Phytochemical and toxicological evoluation of drt leaves of Cynara scolymus

Detalhes bibliográficos
Autor(a) principal: Quemel, Gleicy Kelly China
Data de Publicação: 2021
Outros Autores: Rivera, Juan Gonzalo Bardalez, Barbosa, Ana Victoria de Brito, Maciel, Marianna Paiva, Moura, Gabriel dos Santos
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/16459
Resumo: Indications for the use of medicinal plants for the cure, prevention and treatment of diseases, since ancient times, serve as an important source of information for the search for compounds with therapeutic properties. Cynara scolymus plant, known as Artichoke, presents itself as a vegetable low in calories, rich in fiber and iron, low in fat, carbohydrates, mostly formed by inulin, it is indicated in diets for diabetics and people with constipation, obesity and is also recommended as an anti-anemic. Given these therapeutic indications, this work aims to identify the phytochemical profile in the hydroalcoholic extract and toxicological analysis for in vitro methemoglobin evaluation in the hydroalcoholic and aqueous artichoke extracts. The sample for analysis was acquired from an herbalist in the city of Belém, in the state of Pará, all analyzes were performed in triplicate. The results found for qualitative phytochemical analysis indicated positive for Alkaloids, Triterpenes, Tannins/Phenols and Saponins, the other identifications of metabolites were negative; on the other hand, the results of methemoglobin toxicity in the hydroalcoholic extract at all concentrations showed percentages above the permitted level, and in the aqueous extract, only two concentrations of 600 µg/mL and 500 µg/mL were acceptable for the human body. It is concluded that artichoke has therapeutic activity, but also presented a high percentage of methemoglobin toxicity.
id UNIFEI_aac8b4ec03c36bd2b979fbd5e7125fcf
oai_identifier_str oai:ojs.pkp.sfu.ca:article/16459
network_acronym_str UNIFEI
network_name_str Research, Society and Development
repository_id_str
spelling Phytochemical and toxicological evoluation of drt leaves of Cynara scolymus Evaluación fitoquímica y toxicológica de hojas secas de Cynara scolymusAvaliação fitoquímica e toxicológica das folhas secas da Cynara scolymus Cynara scolymusMetabólitos secundáriosToxicidade.Cynara scolymusMetabolitos secundáriosToxicidad.Cynara scolymusSecondary metabolitesToxicity.Indications for the use of medicinal plants for the cure, prevention and treatment of diseases, since ancient times, serve as an important source of information for the search for compounds with therapeutic properties. Cynara scolymus plant, known as Artichoke, presents itself as a vegetable low in calories, rich in fiber and iron, low in fat, carbohydrates, mostly formed by inulin, it is indicated in diets for diabetics and people with constipation, obesity and is also recommended as an anti-anemic. Given these therapeutic indications, this work aims to identify the phytochemical profile in the hydroalcoholic extract and toxicological analysis for in vitro methemoglobin evaluation in the hydroalcoholic and aqueous artichoke extracts. The sample for analysis was acquired from an herbalist in the city of Belém, in the state of Pará, all analyzes were performed in triplicate. The results found for qualitative phytochemical analysis indicated positive for Alkaloids, Triterpenes, Tannins/Phenols and Saponins, the other identifications of metabolites were negative; on the other hand, the results of methemoglobin toxicity in the hydroalcoholic extract at all concentrations showed percentages above the permitted level, and in the aqueous extract, only two concentrations of 600 µg/mL and 500 µg/mL were acceptable for the human body. It is concluded that artichoke has therapeutic activity, but also presented a high percentage of methemoglobin toxicity.Las indicaciones para el uso de plantas medicinales para la cura, prevención y tratamiento de enfermedades, desde la antigüedad, sirven como una importante fuente de información para la búsqueda de compuestos con propiedades terapéuticas. La planta Cynara scolymus, conocida como Alcachofa, se presenta como un vegetal bajo en calorías, rico en fibra y hierro, bajo en grasas, carbohidratos, formado mayoritariamente por inulina, está indicado en dietas para diabéticos y personas con estreñimiento, obesidad y también se recomienda como antianémico. Dadas estas indicaciones terapéuticas, este trabajo tiene como objetivo identificar el perfil fitoquímico en el extracto hidroalcohólico y el análisis toxicológico para la evaluación in vitro de metahemoglobina en los extractos hidroalcohólicos y acuosos de alcachofa. La muestra para análisis se adquirió de un herbolario de la ciudad de Belém, en el estado de Pará, todos los análisis se realizaron por triplicado, los metabolitos resultaron negativos; por otro lado, los resultados de toxicidad de metahemoglobina en el extracto hidroalcohólico a todas las concentraciones mostraron porcentajes por encima del nivel permitido, y en el extracto acuoso solo dos concentraciones de 600 µg / mL y 500 µg / mL fueron aceptables para el cuerpo humano. Se concluye que la alcachofa tiene actividad terapéutica, pero también presenta un alto porcentaje de toxicidad por metahemoglobina.As indicações do uso de plantas medicinais para cura, prevenção e tratamento de doenças, desde a antiguidade, servem como importante fonte de informação para a busca de compostos com propriedades terapêuticas, a planta Cynara scolymus, conhecida como Alcachofra, apresenta-se como um vegetal de baixo valor calórico, rico em fibras e ferro, baixo teor de gordura, carboidratos, em sua maioria, formados pela inulina, é, indicado em dietas de diabéticos e pessoas com constipação intestinal, obesidade e