Lavender (Lavandula officinalis) essential oil prevents acetaminophen-induced hepatotoxicity by decreasing oxidative stress and inflammatory response
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/13461 |
Resumo: | Acetaminophen (N-acetyl-p-aminophenol, APAP) is the most popular drug recommended and consumed for relieving mild and moderate pain and fever. Although effective in therapeutic doses, APAP overdose induces hepatotoxicity, causing acute liver failure. In this study, the hepatoprotective effects and the underlying mechanisms of Lavandula officinalis essential oil (LEO) were investigated in APAP-induced hepatotoxicity. To evaluate the hepatoprotective effect, Balb /c mice were pretreated with LEO at doses of 200 and 400 mg/kg, once daily for seven days. On the seventh day, mice were treated with APAP (250 mg/kg) to induce hepatotoxicity. LEO significantly decreased serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γ-GT) compared to the APAP group. Besides, a decrease in myeloperoxidase (MPO) activity, nitric oxide (NO), and pro-inflammatory cytokines levels were observed in liver samples of the LEO treated mice. Moreover, pretreatment with LEO showed significant antioxidant activity by decreasing the levels of malondialdehyde (MDA), carbonylated proteins, reactive oxygen species (ROS), and glutathione (GSH), in addition to increasing levels of the hepatic superoxide dismutase (SOD), catalase (CAT), and oxidized glutathione (GSSG). Our results showed that LEO improved liver functions altered by APAP by inhibiting oxidative stress and inflammatory induced by APAP and other oxidative stress-mediated toxicities. |
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Lavender (Lavandula officinalis) essential oil prevents acetaminophen-induced hepatotoxicity by decreasing oxidative stress and inflammatory response El aceite esencial de lavanda (Lavandula officinalis) previene la hepatotoxicidad inducida por el paracetamol al disminuir el estrés oxidativo y la respuesta inflamatoria Óleo essencial de lavanda (Lavandula officinalis) previne a hepatotoxicidade induzida pelo paracetamol ao diminuir o estresse oxidativo e a resposta inflamatória Lesión hepática agudaAceite esencial de lavandaAntioxidanteEstrés oxidativoHepatotoxicidad.Acute Hepatic InjuryLavender Essential OilOxidative StressAntioxidantHepatotoxicity.Lesão hepática agudaÓleo Essencial de LavandaEstresse oxidativoAntioxidanteHepatotoxicidade.Acetaminophen (N-acetyl-p-aminophenol, APAP) is the most popular drug recommended and consumed for relieving mild and moderate pain and fever. Although effective in therapeutic doses, APAP overdose induces hepatotoxicity, causing acute liver failure. In this study, the hepatoprotective effects and the underlying mechanisms of Lavandula officinalis essential oil (LEO) were investigated in APAP-induced hepatotoxicity. To evaluate the hepatoprotective effect, Balb /c mice were pretreated with LEO at doses of 200 and 400 mg/kg, once daily for seven days. On the seventh day, mice were treated with APAP (250 mg/kg) to induce hepatotoxicity. LEO significantly decreased serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γ-GT) compared to the APAP group. Besides, a decrease in myeloperoxidase (MPO) activity, nitric oxide (NO), and pro-inflammatory cytokines levels were observed in liver samples of the LEO treated mice. Moreover, pretreatment with LEO showed significant antioxidant activity by decreasing the levels of malondialdehyde (MDA), carbonylated proteins, reactive oxygen species (ROS), and glutathione (GSH), in addition to increasing levels of the hepatic superoxide dismutase (SOD), catalase (CAT), and oxidized glutathione (GSSG). Our results showed that LEO improved liver functions altered by APAP by inhibiting oxidative stress and inflammatory induced by APAP and other oxidative stress-mediated toxicities.El acetaminofén (N-acetil-p-aminofenol, APAP) es el fármaco más popular recomendado y consumido para aliviar el dolor y la fiebre leves y moderados. Aunque es eficaz en dosis terapéuticas, la sobredosis de APAP induce hepatotoxicidad, provocando insuficiencia hepática aguda. En este estudio, se investigaron los efectos hepatoprotectores y los mecanismos subyacentes del aceite esencial de Lavandula officinalis (LEO) en la hepatotoxicidad inducida por APAP. Para evaluar el efecto hepatoprotector, se pretrató a ratones Balb/c con LEO en dosis de 200 y 400 mg/kg, una vez al día durante siete días. El séptimo día, los ratones se trataron con APAP (250 mg/kg) para inducir hepatotoxicidad. LEO redujo significativamente los niveles séricos de alanina aminotransferasa (ALT), aspartato aminotransferasa (AST), fosfatasa alcalina (ALP) y