Antimicrobial and anti-inflammatory activity of Anadenanthera colubrina (Vell.) Brenan

Detalhes bibliográficos
Autor(a) principal: Lima, Amélia Ruth Nascimento
Data de Publicação: 2020
Outros Autores: Macedo, Raissa Gonçalves, Batista, Gustavo Gomes, Câmara, Gabriel Barbosa, Lima, Rennaly de Freitas, Oliveira, Tharcia Kiara Beserra de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/1770
Resumo: The present study aimed to analyze the antimicrobial and anti-inflammatory activity of A. colubrina (Vell.) Brenan extract through a panel of biological activities. The hydroalcoholic extract of A. colubrina was obtained by maceration, which was rotary evaporated and lyophilized. Minimal Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (CFM) tests were performed microdilution against Candida albicans (ATCC 10231 and clinical strain), Candida tropicalis (ATCC 750) and Candida krusei (ATCC 6258). Anti-inflammatory activity was verified by induced paw edema. According to the tests performed, A. colubrina extract showed strong antifungal activity against C. albicans (ATCC 10231) and C. krusei (MIC: 7.81 μg / mL and 31.25 μg / mL, respectively). For the clinical strain of C. albicans and C. tropicalis, antifungal activity was considered weak (MIC: 500 μg / mL and> 2000 μg / mL, respectively). For the CFM tests, the extract showed fungistatic activity on C. albicans strains (ATCC 10231 and clinical strain) and C. tropicalis (CFM:> 1000 μg / mL,> 2000 μg / mL,> 5000 μg / mL, respectively), with fungicidal effect on C. krusei (CFM: 31.25 μg / mL). About the anti-inflammatory activity, among the concentrations of the extract tested, the one administered at the lower dosage presented a greater reduction of the induced paw edema. According to the above, the anti-Candida potential of A. colubrina. It is interesting to carry out studies that can confirm the anti-inflammatory potential of the test plant.
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spelling Antimicrobial and anti-inflammatory activity of Anadenanthera colubrina (Vell.) BrenanActividad antimicrobiana y antiinflamatoria de Anadenanthera colubrina (Vell.) BrenanAtividade antimicrobiana e anti-inflamatória da Anadenanthera colubrina (Vell.) BrenanMedicinal plantsMicrobial sensitivity testsInflammationPlantas medicinaisTestes de sensibilidade microbianaInflamaçãoPlantas medicinalespruebas de sensibilidad microbianainflamaciónThe present study aimed to analyze the antimicrobial and anti-inflammatory activity of A. colubrina (Vell.) Brenan extract through a panel of biological activities. The hydroalcoholic extract of A. colubrina was obtained by maceration, which was rotary evaporated and lyophilized. Minimal Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (CFM) tests were performed microdilution against Candida albicans (ATCC 10231 and clinical strain), Candida tropicalis (ATCC 750) and Candida krusei (ATCC 6258). Anti-inflammatory activity was verified by induced paw edema. According to the tests performed, A. colubrina extract showed strong antifungal activity against C. albicans (ATCC 10231) and C. krusei (MIC: 7.81 μg / mL and 31.25 μg / mL, respectively). For the clinical strain of C. albicans and C. tropicalis, antifungal activity was considered weak (MIC: 500 μg / mL and> 2000 μg / mL, respectively). For the CFM tests, the extract showed fungistatic activity on C. albicans strains (ATCC 10231 and clinical strain) and C. tropicalis (CFM:> 1000 μg / mL,> 2000 μg / mL,> 5000 μg / mL, respectively), with fungicidal effect on C. krusei (CFM: 31.25 μg / mL). About the anti-inflammatory activity, among the concentrations of the extract tested, the one administered at the lower dosage presented a greater reduction of the induced paw edema. According to the above, the anti-Candida potential of A. colubrina. It is interesting to carry out studies that can confirm the anti-inflammatory potential of the test plant.Este estudio tuvo como objetivo analizar la actividad antimicrobiana y antiinflamatoria del extracto de A. colubrina (Vell.) Brenan a través de