Effect of mulberry leaf extract (Morus nigra L.) on cardiovascular inflammatory process and insulin resistance of dyslipidemic mice
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/25473 |
Resumo: | Objective: To evaluate the effect of mulberry leaf extract on cardiovascular inflammation, insulin resistance and left ventricular hypertrophy in dyslipidemic mice. Methodology: Knockout mice for the LDL receptor gene were divided into four experimental groups (n=20): group S (Standard), fed a standard diet; group SA (Standard / Mulberry), fed a standard diet and mulberry leaves extract; group HL (Hyperlipidic), fed a hyperlipidic diet and group HLA (Hyperlipidic / Mulberry), fed a hyperlipidic diet and mulberry leaves extract. After 15 days of experiment, plasma was collected and the plasma levels of total cholesterol and its fractions, triglycerides, C-reactive protein, insulin, glucose were quantified and the Homa index calculated. Heart and aortic wall tissues were collected to quantify the expression of CD40L by the western blotting method. Histological slides with heart tissue were prepared and stained with hematoxylin and eosin for general histological evaluation and stained with picrosírius red to evaluate the collagen deposit area. Results: Mulberry leaf extract elevated plasma HDL, moderately prevented hypercholesterolemia and did not reduce hypertriglyceridemia in HLA group mice, prevented insulin resistance and consequently hyperinsulinemia, reduced plasma CRP level and prevented increased CD40L expression. Conclusion: Treatment with mulberry leaves extract prevented cardiovascular inflammation and insulin resistance, thus reducing the development of left ventricular hypertrophy. |
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Effect of mulberry leaf extract (Morus nigra L.) on cardiovascular inflammatory process and insulin resistance of dyslipidemic miceEfecto del extracto de hoja de morera (Morus nigra L.) sobre la inflamación cardiovascular y la resistencia a la insulina en ratones dislipidémicosEfeito do extrato das folhas de amoreira (Morus nigra L.) no processo inflamatório cardiovascular e na resistência insulínica de camundongos dislipidêmicosDyslipidemiaCardiac inflammationAortaInsulinMulberry.DislipidemiaInflamação cardíacaAortaInsulinaAmora.DislipidemiaInflamación cardíacaAortaInsulinaMorera.Objective: To evaluate the effect of mulberry leaf extract on cardiovascular inflammation, insulin resistance and left ventricular hypertrophy in dyslipidemic mice. Methodology: Knockout mice for the LDL receptor gene were divided into four experimental groups (n=20): group S (Standard), fed a standard diet; group SA (Standard / Mulberry), fed a standard diet and mulberry leaves extract; group HL (Hyperlipidic), fed a hyperlipidic diet and group HLA (Hyperlipidic / Mulberry), fed a hyperlipidic diet and mulberry leaves extract. After 15 days of experiment, plasma was collected and the plasma levels of total cholesterol and its fractions, triglycerides, C-reactive protein, insulin, glucose were quantified and the Homa index calculated. Heart and aortic wall tissues were collected to quantify the expression of CD40L by the western blotting method. Histological slides with heart tissue were prepared and stained with hematoxylin and eosin for general histological evaluation and stained with picrosírius red to evaluate the collagen deposit area. Results: Mulberry leaf extract elevated plasma HDL, moderately prevented hypercholesterolemia and did not reduce hypertriglyceridemia in HLA group mice, prevented insulin resistance and consequently hyperinsulinemia, reduced plasma CRP level and prevented increased CD40L expression. Conclusion: Treatment with mulberry leaves extract prevented cardiovascular inflammation and insulin resistance, thus reducing the development of left ventricular hypertrophy.Objetivo: Evaluar el efecto del extracto de hoja de morera sobre la inflamación cardiovascular, la resistencia a la insulina y la hipertrofia ventricular izquierda en ratones dislipidémicos. Metodología: Los ratones con el gen del receptor de LDL eliminado se dividieron en cuatro grupos experimentales (n=20): grupo S (Estándar), alimentado con una dieta estándar; grupo SA (Estándar / Morera), alimentado con una dieta estándar y extracto de hoja de morera; grupo HL (Hiperlipídico), alimentado con una dieta hiperlipídica y grupo HLA (Hiperlipídico / Morera), alimentado con una dieta hiperlipídica y extracto de hoja de morera. Tras 15 días de experimento, se recogió el