Can the exacerbated synthesis of inflammatory markers in COVID-19 impair the response to treatments in patients with coronavirus?
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/33562 |
Resumo: | In addition to chronic diseases and empirical therapies against COVID-19, other factors are responsible for the high mortality rate associated with COVID-19. The objective of this study was to verify whether the exacerbated synthesis of inflammatory markers resulting from COVID-19 could compromise patients with coronavirus. The bibliographic research was performed in the Pubmed, LILACS, and SciELO databases between December 2020 and July 2021. For this study, the terms "COVID-19," "Biomarkers," "SARS-COV-2," and “Coronavirus 2019" are in advanced mode to gather the best evidence for the proposal of this manuscript. In the present construct, it is argued that COVID-19 increases the susceptibility of patients to a high stage of inflammation, increasing the virulence factors of the virus and its dissemination through the human body, where the synthesis of inflammatory factors plays a crucial role in the worsening of the cases. The virulence of the virus can be decreased by correcting the synthesis of these inflammatory markers, as it can prevent a less ineffective immune response and even increase the resistance of patients. Consequently, clinical trials in this direction should be carried out from the perspective of modulating responses at the molecular level, to find out how they work and how the underexpression of inflammatory cytokines may reduce the aggravation of patients with coronavirus. |
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Can the exacerbated synthesis of inflammatory markers in COVID-19 impair the response to treatments in patients with coronavirus?¿La síntesis exacerbada de marcadores inflamatorios en COVID-19 puede afectar la respuesta a los tratamientos en pacientes con coronavirus?A síntese exacerbada de marcadores inflamatórios na COVID-19 pode prejudicar a resposta aos tratamentos em pacientes com coronavírus?COVID-19PandemiaSARS-CoV-2Marcadores inflamatórios.COVID-19PandemiaSARS-CoV-2Marcadores inflamatorios.COVID-19PandemicSARS-CoV-2Inflammatory markers.In addition to chronic diseases and empirical therapies against COVID-19, other factors are responsible for the high mortality rate associated with COVID-19. The objective of this study was to verify whether the exacerbated synthesis of inflammatory markers resulting from COVID-19 could compromise patients with coronavirus. The bibliographic research was performed in the Pubmed, LILACS, and SciELO databases between December 2020 and July 2021. For this study, the terms "COVID-19," "Biomarkers," "SARS-COV-2," and “Coronavirus 2019" are in advanced mode to gather the best evidence for the proposal of this manuscript. In the present construct, it is argued that COVID-19 increases the susceptibility of patients to a high stage of inflammation, increasing the virulence factors of the virus and its dissemination through the human body, where the synthesis of inflammatory factors plays a crucial role in the worsening of the cases. The virulence of the virus can be decreased by correcting the synthesis of these inflammatory markers, as it can prevent a less ineffective immune response and even increase the resistance of patients. Consequently, clinical trials in this direction should be carried out from the perspective of modulating responses at the molecular level, to find out how they work and how the underexpression of inflammatory cytokines may reduce the aggravation of patients with coronavirus.Además de las enfermedades crónicas y el uso de terapias empíricas contra la COVID-19, se cree que otros factores son responsables de la alta tasa de mortalidad asociada con la COVID-19. El objetivo de este estudio fue verificar si la síntesis exacerbada de marcadores inflamatorios resultante de la COVID-19 podría comprometer a los pacientes con coronavirus. La búsqueda bibliográfica se realizó en las bases de datos Pubmed, LILACS y SciELO entre diciembre de 2020 