un panel de actividades biológicas. El extracto hidroalcohólico de A. colubrina se obtuvo por maceración, se evaporó por rotación y se liofilizó. Las pruebas de concentración mínima inhibitoria (MIC) y concentración mínima de fungicida (CFM) se realizaron contra Candida albicans (ATCC 10231 y cepa clínica), Candida tropicalis (ATCC 750) y Candida krusei (ATCC 6258) mediante microdilución. La actividad antiinflamatoria se verificó mediante edema de la pata inducido. Dadas las pruebas realizadas, el extracto de A. colubrina mostró una fuerte actividad antifúngica contra C. albicans (ATCC 10231) y C. krusei (MIC: 7,81 µg / ml y 31,25 µg / ml, respectivamente). Para la cepa clínica de C. albicans y C. tropicalis, la actividad antifúngica se consideró débil (MIC: 500 µg / ml y> 2000 µg / ml, respectivamente). Para las pruebas de CFM, el extracto mostró actividad fungistática en C. albicans (ATCC 10231 y cepa clínica) y C. tropicalis (CFM:> 1000 µg / ml,> 2000 µg / ml,> 5000 µg / ml, respectivamente), observando el efecto fungicida solo en C. krusei (CFM: 31.25 µg / mL). Con respecto a la actividad antiinflamatoria, entre las concentraciones del extracto analizado, el administrado en la dosis más baja presentó una mayor reducción del edema inducido de la pata. En consecuencia, el potencial anti-Candida de A. colubrina. Es interesante realizar estudios que puedan confirmar el potencial antiinflamatorio de la planta bajo prueba.O presente estudo teve como objetivo analisar a atividade antimicrobiana e anti-inflamatória do extrato da A. colubrina (Vell.) Brenan através de um painel de atividades biológicas. O extrato hidroalcoólico da A. colubrina foi obtido através de maceração, o qual rotaevaporado e liofilizado. Foram realizados testes de Concentração Inibitória Mínima (CIM) e Concentração Fungicida Mínima (CFM) contra Candida albicans (ATCC 10231 e cepa clínica), Candida tropicalis (ATCC 750) e Candida krusei (ATCC 6258), através da microdiluição. A atividade anti-inflamatória foi verificada através do edema de pata induzido. Diante dos testes realizados, o extrato da A. colubrina demonstrou forte atividade antifúngica contra a C. albicans (ATCC 10231) e a C. krusei (CIM: 7,81 µg/mL e 31,25 µg/mL, respectivamente). Para a cepa clínica da C. albicans e C. tropicalis a atividade antifúngica foi considerada fraca (CIM: 500 µg/mL e >2000 µg/mL, respectivamente). Para os testes de CFM, o extrato demonstrou atividade fungistática sobre as cepas C. albicans, (ATCC 10231 e cepa clínica) e C. tropicalis (CFM: > 1000 µg/mL, > 2000 µg/mL, > 5000 µg/mL, respectivamente), observando-se efeito fungicida apenas sobre a C. krusei (CFM: 31,25 µg/mL). Em relação à atividade anti-inflamatória, dentre as concentrações do extrato testadas, aquela administrada na menor dosagem apresentou maior redução do edema de pata induzido. De acordo com o exposto, é evidente o potencial anti-Candida da A. colubrina. É interessante a realização de estudos que possam confirmar o potencial anti-inflamatório da planta em teste.Research, Society and Development2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/177010.33448/rsd-v9i1.1770Research, Society and Development; Vol. 9 No. 1; e121911770Research, Society and Development; Vol. 9 Núm. 1; e121911770Research, Society and Development; v. 9 n. 1; e1219117702525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/1770/1674Copyright (c) 2020 Amélia Ruth Nascimento Lima, Gustavo Gomes Batista, Raissa Gonçalves Macedo, Gabriel Barbosa Câmara, Tharcia Kiara Beserra de Oliveira, Rennaly de Freitas Limainfo:eu-repo/semantics/openAccessLima, Amélia Ruth NascimentoMacedo, Raissa GonçalvesBatista, Gustavo GomesCâmara, Gabriel BarbosaLima, Rennaly de FreitasOliveira, Tharcia Kiara Beserra de2020-08-19T03:04:08Zoai:ojs.pkp.sfu.ca:article/1770Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:26:40.989264Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Antimicrobial and anti-inflammatory activity of Anadenanthera colubrina (Vell.) Brenan
Actividad antimicrobiana y antiinflamatoria de Anadenanthera colubrina (Vell.) Brenan