plasma y se cuantificaron los niveles plasmáticos de colesterol total y sus fracciones, triglicéridos, proteína C reactiva, insulina, glucosa y se calculó el índice Homa. Se recogieron tejidos de la pared cardíaca y aórtica para cuantificar la expresión de CD40L mediante western blotting. Se prepararon preparaciones histológicas con tejido cardíaco y se tiñeron con hematoxilina y eosina para la evaluación histológica general y se tiñeron con rojo picrosirio para evaluar el área de deposición de colágeno. Resultados: El extracto de hoja de morera elevó el HDL plasmático, previno moderadamente la hipercolesterolemia y no redujo la hipertrigliceridemia en los ratones del grupo HLA, previno la resistencia a la insulina y, en consecuencia, la hiperinsulinemia, redujo el nivel de CRP plasmático y evitó el aumento de la expresión de CD40L. Conclusión: El tratamiento con extracto de hoja de morera previno la inflamación cardiovascular y la resistencia a la insulina, reduciendo así el desarrollo de hipertrofia ventricular izquierda.Objetivo: Avaliar o efeito do extrato das folhas da amoreira na inflamação cardiovascular, na resistência insulínica e na hipertrofia ventricular esquerda de camundongos dislipidêmicos. Metodologia: Camundongos knockout para o gene do receptor LDL foram divididos em quatro grupos experimentais (n=20): grupo S (Standard), alimentados com dieta padrão; grupo SA (Standard /Amoreira), alimentados com dieta padrão e extrato das folhas da amoreira; grupo HL (Hyperlipidic), alimentados com dieta hiperlipídica e grupo HLA (Hyperlipidic/Amoreira), alimentados com dieta hiperlipídica e extrato das folhas da amoreira. Após 15 dias de experimento, foi coletado plasma e quantificado os níveis plasmáticos de colesterol total e suas frações, triglicerídeos, proteína C reativa, insulina, glicose e calculado o índice de Homa. Foram coletados tecidos cardíacos e da parede da aorta para quantificar a expressão do CD40L pelo método de western blotting. Lâminas histológicas com tecido cardíaco foram preparadas e coradas com hematoxilina e eosina, para avaliação histológica geral, e coradas com picrosírius red para avaliar a área de depósito de colágeno. Resultados: O extrato das folhas de amoreira elevou o HDL plasmático, preveniu moderadamente a hipercolesterolemia e não reduziu a hipertrigliceridemia nos camundongos do grupo HLA, preveniu a resistência à insulina e, consequentemente a hiperinsulinemia, reduziu o nível plasmático de PCR e preveniu o aumento da expressão do CD40L. Conclusão: O tratamento com o extrato das folhas de amoreira preveniu a inflamação cardiovascular e a resistência insulínica, reduzindo desta forma, o desenvolvimento da hipertrofia ventricular esquerda.Research, Society and Development2022-01-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2547310.33448/rsd-v11i2.25473Research, Society and Development; Vol. 11 No. 2; e4611225473Research, Society and Development; Vol. 11 Núm. 2; e4611225473Research, Society and Development; v. 11 n. 2; e46112254732525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/25473/22284Copyright (c) 2022 Carlos Roberto Pereira; Ana Luísa Cabral de Faria; Maria das Graças de Souza Carvalho; Brígida Monteiro Vilas Boas ; Erika Kristina Incerpi Garcia; Fabiana Lucio de Oliveira; Leandro dos Santos; Lais Roncato de Carvalho Alves; Aline Manke Nachtigall; Flávia Helena Pereira; José Antônio Dias Garciahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPereira, Carlos RobertoFaria, Ana Luísa Cabral de Carvalho, Maria das Graças de Souza Vilas Boas , Brígida Monteiro Garcia, Erika Kristina Incerpi Oliveira, Fabiana Lucio de Santos, Leandro dos Alves, Lais Roncato de CarvalhoNachtigall, Aline Manke Pereira, Flávia Helena Garcia, José Antônio Dias 2022-02-07T01:42:50Zoai:ojs.pkp.sfu.ca:article/25473Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:43:44.741926Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Effect of mulberry leaf extract (Morus nigra L.) on cardiovascular inflammatory process and insulin resistance of dyslipidemic mice Efecto del extracto de hoja de morera (Morus nigra L.) sobre la inflamación cardiovascular y la resistencia a la insulina en ratones dislipidémicos Efeito do extrato das folhas de amoreira (Morus nigra L.) no processo inflamatório cardiovascular e na resistência insulínica de camundongos dislipidêmicos |
title |
Effect of mulberry leaf extract (Morus nigra L.) on cardiovascular inflammatory process and insulin resistance of dyslipidemic mice |
spellingShingle |