também é recomendada como antianêmico. Diante dessas indicações terapêuticas este trabalho apresenta como objetivo a identificação do perfil fitoquímico no extrato hidroalccólico e análise toxicológica para avaliação de metemoglobina in vitro nos extratos hidroalcóolico e aquoso da alcachofra. A amostra para análise foi adquirida em um ervanário na Cidade de Belém, no estado do Pará, todas as análises foram feitas em triplicatas.Os resultados encontrados para análise fitoquímica qualitativa indicaram positivo para Alcaloides, Triterpenos, Taninos/Fenois e Saponinas, as demais identificações de metabolitos foram negativas; já  os resultados de  toxicidade de metamoglobina no extrato hidroalcolico toas as concentrações apresentaram porcentagens acima do permitido e no extrato aquoso, somente duas concentrações de 600 µg/mL  e 500 µg/mL, foram aceitáveis para o corpo humano. Conclui-se que a alcachofra apresenta atividade terapêutica, porém também apresentou um alto índice de porcentagem de toxicidade de metemoglobina.Research, Society and Development2021-06-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1645910.33448/rsd-v10i7.16459Research, Society and Development; Vol. 10 No. 7; e45810716459Research, Society and Development; Vol. 10 Núm. 7; e45810716459Research, Society and Development; v. 10 n. 7; e458107164592525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/16459/15024Copyright (c) 2021 Gleicy Kelly China Quemel; Juan Gonzalo Bardalez Rivera; Ana Victoria de Brito Barbosa; Marianna Paiva Maciel; Gabriel dos Santos Mourahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessQuemel, Gleicy Kelly ChinaRivera, Juan Gonzalo BardalezBarbosa, Ana Victoria de BritoMaciel, Marianna PaivaMoura, Gabriel dos Santos2021-07-18T21:07:03Zoai:ojs.pkp.sfu.ca:article/16459Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:37:00.310034Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Phytochemical and toxicological evoluation of drt leaves of Cynara scolymus
Evaluación fitoquímica y toxicológica de hojas secas de Cynara scolymus
Avaliação fitoquímica e toxicológica das folhas secas da Cynara scolymus
title Phytochemical and toxicological evoluation of drt leaves of Cynara scolymus
spellingShingle Phytochemical and toxicological evoluation of drt leaves of Cynara scolymus
Quemel, Gleicy Kelly China
Cynara scolymus
Metabólitos secundários
Toxicidade.
Cynara scolymus
Metabolitos secundários
Toxicidad.
Cynara scolymus
Secondary metabolites
Toxicity.
title_short Phytochemical and toxicological evoluation of drt leaves of Cynara scolymus
title_full Phytochemical and toxicological evoluation of drt leaves of Cynara scolymus
title_fullStr Phytochemical and toxicological evoluation of drt leaves of Cynara scolymus
title_full_unstemmed Phytochemical and toxicological evoluation of drt leaves of Cynara scolymus
title_sort Phytochemical and toxicological evoluation of drt leaves of Cynara scolymus
author Quemel, Gleicy Kelly China
author_facet Quemel, Gleicy Kelly China
Rivera, Juan Gonzalo Bardalez
Barbosa, Ana Victoria de Brito
Maciel, Marianna Paiva
Moura, Gabriel dos Santos
author_role author
author2 Rivera, Juan Gonzalo Bardalez
Barbosa, Ana Victoria de Brito
Maciel, Marianna Paiva
Moura, Gabriel dos Santos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Quemel, Gleicy Kelly China
Rivera, Juan Gonzalo Bardalez
Barbosa, Ana Victoria de Brito
Maciel, Marianna Paiva
Moura, Gabriel dos Santos
dc.subject.por.fl_str_mv Cynara scolymus
Metabólitos secundários
Toxicidade.
Cynara scolymus
Metabolitos secundários
Toxicidad.
Cynara scolymus
Secondary metabolites
Toxicity.
topic Cynara scolymus
Metabólitos secundários
Toxicidade.
Cynara scolymus
Metabolitos secundários
Toxicidad.
Cynara scolymus
Secondary metabolites
Toxicity.
description Indications for the use of medicinal plants for the cure, prevention and treatment of diseases, since ancient times, serve as an important source of information for the search for compounds with therapeutic properties. Cynara scolymus plant, known as Artichoke, presents itself as a vegetable low in calories, rich in fiber and iron, low in fat, carbohydrates, mostly formed by inulin, it is indicated in diets for diabetics and people with constipation, obesity and is also recommended as an anti-anemic. Given these therapeutic indications, this work aims to identify the phytochemical profile in the hydroalcoholic extract and toxicological analysis for in vitro methemoglobin evaluation in the hydroalcoholic and aqueous artichoke extracts. The sample for analysis was acquired from an herbalist in the city of Belém, in the state of Pará, all analyzes were performed in triplicate. The results found for qualitative phytochemical analysis indicated positive for Alkaloids, Triterpenes, Tannins/Phenols and Saponins, the other identifications of metabolites were negative; on the other hand, the results of methemoglobin toxicity in the hydroalcoholic extract at all concentrations showed percentages above the permitted level, and in the aqueous extract, only two concentrations of 600 µg/mL and 500 µg/mL were acceptable for the human body. It is concluded that artichoke has therapeutic activity, but also presented a high percentage of methemoglobin toxicity.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/16459
10.33448/rsd-v10i7.16459
url https://rsdjournal.org/index.php/rsd/article/view/16459
identifier_str_mv 10.33448/rsd-v10i7.16459
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/16459/15024
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 7; e45810716459
Research, Society and Development; Vol. 10 Núm. 7; e45810716459
Research, Society and Development; v. 10 n. 7; e45810716459
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052750683439104

Registros relacionados