Persistent musculoskeletal presentations post-chikungunya fever: a case series in a state in northeast Brazil

Detalhes bibliográficos
Autor(a) principal: Debbo, Alejandra
Data de Publicação: 2022
Outros Autores: Carvalho, Vinícius Fernando Alves, Silva, Ângela Maria da, Pacheco, Roque de Almeida, Silva, José Rodrigo Santos, Teles, Weber de Santana, Torres, Ruth Cristini, Barros, Ângela Maria Melo Sá, Silva, Max Cruz da, Silva, Maria Hozana Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/26915
Resumo: Chikungunya fever (CF) is an arbovirosis caused by the Chikungunya virus (CHIKV). The main characteristic of CF is joint pain and more than half of infected patients experience chronic conditions. This case series study evaluated the persistent musculoskeletal presentations of CF in a sample of 72 patients with persistent symptoms (≥1 month) after CF confirmed by laboratory tests (detection of CHIKV by polymerase chain reaction [PCR] and/or immunoglobulin [Ig]M and/or IgG). The patients were followed up for 12 months after treatment at the outpatient clinic of the University Hospital of the Federal University of Sergipe (Hospital Universitário da Universidade Federal de Sergipe - HU/UFS). They were evaluated at admission and after 1 month, 2 months, and then every 3 months for up to 12 months. Painful and/or swollen joints, periarticular symptoms, other important findings on physical examination, and visual analogue pain scale (VAS) were evaluated during all consultations. Main results: Among the patients evaluated, 84.7% were female, the mean age was 53.8 years, and the mean duration of musculoskeletal complaints was 6 months. Comorbidities were present in 61.1% of patients and previous musculoskeletal disease was present in 69.4%. The most frequent presentation on admission was polyarticular, which occurred in 76.4% of cases. The most affected joints were the hands, knees, ankles, and feet. VAS on admission was intense in 66.7% of patients. Tenosynovitis was present in 44.5% of patients and was more frequently reported in the ankles. Corticosteroids and chloroquine were administered to 65.3% and 31.98% of patients, respectively. The findings indicated that persistent musculoskeletal presentations occur frequently after CF. These results provide a better understanding of patient profiles, musculoskeletal involvement, and CF progression, and may guide effective strategies for therapeutic management.
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spelling Persistent musculoskeletal presentations post-chikungunya fever: a case series in a state in northeast BrazilPresentaciones musculoesqueléticas persistentes posfiebre chikungunya: una serie de casos en un estado del noreste de BrasilApresentações musculoesqueléticas persistentes pós-febre chikungunya: uma série de casos em um estado do nordeste brasileiroArboviroseArtralgiaFebre Chikungunya.ArbovirusArtralgiaFiebre Chikungunya.ArbovirosisArthralgiaChikungunya fever.Chikungunya fever (CF) is an arbovirosis caused by the Chikungunya virus (CHIKV). The main characteristic of CF is joint pain and more than half of infected patients experience chronic conditions. This case series study evaluated the persistent musculoskeletal presentations of CF in a sample of 72 patients with persistent symptoms (≥1 month) after CF confirmed by laboratory tests (detection of CHIKV by polymerase chain reaction [PCR] and/or immunoglobulin [Ig]M and/or IgG). The patients were followed up for 12 months after treatment at the outpatient clinic of the University Hospital of the Federal University of Sergipe (Hospital Universitário da Universidade Federal de Sergipe - HU/UFS). They were evaluated at admission and after 1 month, 2 months, and then every 3 months for up to 12 months. Painful and/or swollen joints, periarticular symptoms, other important findings on physical examination, and visual analogue pain scale (VAS) were evaluated during all consultations. Main results: Among the patients evaluated, 84.7% were female, the mean age was 53.8 years, and the mean duration of musculoskeletal complaints was 6 months. Comorbidities were present in 61.1% of patients and previous musculoskeletal disease was present in 69.4%. The most frequent presentation on admission was polyarticular, which occurred in 76.4% of cases. The most affected joints were the hands, knees, ankles, and feet. VAS on admission was intense in 66.7% of patients. Tenosynovitis was present in 44.5% of patients and was more frequently reported in the ankles. Corticosteroids and chloroquine were administered to 65.3% and 31.98% of patients, respectively. The findings indicated that persistent musculoskeletal presentations occur frequently after CF. These results provide a better understanding of patient profiles, musculoskeletal involvement, and CF progression, and may guide effective strategies for therapeutic management.La fiebre chikungunya (FQ) es un arbovirus causado por el virus Chikungunya (CHIKV). La característica principal de la FQ es el dolor en las articulaciones y más de la mitad de los pacientes infectados tienen condiciones crónicas. Este estudio de serie de casos evaluó las presentaciones musculoesqueléticas persistentes de la FQ en una muestra de 72 pacientes con síntomas persistentes (rsimes) después de la FQ confirmada por laboratorio (reacción en cadena de la polimerasa [PCR] detección de CHIKV y/o inmunoglobulina [Ig]M y/ o IgG). Los pacientes fueron seguidos durante 12 meses después del tratamiento en la consulta externa del Hospital Universitario de la Universidad Federal de Sergipe (Hospital Universitario de la Universidad Federal de Sergipe - HU/UFS). Se evaluaron al ingreso y después de 1 mes, 2 meses y luego cada 3 meses hasta 12 meses. Articulaciones dolorosas y/o inflamadas, síntomas periarticulares, otros hallazgos importantes en el examen físico y la escala análoga visual del dolor (EVA) fueron evaluados durante todas las visitas. Principales resultados: Entre los pacientes evaluados, el 84,7% eran del sexo femenino, la edad media fue de 53,8 años y la duración media de las molestias musculoesqueléticas fue de 6 meses. Las comorbilidades estaban presentes en el 61,1% de los pacientes y la enfermedad musculoesquelética previa en el 69,4%. La presentación más frecuente al ingreso fue la poliarticular, que se presentó en el 76,4% de los casos. Las articulaciones más afectadas fueron las manos, rodillas, tobillos y pies. La EVA al ingreso fue intensa en el 66,7% de los pacientes. La tenosinovitis estuvo presente en el 44,5% de los pacientes y se notificó con mayor frecuencia en los tobillos. Se administraron corticoides y cloroquina al 65,3% y al 31,98% de los pacientes, respectivamente. Los hallazgos indicaron que las presentaciones musculoesqueléticas persistentes ocurren con frecuencia después de la FQ. Estos resultados proporcionan una mejor comprensión del perfil de los pacientes, la afectación musculoesquelética y la progresión de la FQ, y pueden orientar estrategias eficaces para el manejo terapéutico.A febre Chikungunya (FC) é uma arbovirose causada pelo vírus Chikungunya (CHIKV). A principal característica da FC é a dor nas articulações e mais da metade dos pacientes infectados apresentam condições crônicas. Este estudo de série de casos avaliou as apresentações musculoesqueléticas persistentes de FC em uma amostra de 72 pacientes com sintomas persistentes (rsimês) após FC confirmada por exames laboratoriais (detecção de CHIKV por reação em cadeia da polimerase [PCR] e/ou imunoglobulina [Ig]M e/ou IgG). Os pacientes foram acompanhados por 12 meses após o tratamento no ambulatório do Hospital Universitário da Universidade Federal de Sergipe (Hospital Universitário da Universidade Federal de Sergipe - HU/UFS). Eles foram avaliados na admissão e após 1 mês, 2 meses e depois a cada 3 meses por até 12 meses. Articulações dolorosas e/ou edemaciadas, sintomas periarticulares, outros achados importantes no exame físico e escala visual analógica de dor (EVA) foram avaliados durante todas as consultas. Principais resultados: Entre os pacientes avaliados, 84,7% eram do sexo feminino, a média de idade foi de 53,8 anos e a duração média das queixas musculoesqueléticas foi de 6 meses. Comorbidades estavam presentes em 61,1% dos pacientes e doença musculoesquelética prévia em 69,4%. A apresentação mais frequente na admissão foi a poliarticular, que ocorreu em 76,4% dos casos. As articulações mais acometidas foram as mãos, joelhos, tornozelos e pés. A EVA na admissão foi intensa em 66,7% dos pacientes. A tenossinovite esteve presente em 44,5% dos pacientes e foi mais frequentemente relatada nos tornozelos. Corticosteróides e cloroquina foram administrados a 65,3% e 31,98% dos pacientes, respectivamente. Os achados indicaram que as apresentações musculoesqueléticas persistentes ocorrem frequentemente após a FC. Esses resultados fornecem uma melhor compreensão do perfil dos pacientes, do envolvimento musculoesquelético e da progressão da FC, e podem orientar estratégias eficazes para o manejo terapêutico.Research, Society and Development2022-03-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2691510.33448/rsd-v11i3.26915Research, Society and Development; Vol. 11 No. 3; e56011326915Research, Society and Development; Vol. 11 Núm. 3; e56011326915Research, Society and Development; v. 11 n. 3; e560113269152525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/26915/23747Copyright (c) 2022 Alejandra Debbo; Vinícius Fernando Alves Carvalho; Ângela Maria da Silva; Roque de Almeida Pacheco; José Rodrigo Santos Silva; Weber de Santana Teles; Ruth Cristini Torres; Ângela Maria Melo Sá Barros; Max Cruz da Silva; Maria Hozana Santos Silvahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessDebbo, AlejandraCarvalho, Vinícius Fernando Alves Silva, Ângela Maria da Pacheco, Roque de Almeida Silva, José Rodrigo Santos Teles, Weber de Santana Torres, Ruth Cristini Barros, Ângela Maria Melo Sá Silva, Max Cruz da Silva, Maria Hozana Santos 2022-03-09T13:44:38Zoai:ojs.pkp.sfu.ca:article/26915Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:44:49.414119Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Persistent musculoskeletal presentations post-chikungunya fever: a case series in a state in northeast Brazil
Presentaciones musculoesqueléticas persistentes posfiebre chikungunya: una serie de casos en un estado del noreste de Brasil
Apresentações musculoesqueléticas persistentes pós-febre chikungunya: uma série de casos em um estado do nordeste brasileiro
title Persistent musculoskeletal presentations post-chikungunya fever: a case series in a state in northeast Brazil
spellingShingle Persistent musculoskeletal presentations post-chikungunya fever: a case series in a state in northeast Brazil
Debbo, Alejandra
Arbovirose
Artralgia
Febre Chikungunya.
