Multiple Endocrine Neoplasia Type 1: A case report

Detalhes bibliográficos
Autor(a) principal: Fortes, Yasmine Maria Leódido
Data de Publicação: 2021
Outros Autores: Fontenelle, Gustavo Eduardo Pires, Erudilho, Eduardo, Zamignan, Reno Leite, Bergamini, Bárbara Raveena Diniz, Almeida, Rebeca Matos de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/14834
Resumo: Objective: To discuss about a rare case of type 1 multiple endocrine neoplasia and discuss issues related to the importance of early diagnosis. Methods: Information provided through medical record review, interview with the patient, photographic record of the exams to which the patient was submitted. Case report: Female, 60 years old, previous history of secondary amenorrhea since she was 18 years old. At the time, stylist gynecologist, in which hyperprolactinemia was verified and bromocriptine was prescribed. She remained without endocrinological follow-up for approximately forty years, when she was referred for specialized consultation. In consultation, hyperprolactinemia, hypercalcemia and elevated PTH were observed. In addition to imaging exams with pituitary microadenoma, thyroid, pancreatic and adrenal nodules. With the clinical diagnosis of NEM1, the patient and some family members are currently being called upon to collect genetic material for analysis and detection of the mutation profile. Conclusion: It was possible to conclude that Multiple Endocrine Neoplasia Type 1, if not diagnosed at the beginning, can cause important hormonal syndromes, just as it is important to be considered among the differential diagnoses.
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spelling Multiple Endocrine Neoplasia Type 1: A case reportNeoplasia Endocrina Múltiple Tipo 1: Informe de un casoNeoplasia Endócrina Múltipla Tipo 1: Um relato de caso HiperparatireoidismoNeoplasia Endócrina Múltipla Tipo 1Hiperprolactinemia.HiperparatiroidismoNeoplasia Endocrina Múltiple Tipo 1Hiperprolactinemia.HyperparathyroidismMultiple Endocrine Neoplasia Type 1Hyperprolactinemia.Objective: To discuss about a rare case of type 1 multiple endocrine neoplasia and discuss issues related to the importance of early diagnosis. Methods: Information provided through medical record review, interview with the patient, photographic record of the exams to which the patient was submitted. Case report: Female, 60 years old, previous history of secondary amenorrhea since she was 18 years old. At the time, stylist gynecologist, in which hyperprolactinemia was verified and bromocriptine was prescribed. She remained without endocrinological follow-up for approximately forty years, when she was referred for specialized consultation. In consultation, hyperprolactinemia, hypercalcemia and elevated PTH were observed. In addition to imaging exams with pituitary microadenoma, thyroid, pancreatic and adrenal nodules. With the clinical diagnosis of NEM1, the patient and some family members are currently being called upon to collect genetic material for analysis and detection of the mutation profile. Conclusion: It was possible to conclude that Multiple Endocrine Neoplasia Type 1, if not diagnosed at the beginning, can cause important hormonal syndromes, just as it is important to be considered among the differential diagnoses.Objetivo: Discutir sobre un caso raro de neoplasia endocrina múltiple tipo 1 y discutir temas relacionados con la importancia del diagnóstico precoz. Métodos: Información aportada mediante revisión de historia clínica, entrevista con el paciente, registro fotográfico de los exámenes a los que se sometió el paciente. Informe de un caso: Mujer de 60 años, antecedente de amenorrea secundaria desde los 18 años. En ese momento, ginecólogo estilista, en el que se verificó hiperprolactinemia y se prescribió bromocriptina. Permaneció sin seguimiento endocrinológico durante aproximadamente cuarenta años, cuando fue remitida para consulta especializada. En consulta se observó hiperprolactinemia, hipercalcemia y elevación de PTH. Además de los exámenes por imágenes con microadenoma hipofisario, nódulos tiroideos, pancreáticos y suprarrenales. Con el diagnóstico clínico de NEM1, el paciente y algunos familiares están siendo llamados a recolectar material genético para el análisis y detección del perfil de mutación. Conclusión: Se pudo concluir que la Neoplasia Endocrina Múltiple Tipo 1, si no se diagnostica al inicio, puede ocasionar importantes síndromes hormonales, así como es importante ser considerada entre los diagnósticos diferenciales.Objetivo: Discorrer a cerca de um caso de rara ocorrência de neoplasia endócrina múltipla tipo 1 e discutir aspectos relacionados à importância do diagnóstico precoce. Métodos: Informações obtidas por vias de revisão do prontuário, entrevista com o paciente, registro fotográfico dos exames aos quais o paciente foi submetido. Relato de caso: Mulher, 60 anos, história pregressa de amenorreia secundária desde os 18 anos.  