Profile of patients with cryptococcosis in a regional hospital in the interior of São Paulo
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/7642 |
Resumo: | Infections caused by Cryptococus spp. are opportunistic, urban, and associated with immunosuppression. Mortality is estimated at 10% in developed countries and 43% in emerging countries. The objective was to evaluate the clinical-epidemiological aspects of cryptococcosis in the region of western São Paulo. This is a cross-sectional study, based on information from the medical records of patients in a hospital in the interior of São Paulo from 2006 to 2018. Descriptive analysis was applied through absolute (n) and relative (%) frequency; and statistics through the x2 and Fisher's Exact tests. Relative Risk (RR) and Odds Ratio (OD) for death were also calculated. Neurocriptococcosis was the primary clinical manifestation of 64.50%. The direct search for CSF was positive in 85.71% of the samples, the immunodiagnosis in 93.80% and the culture, gold standard for fungus, in 55.55% of the cases. The x2 test and Fisher's exact test showed no difference between sex, age group, clinical form of death. RR and OD were considered low. The association of the epidemiological aspects of cryptococcosis with its clinical signs allows the early diagnosis of the disease, reducing severe conditions. Besides, high-performance antiretroviral therapies have dramatically decreased the occurrence of deaths in patients with HIV. |
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Profile of patients with cryptococcosis in a regional hospital in the interior of São PauloPerfil de pacientes con criptococosis en un hospital regional en el interior de São PauloPerfil de pacientes com criptococose em hospital regional do interior de São PauloCriptococoseHIVMuerteRiesgo RelativoOdds ratio.CriptococoseHIVÓbitosRisco RelativoOdds Ratio.HIVDeathRelative RiskCryptococcosisOdds ratio.Infections caused by Cryptococus spp. are opportunistic, urban, and associated with immunosuppression. Mortality is estimated at 10% in developed countries and 43% in emerging countries. The objective was to evaluate the clinical-epidemiological aspects of cryptococcosis in the region of western São Paulo. This is a cross-sectional study, based on information from the medical records of patients in a hospital in the interior of São Paulo from 2006 to 2018. Descriptive analysis was applied through absolute (n) and relative (%) frequency; and statistics through the x2 and Fisher's Exact tests. Relative Risk (RR) and Odds Ratio (OD) for death were also calculated. Neurocriptococcosis was the primary clinical manifestation of 64.50%. The direct search for CSF was positive in 85.71% of the samples, the immunodiagnosis in 93.80% and the culture, gold standard for fungus, in 55.55% of the cases. The x2 test and Fisher's exact test showed no difference between sex, age group, clinical form of death. RR and OD were considered low. The association of the epidemiological aspects of cryptococcosis with its clinical signs allows the early diagnosis of the disease, reducing severe conditions. Besides, high-performance antiretroviral therapies have dramatically decreased the occurrence of deaths in patients with HIV.Las infecciones causadas por Cryptococus spp. son oportunistas, urbanos y asociados con inmunosupresión. La mortalidad se estima en 10% en los países desarrollados y 43% en los países emergentes. El objetivo fue evaluar los aspectos clínico-epidemiológicos de la criptococosis en la región occidental de São Paulo. Este es un estudio transversal, basado en información de los registros médicos de pacientes en un hospital del interior de São Paulo, de 2006 a 2018. El análisis descriptivo se aplicó a través de la frecuencia absoluta (n) y relativa (%); y estadísticas a través de las pruebas x2 y Fisher's Exact. También se calcularon el riesgo relativo (RR) y el odds ratio (OD) para la muerte. La neurocriptococosis fue la principal manifestación clínica en el 64.50%. La búsqueda directa de LCR fue positiva en el 85,71% de las muestras, el inmunodiagnóstico en el 93,80% y el cultivo, patrón oro para hongos, en el 55,55% de los casos. La prueba x2 y la prueba exacta de Fisher no mostraron diferencias entresexo, grupo de edad, forma clínica o muerte. RR y OD se consideraron bajos. La asociación de los aspectos epidemiológicos de la criptococosis con sus signos clínicos permite el diagnóstico precoz de la enfermedad, reduciendo el desarrollo de afecciones graves. Además, las terapias antirretrovirales de alto rendimiento han disminuido drásticamente la aparición de muertes en pacientes con VIH.As infecções causadas por Cryptococus spp. são oportunistas, urbanas e associadas a imunossupressão. A mortalidade é estimada em 10% nos países desenvolvidos e 43% nos emergentes. O Objetivo foi avaliar os aspectos clínico-epidemiológicos da criptococose na região do oeste paulista. Trata-se de estudo transversal, baseado nas informações dos prontuários de pacientes em um hospital do interior de São Paulo, de 2006 a 2018. Aplicou-se análise descritiva por meio da frequência absoluta (n) e relativa (%); e estatística através dos testes x2 e Exato de Fisher. Também foi calculado Risco Relativo (RR) e Odds Ratio (OD) para óbito. A neurocriptococose foi a principal manifestação clínica em 64,50%. A pesquisa direta no líquor foi positiva em 85,71% das amostras, o imunodiagnóstico em 93,80% e a cultura, padrão-ouro para fungo, em 55,55% dos casos. O teste x2 e o Exato de Fisher não demonstraram diferença entre sexo, faixa etária, forma clínica ou óbito. RR e OD foram considerados baixos. A associação dos aspectos epidemiológicos da criptococose com seus sinais clínicos permite o diagnóstico precoce da doença, diminuindo o desenvolvimento de quadros graves. Além disso, as terapias