Comparison of the biochemical and hematological profiles of patients with COVID-19 in their different outcomes: Hospital discharge and death
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/25772 |
Resumo: | Introduction: The virus that causes COVID-19, SARS-CoV-2, has as its main focus of involvement the respiratory tract, even today with many patients evolving to the most severe form. Therefore, it is necessary to identify early signs and symptoms of COVID-19, as well as possible risk factors and signs of poor prognosis involved in the progression of the disease. Objective: The present study aimed to evaluate biochemical, hematological and coagulation tests in patients diagnosed with COVID-19 in order to identify a prognostic pattern for the outcomes of hospital discharge and death from a descriptive data compilation from a public repository. Methodology: Data from patients seen between February 26 and June 27, 2020 at Hospital Sírio-Libanês, made available by a public repository, were divided into two categories for analyses. Demographic data (gender, age and city where the patient resides) and clinical/laboratory data (test results) were analyzed, including the outcome (discharge or death). Results: Older age and male gender were more associated with the outcome of death. D-dimer and blood glucose were higher in the death group, while GFR worsened in both groups and APTT, total bilirubin, serum creatinine, blood glucose, D-dimer and CRP increased in the outcome only of patients who died, the latter reduced in the "hospital discharge" group. Moreover, there were lower rates of hemoglobin, erythrocytes and hematocrit, platelets and lymphocytes, as well as increased leukocytes, neutrophils and basophils in the group of patients who died. Conclusion: The variations found in biochemical parameters suggest especially that hyperglycemia is associated with more severe cases, while the analysis of inflammation confirms by CRP that this condition was more exacerbated in patients who died. In coagulation analysis, increased D-dimer was associated with more severe cases, and in hematology, the results reflect a higher risk of anemia and systemic inflammatory response. |
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Comparison of the biochemical and hematological profiles of patients with COVID-19 in their different outcomes: Hospital discharge and deathComparación de perfiles bioquímicos y hematológicos de pacientes con COVID-19 en sus diferentes desenlaces: alta hospitalaria y muerteComparação dos perfis bioquímicos e hematológicos de pacientes com COVID-19 em seus diferentes desfechos: alta hospitalar e óbito SARS-CoV-2COVID-19BiomarkersPrognosis.SARS-CoV-2COVID-19BiomarcadoresPronóstico.SARS-CoV-2COVID-19BiomarcadoresPrognóstico.Introduction: The virus that causes COVID-19, SARS-CoV-2, has as its main focus of involvement the respiratory tract, even today with many patients evolving to the most severe form. Therefore, it is necessary to identify early signs and symptoms of COVID-19, as well as possible risk factors and signs of poor prognosis involved in the progression of the disease. Objective: The present study aimed to evaluate biochemical, hematological and coagulation tests in patients diagnosed with COVID-19 in order to identify a prognostic pattern for the outcomes of hospital discharge and death from a descriptive data compilation from a public repository. Methodology: Data from patients seen between February 26 and June 27, 2020 at Hospital Sírio-Libanês, made available by a public repository, were divided into two categories for analyses. Demographic data (gender, age and city where the patient resides) and clinical/laboratory data (test results) were analyzed, including the outcome (discharge or death). Results: Older age and male gender were more associated with the outcome of death. D-dimer and blood glucose were higher in the death group, while GFR worsened in both groups and APTT, total bilirubin, serum creatinine, blood glucose, D-dimer and CRP increased in the outcome only of patients who died, the latter reduced in the "hospital discharge" group. Moreover, there were lower rates of hemoglobin, erythrocytes and hematocrit, platelets and lymphocytes, as well as increased leukocytes, neutrophils and basophils in the group of patients who died. Conclusion: The variations found in biochemical parameters suggest especially that hyperglycemia is associated with more severe cases, while the analysis of inflammation confirms by CRP that this condition was more exacerbated in patients who died. In coagulation analysis, increased D-dimer was associated with more severe cases, and in hematology, the results reflect a higher risk of anemia and systemic inflammatory response.Introducción: El virus causante del COVID-19, el SARS-CoV-2, presenta como principal foco de compromiso el tratamiento respiratorio, aún hoy con muchos pacientes evolucionando hacia la forma más grave. Por lo tanto, los signos y síntomas de la COVID-19 deben identificarse de forma temprana, además de los posibles factores de