À época, procurou ginecologista, no qual foi verificado hiperprolactinemia e prescrito bromocriptina. Ficou sem acompanhamento endocrinológico por aproximadamente quarenta anos, quando foi encaminhada para consulta especializada. Em consulta, observado hiperprolactinemia, hipercalcemia e PTH elevado. Além de exames de imagem com microadenoma hipofisário, nódulos na tireoide, pancreáticos e adrenais. Já com o diagnóstico clínico de NEM1, atualmente a paciente e alguns familiares estão sendo convocados para coleta de material genético para análise e provável detecção de perfil de mutação. Considerações finais: Foi possível concluir que o NEM-1 se não diagnosticado no início pode causar síndromes hormonais importantes, assim como é importante considerá-la dentre os diagnósticos diferenciais.Research, Society and Development2021-06-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1483410.33448/rsd-v10i6.14834Research, Society and Development; Vol. 10 No. 6; e36210614834Research, Society and Development; Vol. 10 Núm. 6; e36210614834Research, Society and Development; v. 10 n. 6; e362106148342525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/14834/14195Copyright (c) 2021 Yasmine Maria Leódido Fortes; Gustavo Eduardo Pires Fontenelle; Eduardo Erudilho; Reno Leite Zamignan; Bárbara Raveena Diniz Bergamini; Rebeca Matos de Almeidahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFortes, Yasmine Maria Leódido Fontenelle, Gustavo Eduardo Pires Erudilho, EduardoZamignan, Reno Leite Bergamini, Bárbara Raveena Diniz Almeida, Rebeca Matos de 2021-06-10T22:51:46Zoai:ojs.pkp.sfu.ca:article/14834Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:35:49.630765Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Multiple Endocrine Neoplasia Type 1: A case report
Neoplasia Endocrina Múltiple Tipo 1: Informe de un caso
Neoplasia Endócrina Múltipla Tipo 1: Um relato de caso
title Multiple Endocrine Neoplasia Type 1: A case report
spellingShingle Multiple Endocrine Neoplasia Type 1: A case report
Fortes, Yasmine Maria Leódido
Hiperparatireoidismo
Neoplasia Endócrina Múltipla Tipo 1
Hiperprolactinemia.
Hiperparatiroidismo
Neoplasia Endocrina Múltiple Tipo 1
Hiperprolactinemia.
Hyperparathyroidism
Multiple Endocrine Neoplasia Type 1
Hyperprolactinemia.
title_short Multiple Endocrine Neoplasia Type 1: A case report
title_full Multiple Endocrine Neoplasia Type 1: A case report
title_fullStr Multiple Endocrine Neoplasia Type 1: A case report
title_full_unstemmed Multiple Endocrine Neoplasia Type 1: A case report
title_sort Multiple Endocrine Neoplasia Type 1: A case report
author Fortes, Yasmine Maria Leódido
author_facet Fortes, Yasmine Maria Leódido
Fontenelle, Gustavo Eduardo Pires
Erudilho, Eduardo
Zamignan, Reno Leite
Bergamini, Bárbara Raveena Diniz
Almeida, Rebeca Matos de
author_role author
author2 Fontenelle, Gustavo Eduardo Pires
Erudilho, Eduardo
Zamignan, Reno Leite
Bergamini, Bárbara Raveena Diniz
Almeida, Rebeca Matos de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Fortes, Yasmine Maria Leódido
Fontenelle, Gustavo Eduardo Pires
Erudilho, Eduardo
Zamignan, Reno Leite
Bergamini, Bárbara Raveena Diniz
Almeida, Rebeca Matos de
dc.subject.por.fl_str_mv Hiperparatireoidismo
Neoplasia Endócrina Múltipla Tipo 1
Hiperprolactinemia.
Hiperparatiroidismo
Neoplasia Endocrina Múltiple Tipo 1
Hiperprolactinemia.
Hyperparathyroidism
Multiple Endocrine Neoplasia Type 1
Hyperprolactinemia.
topic Hiperparatireoidismo
Neoplasia Endócrina Múltipla Tipo 1
Hiperprolactinemia.
Hiperparatiroidismo
Neoplasia Endocrina Múltiple Tipo 1
Hiperprolactinemia.
Hyperparathyroidism
Multiple Endocrine Neoplasia Type 1
Hyperprolactinemia.
description Objective: To discuss about a rare case of type 1 multiple endocrine neoplasia and discuss issues related to the importance of early diagnosis. Methods: Information provided through medical record review, interview with the patient, photographic record of the exams to which the patient was submitted. Case report: Female, 60 years old, previous history of secondary amenorrhea since she was 18 years old. At the time, stylist gynecologist, in which hyperprolactinemia was verified and bromocriptine was prescribed. She remained without endocrinological follow-up for approximately forty years, when she was referred for specialized consultation. In consultation, hyperprolactinemia, hypercalcemia and elevated PTH were observed. In addition to imaging exams with pituitary microadenoma, thyroid, pancreatic and adrenal nodules. With the clinical diagnosis of NEM1, the patient and some family members are currently being called upon to collect genetic material for analysis and detection of the mutation profile. Conclusion: It was possible to conclude that Multiple Endocrine Neoplasia Type 1, if not diagnosed at the beginning, can cause important hormonal syndromes, just as it is important to be considered among the differential diagnoses.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14834
10.33448/rsd-v10i6.14834
url https://rsdjournal.org/index.php/rsd/article/view/14834
identifier_str_mv 10.33448/rsd-v10i6.14834
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14834/14195
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 6; e36210614834
Research, Society and Development; Vol. 10 Núm. 6; e36210614834
Research, Society and Development; v. 10 n. 6; e36210614834
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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