antirretrovirais de alto desempenho diminuíram drasticamente a ocorrência de óbitos em pacientes com HIV.Research, Society and Development2020-08-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/764210.33448/rsd-v9i9.7642Research, Society and Development; Vol. 9 No. 9; e598997642Research, Society and Development; Vol. 9 Núm. 9; e598997642Research, Society and Development; v. 9 n. 9; e5989976422525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/7642/6792Copyright (c) 2020 Maikiane Aparecida Nascimento; Elorraine Coutinho Mathias Santos; Valéria Moura de Carvalho; Marielly Sousa Borges; João Pedro Brambilla Ederli; Camila Aparecida Nunes de Albuquerque; Savyla Franciele Soares Silva; Rosana Brambilla Ederli; Bruno Alexandre Soto Soto; Alexandre Martins Portelinha Filho; Daniela Vanessa Morishttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessNascimento, Maikiane AparecidaSantos, Elorraine Coutinho Mathias Carvalho, Valéria Moura deBorges, Marielly Sousa Ederli, João Pedro Brambilla Albuquerque, Camila Aparecida Nunes de Silva, Savyla Franciele Soares Ederli, Rosana Brambilla Soto, Bruno Alexandre Soto Portelinha Filho, Alexandre Martins Moris, Daniela Vanessa 2020-09-18T01:42:11Zoai:ojs.pkp.sfu.ca:article/7642Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:30:18.394720Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Profile of patients with cryptococcosis in a regional hospital in the interior of São Paulo Perfil de pacientes con criptococosis en un hospital regional en el interior de São Paulo Perfil de pacientes com criptococose em hospital regional do interior de São Paulo |
title |
Profile of patients with cryptococcosis in a regional hospital in the interior of São Paulo |
spellingShingle |
Profile of patients with cryptococcosis in a regional hospital in the interior of São Paulo Nascimento, Maikiane Aparecida Criptococose HIV Muerte Riesgo Relativo Odds ratio. Criptococose HIV Óbitos Risco Relativo Odds Ratio. HIV Death Relative Risk Cryptococcosis Odds ratio. |
title_short |
Profile of patients with cryptococcosis in a regional hospital in the interior of São Paulo |
title_full |
Profile of patients with cryptococcosis in a regional hospital in the interior of São Paulo |
title_fullStr |
Profile of patients with cryptococcosis in a regional hospital in the interior of São Paulo |
title_full_unstemmed |
Profile of patients with cryptococcosis in a regional hospital in the interior of São Paulo |
title_sort |
Profile of patients with cryptococcosis in a regional hospital in the interior of São Paulo |
author |
Nascimento, Maikiane Aparecida |
author_facet |
Nascimento, Maikiane Aparecida Santos, Elorraine Coutinho Mathias Carvalho, Valéria Moura de Borges, Marielly Sousa Ederli, João Pedro Brambilla Albuquerque, Camila Aparecida Nunes de Silva, Savyla Franciele Soares Ederli, Rosana Brambilla Soto, Bruno Alexandre Soto Portelinha Filho, Alexandre Martins Moris, Daniela Vanessa |
author_role |
author |
author2 |
Santos, Elorraine Coutinho Mathias Carvalho, Valéria Moura de Borges, Marielly Sousa Ederli, João Pedro Brambilla Albuquerque, Camila Aparecida Nunes de Silva, Savyla Franciele Soares Ederli, Rosana Brambilla Soto, Bruno Alexandre Soto Portelinha Filho, Alexandre Martins Moris, Daniela Vanessa |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nascimento, Maikiane Aparecida Santos, Elorraine Coutinho Mathias Carvalho, Valéria Moura de Borges, Marielly Sousa Ederli, João Pedro Brambilla Albuquerque, Camila Aparecida Nunes de Silva, Savyla Franciele Soares Ederli, Rosana Brambilla Soto, Bruno Alexandre Soto Portelinha Filho, Alexandre Martins Moris, Daniela Vanessa |
dc.subject.por.fl_str_mv |
Criptococose HIV Muerte Riesgo Relativo Odds ratio. Criptococose HIV Óbitos Risco Relativo Odds Ratio. HIV Death Relative Risk Cryptococcosis Odds ratio. |
topic |
Criptococose HIV Muerte Riesgo Relativo Odds ratio. Criptococose HIV Óbitos Risco Relativo Odds Ratio. HIV Death Relative Risk Cryptococcosis Odds ratio. |
description |
Infections caused by Cryptococus spp. are opportunistic, urban, and associated with immunosuppression. Mortality is estimated at 10% in developed countries and 43% in emerging countries. The objective was to evaluate the clinical-epidemiological aspects of cryptococcosis in the region of western São Paulo. This is a cross-sectional study, based on information from the medical records of patients in a hospital in the interior of São Paulo from 2006 to 2018. Descriptive analysis was applied through absolute (n) and relative (%) frequency; and statistics through the x2 and Fisher's Exact tests. Relative Risk (RR) and Odds Ratio (OD) for death were also calculated. Neurocriptococcosis was the primary clinical manifestation of 64.50%. The direct search for CSF was positive in 85.71% of the samples, the immunodiagnosis in 93.80% and the culture, gold standard for fungus, in 55.55% of the cases. The x2 test and Fisher's exact test showed no difference between sex, age group, clinical form of death. RR and OD were considered low. The association of the epidemiological aspects of cryptococcosis with its clinical signs allows the early diagnosis of the disease, reducing severe conditions. Besides, high-performance antiretroviral therapies have dramatically decreased the occurrence of deaths in patients with HIV. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/7642 10.33448/rsd-v9i9.7642 |
url |
https://rsdjournal.org/index.php/rsd/article/view/7642 |
identifier_str_mv |
10.33448/rsd-v9i9.7642 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/7642/6792 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 9; e598997642 Research, Society and Development; Vol. 9 Núm. 9; e598997642 Research, Society and Development; v. 9 n. 9; e598997642 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052739730014208 |