The role of type 2 Diabetes mellitus as a risk factor for Alzheimer's and Parkinson's diseases

Detalhes bibliográficos
Autor(a) principal: Rocha, Kellen Mariane Athaide
Data de Publicação: 2021
Outros Autores: Goulart, Aline da Silva, Costa, Márcio Tavares, Salgueiro, Andréia Caroline Fernandes, Folmer, Vanderlei
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/11673
Resumo: Currently, one of the most significant health problems is the increased incidence of obesity and type 2 Diabetes mellitus (DM2). The most recent epidemiological and clinical research studies have indicated that low physical activity, as well as many genetic and environmental factors are the main causes of these metabolic disorders. It is widely recognized that insulin resistance plays a key role in the development of DM2, disrupting not only the functioning of peripheral tissues, but also the brain. Insulin plays a critical role in the central nervous system participating in neuronal survival, neuroplasticity, memory and cognitive functions. In addition, peripheral insulin resistance results in loss of brain function, which indicates a strong relationship between metabolic disorders, cognitive impairment and the emergence of neurodegenerative diseases. There are links between these different pathologies, such as increased oxidative stress, neuroinflammation, changes in glucose metabolism as well as insulin resistance. Advances in the knowledge of these links may contribute to the development of treatments for the prevention of these pathological events. Based on the above, this study aimed to review the mechanisms associated with DM2 in the development of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases.
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spelling The role of type 2 Diabetes mellitus as a risk factor for Alzheimer's and Parkinson's diseasesEl papel de la Diabetes mellitus tipo 2 como factor de riesgo de las Enfermedades de Alzheimer y ParkinsonO papel do Diabetes mellitus tipo 2 como fator de risco para as Doenças de Alzheimer e ParkinsonNeurodegeneración, diabetes mellitus tipo 2, resistencia a la insulina, estrés oxidativo, neuroinflamación, hiperglucemia, cerebro.NeurodegeneraçãoDiabetes mellitus tipo 2Resistência à insulinaEstresse oxidativoNeuroinflamaçãoHiperglicemiaCérebro.NeurodegenerationType 2 diabetes mellitusInsulin resistanceOxidative stressNeuroinflammationHyperglycemiaBrain.Currently, one of the most significant health problems is the increased incidence of obesity and type 2 Diabetes mellitus (DM2). The most recent epidemiological and clinical research studies have indicated that low physical activity, as well as many genetic and environmental factors are the main causes of these metabolic disorders. It is widely recognized that insulin resistance plays a key role in the development of DM2, disrupting not only the functioning of peripheral tissues, but also the brain. Insulin plays a critical role in the central nervous system participating in neuronal survival, neuroplasticity, memory and cognitive functions. In addition, peripheral insulin resistance results in loss of brain function, which indicates a strong relationship between metabolic disorders, cognitive impairment and the emergence of neurodegenerative diseases. There are links between these different pathologies, such as increased oxidative stress, neuroinflammation, changes in glucose metabolism as well as insulin resistance. Advances in the knowledge of these links may contribute to the development of treatments for the prevention of these pathological events. Based on the above, this study aimed to review the mechanisms associated with DM2 in the development of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases.Actualmente, uno de los problemas de salud más importantes es el aumento de la incidencia de obesidad y Diabetes mellitus tipo 2 (DM2). Los estudios epidemiológicos y clínicos más recientes indican que la baja actividad física, así como muchos factores genéticos y ambientales, son las principales causas de estos trastornos metabólicos. Es ampliamente reconocido que la resistencia a la insulina juega un papel clave en el desarrollo de DM2, alterando no solo el funcionamiento de los tejidos periféricos, sino también el cerebro. La insulina juega un papel fundamental en el sistema nervioso central, participando en la supervivencia neuronal, neuroplasticidad, memoria y funciones cognitivas. Además, la resistencia a la insulina periférica da como resultado la pérdida de la función cerebral, lo que indica una fuerte relación entre los trastornos metabólicos, el deterioro cognitivo y la aparición de enfermedades neurodegenerativas. Existen vínculos entre estas diferentes patologías, como aumento del estrés oxidativo, neuroinflamación, cambios en el metabolismo de la glucosa y también resistencia a la insulina. Los avances en el conocimiento de estos vínculos pueden contribuir al desarrollo de tratamientos para la prevención de estos eventos patológicos. Con base en lo anterior, este estudio tuvo como objetivo revisar los mecanismos asociados a la DM2 en el desarrollo de enfermedades neurodegenerativas, como la Enfermedad de Alzheimer y Enfermedad de Parkinson.Atualmente, um dos problemas de saúde mais significativos é o aumento da incidência de obesidade e Diabetes mellitus tipo 2 (DM2). Os estudos epidemiológicos e clínicos mais recentes indicam que a baixa atividade física, assim como muitos fatores genéticos e ambientais, são as principais causas desses distúrbios metabólicos. É amplamente reconhecido que a resistência à insulina desempenha um papel fundamental no desenvolvimento do DM2, interrompendo não apenas o funcionamento dos tecidos periféricos, mas também do cérebro. A insulina desempenha um papel crítico no sistema nervoso central, participando da sobrevivência neuronal, neuroplasticidade, memória e funções cognitivas. Além disso, a resistência periférica à insulina resulta em perda da função cerebral, o que indica uma forte relação entre distúrbios