y julio de 2021. Para este estudio se utilizaron los términos “COVID-19”, “Biomarcadores”, “SARS-COV-2” y “Coronavirus 2019” están en modo avanzado para recopilar la mejor evidencia para la propuesta de este manuscrito. En el presente constructo se argumenta que el COVID-19 aumenta la susceptibilidad de los pacientes a un estadio alto de inflamación, aumentando los factores de virulencia del virus y su diseminación por el cuerpo humano, donde la síntesis de factores inflamatorios juega un papel crucial en la el empeoramiento de los síntomas casos. La virulencia del virus se puede disminuir corrigiendo la síntesis de estos marcadores inflamatorios, ya que se puede evitar una respuesta inmune menos ineficaz e incluso aumentar la resistencia de los pacientes. En consecuencia, los ensayos clínicos en esta dirección deberían realizarse desde la perspectiva de modular las respuestas a nivel molecular, para conocer cómo actúan y cómo la infraexpresión de las citocinas inflamatorias puede reducir el agravamiento de los pacientes con coronavirus.Além das doenças crônicas e do uso de terapias empíricas contra a COVID-19, acredita-se que outros fatores podem ser responsáveis pela alta taxa de mortalidade associada à COVID-19. O objetivo deste estudo foi verificar se a síntese exacerbada de marcadores inflamatórios decorrentes da COVID-19 poderiam comprometer os pacientes com coronavirus. A pesquisa bibliográfica foi realizada nas bases de dados Pubmed, LILACS e SciELO entre dezembro de 2020 e julho de 2021. Para este estudo, os termos "COVID-19", "Biomarcadores", "SARS-COV-2" e "Coronavírus 2019" foram usados em modo avançado para reunir as melhores evidências para a proposta deste manuscrito. No presente constructo, argumenta-se que a COVID-19 aumenta a susceptibilidade dos pacientes a um elevado estágio de inflamação, aumentando os fatores de virulência do vírus e sua disseminação pelo corpo humano, onde a síntese de fatores inflamatórios desempenha papel crucial no agravamento dos casos. A virulência do vírus pode ser diminuída corrigindo a síntese desses marcadores inflamatórios, pois pode prevenir uma resposta imunológica menos ineficaz e ainda aumentar a resistência dos pacientes. Consequentemente, os ensaios clínicos nesse sentido devem ser realizados sobre a perspectiva de modular as respostas a nível molecular, para descobrir como elas atuam e como a subexpressão de citocinas inflamatórias pode reduzir a agravamento dos pacientes com coronavírus.Research, Society and Development2022-08-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3356210.33448/rsd-v11i11.33562Research, Society and Development; Vol. 11 No. 11; e337111133562Research, Society and Development; Vol. 11 Núm. 11; e337111133562Research, Society and Development; v. 11 n. 11; e3371111335622525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/33562/28490Copyright (c) 2022 Glensimon Souza Silva Cavalcante; Maria Conceição Santana dos Santos; Mirelle de Sousa Braga; Gisele Rosada Dônola Furtado; Krisley Rodrigues Lima Pereira; Erika Elita Araújo Lessa; Kledson Lopes Barbosahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCavalcante, Glensimon Souza Silva Santos, Maria Conceição Santana dos Braga, Mirelle de Sousa Furtado, Gisele Rosada Dônola Pereira, Krisley Rodrigues Lima Lessa, Erika Elita Araújo Barbosa, Kledson Lopes 2022-09-05T13:24:46Zoai:ojs.pkp.sfu.ca:article/33562Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:49:10.437264Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Can the exacerbated synthesis of inflammatory markers in COVID-19 impair the response to treatments in patients with coronavirus? ¿La síntesis exacerbada de marcadores inflamatorios en COVID-19 puede afectar la respuesta a los tratamientos en pacientes con coronavirus? A síntese exacerbada de marcadores inflamatórios na COVID-19 pode prejudicar a resposta aos tratamentos em pacientes com coronavírus? |
title |
Can the exacerbated synthesis of inflammatory markers in COVID-19 impair the response to treatments in patients with coronavirus? |
spellingShingle |
