Body development and serum parameters of sprague-dawley rats fed a diet enriched with hydrogenated vegetable fat and sugar

Detalhes bibliográficos
Autor(a) principal: Corrêa, Mariely Simone Lopes
Data de Publicação: 2021
Outros Autores: Souza, Anna Luiza, Naves, Luciana de Paula, Silva, Danielly Beraldo dos Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/15325
Resumo: Hypercaloric and hyperlipidic diets are often used in obesity research to induce excess weight and dyslipidemia in rats. In this experiment, Sprague-Dawley rats received a hypercaloric diet that was enriched with hydrogenated vegetable fat and sugar but hypoproteic and nutrient deficient. The rats’ body development and serum parameters were evaluated. Nine rats were fed a standard diet, while 27 rats were fed a hypercaloric diet prepared by substituting 15% of the standard diet with hydrogenated vegetable fat and 10% with sugar. Feed and water were provided ad libitum for 63 days. Between 35 and 98 days of age, the rats’ naso-anal length, body weight, and Lee index were measured weekly. At the end of the experimental period, blood samples were obtained to determine the serum levels of total cholesterol, triacylglycerol, and glucose. It was observed that the rats fed the hypercaloric diet containing hydrogenated vegetable fat and sugar exhibited less body development and did not develop either dyslipidemia or obesity although they exhibited increased serum glucose concentration.
id UNIFEI_d038a2369e9978e681266a6866732b11
oai_identifier_str oai:ojs.pkp.sfu.ca:article/15325
network_acronym_str UNIFEI
network_name_str Research, Society and Development
repository_id_str
spelling Body development and serum parameters of sprague-dawley rats fed a diet enriched with hydrogenated vegetable fat and sugarDesarrollo corporal y serios parámetros de las ratas sprague-dawley que alimentan una dieta enriquecida con grasas vegetales y azúcares hidrogenadasDesenvolvimento corporal e parâmetros séricos de ratos sprague-dawley alimentados uma dieta enriquecida com gordura hidrogenada de vegetais e açúcarGlucoseDietCholesterolTriglycerides.GlucosaDietaColesterolTriglicéridos.GlicoseDietaColesterolTriglicerídeos.Hypercaloric and hyperlipidic diets are often used in obesity research to induce excess weight and dyslipidemia in rats. In this experiment, Sprague-Dawley rats received a hypercaloric diet that was enriched with hydrogenated vegetable fat and sugar but hypoproteic and nutrient deficient. The rats’ body development and serum parameters were evaluated. Nine rats were fed a standard diet, while 27 rats were fed a hypercaloric diet prepared by substituting 15% of the standard diet with hydrogenated vegetable fat and 10% with sugar. Feed and water were provided ad libitum for 63 days. Between 35 and 98 days of age, the rats’ naso-anal length, body weight, and Lee index were measured weekly. At the end of the experimental period, blood samples were obtained to determine the serum levels of total cholesterol, triacylglycerol, and glucose. It was observed that the rats fed the hypercaloric diet containing hydrogenated vegetable fat and sugar exhibited less body development and did not develop either dyslipidemia or obesity although they exhibited increased serum glucose concentration.Las dietas hipercalóricas e hiperlipídicas se utilizan a menudo en la investigación sobre la obesidad para inducir sobrepeso y dislipidemia en ratas. En este experimento, las ratas Sprague-Dawley recibieron una dieta alta en calorías que estaba enriquecida con grasa vegetal hidrogenada y azúcar, sin embargo, hipoproteica y deficiente en nutrientes. Se evaluaron el desarrollo corporal y los parámetros séricos de las ratas. Nueve ratas fueron alimentadas con una dieta estándar, mientras que 27 ratas fueron alimentadas con una dieta alta en calorías preparada reemplazando el 15% de la dieta estándar con grasa vegetal hidrogenada y el 10% con azúcar. Se proporcionó alimento y agua ad libitum durante 63 días. Entre los 35 y los 98 días de edad, se midieron semanalmente la longitud nasoanal de las ratas, el peso corporal y el índice de Lee. Al final del período experimental, se obtuvieron muestras de sangre para determinar los niveles séricos de colesterol total, triacilglicerol y glucosa. Se observó que las ratas alimentadas con la dieta alta en calorías que contenía grasas vegetales hidrogenadas y azúcar mostraron un menor desarrollo corporal y no desarrollaron ni dislipidemia ni obesidad, aunque sí mostraron un aumento en la concentración de glucosa sérica.Dietas hipercalóricas e hiperlipídicas são frequentemente utilizadas em pesquisas sobre obesidade para induzir excesso de peso e dislipidemia em ratos. Neste experimento, ratos Sprague-Dawley receberam uma dieta hipercalórica que foi enriquecida com gordura vegetal hidrogenada e açúcar, porém, hipoproteica e deficiente em nutrientes. O desenvolvimento corporal e parâmetros séricos dos ratos foram avaliados. Nove ratos foram alimentados com uma dieta padrão, enquanto 27 ratos foram alimentados com uma dieta hipercalórica preparada substituindo-se 15% da dieta padrão por gordura vegetal hidrogenada e 10% por açúcar. A ração e a água foram fornecidas ad libitum por 63 dias. Entre 35 e 98 