Quality control of effervescent vitamin C tablets sold in the city of Manaus - AM

Detalhes bibliográficos
Autor(a) principal: Melo, Nadia Gomes Mendes
Data de Publicação: 2021
Outros Autores: Maia, Alexandra Galvão, Dantas, Larissa Oliveira, Souza, Ruth Pimentel de, Penafort, Lucilane Maria, Souza, Gabriel Oliveira de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/23487
Resumo: Vitamin C effervescent tablets have been the most used pharmaceutical form in recent times due to its effervescent pharmaceutical form. In addition to the fact that studies show its properties in fighting free radicals as well as strengthening the immune system. With that in mind, this article aimed to analyze 5 effervescent vitamin C tablets, in order to verify if the same standards of quality standards required by Organs responsible bodies. The parameters followed standardized methodology by the substance monograph according to the Brazilian Pharmacopoeia, 6th edition, being physical-chemical determination of pH, friability, average weight and acidity content using the Balentine method by titration. Analyzes were performed in triplicate for greater confidence in the results. After analyzing the data, it was found that sample A did not meet the basic parameters recommended by law, failing the friability test. After the analyses, it was concluded that as they obtained satisfactory results, except for sample A, which failed the friability test, average weight and, most importantly, the dosage test, where it did not reach the 90% restore required by the monograph. The others meet the recommended criteria. Quality control jobs provide a very important tool in relation to the quality of products consumed, protecting the consumer and helping to improve the quality controls of products in the market.
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spelling Quality control of effervescent vitamin C tablets sold in the city of Manaus - AMControl de calidad de tabletas efervescentes de vitamina C comercializadas en la ciudad de Manaus – AMControle de qualidade de comprimidos efervescentes de vitamina C comercializados no município de Manaus - AM Ácido ascórbicoControl de calidadVitamina CDosisBalentine.Ascorbic acidQuality controlVitamin CDosageBalentine.Ácido ascórbicoControle de qualidadeVitamina CDoseamentoBalentine.Vitamin C effervescent tablets have been the most used pharmaceutical form in recent times due to its effervescent pharmaceutical form. In addition to the fact that studies show its properties in fighting free radicals as well as strengthening the immune system. With that in mind, this article aimed to analyze 5 effervescent vitamin C tablets, in order to verify if the same standards of quality standards required by Organs responsible bodies. The parameters followed standardized methodology by the substance monograph according to the Brazilian Pharmacopoeia, 6th edition, being physical-chemical determination of pH, friability, average weight and acidity content using the Balentine method by titration. Analyzes were performed in triplicate for greater confidence in the results. After analyzing the data, it was found that sample A did not meet the basic parameters recommended by law, failing the friability test. After the analyses, it was concluded that as they obtained satisfactory results, except for sample A, which failed the friability test, average weight and, most importantly, the dosage test, where it did not reach the 90% restore required by the monograph. The others meet the recommended criteria. Quality control jobs provide a very important tool in relation to the quality of products consumed, protecting the consumer and helping to improve the quality controls of products in the market.Los comprimidos efervescentes de vitamina C han sido la forma farmacéutica más utilizada en los últimos tiempos debido a su forma farmacéutica efervescente. Además de que los estudios demuestran sus propiedades en la lucha contra los radicales libres, así como en el fortalecimiento del sistema inmunológico. Con eso en mente, este artículo tuvo como objetivo analizar 5 tabletas efervescentes de vitamina C, con el fin de verificar si los mismos estándares de calidad exigidos por los órganos responsables. Los parámetros siguieron la metodología estandarizada por la monografía de sustancias según la Farmacopea Brasileña, 6ª edición, siendo la determinación físico-química del pH, friabilidad, peso promedio y contenido de acidez mediante el método Balentine por titulación. Los análisis se realizaron por triplicado para mayor confianza en los resultados. Luego de analizar los datos, se encontró que la muestra A no cumplía con los parámetros básicos recomendados por la ley, fallando la prueba de friabilidad. Luego de los análisis, se concluyó que como se obtuvieron resultados satisfactorios, a excepción de la muestra A, que no pasó la prueba de friabilidad, peso promedio y, lo más importante, la prueba de dosificación, donde no alcanzó el 90% de restauración requerido por la monografía. Los demás cumplen los criterios recomendados. Los trabajos de control de calidad proporcionan una herramienta muy importante en relación a la calidad de los productos consumidos, protegiendo al consumidor y ayudando a mejorar los controles de calidad de los productos en el mercado.Os comprimidos efervescentes de vitamina C tem sido a forma farmacêutica mais utilizada nos últimos tempos devido sua forma farmacêutica efervescente. Além do fato dos estudos apontarem suas propriedades no combate a radicais livres bem como fortalecimento do sistema imunológico. Pensando nisso, esse artigo teve como objetivo analisar 5 amostras de comprimidos efervescentes de vitamina C, a fim de verificar se os mesmos seguem os padrões de qualidades exigidas pelos órgãos responsáveis. Os parâmetros seguiram metodologia padronizada pela monografia da substância de acordo com a Farmacopeia Brasileira, 6º edição, sendo determinação