gamma-glutamil transferasa (γ-GT) en comparación con el grupo APAP. Además, se observó una disminución en los niveles de actividad de mieloperoxidasa (MPO), óxido nítrico (NO) y citocinas proinflamatorias en muestras de hígado de los ratones tratados con LEO. Además, el pretratamiento con LEO mostró una actividad antioxidante significativa al disminuir los niveles de malondialdehído (MDA), proteínas carboniladas, especies reactivas de oxígeno (ROS) y glutatión (GSH), además de aumentar los niveles de superóxido dismutasa hepática (SOD), catalasa (CAT) y glutatión oxidado (GSSG). Nuestros resultados mostraron que LEO mejoró las funciones hepáticas alteradas por APAP al inhibir el estrés oxidativo e inflamatorio inducido por APAP y otras toxicidades mediadas por estrés oxidativo.O acetaminofeno (N-acetil-p-aminofenol, APAP) é o medicamento popular mais recomendado e consumido para o alívio da dor e febre leves e moderadas. Embora eficaz em doses terapêuticas, a overdose de APAP induz hepatotoxicidade, causando insuficiência hepática aguda. Neste estudo, os efeitos hepatoprotetores e os mecanismos subjacentes do óleo essencial de Lavandula officinalis (LEO) foram investigados na hepatotoxicidade induzida por APAP. Para avaliar o efeito hepatoprotetor, camundongos Balb/c foram pré-tratados com LEO nas doses de 200 e 400 mg/kg, uma vez ao dia, durante sete dias. No sétimo dia, os camundongos foram tratados com APAP (250 mg/kg) para induzir a hepatotoxicidade. LEO diminuiu significativamente os níveis séricos de alanina aminotransferase (ALT), aspartato aminotransferase (AST), fosfatase alcalina (ALP) e gama-glutamil transferase (γ-GT) em comparação com o grupo APAP. Além disso, uma diminuição na atividade da mieloperoxidase (MPO), óxido nítrico (NO) e níveis de citocinas pró-inflamatórias foram observados em amostras de fígado dos camundongos tratados com LEO. Além disso, o pré-tratamento com LEO apresentou atividade antioxidante significativa pela diminuição dos níveis de malondialdeído (MDA), proteínas carboniladas, espécies reativas de oxigênio (ROS) e glutationa (GSH), além de aumentar os níveis da superóxido dismutase hepática (SOD), catalase (CAT) e glutationa oxidada (GSSG). Nossos resultados mostraram que o LEO melhorou as funções hepáticas alteradas pelo APAP ao inibir o estresse oxidativo e a inflamação induzida pelo APAP.Research, Society and Development2021-03-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1346110.33448/rsd-v10i3.13461Research, Society and Development; Vol. 10 No. 3; e43410313461Research, Society and Development; Vol. 10 Núm. 3; e43410313461Research, Society and Development; v. 10 n. 3; e434103134612525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/13461/12154Copyright (c) 2021 Gabriel Fernando Esteves Cardia; Francielli Maria de Souza Silva-Comar ; Expedito Leite Silva; Edvalkia Magna Teobaldo da Rocha; Jurandir Fernando Comar; Saulo Euclides Silva-Filho; Mayara Zagotto; Nancy Sayuri Uchida; Ciomar Aparecida Bersani-Amado; Roberto Kenji Nakamura Cumanhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCardia, Gabriel Fernando Esteves Silva-Comar , Francielli Maria de SouzaSilva, Expedito Leite Rocha, Edvalkia Magna Teobaldo daComar, Jurandir Fernando Silva-Filho, Saulo Euclides Zagotto, MayaraUchida, Nancy SayuriBersani-Amado, Ciomar Aparecida Cuman, Roberto Kenji Nakamura2021-03-28T12:03:35Zoai:ojs.pkp.sfu.ca:article/13461Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:34:47.726477Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Lavender (Lavandula officinalis) essential oil prevents acetaminophen-induced hepatotoxicity by decreasing oxidative stress and inflammatory response El aceite esencial de lavanda (Lavandula officinalis) previene la hepatotoxicidad inducida por el paracetamol al disminuir el estrés oxidativo y la respuesta inflamatoria Óleo essencial de lavanda (Lavandula officinalis) previne a hepatotoxicidade induzida pelo paracetamol ao diminuir o estresse oxidativo e a resposta inflamatória |
| title |
Lavender (Lavandula officinalis) essential oil prevents acetaminophen-induced hepatotoxicity by decreasing oxidative stress and inflammatory response |
| spellingShingle |
Lavender (Lavandula officinalis) essential oil prevents acetaminophen-induced hepatotoxicity by decreasing oxidative stress and inflammatory response Cardia, Gabriel Fernando Esteves Lesión hepática aguda Aceite esencial de lavanda Antioxidante Estrés oxidativo Hepatotoxicidad. Acute Hepatic Injury Lavender Essential Oil Oxidative Stress Antioxidant Hepatotoxicity. Lesão hepática aguda Óleo Essencial de Lavanda Estresse oxidativo Antioxidante Hepatotoxicidade. |
| title_short |
