y remodelación tisular: una revisión narrativa Segurança e eficácia da celulose bacteriana obtida a partir do melaço de cana-de-açúcar no processo de cicatrização e remodelamento tecidual: uma revisão narrativaBiopolymersEquipment safetyEfficacyWound healing.BiopolimeroSeguridad de equiposEficáciaCicatrización de heridas.BiopolímerosSegurança de equipamentosEficáciaCicatrização.This study aimed to analyse the safety and efficacy of bacterial cellulose (CB) produced from sugarcane molasses, through studies conducted and published by the Sugarcane Biopolymers Research Group, POLISA©, Biopolymers for Health. This is a narrative review of the literature that was conducted from the collection of publications on sugarcane biopolymers, linked to POLISA©, Biopolymers for Health researchers. Twenty one studies published between the years 2002 to 2020 were selected, of which 11 studies related to pre-clinical evaluation and 10 to clinical evaluation. Studies involving toxicological and biocompatibility assessments described the safety and risks related to the use of CB, while those of clinical evaluation investigated the healing process and tissue remodelling, and estimated its effectiveness as a dressing. In conclusion, CB did not prove to be cytotoxic, genotoxic or acutely toxic, showing high biocompatibility, in addition, it proved to be effective in inducing the healing process and tissue remodeling.Este estudio analizó la seguridad y eficacia de la celulosa bacteriana (CB) producida a partir de la melaza de caña de azúcar, a través de estudios realizados y publicados por el Grupo de Investigación de Biopolímeros de Caña de Azúcar, vinculado a POLISA© ©, Biopolímeros para la Salud. Se trata de una revisión narrativa de la literatura que se realizó desde el colección de publicaciones sobre biopolímero de caña de azúcar, vinculado a POLISA©, Biopolímeros para la Salud. Se seleccionaron 21 estudios publicados entre los años 2002 a 2020, de los cuales 11 estudios relacionados con la evaluación preclínica y 10 con la evaluación clínica. Los estudios que involucraron evaluaciones toxicológicas y de biocompatibilidad describieron la seguridad y los riesgos que enfrenta el uso del CB, mientras que los de evaluación clínica investigaron el proceso de curación y remodelación tisular y estimaron su efectividad como apósito. En general, el CB bacteriana no resultó ser citotóxico, genotóxico o agudamente tóxico, presentando alta biocompatibilidad, además, demostró ser efectivo en inducir el proceso de cicatrización y remodelación tisular.Este estudo teve como objetivo analisar a segurança e eficácia da celulose bacteriana (CB) produzida a partir do melaço de cana-de- açúcar, através de estudos conduzidos e publicados pelo Grupo de Pesquisa sobre Biopolímeros de Cana-de-Açúcar, vinculados à POLISA©, Biopolímeros para Saúde. Trata-se de uma revisão narrativa da literatura que foi conduzida a partir do acervo de publicações sobre biopolímero de cana-de-açúcar, vinculados à POLISA©, Biopolímeros para Saúde. Foram selecionados 21 estudos publicados entre os anos de 2002 a 2020, sendo 11 estudos relacionados à avaliação pré-clínica e 10 à avaliação clínica. Os estudos envolvendo a avaliação toxicológica e de biocompatibilidade descreveram a segurança e os riscos frente ao uso da CB, enquanto que os de avaliação clínica investigaram o processo de cicatrização e remodelamento tecidual, a fim de estimar a sua eficácia como curativo. De modo geral, a CB não demonstrou ser citotóxico, genotóxico ou agudamente tóxico, apresentando alta biocompatibilidade, além disso, mostrou-se eficaz ao induzir o processo de cicatrização e remodelamento tecidual.Research, Society and Development2021-12-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2277310.33448/rsd-v10i16.22773Research, Society and Development; Vol. 10 No. 16; e50101622773Research, Society and Development; Vol. 10 Núm. 16; e50101622773Research, Society and Development; v. 10 n. 16; e501016227732525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/22773/20708Copyright (c) 2021 Lara Emanuele Santana Santos; Rafaela de Siqueira Ferraz Carvalho; Kelly Monteiro dos Santos ; René Duarte Martins; Flávia Cristina Morone Pintohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Lara Emanuele SantanaCarvalho, Rafaela de Siqueira FerrazSantos , Kelly Monteiro dosMartins, René DuartePinto, Flávia Cristina Morone2021-12-20T11:03:07Zoai:ojs.pkp.sfu.ca:article/22773Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:41:50.742447Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Safety and efficacy of bacterial cellulose obtained from sugarcane molasses in the healing and tissue remodeling process: a narrative review
Seguridad y eficacia de la celulosa bacteriana obtenida de la melaza de caña de azúcar en el proceso de cicatrización y remodelación tisular: una revisión narrativa
Segurança e eficácia da celulose bacteriana obtida a partir do melaço de cana-de-açúcar no processo de cicatrização e remodelamento tecidual: uma revisão narrativa
title Safety and efficacy of bacterial cellulose obtained from sugarcane molasses in the healing and tissue remodeling process: a narrative review
spellingShingle Safety and efficacy of bacterial cellulose obtained from sugarcane molasses in the healing and tissue remodeling process: a narrative review
Santos, Lara Emanuele Santana
Biopolymers
Equipment safety
Efficacy
Wound healing.