físico-química do pH, de friabilidade, peso médio e o Teor de acidez usando o método Balentine por titulação. As análises foram realizadas em triplicata para maior confiabilidade dos resultados. Verificou-se após análise dos dados que a amostra A não atendeu aos parâmetros básicos preconizados pela legislação, sendo reprovada no teste de friabilidade. Após as análises, concluiu-se que as amostras obtiveram resultados satisfatórios com exceção da amostra A que foi reprovada no teste de friabilidade, peso médio e o mais importante no teste de doseamento, onde não alcançou os 90% mínimos exigidos pela monografia. As demais amostras atenderam aos critérios preconizados. Trabalhos de controle de qualidade fornecem uma ferramenta muito importante em relação a qualidade dos produtos consumidos, protegendo o consumidor e ajudando no aperfeiçoamento dos controles de qualidades dos produtos no mercado.Research, Society and Development2021-11-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2348710.33448/rsd-v10i15.23487Research, Society and Development; Vol. 10 No. 15; e586101523487Research, Society and Development; Vol. 10 Núm. 15; e586101523487Research, Society and Development; v. 10 n. 15; e5861015234872525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/23487/20485Copyright (c) 2021 Nadia Gomes Mendes Melo; Alexandra Galvão Maia; Larissa Oliveira Dantas; Ruth Pimentel de Souza; Lucilane Maria Penafort; Gabriel Oliveira de Souzahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMelo, Nadia Gomes Mendes Maia, Alexandra Galvão Dantas, Larissa Oliveira Souza, Ruth Pimentel dePenafort, Lucilane Maria Souza, Gabriel Oliveira de 2021-12-06T10:13:53Zoai:ojs.pkp.sfu.ca:article/23487Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:42:20.532561Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Quality control of effervescent vitamin C tablets sold in the city of Manaus - AM
Control de calidad de tabletas efervescentes de vitamina C comercializadas en la ciudad de Manaus – AM
Controle de qualidade de comprimidos efervescentes de vitamina C comercializados no município de Manaus - AM
title Quality control of effervescent vitamin C tablets sold in the city of Manaus - AM
spellingShingle Quality control of effervescent vitamin C tablets sold in the city of Manaus - AM
Melo, Nadia Gomes Mendes
Ácido ascórbico
Control de calidad
Vitamina C
Dosis
Balentine.
Ascorbic acid
Quality control
Vitamin C
Dosage
Balentine.
Ácido ascórbico
Controle de qualidade
Vitamina C
Doseamento
Balentine.
title_short Quality control of effervescent vitamin C tablets sold in the city of Manaus - AM
title_full Quality control of effervescent vitamin C tablets sold in the city of Manaus - AM
title_fullStr Quality control of effervescent vitamin C tablets sold in the city of Manaus - AM
title_full_unstemmed Quality control of effervescent vitamin C tablets sold in the city of Manaus - AM
title_sort Quality control of effervescent vitamin C tablets sold in the city of Manaus - AM
author Melo, Nadia Gomes Mendes
author_facet Melo, Nadia Gomes Mendes
Maia, Alexandra Galvão
Dantas, Larissa Oliveira
Souza, Ruth Pimentel de
Penafort, Lucilane Maria
Souza, Gabriel Oliveira de
author_role author
author2 Maia, Alexandra Galvão
Dantas, Larissa Oliveira
Souza, Ruth Pimentel de
Penafort, Lucilane Maria
Souza, Gabriel Oliveira de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Melo, Nadia Gomes Mendes
Maia, Alexandra Galvão
Dantas, Larissa Oliveira
Souza, Ruth Pimentel de
Penafort, Lucilane Maria
Souza, Gabriel Oliveira de
dc.subject.por.fl_str_mv Ácido ascórbico
Control de calidad
Vitamina C
Dosis
Balentine.
Ascorbic acid
Quality control
Vitamin C
Dosage
Balentine.
Ácido ascórbico
Controle de qualidade
Vitamina C
Doseamento
Balentine.
topic Ácido ascórbico
Control de calidad
Vitamina C
Dosis
Balentine.
Ascorbic acid
Quality control
Vitamin C
Dosage
Balentine.
Ácido ascórbico
Controle de qualidade
Vitamina C
Doseamento
Balentine.
description Vitamin C effervescent tablets have been the most used pharmaceutical form in recent times due to its effervescent pharmaceutical form. In addition to the fact that studies show its properties in fighting free radicals as well as strengthening the immune system. With that in mind, this article aimed to analyze 5 effervescent vitamin C tablets, in order to verify if the same standards of quality standards required by Organs responsible bodies. The parameters followed standardized methodology by the substance monograph according to the Brazilian Pharmacopoeia, 6th edition, being physical-chemical determination of pH, friability, average weight and acidity content using the Balentine method by titration. Analyzes were performed in triplicate for greater confidence in the results. After analyzing the data, it was found that sample A did not meet the basic parameters recommended by law, failing the friability test. After the analyses, it was concluded that as they obtained satisfactory results, except for sample A, which failed the friability test, average weight and, most importantly, the dosage test, where it did not reach the 90% restore required by the monograph. The others meet the recommended criteria. Quality control jobs provide a very important tool in relation to the quality of products consumed, protecting the consumer and helping to improve the quality controls of products in the market.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/23487
10.33448/rsd-v10i15.23487
url https://rsdjournal.org/index.php/rsd/article/view/23487
identifier_str_mv 10.33448/rsd-v10i15.23487
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/23487/20485
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 15; e586101523487
Research, Society and Development; Vol. 10 Núm. 15; e586101523487
Research, Society and Development; v. 10 n. 15; e586101523487
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052834549596160

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