Can the exacerbated synthesis of inflammatory markers in COVID-19 impair the response to treatments in patients with coronavirus? Cavalcante, Glensimon Souza Silva COVID-19 Pandemia SARS-CoV-2 Marcadores inflamatórios. COVID-19 Pandemia SARS-CoV-2 Marcadores inflamatorios. COVID-19 Pandemic SARS-CoV-2 Inflammatory markers. |
title_short |
Can the exacerbated synthesis of inflammatory markers in COVID-19 impair the response to treatments in patients with coronavirus? |
title_full |
Can the exacerbated synthesis of inflammatory markers in COVID-19 impair the response to treatments in patients with coronavirus? |
title_fullStr |
Can the exacerbated synthesis of inflammatory markers in COVID-19 impair the response to treatments in patients with coronavirus? |
title_full_unstemmed |
Can the exacerbated synthesis of inflammatory markers in COVID-19 impair the response to treatments in patients with coronavirus? |
title_sort |
Can the exacerbated synthesis of inflammatory markers in COVID-19 impair the response to treatments in patients with coronavirus? |
author |
Cavalcante, Glensimon Souza Silva |
author_facet |
Cavalcante, Glensimon Souza Silva Santos, Maria Conceição Santana dos Braga, Mirelle de Sousa Furtado, Gisele Rosada Dônola Pereira, Krisley Rodrigues Lima Lessa, Erika Elita Araújo Barbosa, Kledson Lopes |
author_role |
author |
author2 |
Santos, Maria Conceição Santana dos Braga, Mirelle de Sousa Furtado, Gisele Rosada Dônola Pereira, Krisley Rodrigues Lima Lessa, Erika Elita Araújo Barbosa, Kledson Lopes |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Cavalcante, Glensimon Souza Silva Santos, Maria Conceição Santana dos Braga, Mirelle de Sousa Furtado, Gisele Rosada Dônola Pereira, Krisley Rodrigues Lima Lessa, Erika Elita Araújo Barbosa, Kledson Lopes |
dc.subject.por.fl_str_mv |
COVID-19 Pandemia SARS-CoV-2 Marcadores inflamatórios. COVID-19 Pandemia SARS-CoV-2 Marcadores inflamatorios. COVID-19 Pandemic SARS-CoV-2 Inflammatory markers. |
topic |
COVID-19 Pandemia SARS-CoV-2 Marcadores inflamatórios. COVID-19 Pandemia SARS-CoV-2 Marcadores inflamatorios. COVID-19 Pandemic SARS-CoV-2 Inflammatory markers. |
description |
In addition to chronic diseases and empirical therapies against COVID-19, other factors are responsible for the high mortality rate associated with COVID-19. The objective of this study was to verify whether the exacerbated synthesis of inflammatory markers resulting from COVID-19 could compromise patients with coronavirus. The bibliographic research was performed in the Pubmed, LILACS, and SciELO databases between December 2020 and July 2021. For this study, the terms "COVID-19," "Biomarkers," "SARS-COV-2," and “Coronavirus 2019" are in advanced mode to gather the best evidence for the proposal of this manuscript. In the present construct, it is argued that COVID-19 increases the susceptibility of patients to a high stage of inflammation, increasing the virulence factors of the virus and its dissemination through the human body, where the synthesis of inflammatory factors plays a crucial role in the worsening of the cases. The virulence of the virus can be decreased by correcting the synthesis of these inflammatory markers, as it can prevent a less ineffective immune response and even increase the resistance of patients. Consequently, clinical trials in this direction should be carried out from the perspective of modulating responses at the molecular level, to find out how they work and how the underexpression of inflammatory cytokines may reduce the aggravation of patients with coronavirus. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/33562 10.33448/rsd-v11i11.33562 |
url |
https://rsdjournal.org/index.php/rsd/article/view/33562 |
identifier_str_mv |
10.33448/rsd-v11i11.33562 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/33562/28490 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 11; e337111133562 Research, Society and Development; Vol. 11 Núm. 11; e337111133562 Research, Society and Development; v. 11 n. 11; e337111133562 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052837355585536 |