Lavender (Lavandula officinalis) essential oil prevents acetaminophen-induced hepatotoxicity by decreasing oxidative stress and inflammatory response |
| title_full |
Lavender (Lavandula officinalis) essential oil prevents acetaminophen-induced hepatotoxicity by decreasing oxidative stress and inflammatory response |
| title_fullStr |
Lavender (Lavandula officinalis) essential oil prevents acetaminophen-induced hepatotoxicity by decreasing oxidative stress and inflammatory response |
| title_full_unstemmed |
Lavender (Lavandula officinalis) essential oil prevents acetaminophen-induced hepatotoxicity by decreasing oxidative stress and inflammatory response |
| title_sort |
Lavender (Lavandula officinalis) essential oil prevents acetaminophen-induced hepatotoxicity by decreasing oxidative stress and inflammatory response |
| author |
Cardia, Gabriel Fernando Esteves |
| author_facet |
Cardia, Gabriel Fernando Esteves Silva-Comar , Francielli Maria de Souza Silva, Expedito Leite Rocha, Edvalkia Magna Teobaldo da Comar, Jurandir Fernando Silva-Filho, Saulo Euclides Zagotto, Mayara Uchida, Nancy Sayuri Bersani-Amado, Ciomar Aparecida Cuman, Roberto Kenji Nakamura |
| author_role |
author |
| author2 |
Silva-Comar , Francielli Maria de Souza Silva, Expedito Leite Rocha, Edvalkia Magna Teobaldo da Comar, Jurandir Fernando Silva-Filho, Saulo Euclides Zagotto, Mayara Uchida, Nancy Sayuri Bersani-Amado, Ciomar Aparecida Cuman, Roberto Kenji Nakamura |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cardia, Gabriel Fernando Esteves Silva-Comar , Francielli Maria de Souza Silva, Expedito Leite Rocha, Edvalkia Magna Teobaldo da Comar, Jurandir Fernando Silva-Filho, Saulo Euclides Zagotto, Mayara Uchida, Nancy Sayuri Bersani-Amado, Ciomar Aparecida Cuman, Roberto Kenji Nakamura |
| dc.subject.por.fl_str_mv |
Lesión hepática aguda Aceite esencial de lavanda Antioxidante Estrés oxidativo Hepatotoxicidad. Acute Hepatic Injury Lavender Essential Oil Oxidative Stress Antioxidant Hepatotoxicity. Lesão hepática aguda Óleo Essencial de Lavanda Estresse oxidativo Antioxidante Hepatotoxicidade. |
| topic |
Lesión hepática aguda Aceite esencial de lavanda Antioxidante Estrés oxidativo Hepatotoxicidad. Acute Hepatic Injury Lavender Essential Oil Oxidative Stress Antioxidant Hepatotoxicity. Lesão hepática aguda Óleo Essencial de Lavanda Estresse oxidativo Antioxidante Hepatotoxicidade. |
| description |
Acetaminophen (N-acetyl-p-aminophenol, APAP) is the most popular drug recommended and consumed for relieving mild and moderate pain and fever. Although effective in therapeutic doses, APAP overdose induces hepatotoxicity, causing acute liver failure. In this study, the hepatoprotective effects and the underlying mechanisms of Lavandula officinalis essential oil (LEO) were investigated in APAP-induced hepatotoxicity. To evaluate the hepatoprotective effect, Balb /c mice were pretreated with LEO at doses of 200 and 400 mg/kg, once daily for seven days. On the seventh day, mice were treated with APAP (250 mg/kg) to induce hepatotoxicity. LEO significantly decreased serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γ-GT) compared to the APAP group. Besides, a decrease in myeloperoxidase (MPO) activity, nitric oxide (NO), and pro-inflammatory cytokines levels were observed in liver samples of the LEO treated mice. Moreover, pretreatment with LEO showed significant antioxidant activity by decreasing the levels of malondialdehyde (MDA), carbonylated proteins, reactive oxygen species (ROS), and glutathione (GSH), in addition to increasing levels of the hepatic superoxide dismutase (SOD), catalase (CAT), and oxidized glutathione (GSSG). Our results showed that LEO improved liver functions altered by APAP by inhibiting oxidative stress and inflammatory induced by APAP and other oxidative stress-mediated toxicities. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-03-21 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://rsdjournal.org/index.php/rsd/article/view/13461 10.33448/rsd-v10i3.13461 |
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https://rsdjournal.org/index.php/rsd/article/view/13461 |
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10.33448/rsd-v10i3.13461 |
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eng |
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eng |
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https://rsdjournal.org/index.php/rsd/article/view/13461/12154 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 10 No. 3; e43410313461 Research, Society and Development; Vol. 10 Núm. 3; e43410313461 Research, Society and Development; v. 10 n. 3; e43410313461 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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