Effect of mulberry leaf extract (Morus nigra L.) on cardiovascular inflammatory process and insulin resistance of dyslipidemic mice Pereira, Carlos Roberto Dyslipidemia Cardiac inflammation Aorta Insulin Mulberry. Dislipidemia Inflamação cardíaca Aorta Insulina Amora. Dislipidemia Inflamación cardíaca Aorta Insulina Morera. |
title_short |
Effect of mulberry leaf extract (Morus nigra L.) on cardiovascular inflammatory process and insulin resistance of dyslipidemic mice |
title_full |
Effect of mulberry leaf extract (Morus nigra L.) on cardiovascular inflammatory process and insulin resistance of dyslipidemic mice |
title_fullStr |
Effect of mulberry leaf extract (Morus nigra L.) on cardiovascular inflammatory process and insulin resistance of dyslipidemic mice |
title_full_unstemmed |
Effect of mulberry leaf extract (Morus nigra L.) on cardiovascular inflammatory process and insulin resistance of dyslipidemic mice |
title_sort |
Effect of mulberry leaf extract (Morus nigra L.) on cardiovascular inflammatory process and insulin resistance of dyslipidemic mice |
author |
Pereira, Carlos Roberto |
author_facet |
Pereira, Carlos Roberto Faria, Ana Luísa Cabral de Carvalho, Maria das Graças de Souza Vilas Boas , Brígida Monteiro Garcia, Erika Kristina Incerpi Oliveira, Fabiana Lucio de Santos, Leandro dos Alves, Lais Roncato de Carvalho Nachtigall, Aline Manke Pereira, Flávia Helena Garcia, José Antônio Dias |
author_role |
author |
author2 |
Faria, Ana Luísa Cabral de Carvalho, Maria das Graças de Souza Vilas Boas , Brígida Monteiro Garcia, Erika Kristina Incerpi Oliveira, Fabiana Lucio de Santos, Leandro dos Alves, Lais Roncato de Carvalho Nachtigall, Aline Manke Pereira, Flávia Helena Garcia, José Antônio Dias |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira, Carlos Roberto Faria, Ana Luísa Cabral de Carvalho, Maria das Graças de Souza Vilas Boas , Brígida Monteiro Garcia, Erika Kristina Incerpi Oliveira, Fabiana Lucio de Santos, Leandro dos Alves, Lais Roncato de Carvalho Nachtigall, Aline Manke Pereira, Flávia Helena Garcia, José Antônio Dias |
dc.subject.por.fl_str_mv |
Dyslipidemia Cardiac inflammation Aorta Insulin Mulberry. Dislipidemia Inflamação cardíaca Aorta Insulina Amora. Dislipidemia Inflamación cardíaca Aorta Insulina Morera. |
topic |
Dyslipidemia Cardiac inflammation Aorta Insulin Mulberry. Dislipidemia Inflamação cardíaca Aorta Insulina Amora. Dislipidemia Inflamación cardíaca Aorta Insulina Morera. |
description |
Objective: To evaluate the effect of mulberry leaf extract on cardiovascular inflammation, insulin resistance and left ventricular hypertrophy in dyslipidemic mice. Methodology: Knockout mice for the LDL receptor gene were divided into four experimental groups (n=20): group S (Standard), fed a standard diet; group SA (Standard / Mulberry), fed a standard diet and mulberry leaves extract; group HL (Hyperlipidic), fed a hyperlipidic diet and group HLA (Hyperlipidic / Mulberry), fed a hyperlipidic diet and mulberry leaves extract. After 15 days of experiment, plasma was collected and the plasma levels of total cholesterol and its fractions, triglycerides, C-reactive protein, insulin, glucose were quantified and the Homa index calculated. Heart and aortic wall tissues were collected to quantify the expression of CD40L by the western blotting method. Histological slides with heart tissue were prepared and stained with hematoxylin and eosin for general histological evaluation and stained with picrosírius red to evaluate the collagen deposit area. Results: Mulberry leaf extract elevated plasma HDL, moderately prevented hypercholesterolemia and did not reduce hypertriglyceridemia in HLA group mice, prevented insulin resistance and consequently hyperinsulinemia, reduced plasma CRP level and prevented increased CD40L expression. Conclusion: Treatment with mulberry leaves extract prevented cardiovascular inflammation and insulin resistance, thus reducing the development of left ventricular hypertrophy. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-18 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/25473 10.33448/rsd-v11i2.25473 |
url |
https://rsdjournal.org/index.php/rsd/article/view/25473 |
identifier_str_mv |
10.33448/rsd-v11i2.25473 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/25473/22284 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 2; e4611225473 Research, Society and Development; Vol. 11 Núm. 2; e4611225473 Research, Society and Development; v. 11 n. 2; e4611225473 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052810494214144 |