riesgo y signos de mal pronóstico implicados en la progresión de la enfermedad. Objetivo: Por lo tanto, el presente estudio tuvo como objetivo evaluar las pruebas bioquímicas, hematológicas y de coagulación en pacientes diagnosticados de COVID-19 con el fin de identificar un patrón pronóstico para los resultados de alta hospitalaria y muerte a partir de una recopilación de datos descriptivos de un repositorio público. Metodología: los datos de los pacientes atendidos entre el 26 de febrero y el 27 de junio de 2020 en el Hospital Sirio-Libanés, puestos a disposición por un repositorio público, fueron divididos en dos categorías para su análisis. Se analizaron los datos demográficos (sexo, edad y ciudad de residencia del paciente) y los datos clínicos/laboratorios (resultados de las pruebas), incluido el resultado (alta o muerte). Resultados: La edad avanzada y el sexo masculino se asociaron más con el resultado de muerte. El dímero D y la glucemia fueron más elevados en el grupo de muerte, mientras que la TFG empeoró en ambos grupos y el TTPA, la bilirrubina total, la creatinina sérica, la glucemia, el dímero D y la PCR aumentaron en el desenlace sólo en los pacientes que murieron, reduciéndose esta última en el grupo de "alta hospitalaria". Además, había tasas más bajas de hemoglobina, eritrocitos y hematocrito, plaquetas y linfocitos, así como un aumento de leucocitos, neutrófilos y basófilos en el grupo de pacientes que murieron. Conclusión: Las variaciones encontradas en los parámetros bioquímicos sugieren especialmente que la hiperglucemia está asociada a los casos más graves, mientras que el análisis de la inflamación confirma por PCR que esta condición estaba más exacerbada en los pacientes que murieron. En los análisis de coagulación, el aumento del dímero D se asoció a cuadros más graves y, en los hematológicos, los resultados reflejan un mayor riesgo de anemia y de respuesta inflamatoria sistémica.Introdução: O vírus causador da COVID-19, SARS-CoV-2, apresenta como principal foco de comprometimento o trato respiratório, ainda hoje com muitos pacientes evoluindo para a forma mais grave. Por isso, deve-se identificar precocemente sinais e sintomas da COVID-19, além de possíveis fatores de risco e sinais de mau prognóstico envolvidos na progressão da doença. Objetivo: Desta forma, o presente trabalho teve por objetivo avaliar exames bioquímicos, hematológicos e de coagulação em pacientes diagnosticados com a COVID-19, a fim de identificar um padrão de prognóstico para os desfechos de alta hospitalar e óbito a partir de um compilado de dados descritivos de um repositório público. Metodologia: dados de pacientes atendidos entre 26 de fevereiro e 27 de junho de 2020 no Hospital Sírio-Libanês, disponibilizado por um repositório público, foram divididos em duas categorias para análises. Foram analisados os dados demográficos (gênero, idade e cidade onde o paciente reside) e dados clínicos/laboratoriais (resultados de exames), incluindo o desfecho (alta ou óbito). Resultados: Idade mais avançada e gênero masculino foram mais associados com o desfecho de óbito. Dímero-D e glicemia foram mais altas no grupo óbito, enquanto a TFG apresentou piora em ambos os grupos e TTPA, bilirrubina total, creatinina sérica, glicemia, dímero-D e PCR aumentaram no desfecho apenas dos pacientes que vieram à óbito, tendo esse último reduzido no grupo “alta hospitalar”. Além disso, houve menores índices de hemoglobina, eritrócitos e hematócrito, plaquetas e linfócitos, assim como aumento de leucócitos, neutrófilos e basófilos no grupo de pacientes que evoluiu para óbito. Conclusão: As variações encontradas nos parâmetros bioquímicos sugerem especialmente que a hiperglicemia está associada a casos mais graves, enquanto a análise de inflamação confirma pela PCR que esta condição foi mais exacerbada nos pacientes que morreram. Na análise de coagulação, o aumento do dímero-D foi associado a quadros mais graves e, nos hematológicos, os resultados refletem maior risco de anemia e resposta inflamatória sistêmica.Research, Society and Development2022-01-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2577210.33448/rsd-v11i2.25772Research, Society and Development; Vol. 11 No. 2; e25611225772Research, Society and Development; Vol. 11 Núm. 2; e25611225772Research, Society and Development; v. 11 n. 2; e256112257722525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/25772/22522Copyright (c) 2022 Gabriel Frateschi Rebello da Silva; Alexandra Alejo Callante; Débora Pereira do Nascimento; Iago Portolani de Araújo; Carolina Heitmann Mares Azevedo Ribeiro; Ana Cristina Lo Pretehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Gabriel Frateschi Rebello daCallante, Alexandra Alejo Nascimento, Débora Pereira doAraújo, Iago Portolani deRibeiro, Carolina Heitmann Mares Azevedo Lo Prete, Ana Cristina2022-02-07T01:42:50Zoai:ojs.pkp.sfu.ca:article/25772Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:43:58.566364Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Comparison of the biochemical and hematological profiles of patients with COVID-19 in their different outcomes: Hospital discharge and death Comparación de perfiles bioquímicos y hematológicos de pacientes con COVID-19 en sus diferentes desenlaces: alta hospitalaria y muerte Comparação dos perfis bioquímicos e hematológicos de pacientes com COVID-19 em seus diferentes desfechos: alta hospitalar e óbito |
