Cannabinoids as a possible alternative in the treatment of psoriasis

Detalhes bibliográficos
Autor(a) principal: Coimbra, Beatriz Zimermano
Data de Publicação: 2022
Outros Autores: Bertozzi, João Gabriel, Borges, Ericks Domiciano, Pitliuk, Rubens, Fucci, Tatyanny Paula Pinto da Costa Santos, Abreu , Marilda Aparecida Milanez Morgado de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/34651
Resumo: With strong genetic predisposition, relationship with the environment and autoimmune pathogenic traits, psoriasis is a chronic, non-infectious disease that affects people regardless of age or gender. Treatment aims to control the differentiation and proliferation of keratinocytes. With this in mind, the objective of this narrative review is to analyze the existing literature involving the effects of Cannabis sativa in the treatment of the disease, focusing on its effectiveness. An active search in Google Scholar, Pubmed and LILACS databases showed that cannabinoids have therapeutic potential in psoriasis, mainly in relation to the proliferation of keratinocytes and the modulation of inflammation, but most of the available studies are in vitro. More clinical studies in humans are needed for better elucidation, so that cannabinoids can be recommended as a safe and effective treatment in psoriasis.
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spelling Cannabinoids as a possible alternative in the treatment of psoriasis Los cannabinoides como posible alternativa en el tratamiento de la psoriasis Canabinóides como possível alternativa no tratamento de psoríase CannabidiolSoriasisTratamiento.CanabidiolPsoríaseTratamento.CannabidiolPsoriasisTreatment.With strong genetic predisposition, relationship with the environment and autoimmune pathogenic traits, psoriasis is a chronic, non-infectious disease that affects people regardless of age or gender. Treatment aims to control the differentiation and proliferation of keratinocytes. With this in mind, the objective of this narrative review is to analyze the existing literature involving the effects of Cannabis sativa in the treatment of the disease, focusing on its effectiveness. An active search in Google Scholar, Pubmed and LILACS databases showed that cannabinoids have therapeutic potential in psoriasis, mainly in relation to the proliferation of keratinocytes and the modulation of inflammation, but most of the available studies are in vitro. More clinical studies in humans are needed for better elucidation, so that cannabinoids can be recommended as a safe and effective treatment in psoriasis.Con una fuerte predisposición genética, rasgos patogénicos autoinmunes y una fuerte relación con el medio ambiente, la psoriasis es una enfermedad crónica, no infecciosa, que afecta a personas de todas las edades, sin predilección por el sexo. Su tratamiento tiene como objetivo controlar la diferenciación y proliferación de los queratinocitos. Teniendo esto en cuenta, el objetivo de esta revisión narrativa es analizar lo ya documentado en la literatura sobre los efectos del Cannabis sativa en el tratamiento de la enfermedad, centrándonos en su eficacia. Para ello se realizó una búsqueda activa sobre el tema en las bases de datos Google Scholar, Pubmed y LILACS. Se encontró que los cannabinoides tienen un potencial terapéutico en la psoriasis, principalmente en relación con la proliferación de queratinocitos y la modulación de la inflamación, pero la mayoría de los estudios disponibles son in vitro. Se necesitan más estudios clínicos en humanos para una mejor elucidación, de modo que los cannabinoides se instituyan como un tratamiento seguro y eficaz en la psoriasis.Com uma forte predisposição genética, traços patogênicos autoimunes e com grande relação ao meio ambiente, a psoríase é uma doença crônica, não infecciosa, que acomete pessoas de todas as idades, sem predileção por sexo. O seu tratamento tem como principal objetivo controlar a diferenciação e a proliferação dos queratinócitos. Tendo isso em vista, o objetivo desta revisão narrativa é fazer uma análise do que já está documentado na literatura, envolvendo os efeitos da Cannabis sativa no tratamento da psoríase, com enfoque na sua efetividade. Para isso, foi feita uma busca ativa sobre o tema nas bases de dados Google Acadêmico, Pubmed e LILACS. Foi verificado que os canabinoides possuem um potencial terapêutico na psoríase, principalmente em relação à proliferação dos queratinócitos e na modulação da inflamação, porém a maioria dos estudos disponíveis são in vitro. É necessário a realização de mais estudos clínicos em humanos para melhor elucidação da eficácia e segurança dos canabinoides no tratamento da psoríase.      