Biopolimero
Seguridad de equipos
Eficácia
Cicatrización de heridas.
Biopolímeros
Segurança de equipamentos
Eficácia
Cicatrização.
title_short Safety and efficacy of bacterial cellulose obtained from sugarcane molasses in the healing and tissue remodeling process: a narrative review
title_full Safety and efficacy of bacterial cellulose obtained from sugarcane molasses in the healing and tissue remodeling process: a narrative review
title_fullStr Safety and efficacy of bacterial cellulose obtained from sugarcane molasses in the healing and tissue remodeling process: a narrative review
title_full_unstemmed Safety and efficacy of bacterial cellulose obtained from sugarcane molasses in the healing and tissue remodeling process: a narrative review
title_sort Safety and efficacy of bacterial cellulose obtained from sugarcane molasses in the healing and tissue remodeling process: a narrative review
author Santos, Lara Emanuele Santana
author_facet Santos, Lara Emanuele Santana
Carvalho, Rafaela de Siqueira Ferraz
Santos , Kelly Monteiro dos
Martins, René Duarte
Pinto, Flávia Cristina Morone
author_role author
author2 Carvalho, Rafaela de Siqueira Ferraz
Santos , Kelly Monteiro dos
Martins, René Duarte
Pinto, Flávia Cristina Morone
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santos, Lara Emanuele Santana
Carvalho, Rafaela de Siqueira Ferraz
Santos , Kelly Monteiro dos
Martins, René Duarte
Pinto, Flávia Cristina Morone
dc.subject.por.fl_str_mv Biopolymers
Equipment safety
Efficacy
Wound healing.
Biopolimero
Seguridad de equipos
Eficácia
Cicatrización de heridas.
Biopolímeros
Segurança de equipamentos
Eficácia
Cicatrização.
topic Biopolymers
Equipment safety
Efficacy
Wound healing.
Biopolimero
Seguridad de equipos
Eficácia
Cicatrización de heridas.
Biopolímeros
Segurança de equipamentos
Eficácia
Cicatrização.
description This study aimed to analyse the safety and efficacy of bacterial cellulose (CB) produced from sugarcane molasses, through studies conducted and published by the Sugarcane Biopolymers Research Group, POLISA©, Biopolymers for Health. This is a narrative review of the literature that was conducted from the collection of publications on sugarcane biopolymers, linked to POLISA©, Biopolymers for Health researchers. Twenty one studies published between the years 2002 to 2020 were selected, of which 11 studies related to pre-clinical evaluation and 10 to clinical evaluation. Studies involving toxicological and biocompatibility assessments described the safety and risks related to the use of CB, while those of clinical evaluation investigated the healing process and tissue remodelling, and estimated its effectiveness as a dressing. In conclusion, CB did not prove to be cytotoxic, genotoxic or acutely toxic, showing high biocompatibility, in addition, it proved to be effective in inducing the healing process and tissue remodeling.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-06
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/22773
10.33448/rsd-v10i16.22773
url https://rsdjournal.org/index.php/rsd/article/view/22773
identifier_str_mv 10.33448/rsd-v10i16.22773
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/22773/20708
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 16; e50101622773
Research, Society and Development; Vol. 10 Núm. 16; e50101622773
Research, Society and Development; v. 10 n. 16; e50101622773
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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