title |
Comparison of the biochemical and hematological profiles of patients with COVID-19 in their different outcomes: Hospital discharge and death |
spellingShingle |
Comparison of the biochemical and hematological profiles of patients with COVID-19 in their different outcomes: Hospital discharge and death Silva, Gabriel Frateschi Rebello da SARS-CoV-2 COVID-19 Biomarkers Prognosis. SARS-CoV-2 COVID-19 Biomarcadores Pronóstico. SARS-CoV-2 COVID-19 Biomarcadores Prognóstico. |
title_short |
Comparison of the biochemical and hematological profiles of patients with COVID-19 in their different outcomes: Hospital discharge and death |
title_full |
Comparison of the biochemical and hematological profiles of patients with COVID-19 in their different outcomes: Hospital discharge and death |
title_fullStr |
Comparison of the biochemical and hematological profiles of patients with COVID-19 in their different outcomes: Hospital discharge and death |
title_full_unstemmed |
Comparison of the biochemical and hematological profiles of patients with COVID-19 in their different outcomes: Hospital discharge and death |
title_sort |
Comparison of the biochemical and hematological profiles of patients with COVID-19 in their different outcomes: Hospital discharge and death |
author |
Silva, Gabriel Frateschi Rebello da |
author_facet |
Silva, Gabriel Frateschi Rebello da Callante, Alexandra Alejo Nascimento, Débora Pereira do Araújo, Iago Portolani de Ribeiro, Carolina Heitmann Mares Azevedo Lo Prete, Ana Cristina |
author_role |
author |
author2 |
Callante, Alexandra Alejo Nascimento, Débora Pereira do Araújo, Iago Portolani de Ribeiro, Carolina Heitmann Mares Azevedo Lo Prete, Ana Cristina |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Gabriel Frateschi Rebello da Callante, Alexandra Alejo Nascimento, Débora Pereira do Araújo, Iago Portolani de Ribeiro, Carolina Heitmann Mares Azevedo Lo Prete, Ana Cristina |
dc.subject.por.fl_str_mv |
SARS-CoV-2 COVID-19 Biomarkers Prognosis. SARS-CoV-2 COVID-19 Biomarcadores Pronóstico. SARS-CoV-2 COVID-19 Biomarcadores Prognóstico. |
topic |
SARS-CoV-2 COVID-19 Biomarkers Prognosis. SARS-CoV-2 COVID-19 Biomarcadores Pronóstico. SARS-CoV-2 COVID-19 Biomarcadores Prognóstico. |
description |
Introduction: The virus that causes COVID-19, SARS-CoV-2, has as its main focus of involvement the respiratory tract, even today with many patients evolving to the most severe form. Therefore, it is necessary to identify early signs and symptoms of COVID-19, as well as possible risk factors and signs of poor prognosis involved in the progression of the disease. Objective: The present study aimed to evaluate biochemical, hematological and coagulation tests in patients diagnosed with COVID-19 in order to identify a prognostic pattern for the outcomes of hospital discharge and death from a descriptive data compilation from a public repository. Methodology: Data from patients seen between February 26 and June 27, 2020 at Hospital Sírio-Libanês, made available by a public repository, were divided into two categories for analyses. Demographic data (gender, age and city where the patient resides) and clinical/laboratory data (test results) were analyzed, including the outcome (discharge or death). Results: Older age and male gender were more associated with the outcome of death. D-dimer and blood glucose were higher in the death group, while GFR worsened in both groups and APTT, total bilirubin, serum creatinine, blood glucose, D-dimer and CRP increased in the outcome only of patients who died, the latter reduced in the "hospital discharge" group. Moreover, there were lower rates of hemoglobin, erythrocytes and hematocrit, platelets and lymphocytes, as well as increased leukocytes, neutrophils and basophils in the group of patients who died. Conclusion: The variations found in biochemical parameters suggest especially that hyperglycemia is associated with more severe cases, while the analysis of inflammation confirms by CRP that this condition was more exacerbated in patients who died. In coagulation analysis, increased D-dimer was associated with more severe cases, and in hematology, the results reflect a higher risk of anemia and systemic inflammatory response. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/25772 10.33448/rsd-v11i2.25772 |
url |
https://rsdjournal.org/index.php/rsd/article/view/25772 |
identifier_str_mv |
10.33448/rsd-v11i2.25772 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/25772/22522 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 2; e25611225772 Research, Society and Development; Vol. 11 Núm. 2; e25611225772 Research, Society and Development; v. 11 n. 2; e25611225772 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052826487095296 |