Research, Society and Development2022-09-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3465110.33448/rsd-v11i11.34651Research, Society and Development; Vol. 11 No. 11; e450111134651Research, Society and Development; Vol. 11 Núm. 11; e450111134651Research, Society and Development; v. 11 n. 11; e4501111346512525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/34651/29191Copyright (c) 2022 Beatriz Zimermano Coimbra; João Gabriel Bertozzi; Ericks Domiciano Borges; Rubens Pitliuk; Tatyanny Paula Pinto da Costa Santos Fucci; Marilda Aparecida Milanez Morgado de Abreu https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCoimbra, Beatriz Zimermano Bertozzi, João Gabriel Borges, Ericks Domiciano Pitliuk, RubensFucci, Tatyanny Paula Pinto da Costa Santos Abreu , Marilda Aparecida Milanez Morgado de 2022-09-05T13:24:46Zoai:ojs.pkp.sfu.ca:article/34651Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:49:52.171231Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Cannabinoids as a possible alternative in the treatment of psoriasis
Los cannabinoides como posible alternativa en el tratamiento de la psoriasis
Canabinóides como possível alternativa no tratamento de psoríase
title Cannabinoids as a possible alternative in the treatment of psoriasis
spellingShingle Cannabinoids as a possible alternative in the treatment of psoriasis
Coimbra, Beatriz Zimermano
Cannabidiol
Soriasis
Tratamiento.
Canabidiol
Psoríase
Tratamento.
Cannabidiol
Psoriasis
Treatment.
title_short Cannabinoids as a possible alternative in the treatment of psoriasis
title_full Cannabinoids as a possible alternative in the treatment of psoriasis
title_fullStr Cannabinoids as a possible alternative in the treatment of psoriasis
title_full_unstemmed Cannabinoids as a possible alternative in the treatment of psoriasis
title_sort Cannabinoids as a possible alternative in the treatment of psoriasis
author Coimbra, Beatriz Zimermano
author_facet Coimbra, Beatriz Zimermano
Bertozzi, João Gabriel
Borges, Ericks Domiciano
Pitliuk, Rubens
Fucci, Tatyanny Paula Pinto da Costa Santos
Abreu , Marilda Aparecida Milanez Morgado de
author_role author
author2 Bertozzi, João Gabriel
Borges, Ericks Domiciano
Pitliuk, Rubens
Fucci, Tatyanny Paula Pinto da Costa Santos
Abreu , Marilda Aparecida Milanez Morgado de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Coimbra, Beatriz Zimermano
Bertozzi, João Gabriel
Borges, Ericks Domiciano
Pitliuk, Rubens
Fucci, Tatyanny Paula Pinto da Costa Santos
Abreu , Marilda Aparecida Milanez Morgado de
dc.subject.por.fl_str_mv Cannabidiol
Soriasis
Tratamiento.
Canabidiol
Psoríase
Tratamento.
Cannabidiol
Psoriasis
Treatment.
topic Cannabidiol
Soriasis
Tratamiento.
Canabidiol
Psoríase
Tratamento.
Cannabidiol
Psoriasis
Treatment.
description With strong genetic predisposition, relationship with the environment and autoimmune pathogenic traits, psoriasis is a chronic, non-infectious disease that affects people regardless of age or gender. Treatment aims to control the differentiation and proliferation of keratinocytes. With this in mind, the objective of this narrative review is to analyze the existing literature involving the effects of Cannabis sativa in the treatment of the disease, focusing on its effectiveness. An active search in Google Scholar, Pubmed and LILACS databases showed that cannabinoids have therapeutic potential in psoriasis, mainly in relation to the proliferation of keratinocytes and the modulation of inflammation, but most of the available studies are in vitro. More clinical studies in humans are needed for better elucidation, so that cannabinoids can be recommended as a safe and effective treatment in psoriasis.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-18
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/34651
10.33448/rsd-v11i11.34651
url https://rsdjournal.org/index.php/rsd/article/view/34651
identifier_str_mv 10.33448/rsd-v11i11.34651
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/34651/29191
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 11; e450111134651
Research, Society and Development; Vol. 11 Núm. 11; e450111134651
Research, Society and Development; v. 11 n. 11; e450111134651
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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