dias de idade, o comprimento naso-anal dos ratos, o peso corporal e o índice de Lee foram medidos semanalmente. Ao final do período experimental, amostras de sangue foram obtidas para determinar os níveis séricos de colesterol total, triacilglicerol e glicose. Observou-se que os ratos alimentados com a dieta hipercalórica contendo gordura vegetal hidrogenada e açúcar apresentaram menor desenvolvimento corporal e não desenvolveram nem dislipidemia nem obesidade, embora tenham exibido aumento da concentração sérica de glicose.ude the abstract in PortugueseResearch, Society and Development2021-06-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1532510.33448/rsd-v10i7.15325Research, Society and Development; Vol. 10 No. 7; e43310715325Research, Society and Development; Vol. 10 Núm. 7; e43310715325Research, Society and Development; v. 10 n. 7; e433107153252525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/15325/20287Copyright (c) 2021 Mariely Simone Lopes Corrêa; Anna Luiza Souza; Luciana de Paula Naves; Danielly Beraldo dos Santos Silvahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCorrêa, Mariely Simone LopesSouza, Anna LuizaNaves, Luciana de Paula Silva, Danielly Beraldo dos Santos2021-07-18T21:07:03Zoai:ojs.pkp.sfu.ca:article/15325Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:36:10.733102Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Body development and serum parameters of sprague-dawley rats fed a diet enriched with hydrogenated vegetable fat and sugar
Desarrollo corporal y serios parámetros de las ratas sprague-dawley que alimentan una dieta enriquecida con grasas vegetales y azúcares hidrogenadas
Desenvolvimento corporal e parâmetros séricos de ratos sprague-dawley alimentados uma dieta enriquecida com gordura hidrogenada de vegetais e açúcar
title Body development and serum parameters of sprague-dawley rats fed a diet enriched with hydrogenated vegetable fat and sugar
spellingShingle Body development and serum parameters of sprague-dawley rats fed a diet enriched with hydrogenated vegetable fat and sugar
Corrêa, Mariely Simone Lopes
Glucose
Diet
Cholesterol
Triglycerides.
Glucosa
Dieta
Colesterol
Triglicéridos.
Glicose
Dieta
Colesterol
Triglicerídeos.
title_short Body development and serum parameters of sprague-dawley rats fed a diet enriched with hydrogenated vegetable fat and sugar
title_full Body development and serum parameters of sprague-dawley rats fed a diet enriched with hydrogenated vegetable fat and sugar
title_fullStr Body development and serum parameters of sprague-dawley rats fed a diet enriched with hydrogenated vegetable fat and sugar
title_full_unstemmed Body development and serum parameters of sprague-dawley rats fed a diet enriched with hydrogenated vegetable fat and sugar
title_sort Body development and serum parameters of sprague-dawley rats fed a diet enriched with hydrogenated vegetable fat and sugar
author Corrêa, Mariely Simone Lopes
author_facet Corrêa, Mariely Simone Lopes
Souza, Anna Luiza
Naves, Luciana de Paula
Silva, Danielly Beraldo dos Santos
author_role author
author2 Souza, Anna Luiza
Naves, Luciana de Paula
Silva, Danielly Beraldo dos Santos
author2_role author
author
author
dc.contributor.author.fl_str_mv Corrêa, Mariely Simone Lopes
Souza, Anna Luiza
Naves, Luciana de Paula
Silva, Danielly Beraldo dos Santos
dc.subject.por.fl_str_mv Glucose
Diet
Cholesterol
Triglycerides.
Glucosa
Dieta
Colesterol
Triglicéridos.
Glicose
Dieta
Colesterol
Triglicerídeos.
topic Glucose
Diet
Cholesterol
Triglycerides.
Glucosa
Dieta
Colesterol
Triglicéridos.
Glicose
Dieta
Colesterol
Triglicerídeos.
description Hypercaloric and hyperlipidic diets are often used in obesity research to induce excess weight and dyslipidemia in rats. In this experiment, Sprague-Dawley rats received a hypercaloric diet that was enriched with hydrogenated vegetable fat and sugar but hypoproteic and nutrient deficient. The rats’ body development and serum parameters were evaluated. Nine rats were fed a standard diet, while 27 rats were fed a hypercaloric diet prepared by substituting 15% of the standard diet with hydrogenated vegetable fat and 10% with sugar. Feed and water were provided ad libitum for 63 days. Between 35 and 98 days of age, the rats’ naso-anal length, body weight, and Lee index were measured weekly. At the end of the experimental period, blood samples were obtained to determine the serum levels of total cholesterol, triacylglycerol, and glucose. It was observed that the rats fed the hypercaloric diet containing hydrogenated vegetable fat and sugar exhibited less body development and did not develop either dyslipidemia or obesity although they exhibited increased serum glucose concentration.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/15325
10.33448/rsd-v10i7.15325
url https://rsdjournal.org/index.php/rsd/article/view/15325
identifier_str_mv 10.33448/rsd-v10i7.15325
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/15325/20287
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 7; e43310715325
Research, Society and Development; Vol. 10 Núm. 7; e43310715325
Research, Society and Development; v. 10 n. 7; e43310715325
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052785517133824

Registros relacionados