Atividade antimicrobiana e anti-inflamatória da Anadenanthera colubrina (Vell.) Brenan
title Antimicrobial and anti-inflammatory activity of Anadenanthera colubrina (Vell.) Brenan
spellingShingle Antimicrobial and anti-inflammatory activity of Anadenanthera colubrina (Vell.) Brenan
Lima, Amélia Ruth Nascimento
Medicinal plants
Microbial sensitivity tests
Inflammation
Plantas medicinais
Testes de sensibilidade microbiana
Inflamação
Plantas medicinales
pruebas de sensibilidad microbiana
inflamación
title_short Antimicrobial and anti-inflammatory activity of Anadenanthera colubrina (Vell.) Brenan
title_full Antimicrobial and anti-inflammatory activity of Anadenanthera colubrina (Vell.) Brenan
title_fullStr Antimicrobial and anti-inflammatory activity of Anadenanthera colubrina (Vell.) Brenan
title_full_unstemmed Antimicrobial and anti-inflammatory activity of Anadenanthera colubrina (Vell.) Brenan
title_sort Antimicrobial and anti-inflammatory activity of Anadenanthera colubrina (Vell.) Brenan
author Lima, Amélia Ruth Nascimento
author_facet Lima, Amélia Ruth Nascimento
Macedo, Raissa Gonçalves
Batista, Gustavo Gomes
Câmara, Gabriel Barbosa
Lima, Rennaly de Freitas
Oliveira, Tharcia Kiara Beserra de
author_role author
author2 Macedo, Raissa Gonçalves
Batista, Gustavo Gomes
Câmara, Gabriel Barbosa
Lima, Rennaly de Freitas
Oliveira, Tharcia Kiara Beserra de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Amélia Ruth Nascimento
Macedo, Raissa Gonçalves
Batista, Gustavo Gomes
Câmara, Gabriel Barbosa
Lima, Rennaly de Freitas
Oliveira, Tharcia Kiara Beserra de
dc.subject.por.fl_str_mv Medicinal plants
Microbial sensitivity tests
Inflammation
Plantas medicinais
Testes de sensibilidade microbiana
Inflamação
Plantas medicinales
pruebas de sensibilidad microbiana
inflamación
topic Medicinal plants
Microbial sensitivity tests
Inflammation
Plantas medicinais
Testes de sensibilidade microbiana
Inflamação
Plantas medicinales
pruebas de sensibilidad microbiana
inflamación
description The present study aimed to analyze the antimicrobial and anti-inflammatory activity of A. colubrina (Vell.) Brenan extract through a panel of biological activities. The hydroalcoholic extract of A. colubrina was obtained by maceration, which was rotary evaporated and lyophilized. Minimal Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (CFM) tests were performed microdilution against Candida albicans (ATCC 10231 and clinical strain), Candida tropicalis (ATCC 750) and Candida krusei (ATCC 6258). Anti-inflammatory activity was verified by induced paw edema. According to the tests performed, A. colubrina extract showed strong antifungal activity against C. albicans (ATCC 10231) and C. krusei (MIC: 7.81 μg / mL and 31.25 μg / mL, respectively). For the clinical strain of C. albicans and C. tropicalis, antifungal activity was considered weak (MIC: 500 μg / mL and> 2000 μg / mL, respectively). For the CFM tests, the extract showed fungistatic activity on C. albicans strains (ATCC 10231 and clinical strain) and C. tropicalis (CFM:> 1000 μg / mL,> 2000 μg / mL,> 5000 μg / mL, respectively), with fungicidal effect on C. krusei (CFM: 31.25 μg / mL). About the anti-inflammatory activity, among the concentrations of the extract tested, the one administered at the lower dosage presented a greater reduction of the induced paw edema. According to the above, the anti-Candida potential of A. colubrina. It is interesting to carry out studies that can confirm the anti-inflammatory potential of the test plant.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/1770
10.33448/rsd-v9i1.1770
url https://rsdjournal.org/index.php/rsd/article/view/1770
identifier_str_mv 10.33448/rsd-v9i1.1770
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/1770/1674
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 1; e121911770
Research, Society and Development; Vol. 9 Núm. 1; e121911770
Research, Society and Development; v. 9 n. 1; e121911770
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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