Arbovirus
Artralgia
Fiebre Chikungunya.
Arbovirosis
Arthralgia
Chikungunya fever.
title_short Persistent musculoskeletal presentations post-chikungunya fever: a case series in a state in northeast Brazil
title_full Persistent musculoskeletal presentations post-chikungunya fever: a case series in a state in northeast Brazil
title_fullStr Persistent musculoskeletal presentations post-chikungunya fever: a case series in a state in northeast Brazil
title_full_unstemmed Persistent musculoskeletal presentations post-chikungunya fever: a case series in a state in northeast Brazil
title_sort Persistent musculoskeletal presentations post-chikungunya fever: a case series in a state in northeast Brazil
author Debbo, Alejandra
author_facet Debbo, Alejandra
Carvalho, Vinícius Fernando Alves
Silva, Ângela Maria da
Pacheco, Roque de Almeida
Silva, José Rodrigo Santos
Teles, Weber de Santana
Torres, Ruth Cristini
Barros, Ângela Maria Melo Sá
Silva, Max Cruz da
Silva, Maria Hozana Santos
author_role author
author2 Carvalho, Vinícius Fernando Alves
Silva, Ângela Maria da
Pacheco, Roque de Almeida
Silva, José Rodrigo Santos
Teles, Weber de Santana
Torres, Ruth Cristini
Barros, Ângela Maria Melo Sá
Silva, Max Cruz da
Silva, Maria Hozana Santos
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Debbo, Alejandra
Carvalho, Vinícius Fernando Alves
Silva, Ângela Maria da
Pacheco, Roque de Almeida
Silva, José Rodrigo Santos
Teles, Weber de Santana
Torres, Ruth Cristini
Barros, Ângela Maria Melo Sá
Silva, Max Cruz da
Silva, Maria Hozana Santos
dc.subject.por.fl_str_mv Arbovirose
Artralgia
Febre Chikungunya.
Arbovirus
Artralgia
Fiebre Chikungunya.
Arbovirosis
Arthralgia
Chikungunya fever.
topic Arbovirose
Artralgia
Febre Chikungunya.
Arbovirus
Artralgia
Fiebre Chikungunya.
Arbovirosis
Arthralgia
Chikungunya fever.
description Chikungunya fever (CF) is an arbovirosis caused by the Chikungunya virus (CHIKV). The main characteristic of CF is joint pain and more than half of infected patients experience chronic conditions. This case series study evaluated the persistent musculoskeletal presentations of CF in a sample of 72 patients with persistent symptoms (≥1 month) after CF confirmed by laboratory tests (detection of CHIKV by polymerase chain reaction [PCR] and/or immunoglobulin [Ig]M and/or IgG). The patients were followed up for 12 months after treatment at the outpatient clinic of the University Hospital of the Federal University of Sergipe (Hospital Universitário da Universidade Federal de Sergipe - HU/UFS). They were evaluated at admission and after 1 month, 2 months, and then every 3 months for up to 12 months. Painful and/or swollen joints, periarticular symptoms, other important findings on physical examination, and visual analogue pain scale (VAS) were evaluated during all consultations. Main results: Among the patients evaluated, 84.7% were female, the mean age was 53.8 years, and the mean duration of musculoskeletal complaints was 6 months. Comorbidities were present in 61.1% of patients and previous musculoskeletal disease was present in 69.4%. The most frequent presentation on admission was polyarticular, which occurred in 76.4% of cases. The most affected joints were the hands, knees, ankles, and feet. VAS on admission was intense in 66.7% of patients. Tenosynovitis was present in 44.5% of patients and was more frequently reported in the ankles. Corticosteroids and chloroquine were administered to 65.3% and 31.98% of patients, respectively. The findings indicated that persistent musculoskeletal presentations occur frequently after CF. These results provide a better understanding of patient profiles, musculoskeletal involvement, and CF progression, and may guide effective strategies for therapeutic management.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/26915
10.33448/rsd-v11i3.26915
url https://rsdjournal.org/index.php/rsd/article/view/26915
identifier_str_mv 10.33448/rsd-v11i3.26915
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/26915/23747
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 3; e56011326915
Research, Society and Development; Vol. 11 Núm. 3; e56011326915
Research, Society and Development; v. 11 n. 3; e56011326915
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
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instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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