metabólicos, comprometimento cognitivo e o surgimento de doenças neurodegenerativas. Existem ligações entre essas diferentes patologias, como aumento do estresse oxidativo, neuroinflamação, alterações no metabolismo da glicose e também resistência à insulina. Avanços no conhecimento dessas ligações podem contribuir para o desenvolvimento de tratamentos para a prevenção desses eventos patológicos. Com base no exposto, este estudo teve como objetivo revisar os mecanismos associados ao DM2 no desenvolvimento de doenças neurodegenerativas, como Doença de Alzheimer e Doença de Parkinson.Research, Society and Development2021-01-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1167310.33448/rsd-v10i1.11673Research, Society and Development; Vol. 10 No. 1; e23410111673Research, Society and Development; Vol. 10 Núm. 1; e23410111673Research, Society and Development; v. 10 n. 1; e234101116732525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/11673/10449Copyright (c) 2021 Kellen Mariane Athaide Rocha; Aline da Silva Goulart; Márcio Tavares Costa; Andréia Caroline Fernandes Salgueiro; Vanderlei Folmerhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRocha, Kellen Mariane Athaide Goulart, Aline da SilvaCosta, Márcio TavaresSalgueiro, Andréia Caroline Fernandes Folmer, Vanderlei2021-02-20T21:19:23Zoai:ojs.pkp.sfu.ca:article/11673Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:33:25.698684Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv The role of type 2 Diabetes mellitus as a risk factor for Alzheimer's and Parkinson's diseases
El papel de la Diabetes mellitus tipo 2 como factor de riesgo de las Enfermedades de Alzheimer y Parkinson
O papel do Diabetes mellitus tipo 2 como fator de risco para as Doenças de Alzheimer e Parkinson
title The role of type 2 Diabetes mellitus as a risk factor for Alzheimer's and Parkinson's diseases
spellingShingle The role of type 2 Diabetes mellitus as a risk factor for Alzheimer's and Parkinson's diseases
Rocha, Kellen Mariane Athaide
Neurodegeneración, diabetes mellitus tipo 2, resistencia a la insulina, estrés oxidativo, neuroinflamación, hiperglucemia, cerebro.
Neurodegeneração
Diabetes mellitus tipo 2
Resistência à insulina
Estresse oxidativo
Neuroinflamação
Hiperglicemia
Cérebro.
Neurodegeneration
Type 2 diabetes mellitus
Insulin resistance
Oxidative stress
Neuroinflammation
Hyperglycemia
Brain.
title_short The role of type 2 Diabetes mellitus as a risk factor for Alzheimer's and Parkinson's diseases
title_full The role of type 2 Diabetes mellitus as a risk factor for Alzheimer's and Parkinson's diseases
title_fullStr The role of type 2 Diabetes mellitus as a risk factor for Alzheimer's and Parkinson's diseases
title_full_unstemmed The role of type 2 Diabetes mellitus as a risk factor for Alzheimer's and Parkinson's diseases
title_sort The role of type 2 Diabetes mellitus as a risk factor for Alzheimer's and Parkinson's diseases
author Rocha, Kellen Mariane Athaide
author_facet Rocha, Kellen Mariane Athaide
Goulart, Aline da Silva
Costa, Márcio Tavares
Salgueiro, Andréia Caroline Fernandes
Folmer, Vanderlei
author_role author
author2 Goulart, Aline da Silva
Costa, Márcio Tavares
Salgueiro, Andréia Caroline Fernandes
Folmer, Vanderlei
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rocha, Kellen Mariane Athaide
Goulart, Aline da Silva
Costa, Márcio Tavares
Salgueiro, Andréia Caroline Fernandes
Folmer, Vanderlei
dc.subject.por.fl_str_mv Neurodegeneración, diabetes mellitus tipo 2, resistencia a la insulina, estrés oxidativo, neuroinflamación, hiperglucemia, cerebro.
Neurodegeneração
Diabetes mellitus tipo 2
Resistência à insulina
Estresse oxidativo
Neuroinflamação
Hiperglicemia
Cérebro.
Neurodegeneration
Type 2 diabetes mellitus
Insulin resistance
Oxidative stress
Neuroinflammation
Hyperglycemia
Brain.
topic Neurodegeneración, diabetes mellitus tipo 2, resistencia a la insulina, estrés oxidativo, neuroinflamación, hiperglucemia, cerebro.
Neurodegeneração
Diabetes mellitus tipo 2
Resistência à insulina
Estresse oxidativo
Neuroinflamação
Hiperglicemia
Cérebro.
Neurodegeneration
Type 2 diabetes mellitus
Insulin resistance
Oxidative stress
Neuroinflammation
Hyperglycemia
Brain.
description Currently, one of the most significant health problems is the increased incidence of obesity and type 2 Diabetes mellitus (DM2). The most recent epidemiological and clinical research studies have indicated that low physical activity, as well as many genetic and environmental factors are the main causes of these metabolic disorders. It is widely recognized that insulin resistance plays a key role in the development of DM2, disrupting not only the functioning of peripheral tissues, but also the brain. Insulin plays a critical role in the central nervous system participating in neuronal survival, neuroplasticity, memory and cognitive functions. In addition, peripheral insulin resistance results in loss of brain function, which indicates a strong relationship between metabolic disorders, cognitive impairment and the emergence of neurodegenerative diseases. There are links between these different pathologies, such as increased oxidative stress, neuroinflammation, changes in glucose metabolism as well as insulin resistance. Advances in the knowledge of these links may contribute to the development of treatments for the prevention of these pathological events. Based on the above, this study aimed to review the mechanisms associated with DM2 in the development of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/11673
10.33448/rsd-v10i1.11673
url https://rsdjournal.org/index.php/rsd/article/view/11673
identifier_str_mv 10.33448/rsd-v10i1.11673
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/11673/10449
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 1; e23410111673
Research, Society and Development; Vol. 10 Núm. 1; e23410111673
Research, Society and Development; v. 10 n. 1; e23410111673
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052641161773056

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